JP5613559B2 - オーラルケア配合物における、モノ−、ジ−及びポリオールアルコキシレートホスフェートエステル、及びその使用方法 - Google Patents
オーラルケア配合物における、モノ−、ジ−及びポリオールアルコキシレートホスフェートエステル、及びその使用方法 Download PDFInfo
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- JP5613559B2 JP5613559B2 JP2010512336A JP2010512336A JP5613559B2 JP 5613559 B2 JP5613559 B2 JP 5613559B2 JP 2010512336 A JP2010512336 A JP 2010512336A JP 2010512336 A JP2010512336 A JP 2010512336A JP 5613559 B2 JP5613559 B2 JP 5613559B2
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- oral care
- care composition
- composition according
- organophosphorus
- water
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- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229960000581 salicylamide Drugs 0.000 description 1
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
- 229950000975 salicylanilide Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000001296 salvia officinalis l. Substances 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229940045919 sodium polymetaphosphate Drugs 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- QHGNHLZPVBIIPX-UHFFFAOYSA-N tin(ii) oxide Chemical class [Sn]=O QHGNHLZPVBIIPX-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- VVGOCOMZRGWHPI-UHFFFAOYSA-N trans-hept-4-enal Natural products CCC=CCCC=O VVGOCOMZRGWHPI-UHFFFAOYSA-N 0.000 description 1
- AYNNSCRYTDRFCP-UHFFFAOYSA-N triazene Chemical group NN=N AYNNSCRYTDRFCP-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- PQGFRBOHUKOXQZ-FSCNPAMSSA-J tris[[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl]oxy]stannyl (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Sn+4].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PQGFRBOHUKOXQZ-FSCNPAMSSA-J 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- 229910001930 tungsten oxide Inorganic materials 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/90—Antigen-antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/901—Electrodepositable compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/901—Electrodepositable compositions
- Y10S524/902—Electrostatic spray
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
本出願は、2007年6月12日に出願された米国仮出願第60/943,490号の利益を主張し、参照により、その全体を本明細書に援用する。
本出願は、歯磨き剤及び他のオーラルケア製品に有用な組成物に関する。特に、本発明は、モノアルキル及びジアルキルホスフェートエステルの水溶性塩から本質的に成る界面活性剤を含むオーラルケア組成物に関する。本発明は、疎水性材料並びに親水性材料に関するこれらの表面の付着特性を変えるための、表面改質剤としての、モノ−、ジ−及びポリオールホスフェートエステルを含むオーラルケア配合物を含む。
(a)艶出剤(研磨剤)、起泡剤(sudsing agent)(界面活性剤)、バインダー、保湿剤、薬剤、過酸化物供給源、重炭酸アルカリ金属(alkali metal bicarbonate salt)、増粘材料、水、二酸化チタン、香味剤、甘味剤、キシリトール、着色剤、水及びそれらの混合物から成る群から選択される、少なくとも1種の成分約10%〜約99%;及び
(b)下記を含む、イオン性親水化(hydrophilizing)剤;
(b)(I)下記から選択される有機リン材料:
(b)(I)(1)次の構造(I)に従う有機リン化合物:
各R1及び各R2は、独立して、存在しないか又はOであるが、R1及びR2の少なくとも一方はOであり、
各R3は、独立して、所望により、アルキレンオキシ又はポリ(アルキレンオキシ)基の1つ又は2つ以上の炭素原子上に、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール又はアリールオキシにより置換されてもよいアルキレンオキシ又はポリ(アルキレンオキシ)であり、
R5及び各R4は、独立して、存在しないか、あるいは所望により、アルキレンオキシ又はポリ(アルキレンオキシ)基の1つ又は2つ以上の炭素原子上に、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール又はアリールオキシにより置換されてもよいアルキレンオキシ又はポリ(アルキレンオキシ)であり、
R6及びR8は、それぞれ、そして各R7は、独立して、H若しくは(C1〜C30)炭化水素、又は−POR9R10であり、上記炭化水素は、1つ若しくは2つ以上の炭素原子上に、ヒドロキシル、フッ素、アルキル、アルケニル若しくはアリールにより所望により置換されていてもよく、そして/又は1若しくは2以上の位置のところで、O,N若しくはSヘテロ原子により所望により割り込まれてもよく、
R9及びR10は、それぞれ独立して、ヒドロキシル、アルコキシ、アリールオキシ又は(C1〜C30)炭化水素であり、上記炭化水素は、1つ若しくは2つ以上の炭素原子上に、ヒドロキシル、フッ素、アルキル、アルケニル若しくはアリールで所望により置換されていてもよく、そして/又は1若しくは2以上の位置において、O,N若しくはSヘテロ原子により割り込まれてもよく、そして
mは、1〜5の整数である);
(b)(I)(2)構造(I)に従う有機リン化合物の塩;
(b)(I)(3)構造(I)に従う1種又は2種以上の有機リン化合物の2又は3以上の分子の縮合反応生成物;及び
(b)(I)(4) (b)(I)(1)、(b)(I)(2)及び(b)(I)(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物を含む混合物;
(b)(II)下記から選択されるビニルアルコール材料;
(b)(II)(1)次の構造(I−a)に従うモノマー単位を含むポリマー:
(b)(II)(3)1種又は2種以上のポリマー(b)(II)(1)の2又は3以上の分子の反応生成物:並びに
(b)(II)(4) (b)(II)(1)、(b)(II)(2)及び(b)(II)(3)の、2又は3以上の、ポリマー、塩及び/又は反応生成物を含む混合物。
本発明はまた、有機リン材料、研磨剤(艶出剤)及び所望による液体を含む歯清浄製品に関する。
(a)本明細書に記載される有機リン材料を含む、抗汚染薬剤;
(b)アルコール:及び
(c)水:
を含む口内洗浄剤を提供する。
cos(θ)*γlv=γsv−γsl
(接触角θ、固相及び気相の間の界面エネルギーγsv、固相及び液相の間の界面エネルギーγsl、及び液相及び気相の間の界面エネルギーγlv、そしてγsvは、固体の表面エネルギーを表す)
を用いて見積もられる。
オーラルケア用組成物は、多種多様の製品、例えば、練り歯磨き、口内洗浄剤及びリンスを含む。
本発明は、界面活性剤と、下記から選択される有機リン材料を含む親水化剤とを含むオーラルケア組成物を含む;
(1)次の構造(I)に従う有機リン化合物:
各R1及び各R2は、独立して、存在しないか又はOであるが、R1及びR2の少なくとも一方はOであり、
各R3は、独立して、所望により、アルキレンオキシ又はポリ(アルキレンオキシ)基の1つ又は2つ以上の炭素原子上に、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール又はアリールオキシにより置換されてもよいアルキレンオキシ又はポリ(アルキレンオキシ)であり、
R5及び各R4は、独立して、存在しないか、あるいは所望により、アルキレンオキシ又はポリ(アルキレンオキシ)基の1つ又は2つ以上の炭素原子上に、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール又はアリールオキシにより置換されてもよいアルキレンオキシ又はポリ(アルキレンオキシ)であり、
R6及びR8は、それぞれ、そして各R7は、独立して、H若しくは(C1〜C30)炭化水素、又は−POR9R10であり、上記炭化水素は、1つ若しくは2つ以上の炭素原子上に、ヒドロキシル、フッ素、アルキル、アルケニル若しくはアリールにより所望により置換されていてもよく、そして/又は1若しくは2以上の位置のところで、O,N若しくはSヘテロ原子により所望により割り込まれてもよく、
R9及びR10は、それぞれ独立して、ヒドロキシル、アルコキシ、アリールオキシ又は(C1〜C30)炭化水素であり、上記炭化水素は、1つ若しくは2つ以上の炭素原子上に、ヒドロキシル、フッ素、アルキル、アルケニル若しくはアリールで所望により置換されていてもよく、そして/又は1若しくは2以上の位置において、O,N若しくはSヘテロ原子により割り込まれてもよく、そして
mは、1〜5の整数である);
(2)構造(I)に従う有機リン化合物の塩;
(3)構造(I)に従う1種又は2種以上の有機リン化合物の2又は3以上の分子の縮合反応生成物:並びに
(4) (1)、(2)及び(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物。
本明細書において、用語「アルコキシル」は、アルキル基で置換されているオキシ基、例えば、メトキシル、エトキシル、プロポキシル、イソプロポキシル、又はブトキシルを意味する(所望により、上記基の1つ又は2つ以上の炭素原子上で、さらに置換されていてもよい)。
本明細書において、用語「アルケニル」は、1又は2以上の炭素−炭素二重結合を含む、不飽和の直鎖、分岐鎖又は環式の炭化水素基、例えば、エテニル、1−プロペニル又は2−プロペニル(所望により、上記基の1つ又は2つ以上の炭素原子上で、置換されていてもよい)を意味する。
実施形態の一つでは、R6及びR8は、それぞれ、そして各R7は、独立して、H、(C1〜C30)アルキル、(C1〜C30)アルケニル又は(C7〜C30)アルカリルである。
(II)(1)次の構造(II)に従う有機ホスフェートエステル:
(II)(2)構造(II)に従う有機リン化合物の塩;
(II)(3)構造(II)に従う1種又は2種以上の有機リン化合物の2つ又は3つ以上の分子の縮合反応生成物:並びに
(II)(4) (II)(1)、(II)(2)及び(II)(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物。
(III)(1)次の構造(III)に従う有機ホスホネートエステル:
(III)(2)構造(III)に従う有機リン化合物の塩;
(III)(3)構造(III)に従う1種又は2種以上の有機リン化合物の2つ又は3つ以上の分子の縮合反応生成物:並びに
(III)(4)(III)(1)、(III)(2)及び(III)(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物。
(IV)(1)次の構造(IV)に従う有機ホスホネートエステル:
(IV)(2)構造(IV)に従う有機リン化合物の塩;
(IV)(3)構造(IV)に従う1種又は2種以上の有機リン化合物の2つ又は3つ以上の分子の縮合反応生成物:並びに
(IV)(4) (IV)(1)、(IV)(2)及び(IV)(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物。
各R12及び各R13は、独立して、H、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール、アリールオキシであるか、又は隣接する炭素原子と結合している2つのR12基が縮合して、それらが結合している炭素原子と共に、(C6〜C8)炭化水素環を形成し、
R20は、H、ヒドロキシル、アルキル、ヒドロキシアルキル、アルコキシ、アルケニル、アリール又はアリールオキシであり、
R22は、ヒドロキシル又はヒドロキシアルキルであるが、R20及びR22は、それぞれ、ヒドロキシルではない、
R23及びR21は、それぞれ独立して、メチレン又はポリ(メチレン)であり、
p,p’,p’’,q,及びxは、それぞれ独立して、2〜5の整数であり、
各r,s,r’,r’’及びyは、独立して、0〜25の数であるが、r及びsの少なくとも一方は0ではない、
uは、2〜10の整数であり、
v及びwは、それぞれ、1〜25の数であり、そして
t,t’,及びt’’は、それぞれ、1〜25の数であるが、
数(r+s)×tの積が約100以下であり、数(v+r’)×t’の積が約100以下であり、そして数(w+r’’)×t’’の積が約100以下である)。
実施形態の一つでは、各R3は、独立して、構造(V)、(VI)又は(VII)に従う2価基(式中、R12、R13、R20、R21、R22、R23,p,p’,p’’,q,r,r’,r’’,s,t,t’’,t,u,v,w,x,及びyは、上述の通りであり、そしてR4及びR5は、それぞれ独立して、存在しないか又はR3である)である。
R6及びR8は、それぞれ、そして各R7は、独立して、H若しくは(C1〜C30)炭化水素、又は−POR9R10であり、上記炭化水素は、1つ若しくは2つ以上の炭素原子上に、ヒドロキシル、フッ素、アルキル、アルケニル若しくはアリールにより所望により置換されていてもよく、そして/又は1若しくは2以上の位置のところで、O,N若しくはSヘテロ原子により所望により割り込まれてもよく、さらに典型的には、R6、R8及び各R7は、それぞれ、Hであり、
R4及びR5は、それぞれ、存在せず、
各R3は、独立して、構造(V)、(VI)又は(VII)に従う2価基であり、そして
mは、1〜5の整数である。
R6、R8及び各R7は、それぞれ、Hであり、
R4及びR5は、それぞれ、存在せず、
各R3は、独立して、構造(V)に従う2価基であり、
各pは、独立して、2、3又は4であり、さらに典型的には、2又は3であり、
各rは、独立して、1〜約100の数、さらに典型的には2〜約50の数であり、
各sは、0であり、
各tは、1であり、及び
mは、1〜5の整数である。
(X)(1)次の構造(IX)に従う有機リン化合物:
pは、2、3又は4であり、さらに典型的には2又は3であり、
rは、4〜約50の数である);
(IX)(2)構造(IX)に従う有機リン化合物の塩:並びに
(IX)(3) (IX)(1)及び(IX)(2)の、2種又は3種以上の、化合物及び/又は塩を含む混合物。
R6、R8及び各R7は、それぞれ、Hであり、
R4及びR5は、それぞれ、存在せず、
各R3は、独立して、構造(VI)に従う2価基であり、
R12基が縮合して、それらが結合している炭素原子を含む、(C6〜C8)炭化水素環を形成し、
各R13は、Hであり、
p’は、2又は3であり、
uは、2であり、
vは、1であり、
r’は、1〜25の数であり、
t’は、1〜25の数であり、
数(v+r’)×t’の積が、約100以下であり、そして
mは、1〜5の整数である。
R6、R8及び各R7は、それぞれ、Hであり、
R4及びR5は、それぞれ、存在せず、
各R3は、独立して、構造(VII)に従う2価基であり、
R20は、ヒドロキシル又はヒドロキシアルキルであり、
R22は、H、アルキル、ヒドロキシル又はヒドロキシアルキルであり、
R23及びR21は、それぞれ独立して、メチレン、ジ(メチレン)又はトリ(メチレン)であり、
wは、1又は2であり、
p’’は、2又は3であり、
r’’は、1〜25の数であり、
t’’は、1〜25の数であり、
数(w+r’’)×t’’の積が、約100以下であり、そして
mは、1〜5の整数である。
実施形態の一つでは、有機リン材料(b)(I)は、構造(I)に従う2つ又は3つ以上の分子の縮合反応生成物を含む。
に従う直鎖の縮合反応生成物を含む。
例示的な架橋された縮合反応生成物網目の一部を、次の構造(XI):
R1、R2、R4、R5、R6、R7、R8及びmは、それぞれ、上述の通りであり、そして
各R3’は、独立して、構造(I)に従う化合物のR3基の残差であり、R3基は、アルキレンオキシ又はポリ(アルキレンオキシ)部分の1つ又は2つ以上の炭素原子上に、ヒドロキシル−、ヒドロキシアルキル−、ヒドロキシアルキレンオキシ−又はヒドロキシポリ(アルキレンオキシ)−により置換されたアルキレンオキシ又はポリ(アルキレンオキシ)部分であり、そして−R3’−R4−及び−R3’−R5−は、それぞれ、R3基と、構造(I)に従う化合物の別の分子の−R3’−R5−又はR8−R5−基との縮合により形成された結合を表す)
により具体的に説明される。
実施形態の一つでは、有機リン材料(b)(I)は、構造(I)に従う有機リン化合物に由来するアニオン(例えば、ヒドロキシル又はヒドロキシアルキル置換基の脱プロトン化)と、塩基に由来する1又は2以上の正に帯電した対イオンとを含む塩の状態にある。
実施形態の一つでは、上記カチオンは、一価のカチオン、例えば、Na+又はK+である。
実施形態の一つでは、上記オーラルケア製品は、親水化材料として、ビニルアルコール材料(b)(II)を含む。
改良された水への溶解性及び改良された加工性を提示する実施形態の一つでは、上記ビニルアルコール材料(b)(II)は、構造(I−a)に従うモノマー単位を含むポリマー(「ビニルアルコールポリマー」)を含む。
実施形態の一つでは、上記ビニルアルコールポリマーは、構造(I−a)に従うモノマー単位から単に成るビニルアルコールホモポリマーである。
実施形態の一つでは、構造(I−a)に従うモノマー単位を含むポリマーは、ランダムコポリマーである。別の実施形態では、構造(I−a)に従うモノマー単位を含むコポリマーは、ブロックコポリマーである。
別の実施形態では、上記ビニルアルコールポリマーは、水性反応媒体内で、1種又は2種以上の界面活性剤の存在下で、エマルション重合技法により製造される。
実施形態の一つでは、上記ビニルアルコール材料は、ビニルアルコールポリマーの塩、例えば、ナトリウム又はカリウム塩を含む。
本明細書に記載される有機リン材料はまた、様々なオーラルケア製品で用いられうる。本発明に従う組成物は、任意の形態で提供されることができ、そして複数の方式で用いられうる。従って、本発明に従う組成物は、ペースト、ゲル又は液体の状態であることができる。例えば、上記有機リン材料は、練り歯磨き(例えば、米国特許第5,939,052号明細書に記載されるもの)、及び口内洗浄剤(例えば、米国特許第6,767,560号明細書に記載されるもの)、及び他の歯磨き剤(例えば、米国特許出願公開第2004/0185207号明細書に記載されるもの)内で用いられることができる(このパラグラフで論じた各文献を参照することにより、本明細書に援用する)。
上記組成物のpH、又は本発明に従う組成物の使用のpHは、用途によって変わりうる。上記組成物のpHは重要ではなく、そして約2〜約12、好ましくは約4〜約10、そして最も好ましくは約6〜約8の範囲内にあることができる。上記pHは、緩衝剤、例えば、クエン酸を用いて調整することができる。
上記組成物は、所望によるすすぎの後、歯の表面に堆積されたホスフェートエステルの量が、処理された表面の、典型的には0.0001〜10mg/m2、例えば、0.001〜5mg/m2となるような量で用いられうる。
本発明の有機リン材料に加えて、本発明のオーラルケア製品、例えば、口内洗浄剤、チューインガム、可溶性のオーラルケアストリップ(LISTERINE(商標)オーラルケアストリップと同様)、舐剤及び練り歯磨きは、添加剤成分を含む。上記製品に対するさらなる背景技術は、1998年3月6日に出願され、国際公開第98/38973号として公開されたPCT出願番号PCT/US98/04474号明細書、並びに米国特許第6,864,314号明細書に提供される(参照により、その全体を本明細書に援用する)。
研磨艶出材料がまた、上記練り歯磨き組成物に含まれうる。本発明の組成物中で用いることが企図される研磨艶出材料は、象牙質を過度に研磨しない任意の材料であることができる。典型的な研磨艶出材料には、シリカ、例えば、シリカゲル及び沈降シリカ;アルミナ;ホスフェート、例えば、無機オルトホスフェート、ピロホスフェート、メタホスフェート、ポリホスフェート及びヘキサメタホスフェート;及びそれらの混合物が含まれる。具体例には、オルトリン酸二カルシウム二水和物、ピロリン酸カルシウム、トリリン酸カルシウム、ポリメタリン酸カルシウム、不溶性ポリメタリン酸ナトリウム、アルミナ水和物、β−ピロリン酸カルシウム、炭酸カルシウム及び樹脂研磨材、例えば、ウレア及びホルムアルデヒドの粒子状の縮合生成物、並びにその他、例えば、1962年12月25日に発行された、Cooleyらによる米国特許第3,070,510号明細書(参照により、本明細書に援用する)に開示されるものが含まれる。研磨剤の混合物をまた用いることができる。
保湿剤はまた、オーラルケア製品、例えば、練り歯磨き又はゲルに望ましい成分である。上記保湿剤は、一般的に、上記オーラルケア組成物の約0重量%〜85重量%、そして好ましくは約15重量%〜55重量%を構成する。好ましくは、練り歯磨き又はゲルにおいて、上記保湿剤は、上記配合物の約5重量%〜約85重量%、そして好ましくは上記配合物の約10重量%〜約70重量%を構成する。屈折率が重要な検討材料である半透明ゲルでは、不透明なペーストよりも、水に対する保湿剤の高い割合を用いることが好ましい。ゲルにおいて、保湿剤:水の割合は、好ましくは0.5:1を超え、そしてさらに好ましくは、1:1を超える。
抗う蝕剤をまた、本発明に従う組成物と共に用いることができる。従って、本発明のオーラルケア組成物は、遊離のフッ化物イオンを供給することができる可溶性のフッ化物供給源を導入することができる。例えば、本発明に従う口腔衛生組成物は、口腔ヘルスケア組成物に一般的に用いられるもの、例えば、フッ化ナトリウム、フッ化第一スズ、インジウムフルオリド、モノフルオロリン酸ナトリウム、フッ化亜鉛アンモニウム、フッ化スズアンモニウム、フッ化カルシウム及びコバルトアンモニウムフルオリド等を含むことができる。本発明の組成物は、約50ppm〜約3500ppm、そして好ましくは約500ppm〜約3000ppmの遊離のフッ化物イオンを供給することができる可溶性のフッ化物イオン供給源を含む。フッ化ナトリウムが、最も好ましい可溶性フッ化物イオン供給源である。1960年7月26日に発行されたNorrisらの米国特許第2,946,725号明細書、及び1972年7月18日に発行された、Widderらの米国特許第3,678,154号明細書は、上記フッ化物イオン供給源並びにその他を開示する。両特許を参照し、それら全体を本明細書に援用する。
口腔ヘルスケア組成物用に好適な染料/着色剤、すなわちFD&C Blue #1,FD&C Yellow #10,FD&C Red #40等が含まれる。種々の他の所望による成分、例えば、防腐剤;ビタミン、例えば、ビタミンC及びE;及び他の抗プラーク剤、例えば、第一錫塩、銅塩、ストロンチウム塩及びマグネシウム塩がまた、本発明の組成物中に含まれうる。上記組成物はまた、抗歯石剤、例えば、水溶性のポリホスフェートのアルカリ金属塩、緩衝剤、例えば、オルトリン酸アルカリ金属、リン酸、アルカリ金属グリセロホスフェート、タルトレート、又はシトレート、他の抗う蝕剤、例えば、グリセロリン酸カルシウム、トリメタリン酸ナトリウム;抗汚染化合物、例えば、シリコーンポリマー;植物抽出物;並びにそれらの混合物を含む。さらに、ポリマー、特にアニオン性ポリマー、例えば、ポリカルボキシレート又はポリスルホネート、又はカルボキシレート及びスルホネート部分の両方を含むポリマー、又はホスホネートポリマーを用いることができる。
本発明の組成物は、それぞれ、緩衝剤を含むことができる。本明細書において、緩衝剤は、上記組成物を、pH約6.5〜pH約10に調整するために用いられうる薬剤を指す。これらの薬剤には、アルカリ金属水酸化物、カーボネート、セスキカーボネート、ボラート、シリケート、ホスフェート、イミダゾール、及びそれらの混合物が含まれる。特定の緩衝剤には、モノリン酸ナトリウム、トリリン酸ナトリウム、水酸化ナトリウム、水酸化カリウム、炭酸アルカリ金属塩、炭酸ナトリウム、イミダゾール、ピロホスフェート塩、クエン酸及びクエン酸ナトリウムが含まれる。緩衝剤は、本発明の組成物の約0.1重量%〜約30重量%、好ましくは約1重量%〜約10重量%、そしてさらに好ましくは約1.5重量%〜約3重量%の濃度で用いられる。
上記ピロホスフェート塩は、さらに詳細には、Kirk&Othmer,Encyclopedia of Chemical Technology,Third Edition,Volume 17,Wiley−Interscience Publishers(1982)に記載されている(参照により、Kirk&Othmerに組み込まれている全ての参考文献を含むその全体を、本明細書に援用する)。
練り歯磨き状の本発明の組成物は、望ましい粘稠度を提供するための、いくつかの増粘材料又はバインダーを含むのが典型的である。好ましい増粘剤は、カルボキシビニルポリマー、カラギーナン、ヒドロキシエチルセルロース、及びセルロースエーテルの水溶性塩、例えば、カルボキシルメチルセルロースナトリウム及びヒドロキシエチルセルロースナトリウムである。天然のゴム、例えば、カラヤゴム、キサンタンガム、アラビアゴム、及びトラガカントガムをまた用いることができる。コロイド状のケイ酸アルミニウム・マグネシウム又は微粉化されたシリカを、テクスチャをさらに改良するための増粘剤の一部として用いることができる。増粘剤は、上記歯磨き剤組成物の約0.1重量%〜約15重量%の量で用いられうる。
商業的に好適な口腔組成物の調製時に用いられる水は、好ましくは、低いイオン含有率を有し、そして有機系不純物を含まないべきである。水は、本明細書における組成物の、一般的には約5重量%〜約70重量%、そして好ましくは約10重量%〜約50重量を構成することができる。水の量には、遊離の水+他の材料、例えば、ソルビトール、シリカ、界面活性剤溶液、及び/又は着色溶液と共に導入された水が含まれる。
本発明は、上記組成物中に過酸化物供給源を含むことができる。上記過酸化物供給源は、過酸化水素、過酸化カルシウム、過酸化尿素、及びそれらの混合物から成る群から選択されうる。好ましい過酸化物供給源は、過酸化カルシウムである。下記の量は、過酸化物原材料の量を表すが、上記過酸化物供給源は、上記過酸化物原材料以外の成分を含むことができる。本発明の組成物は、上記歯磨き剤組成物の約0.01重量%〜約10重量%、好ましくは約0.1重量%〜約5重量%、さらに好ましくは約0.2重量%〜約3重量%、そして最も好ましくは約0.3重量%〜約0.8重量%の過酸化物供給源を含むことができる。
本発明はまた、重炭酸アルカリ金属を含むことができる。重炭酸アルカリ金属は、水に可溶であり、安定化されていない限り、水性系に二酸化炭素を放出する傾向がある。重曹としても知られる重炭酸ナトリウムはまた、好ましい重炭酸アルカリ金属である。上記重炭酸アルカリ金属はまた、緩衝材として作用する。本発明の組成物は、上記歯磨き剤組成物の約0.5重量%〜約50重量%、好ましくは約0.5重量%〜約30重量%、さらに好ましくは約2重量%〜約20重量%、そして最も好ましくは約5重量%〜約18重量%の重炭酸アルカリ金属を含むことができる。
本発明の組成物はまた、一般的に気泡剤と称される、界面活性剤を含むことができる。上記界面活性剤は、適度に安定であり、そして広いpH範囲の全体で気泡するものであることが好ましい。上記界面活性剤は、アニオン性、非イオン性、両性、双極性、カチオン性、又はそれらの混合物であることができる。本明細書において有用なアニオン性界面活性剤は、アルキル基内に8〜20個の炭素原子を有するアルキルスルフェートの水溶性塩(例えば、アルキル硫酸ナトリウム)と、8〜20個の炭素原子を有する脂肪酸のスルホン化モノグリセリドの水溶性塩とを含む。ラウリル硫酸ナトリウム及びココナッツモノグリセリドスルホン酸ナトリウムが、この種のアニオン性界面活性剤の例である。他の好適なアニオン性界面活性剤は、サルコシネート(sarcosinate)、例えば、ラウロイルサルコシンナトリウム(sodium lauroyl sarcosinate)、タウレート、ラウリルスルホ酢酸ナトリウム、ラウロイルイセチオン酸ナトリウム、ラウレス(laureth)カルボン酸ナトリウム、及びドデシルベンゼンスルホン酸ナトリウムである。アニオン性界面活性剤の混合物をまた用いることができる。複数の好適なアニオン性界面活性剤は、1976年5月25日に発行された、Agricolaらの米国特許第3,959,458号明細書(参照により、本明細書に援用する)に開示されている。
二酸化チタンをまた、本発明の組成物に添加することができる。二酸化チタンは、上記組成物に不透明性を付与する白色粉末である。二酸化チタンは、一般的に、上記組成物の約0.25重量%〜約5重量%を構成する。
他の着色剤をまた、本発明の組成物に添加することができる。上記着色剤は、水性溶液、好ましくは水溶液中の1%着色剤の状態であることができる。着色溶液は、一般的に、上記組成物の約0.01重量%〜約5重量%を構成する。
香味システムをまた、上記組成物に添加することができる。好適な香味料成分には、ウィンターグリーンのオイル、ペパーミントのオイル、スペアミントのオイル、クローブ・バドオイル(clove bud oil)、メントール、アネトール、メチルサリチレート、オイカリプトール、カッシア、1−メンチルアセテート、セージ、オイゲノール、パセリオイル、オキサノン(oxanone)、α−イオノン(irisone)、マヨラナ、レモン、オレンジ、プロペニルグアエトール(guaethol)、桂皮、バニリン、エチルバニリン、ヘリオトロピン、4−cis−ヘプテナール、ジアセチル、メチル−para−tert−ブチルフェニルアセテート、及びそれらの混合物が含まれる。クーラントがまた、上記香味システムの一部であることができる。本発明の組成物における好ましいクーラントは、パラメンタンカルボキシアミド油薬剤、例えば、N−エチル−p−メンタン−3−カルボキサミド(「WS−3」として市販されている)及びそれらの混合物である。香味システムは、上記組成物の約0.001重量%〜約5重量%の濃度で、上記組成物中で用いられるのが一般的である。
本発明はまた、他の薬剤、例えば、抗菌薬及び抗微生物薬を含むことができる。好適な抗菌薬には、フェノール類及びサリチルアミドが含まれる。
この例では、卵殻(歯の置換物として)を、緑茶/紅茶汚染物を用いて汚染した。
図1は、市販の練り歯磨きを用いてブラシをかけ、次いで、緑茶(左)及び紅茶(右)で汚染し、次いで市販の練り歯磨きを用いてさらにブラシをかけた卵殻の写真を示す。これは、茶汚染物を除去しなかった。
図5は、CaCO3結晶(歯の追加の置換物として)上の純粋な脱イオン水の下、ヘキサデカンの液滴を示す。図7は、図5のうち、接触角を示す標識を付したものである。図7は、接触角が60°〜80°であることを示している。
Claims (21)
- 下記を含むオーラルケア組成物;
(a)艶出剤(研磨剤)、起泡剤(界面活性剤)、バインダー、保湿剤、薬剤、過酸化物供給源、重炭酸アルカリ金属塩、増粘材料、水、二酸化チタン、香味剤、甘味剤、キシリトール、着色剤、水及びそれらの混合物から成る群から選択される、10%〜99%の、少なくとも1種の成分;及び
(b)下記より選ばれる有機リン化合物を含む、有効量の抗汚染薬剤:
(b)(I)(1)次の構造(I)で表される有機リン化合物:
各R1及び各R2は、Oであり、
各R3は、-(CpH2pO)r-であり、ここで各pは独立して2、3又は4であり、rは1〜100の整数であり、
R5及び各R4は、存在せず、
R6、R7及びR8は、Hであり、そして
mは、1〜5の整数である);
(b)(I)(2)構造(I)で表される有機リン化合物の塩;
(b)(I)(3)構造(I)で表される1種又は2種以上の有機リン化合物の2又は3以上の分子の縮合反応生成物:又は
(b)(I)(4) (b)(I)(1)、(b)(I)(2)及び(b)(I)(3)の、2種又は3種以上の、化合物、塩及び/又は反応生成物を含む混合物。 - 緩衝剤として、炭酸ナトリウムをさらに含む、請求項1又は2に記載のオーラルケア組成物。
- シリカ、アルミナ、ホスフェート、オルトホスフェート、ポリメタホスフェート、β−ピロリン酸カルシウム、炭酸カルシウム、及びそれらの混合物から成る群から選択される研磨艶出材料、並びに水をさらに含む、請求項1〜3のいずれか一項に記載のオーラルケア組成物。
- 0.01%〜10%の過酸化物供給源を含む、請求項1〜4のいずれか一項に記載のオーラルケア組成物。
- 前記有機リン材料が、液状キャリア中に存在する、請求項1〜5のいずれか一項に記載のオーラルケア組成物。
- 前記有機リン材料、界面活性剤、研磨剤及び所望による液体を含む歯清浄製品である、請求項1〜6のいずれか一項に記載のオーラルケア組成物。
- 前記研磨剤が、ケイ酸、コロイダルシリカ、ヒュームドシリカ、不溶性メタリン酸ナトリウム、不溶性アルミノケイ酸ナトリウム、重炭酸ナトリウム、又はそれらの混合物の1種又は2種以上を含む研磨剤系である、請求項7に記載のオーラルケア組成物。
- 前記歯清浄製品が、練り歯磨き又は歯清浄ゲルである、請求項7又は8に記載のオーラルケア組成物。
- 前記歯清浄製品が、少なくとも0.5:1の、保湿剤:水の比を有する半透明ゲルである、請求項7〜9のいずれか一項に記載のオーラルケア組成物。
- 有効量の前記有機リン材料と、20重量%〜95重量%の艶出剤とを含む歯磨き粉である、請求項1〜6のいずれか一項に記載のオーラルケア組成物。
- 歯から汚染物を除去するために有効な量の有機リン材料;アルコール;保湿剤;及び水を含む口内洗浄剤である、請求項1〜6のいずれか一項に記載のオーラルケア組成物。
- 1種又は2種以上の、着香剤、甘味剤、抗歯石剤、抗う蝕剤、緩衝剤、又は加工助剤をさらに含む、請求項12に記載のオーラルケア組成物。
- mが、2〜5の整数である、請求項1〜13のいずれか一項に記載のオーラルケア組成物。
- 前記有機リン材料が、構造(I)で表される1種又は2種以上の有機リン化合物の2又は3以上の分子の縮合反応生成物より選ばれる、請求項1記載のオーラルケア組成物。
- 前記ビニルアルコール材料が50,000〜200,000の重量平均分子量及び少なくとも88%の加水分解度を有する、請求項2記載のオーラルケア組成物。
- 請求項1〜6のいずれか一項に記載のオーラルケア組成物を含む、チューインガム。
- 請求項1〜6のいずれか一項に記載のオーラルケア組成物を含む、オーラルケアストリップ。
- 請求項1〜6のいずれか一項に記載のオーラルケア組成物を含む、舐剤。
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-
2008
- 2008-06-12 US US12/137,647 patent/US7550419B2/en active Active
- 2008-06-12 CN CN2008800199836A patent/CN101677933B/zh not_active Expired - Fee Related
- 2008-06-12 EP EP08770773.3A patent/EP2164455B1/en not_active Not-in-force
- 2008-06-12 AU AU2008266172A patent/AU2008266172B2/en not_active Ceased
- 2008-06-12 JP JP2010512336A patent/JP5613559B2/ja not_active Expired - Fee Related
- 2008-06-12 CA CA2690744A patent/CA2690744A1/en not_active Abandoned
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US7550419B2 (en) | 2009-06-23 |
AU2008266172A1 (en) | 2008-12-24 |
US20090238775A1 (en) | 2009-09-24 |
US8263049B2 (en) | 2012-09-11 |
US7919073B2 (en) | 2011-04-05 |
EP2164455A1 (en) | 2010-03-24 |
US20110177012A1 (en) | 2011-07-21 |
CN101677933B (zh) | 2013-07-17 |
AU2008266172B2 (en) | 2014-04-17 |
JP2010529207A (ja) | 2010-08-26 |
US20080311055A1 (en) | 2008-12-18 |
WO2008157197A1 (en) | 2008-12-24 |
CA2690744A1 (en) | 2008-12-24 |
CN101677933A (zh) | 2010-03-24 |
EP2164455B1 (en) | 2018-08-15 |
EP2164455A4 (en) | 2015-08-26 |
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