JP5578302B2 - 組成物 - Google Patents
組成物 Download PDFInfo
- Publication number
- JP5578302B2 JP5578302B2 JP2008260691A JP2008260691A JP5578302B2 JP 5578302 B2 JP5578302 B2 JP 5578302B2 JP 2008260691 A JP2008260691 A JP 2008260691A JP 2008260691 A JP2008260691 A JP 2008260691A JP 5578302 B2 JP5578302 B2 JP 5578302B2
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- JP
- Japan
- Prior art keywords
- parts
- substituted cyclohexene
- food
- extract
- ginger
- Prior art date
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Landscapes
- Medicines Containing Plant Substances (AREA)
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Description
3位の絶対配置がR及び/又はS配置であって4位の絶対配置がR及び/又はS配置である化合物を指し、
3位と4位の立体配置がトランスを示す下記式(2)で表される置換シクロヘキセン
ジャワショウガの乾燥物5kgを粉砕機で粉砕してジャワショウガ粉末4.7kgを得た。
バングレ5kgの裁断物をメタノール40Lに2週間浸漬し、抽出液を減圧濃縮乾固してバングレエキスを350g得た。
実施例2のバングレエキス(23.9g)を水/酢酸エチルで分配し、酢酸エチル層を減圧下溶媒留去して20.1gを得、シリカゲルカラムクロマトグラフィー(溶出液:ヘキサン/酢酸エチル=3:2)により、10個のフラクションに分画した。フラクション6(1.585g)を逆相(ODS)カラムクロマトグラフィー(溶出液:80%メタノール)により8個のフラクションに分画した。フラクション6(307mg)をシリカゲルカラムクロマトグラフィー(溶出液:塩化メチレン/酢酸エチル=19:1)により8個のフラクションに分画した。フラクション2(69mg)をシリカゲルカラムクロマトグラフィー(溶出液:ヘキサン/酢酸エチル=7:3)により4個のフラクションに分画した。フラクション3(58mg)を逆相(ODS)カラムクロマトグラフィー(溶出液:90%メタノール)により分離精製して化合物2(33mg)、化合物3(18mg)及び化合物4(1mg)を得た。
ラット副腎髄質褐色細胞PC12を、ラット尾由来コラーゲンでコーティングされた培養フラスコ内の10%HS、5%FBS及び1%ペニシリン−ストレプトマシン含有DMEM培地中、湿度95%、二酸化炭素5%、37℃環境下のインキュベーター内で培養後、PC12細胞を単離した。この細胞(2000細胞/cm2)をコラーゲンコーティング48ウエルプレートの各ウエルに播種し、10%HS、5%FBS含有DMEM培地中24時間同環境下のインキュベーター内で培養した後、試料を含む2%HS、1%FBS含有DMEM培地に交換した。同環境下96時間培養後、細胞形態を顕微鏡観察して突起の伸展を確認及び写真撮影した。試料調製は、実施例2で製造したバングレエキスの場合20mgを50%エタノールに溶解し、実施例3で単離した化合物の場合50%エタノールに溶解後培地で100倍希釈、又はDMSOに溶解後培地で1000倍希釈して行った。陽性対照にはNGF10ng/mLを使用した。
実施例2のバングレエキス100g、デキストリン(マックス1000、松谷化学製)100g、乳糖200g及びステアリン酸マグネシウム2gを混合し、本混合物を単発式打錠機で打錠し、直径8mm、重量200mgの錠剤(バングレエキス99mg含有)を製造した。
実施例2のバングレエキス100g、コーンスターチ30g、アビセル20g及びりん酸一水素カルシウム10gを混合し、本混合物をゼラチンカプセルに充填して硬カプセルを製造した。
実施例2のバングレエキス1部、グラニュー糖280部、水飴210部、クエン酸5部、香料1部及び色素1部を配合してキャンディーを製造した。本キャンディーの味は良好であった。
実施例2のバングレエキス1部、冷凍濃縮温州みかん果汁25部、果糖ブドウ糖液糖55部、クエン酸1部、L−アスコルビン酸0.1部、香料1部、色素0.5部及び水400部を配合してジュースを製造した。本ジュースはみかんの風味や色に変化がなかった。
実施例2のバングレエキス1部、チューインガムベース300部、ショ糖800部、水飴300部、軟化剤60、香料13部及び色素1部を配合してチューインガムを製造した。本チューインガムの味は良好であった。
実施例2のバングレエキス1部、チョコレート220部、ショ糖75、カカオバター100部及び全脂粉乳100部を配合してチョコレートを製造した。配合されたバングレエキスがチョコレートの風味や色に影響を与えることはなく、美味しいものであった。
実施例1のジャワショウガ粉末1部、薄力粉2.3部、全卵1.6部、マーガリン1.9部、上白糖2.5部、ベーキングパウダー0.02及び水0.73部を配合してクッキーを製造した。本クッキーは風味がよく、味は良好であった。
実施例1のジャワショウガ粉末1部、餅粉5部、食塩0.1部及び水6部を配合しておかきを製造した。本おかきは風味が良く、良好な味であった。
実施例1のジャワショウガ粉末1部、薄力粉2部、全卵1部、牛乳1部、食塩0.05部、バニラエッセンス適量及び水2部を配合してクレープを製造した。本クレープは良好な風味と味を有していた。
ジャワショウガ8kgに水2kgを加えながら粉砕機で粉砕後、更に超音波破砕機で微粉末状にしてジャワショウガペースト10kgを得た。
実施例13のジャワショウガペースト1部に水2部を加えて混合してジュースを製造した。本ジュースは風味がよく、美味しいものであった。
実施例1のジャワショウガ粉末1部、ミートミール2.4部、チキンエキス0.35部、植物油脂0.3部、炭水化物1.2部、炭酸カルシウム0.03部、食塩0.01部、複合ビタミン剤0.05部及び水0.6部を配合してドッグフードを製造した。
Claims (6)
- 神経細胞突起伸展するための下記式(1)で表される置換シクロヘキセンを有効成分として含有してなることを特徴とする組成物
- 前記置換シクロヘキセンの式(1)中のR1、R2及びR3がメトキシ基でありR4が水酸基又はメトキシ基であることを特徴とする請求項1記載の組成物
- 前記置換シクロヘキセンの原料がショウガ科の植物であることを特徴とする請求項1記載の組成物
- 前記ショウガ科の植物がジャワショウガであることを特徴とする請求項3記載の組成物
- 神経細胞突起伸展するための下記式(1)で表される置換シクロヘキセンを有効成分として含有する組成物を添加してなることを特徴とする飲食品
- 神経細胞突起伸展するための下記式(1)で表される置換シクロヘキセンを有効成分として含有する組成物を添加してなることを特徴とする神経疾患用の予防及び治療剤
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