JP5684702B2 - 関節形成術を受ける関節のコンピュータモデルを生成する際の画像セグメント化のための方法 - Google Patents
関節形成術を受ける関節のコンピュータモデルを生成する際の画像セグメント化のための方法 Download PDFInfo
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Description
本出願は、2008年4月30日出願の米国仮特許出願第61/126,102号「関節形成術を受ける関節のコンピュータモデルを生成する際の画像セグメント化のためのシステムおよび方法」の優先権を主張し、かつ、2009年4月14日出願(速達便番号第EV681 612 934 US)の米国非仮特許出願第12/______号「関節形成術を受ける関節のコンピュータモデルを生成する際の画像セグメント化のためのシステムおよび方法」の優先権を主張する。これらの出願はどちらも、その全体が参照によって本明細書に組み込まれる。
本発明は、画像セグメント化に関する。特に、本発明は、関節形成術を受ける関節のコンピュータモデルを生成する際の画像セグメント化に関し、そのコンピュータモデルは関節形成術用ジグを設計および製造する際に使用可能である。
∇f(x、y、z)=(∂f/∂x,∂f/∂y,∂f/∂z)
Claims (36)
- 1つの骨の画像を複数の領域に区分する方法であって、
前記1つの骨の複数の体積画像スライスを獲得する行為と、
前記骨の異なる範囲にわたって選択的な解像度を利用する行為と、
前記骨に関連する複数のスプライン曲線を生成する行為と、
前記複数のスプライン曲線の少なくとも1つが前記骨の表面に追従することを検証する行為と、
前記複数のスプライン曲線の前記少なくとも1つに基づいて三次元(3D)メッシュ表示を作成する行為とを備える方法。 - 前記複数のスライスの間の均一な間隔が2ミリメートルである、請求項1に記載の方法。
- 前記複数のスライスが矢状方向、横断方向または冠状方向である、請求項1に記載の方法。
- 前記体積画像スライスが第2の骨と接触する骨の部分を表す、請求項1に記載の方法。
- 前記複数の画像スライス中の少なくとも1つの画像スライスが、ボクセル体積平均化を通じて歪んだボクセルを含む、請求項1に記載の方法。
- 前記複数のスプライン曲線が前記骨の形状および方向を定義する、請求項1に記載の方法。
- 本方法が前記骨の設計モデルを生じる、請求項1に記載の方法。
- 前記検証する行為が、前記複数の画像スライス中の隣接する画像スライスを検査する行為を備える、請求項1に記載の方法。
- 1つの骨の画像を複数の領域に区分する方法であって、
前記1つの骨の複数の体積画像スライスを獲得する行為と、
前記骨の異なる領域にわたって選択的な解像度を利用する行為と、
前記骨に関連する複数のスプライン曲線を生成する行為と、
前記複数のスプライン曲線の少なくとも1つが前記骨の表面に追従することを検証する行為と、
前記複数のスプライン曲線の前記少なくとも1つに基づいて三次元(3D)メッシュ表示を作成する行為と、
骨モデルの表示を前記骨の前記画像に統合する行為と、を備える方法。 - 前記骨モデルの前記表示が損傷のある海綿質または骨質を有さない、請求項9に記載の方法。
- 骨モデルの表示を生成する方法であって、
複数のスライスとして前記表示の画像スキャンを獲得する行為と、
1つ以上のセグメント化曲線を使用して前記複数のスライス中の各スライスをセグメント化する行為と、
前記表示のメッシュを生成するステップと、
連続する画像スキャンの間で前記骨の境界範囲が安定している範囲を含むように前記複数のスライス中の各スライスを調整する行為と、
アンカーセグメント化が前記骨モデルの前記表示の境界に追従するように前記アンカーセグメント化を生成する行為とを備える方法。 - 前記セグメント化する行為が、前記骨モデルの前記表示に関連する軟骨のセグメント化を除外する、請求項11に記載の方法。
- 前記画像スキャンを獲得する前記行為が磁気共鳴映像法(MRI)の使用を通じて行われる、請求項11に記載の方法。
- 前記骨モデルの前記表示の少なくとも一部が2つのセグメント化曲線の間に存在する、請求項11に記載の方法。
- ガウス平滑化が利用される、請求項11に記載の方法。
- 前記骨モデルの前記表示の前記境界が皮質骨と海綿質骨との間の境界を備える、請求項11に記載の方法。
- さらに、複数の皮質および海綿質の境界範囲を互いに接続してアンカーセグメント化を獲得する行為を備える、請求項11に記載の方法。
- 前記複数の皮質および海綿質の境界が解体している、請求項17に記載の方法。
- 少なくとも1つの海綿質ボクセルが前記アンカーセグメント化の内部にあり少なくとも1つの皮質ボクセルが前記アンカーセグメント化の外部にある、請求項11に記載の方法。
- 骨増殖体が前記アンカーセグメント化から除外される、請求項11に記載の方法。
- 少なくとも1つの皮質ボクセルが前記骨モデルの前記表示の前記境界に沿っており、少なくとも1つの海綿質ボクセルが前記骨モデルの前記表示の前記境界に隣接している、請求項11に記載の方法。
- さらに、前記骨モデルの前記表示を表す3Dメッシュを生成する行為を備える、請求項11に記載の方法。
- さらに、隣接するセグメント化曲線の点の配置を比較することによって、前記1つ以上のセグメント化曲線上の点を再配置する行為を備える、請求項11に記載の方法。
- 骨モデルの表示を使用して目標骨をセグメント化する方法であって、
前記表示のセグメント化された形を前記目標骨の画像スキャンに位置合わせする行為と、
前記目標骨の境界の近くの前記表示の前記セグメント化された形の前記位置合わせを改良する行為と、
前記表示の前記セグメント化された形からメッシュを生成する行為と、
前記メッシュと前記目標骨の前記画像スキャンからの1つ以上のスライスとの交点に近似する複数のスプライン曲線を生成する行為とを備える方法。 - 前記方法が関節に対して実行される、請求項24に記載の方法。
- さらに、1つ以上のスライスに変換を適用する行為を備える、請求項24に記載の方法。
- 前記変換を適用する前記行為が、複数のスライスを横切らずに前記スライスの平面内で点を移動させる行為を含む、請求項26に記載の方法。
- 改良する前記行為が、隣接するスライスの1つ以上のボクセルを平均する行為を備える、請求項24に記載の方法。
- さらに、前記複数のスプライン曲線の少なくとも1つが前記目標骨の表面に追従することを検証する行為を備える、請求項24に記載の方法。
- 検証する前記行為が、少なくとも2つの隣接するスライスを比較する行為を備える、請求項29に記載の方法。
- 骨モデルの表示から目標骨への位置合わせを改良するための方法であって、
アンカーセグメント化メッシュを変換する行為と、
前記変換されたアンカーセグメント化メッシュの周囲の複数の無作為点を生成する行為と、
前記複数の点の中の各点が、インダーク−アウトライト、インライト−アウトダーク、またはダーク−イン−ライトといったメッシュの1つ以上の内部にあるかを決定する行為と、
前記複数の点の1つ以上が前記変換されたアンカーセグメント化メッシュの表面の閾値距離内にあるか否かを決定する行為と、
前記点が前記インダーク−アウトライト、インライト−アウトダーク、またはダーク−イン−ライトメッシュ内にあるか否かに応じて、かつ前記点が前記変換されたアンカーセグメント化メッシュの内部または外部にあるかを決定するため、前記複数の点の中の各点を暗い点または明るい点として追加する行為とを備える方法。 - 前記複数の点が画像スライス内にある、請求項31に記載の方法。
- 前記各点が閾値距離内にあるかを決定する行為が、
前記アンカーセグメント化メッシュを各画像スライスと交差させる行為と、
前記アンカーセグメント化と交差する前記画像スライスの1つ以上のピクセルに注意する行為と、
前記閾値外の前記1つ以上のピクセルをフィルタリングする行為とを備える、請求項31に記載の方法。 - 前記フィルタリングする行為が膨張フィルタを使用して行われる、請求項33に記載の方法。
- 前記閾値距離が0.75ミリメートルである、請求項31に記載の方法。
- 前記変換する行為が1つ以上のスプライン曲線を生成する行為を備える、請求項31に記載の方法。
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US12610208P | 2008-04-30 | 2008-04-30 | |
US61/126,102 | 2008-04-30 | ||
US12/386,105 US8311306B2 (en) | 2008-04-30 | 2009-04-14 | System and method for image segmentation in generating computer models of a joint to undergo arthroplasty |
US12/386,105 | 2009-04-14 | ||
PCT/US2009/040629 WO2009134620A2 (en) | 2008-04-30 | 2009-04-15 | System and method for image segmentation in generating computer models of a joint to undergo arthroplasty |
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US8735773B2 (en) | 2007-02-14 | 2014-05-27 | Conformis, Inc. | Implant device and method for manufacture |
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WO2009134620A3 (en) | 2009-12-30 |
AU2009241518B2 (en) | 2013-07-18 |
CA2721762A1 (en) | 2009-11-05 |
TW200950745A (en) | 2009-12-16 |
US20090274350A1 (en) | 2009-11-05 |
JP2011519605A (ja) | 2011-07-14 |
AU2009241518A1 (en) | 2009-11-05 |
US20130039551A1 (en) | 2013-02-14 |
EP2281265A2 (en) | 2011-02-09 |
EP3327626A1 (en) | 2018-05-30 |
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