JP5552670B2 - 抗酸化物質のセンサ、検出方法、および組成物 - Google Patents
抗酸化物質のセンサ、検出方法、および組成物 Download PDFInfo
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- JP5552670B2 JP5552670B2 JP2010176855A JP2010176855A JP5552670B2 JP 5552670 B2 JP5552670 B2 JP 5552670B2 JP 2010176855 A JP2010176855 A JP 2010176855A JP 2010176855 A JP2010176855 A JP 2010176855A JP 5552670 B2 JP5552670 B2 JP 5552670B2
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- antioxidant
- supplement
- tocopherol
- orac
- oxygen
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K36/18—Magnoliophyta (angiosperms)
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- G01F1/56—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects
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Description
AUCBLNKは、ブランク曲線下面積値であって、
AUCTRLXは、Trolox(登録商標)の曲線下面積値であって、
SMPは、試料である。
本発明の栄養補助食品では、世界各地域の長寿人々の飲食物に顕著な5つの成分をそれぞれ、抗酸化組成物へと組み合わされる。本発明者は、長寿で知られる地域における飲食物の広範囲な研究に基づき、成分を選択した。本発明者は、これら地域での飲食物がフラボノールおよびトコフェロールを多く含むことを認識した。本発明者は、さらに、ある種の天然化合物が、抗酸化活性を再活性化させるビタミンCなどの分子と好適に相互作用することも認識した。実際、広範囲にわたる研究では、ビタミンCがαトコフェロールなどの再生で果たす役割を裏付けている(PizzornoおよびMurray、Textbook of Natural Medicine、1999、第2版、New York、Churchill Livingston)。
ORAC(o)アッセイが親油性抗酸化活性および疎油性抗酸化活性の双方を検出可能であることを示すため、既知濃度の親油性抗酸化物質および疎油性抗酸化物質の特定の組み合わせの効果に関する、さらに例えばブドウ種抽出物および緑茶抽出物それぞれ単独での場合と比較しつつ、ブドウ種抽出物および緑茶抽出物を加えることによる前記効果の増強とに関する一連の研究が行われた。図15は、異なる比のケルセチンおよび混合トコフェロールにより得られたORAC(o)値を示したグラフである。図16は、異なる比のブドウ種抽出物(grape seed extract、略称GES)および緑茶抽出物(green tea extract、略称GTE)についてORAC(o)値を示したグラフである。GSEおよびGTEの抗酸化活性に関する最大比を決定した後、これら2つを、ケルセチンおよび混合トコフェロールについて最適化した比で組み合わせた。図17は、ケルセチン:混合トコフェロールと、ブドウ種抽出物および緑茶抽出物との最大比の組み合わせについて、ORAC(o)値を示したグラフである。これにより、ケルセチンおよび混合トコフェロールの組み合わせと、GSEと、GTEとが、栄養補助食品の抗酸化能を最大化することがわかった。
抗酸化物質は、生体基質の酸化を遅延または防止できる任意の物質と定義される。抗酸化物質を含有する果物および野菜を多く含んだ飲食物は、酸化ストレスが原因と考えられる病理疾患の発生減少に関与すると考えられてきた。但し、単離した抗酸化化合物を補給しても、一部のケースでは健康改善に効果が見られないことが多く、他のケースでは危険でさえある。果物および野菜を多く摂取することによる抗酸化物質の利点は、必ずしも単一の抗酸化物質から来るものではなく、むしろこれらの食品に存在する異なる抗酸化物質の組み合わせの協動作用から来るものであることが示唆されている。この単一抗酸化物質の重視により、抗酸化物質に富んだ飲食物の保護効果を科学者がいまだ栄養補給剤で再現できない理由が説明できると考えられる。
Claims (20)
- 抗酸化物質栄養補助食品であって、
単離および精製された疎油性抗酸化物質と単離および精製された親油性抗酸化物質とを10:90、15:85、30:70、40:60、60:40、70:30、85:15または90:10の割合で有し、さらに、
ビタミンCを有する植物源であって、前記植物源はオーストラリアブッシュプラム(Australian bush plum、学名:Terminalia ferdinandiana)であり、前記疎油性抗酸化物質と前記親油性抗酸化物質と前記植物源との重量に対して15〜70重量%である、前記植物源を有し、
前記疎油性抗酸化物質および前記親油性抗酸化物質は、合わせて6,000μMol Trolox(登録商標)等量(Trolox Equivalent、略称TE)/グラムより大きい溶存酸素値を含有するものである
抗酸化物質栄養補助食品。 - 請求項1記載の補助食品において、前記疎油性抗酸化物質および前記親油性抗酸化物質は、時限放出されるものである、補助食品。
- 請求項1記載の補助食品において、前記親油性抗酸化物質は、α(アルファ)トコフェロールと、β(ベータ)トコフェロールと、δ(デルタ)トコフェロールと、ε(イプシロン)トコフェロールと、γ(ガンマ)トコフェロールと、ζ(ゼータ)トコフェロールと、η(イータ)トコフェロールと、ξ1(クサイ1)トコフェロールと、ξ2(クサイ2)トコフェロールと、σ(シグマ)トコフェロールと、αトコトリエノールと、βトコトリエノールと、δトコトリエノールと、γトコトリエノールと、これらの類縁体と、これらの薬理上許容される塩と、これらの組み合わせからなる群から選択される1若しくはそれ以上のビタミンEからなる群から選択されるものである、補助食品。
- 請求項1記載の補助食品において、前記疎油性抗酸化物質は、ケルセチンと、ケンフェロールと、ミリセチンと、アピゲニンと、これらの誘導体と、類縁体と、薬理上許容される塩と、これらの組み合わせとからなる群から選択されるものである、補助食品。
- 請求項1記載の補助食品において、この補助食品は、さらに、
2若しくはそれ以上の必須糖類を含有するものである、補助食品。 - 請求項1記載の補助食品において、この補助食品は、さらに、
ガラクトースと、ガラクトサミンと、グルコサミンと、グルコースと、マンノースと、アセチル化マンノースと、N−アセチルノイラミン酸と、フコースと、N−アセチルガラクトサミンと、N−アセチルグルコサミンと、キシロースから選択される2若しくはそれ以上の糖類を含有するものである、補助食品。 - 請求項1記載の補助食品において、前記オーストラリアブッシュプラムは、野生のオーストラリアブッシュプラム(Australian bush plum、学名:Terminalia ferdinandiana)を含有するものである、補助食品。
- 請求項1記載の補助食品において、この補助食品は、さらに、
1若しくはそれ以上のプロバイオティックスを含有するものである、補助食品。 - 請求項1記載の補助食品において、この補助食品は、さらに、
乳酸菌種およびビフィドバクテリウム属の種(ビフィズス菌)から選択される1若しくはそれ以上のプロバイオティックスを含有するものである、補助食品。 - 請求項1記載の補助食品において、前記補助食品は、全体的に酸素不浸透性の表面を提供するよう圧縮されるものである、補助食品。
- 請求項1記載の補助食品において、前記補助食品は、ローラー圧縮された粒子か、カプセルか、錠剤か、小型錠剤(mini−tab)か、カプレットか、発泡錠または、これらの組み合わせである、補助食品。
- 請求項1記載の補助食品において、前記疎油性抗酸化物質および前記親油性抗酸化物質は、7000μMol Trolox(登録商標)等量(TE)/グラムより大きい抗酸化物質値を有するものである、補助食品。
- 請求項1記載の補助食品において、この補助食品は、前記単離および精製された親油性抗酸化物質を有し、前記疎油性抗酸化物質および前記親油性抗酸化物質は、患者に与えた場合、ORAC(ベータ−フィコエリトリン)によって測定される患者のベースライン抗酸化物質レベルに13%を超える増加をもたらすものである、補助食品。
- 栄養補助食品であって、
栄養的に有効な量の2若しくはそれ以上の必須糖類と、
単離および精製された疎油性酸素ラジカルクエンチャーと単離および精製された親油性酸素ラジカルクエンチャーとを10:90、15:85、30:70、40:60、60:40、70:30、85:15または90:10の割合で有し、さらに、
ビタミンCを有する植物源であって、前記植物源はオーストラリアブッシュプラム(Australian bush plum、学名:Terminalia ferdinandiana)であり、前記疎油性抗酸化物質と前記親油性抗酸化物質と前記植物源との重量に対して15〜70重量%である、前記植物源を有し、
前記疎油性酸素ラジカルクエンチャーおよび前記親油性酸素ラジカルクエンチャーは、合わせて6,000μMol Trolox(登録商標)等量(TE)/グラムより大きい酸素ラジカルクエンチャー値を有するものである
栄養補助食品。 - 請求項14記載の補助食品において、前記疎油性酸素ラジカルクエンチャーおよび前記親油性酸素ラジカルクエンチャーは、患者に与えた場合、ORAC(ベータ−フィコエリトリン)によって測定される患者のベースライン抗酸化物質レベルに13%を超える増加をもたらすものである、補助食品。
- 請求項14記載の補助食品において、前記疎油性酸素ラジカルクエンチャーおよび前記親油性酸素ラジカルクエンチャーは、徐放用に包装されるものである、補助食品。
- 請求項14記載の補助食品において、前記親油性酸素ラジカルクエンチャーは、α(アルファ)トコフェロールと、β(ベータ)トコフェロールと、δ(デルタ)トコフェロールと、ε(イプシロン)トコフェロールと、γ(ガンマ)トコフェロールと、ζ(ゼータ)トコフェロールと、η(イータ)トコフェロールと、ξ1(クサイ1)トコフェロールと、ξ2(クサイ2)トコフェロールと、σ(シグマ)トコフェロールと、αトコトリエノールと、βトコトリエノールと、δトコトリエノールと、γトコトリエノールと、これらの類縁体と、これらの薬理上許容される塩と、これらの組み合わせからなる群から選択される1若しくはそれ以上のビタミンEからなる群から選択されるものである、補助食品。
- 請求項14記載の補助食品において、前記疎油性酸素ラジカルクエンチャーは、フラボノールと、ケルセチンと、ケンフェロールと、ミリセチンと、アピゲニンと、これらの誘導体と類縁体と薬理上許容される塩と、これらの組み合わせからなる群から選択されるものである、補助食品。
- 請求項14記載の補助食品において、この補助食品は、さらに、
ガラクトースと、グルコースと、マンノースと、N−アセチルノイラミン酸と、フコースと、N−アセチルガラクトサミンと、N−アセチルグルコサミンと、キシロースと、これらの誘導体と類縁体と薬理上許容される塩と、これらの組み合わせからなる群から選択される2若しくはそれ以上の糖類をさらに含有するものである、補助食品。 - 請求項14記載の補助食品において、この補助食品は、さらに、
ガラクトースと、グルコースと、マンノースと、N−アセチルノイラミン酸と、フコースと、N−アセチルガラクトサミンと、N−アセチルグルコサミンと、キシロースと、これらの誘導体と類縁体と薬理上許容される塩と、これらの組み合わせからなる群から選択される6若しくはそれ以上の糖類を含有するものである、補助食品。
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Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050214413A1 (en) * | 2003-08-26 | 2005-09-29 | Mannatech, Inc. | Methods and compositions for modified release of nutritional supplements |
US7999003B2 (en) * | 2003-08-26 | 2011-08-16 | Mannatech, Incorporated | Antioxidant compositions and methods thereto |
US7175862B2 (en) * | 2004-01-28 | 2007-02-13 | Access Business Group International Llc | Method of preparing kakadu plum powder |
KR100686659B1 (ko) * | 2004-02-19 | 2007-02-27 | 너스킨 인터어내셔날 인코포레이팃드 | 바이오 광 피드백 제어 장치 및 방법 |
WO2007039262A1 (en) * | 2005-09-30 | 2007-04-12 | Dsm Ip Assets B.V. | Novel compositions containing polyphenols |
US20070166275A1 (en) * | 2006-01-19 | 2007-07-19 | Mary Kay Inc. | Compositions comprising kakadu plum extract or acai berry extract |
KR20100014799A (ko) * | 2007-01-17 | 2010-02-11 | 엔베쎄 뉴트라쇠틱 비지니스 컨썰팅 | 과일 및 야채를 함유하는 항산화 음식조성물, 그 제조 방법 및 용도 |
WO2008116108A2 (en) * | 2007-03-20 | 2008-09-25 | Pulse Health Llc | Non-invasive human-health-measurement system and method |
CN101720226B (zh) * | 2007-05-11 | 2013-01-30 | 芦荟研究实验室公司 | 用于皮肤增强的芦荟制剂 |
CN101632458A (zh) * | 2008-07-21 | 2010-01-27 | 应维潮 | 生产高orac值的葡萄提取物的方法以及所生产的葡萄提取物 |
KR100996450B1 (ko) * | 2008-08-21 | 2010-11-25 | 한국과학기술연구원 | 표면 플라즈몬 공명의 원리를 이용한 산소센서와 표면 플라즈몬 공명의 원리를 이용한 산소센서가 포함된 산소투과도 측정장치 |
WO2010033034A1 (en) * | 2008-09-19 | 2010-03-25 | Epax As | Antioxidant composition for marine oils comprising tocopherol, rosemary extract, ascorbic acid and green tea extract |
US7833829B2 (en) * | 2008-10-28 | 2010-11-16 | Honeywell International Inc. | MEMS devices and methods of assembling micro electromechanical systems (MEMS) |
FR2937866B1 (fr) | 2008-10-30 | 2010-11-26 | Natura Cosmeticos Sa | Complexe antioxydant, compositions cosmetiques et pharmaceutiques contenant ledit complexe et utilisation dudit complexe |
CN102216318B (zh) * | 2008-11-19 | 2013-09-11 | 森永乳业株式会社 | 抗氧化剂 |
US7897183B2 (en) * | 2008-12-23 | 2011-03-01 | The Dial Corporation | Synergistic antioxidant combinations of herb extracts and methods relating thereto |
US8986748B2 (en) * | 2008-12-23 | 2015-03-24 | The Dial Corporation | Combinations of herb extracts having synergistic antioxidant effect, and methods relating thereto |
US8198091B2 (en) * | 2008-12-24 | 2012-06-12 | Brunswick Laboratories, Llc | Method for assaying the antioxidant capacity of a skin care product |
KR101772139B1 (ko) | 2009-08-28 | 2017-08-28 | 마리 케이 인코포레이티드 | 피부 케어 제형 |
US20110136245A1 (en) * | 2009-10-20 | 2011-06-09 | Parker Tory L | Synergistic interactions of phenolic compounds found in food |
US8551419B2 (en) * | 2010-03-12 | 2013-10-08 | Amcor Limited | Container having an oxygen scavenging indication system |
US8524157B2 (en) * | 2010-03-12 | 2013-09-03 | Amcor Limited | Container having an oxygen scavenging activation system |
US8496885B2 (en) * | 2010-03-12 | 2013-07-30 | Amcor Limited | Container having oxygen scavenging system |
MX343089B (es) | 2010-06-25 | 2016-10-24 | Amcor Ltd | Sistema de depuración de oxígeno para un recipiente. |
US20130203171A1 (en) * | 2010-10-14 | 2013-08-08 | Sportsman Consulting Llc | Analytical method and titration device |
CA2837751C (en) | 2011-02-02 | 2018-01-09 | Justbio Inc. | Functional foods and beverages with synergistic properties to promote homeostasis |
KR101274604B1 (ko) | 2011-07-13 | 2013-06-13 | 매일유업주식회사 | N―아세틸뉴라민산을 포함하는 글리코마크로펩티드 뉴라미니다아제 분해물을 유효성분으로 하는 천연 항균제 조성물 |
CN102507522B (zh) * | 2011-11-07 | 2014-01-29 | 上海智城分析仪器制造有限公司 | 一种氧自由基吸收能力测定分析仪中数据采集方法及加热*** |
RU2486499C1 (ru) * | 2012-04-10 | 2013-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уральский государственный экономический университет" (ФГБОУ ВПО "УрГЭУ") | Способ определения оксидантной/антиоксидантной активности веществ и устройство для его осуществления |
CA2979690A1 (en) | 2015-03-16 | 2016-09-22 | Nature's Sunshine Products, Inc. | Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations |
RU2612132C2 (ru) * | 2015-07-16 | 2017-03-02 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Способ потенциометрического определения скорости генерирования пероксильных радикалов |
EP3717899A4 (en) | 2017-12-01 | 2021-08-04 | MKS Instruments | MULTI-SENSOR GAS SAMPLING DETECTION SYSTEM FOR RADICAL GAS AND SHORT-LIFE MOLECULES AND PROCESS FOR USE |
JP2019113375A (ja) * | 2017-12-22 | 2019-07-11 | サッポロホールディングス株式会社 | 腸内環境評価方法、大腸炎罹患リスク評価方法、及び腸内環境改善物質のスクリーニング方法 |
GB201804837D0 (en) * | 2018-03-26 | 2018-05-09 | Pepsis Ltd | Diagnostic methods in treatments in equine dieases |
CN108613952A (zh) * | 2018-04-14 | 2018-10-02 | 河北工业职业技术学院 | 一种杨梅素的分析测定方法 |
KR102631708B1 (ko) | 2018-06-19 | 2024-01-31 | 삼성전자주식회사 | 항산화 지수 측정 장치 및 방법 |
KR102544670B1 (ko) | 2018-07-27 | 2023-06-16 | 삼성전자주식회사 | 항산화 센서, 항산화 신호 측정 방법 및 항산화 레벨 판단 방법 |
KR102022338B1 (ko) * | 2018-08-06 | 2019-09-18 | 이건무 | 당과 아미노산을 함유하는 안정한 수액제 조성물 |
CN110146454B (zh) * | 2019-05-16 | 2021-07-09 | 江南大学 | 通过构建可分离再生体系验证抗氧化剂间再生作用的方法 |
EP4289417A1 (en) * | 2022-06-08 | 2023-12-13 | Tradichem Industrial Services, S.L. | Process for preparing high-density quercetin |
CN115651761A (zh) * | 2022-10-12 | 2023-01-31 | 中国林业科学研究院林产化学工业研究所 | 基于协同效应延长橄榄油货架期的内源性多酚的添加方法 |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2726689A (en) * | 1953-03-30 | 1955-12-13 | Robert L Busby | Motor attachment device for power tools |
US3585719A (en) * | 1967-10-19 | 1971-06-22 | Stanley Edward Kivela | Power tools |
US4317282A (en) * | 1980-06-30 | 1982-03-02 | Pace Paul D | Wood sanding, grass and wood cutting electric drill attachment device |
US4851224A (en) * | 1986-06-05 | 1989-07-25 | Carrington Laboratories, Inc. | Process for preparation of aloe products |
US4457918A (en) * | 1982-05-12 | 1984-07-03 | The General Hospital Corporation | Glycosides of vitamins A, E and K |
US4521410A (en) * | 1984-05-03 | 1985-06-04 | The General Hospital Corporation | Vitamin D glycosyl orthoesters |
JPS6131095A (ja) | 1984-07-24 | 1986-02-13 | Kazutaka Shinohara | 粘質多糖及びその製造方法 |
SE452776B (sv) | 1986-04-02 | 1987-12-14 | Johansson Hanna Maria E | Forfarande for framstellning av oligosackarider |
FR2601021B2 (fr) * | 1986-07-07 | 1988-11-18 | Pasteur Institut | Fraction immunogene active a l'egard des bilharzioses, sa preparation, compositions immunisantes la contenant |
US5128143A (en) * | 1988-09-19 | 1992-07-07 | Edward Mendell Co., Inc. | Sustained release excipient and tablet formulation |
US4972589A (en) * | 1989-08-31 | 1990-11-27 | Povleski Robert W | Cutting and sanding attachments for a hand drill |
US5202122A (en) * | 1989-10-30 | 1993-04-13 | Humanetics Corporation | Process for enhancing the hypocholesterolemic effect of edible pulp and the product obtained thereby |
US5543514A (en) * | 1989-12-21 | 1996-08-06 | Board Of Regents, The University Of Texas System | Water-soluble sapphyrins |
US5180674A (en) | 1990-04-16 | 1993-01-19 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
SE9003614L (sv) | 1990-11-13 | 1992-05-14 | Kurt G I Nilsson | Kosmetisk produkt |
GB9027131D0 (en) | 1990-12-14 | 1991-02-06 | Rice Evans Catherine | Diagnostic test |
US5578307A (en) * | 1992-01-17 | 1996-11-26 | Alfatec-Pharma Gmbh | Shaped articles containing plant extract(s), in particular pellets, and their pharmaceutical or cosmetic use |
DE4201172C1 (en) * | 1992-01-17 | 1993-07-22 | Alfatec-Pharma Gmbh, 6900 Heidelberg, De | Pellets contg. Aloe vera extract - useful, e.g. as antiinflammatory of antibiotic agents, or for treating gastric ulcers |
KR950001449B1 (ko) * | 1992-07-03 | 1995-02-24 | 풀무원식품주식회사 | 알로에를 주원료로 한 건강보조식품의 제조방법 |
EP0601417A3 (de) * | 1992-12-11 | 1998-07-01 | Hoechst Aktiengesellschaft | Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung |
US5648377A (en) * | 1993-12-21 | 1997-07-15 | Indena S.P.A. | Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals |
IT1265312B1 (it) * | 1993-12-21 | 1996-10-31 | Indena Spa | Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di |
US5928668A (en) * | 1993-12-21 | 1999-07-27 | Applied Analytical Industries, Inc. | Method for dry blend compression of medicaments |
IL109539A0 (en) * | 1994-05-03 | 1994-08-26 | Yissum Res Dev Co | Substained-release pharmaceutical system for the delivery of antioxidants |
US5518590A (en) | 1994-06-21 | 1996-05-21 | Pennzoil Products Company | Electrochemical sensors for motor oils and other lubricants |
ES2194044T3 (es) * | 1994-07-26 | 2003-11-16 | Black & Decker Inc | Herramienta motorizada con sistema de impulsion modular y metodo de montaje del sistema de impulsion modular. |
JPH0840923A (ja) * | 1994-07-28 | 1996-02-13 | Masatoshi Nakano | 栄養補助剤 |
US5569458A (en) * | 1994-09-14 | 1996-10-29 | Greenberg; Mike | Nutritional formula |
DE4444238A1 (de) * | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
FR2729857B1 (fr) * | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
US5849709A (en) * | 1995-05-10 | 1998-12-15 | Glycomed Incorporated | Saccharopeptides and derivatives thereof |
US6063403A (en) | 1995-06-22 | 2000-05-16 | Akzo Nobel N.V. | Compressed dry-granulation desogestrel tablets |
JP3510717B2 (ja) * | 1995-09-29 | 2004-03-29 | 三栄源エフ・エフ・アイ株式会社 | 活性酸素・フリーラジカル消去活性を有する飲食品 |
US6638415B1 (en) * | 1995-11-16 | 2003-10-28 | Lifescan, Inc. | Antioxidant sensor |
US6929807B1 (en) * | 1996-08-09 | 2005-08-16 | Mannatech, Inc. | Compositions of plant carbohydrates as dietary supplements |
IL128335A0 (en) * | 1996-08-09 | 2000-01-31 | Mannatech Inc | Compositions of plant carbohydrates as dietary supplements |
US6086910A (en) | 1997-09-19 | 2000-07-11 | The Howard Foundation | Food supplements |
US6642277B1 (en) * | 1996-09-20 | 2003-11-04 | The Howard Foundation | Food supplements containing polyphenols |
US6632349B1 (en) * | 1996-11-15 | 2003-10-14 | Lifescan, Inc. | Hemoglobin sensor |
US6177260B1 (en) | 1997-07-11 | 2001-01-23 | The Hong Kong Polytechnic University | Measurement of antioxidant (reducing) power and/or antioxidant concentration |
US6500456B1 (en) * | 1997-10-03 | 2002-12-31 | Warner-Lambert Company | Compressed nitroglycerin tablet and its method of manufacture |
US6114177A (en) | 1997-11-12 | 2000-09-05 | Phytochem Technologies, Inc. | Fluorometric assay for measurement of antioxidant activity |
US6429021B1 (en) | 1998-03-19 | 2002-08-06 | Amway Corporation | Antioxidant activity profile assay |
FR2780647B1 (fr) | 1998-07-03 | 2002-03-08 | Lanatech | Composition cosmetique exploitant des effets antiradicalaires synergiques |
IT1302307B1 (it) | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
US6036403A (en) * | 1998-09-03 | 2000-03-14 | Raytheon Company | Cable burial system |
DE19846148C2 (de) | 1998-10-01 | 2002-10-10 | Igor Popov | Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität |
US6258846B1 (en) * | 1999-06-01 | 2001-07-10 | Drugtech Corporation | Nutritional supplements |
US6048260A (en) * | 1999-07-01 | 2000-04-11 | Roto-Zip Tool Corporation | Angle attachment for power tool |
US6805880B1 (en) | 1999-08-20 | 2004-10-19 | Ferrosan A/S | Pharmaceutical delivery system for vitamin C and vitamin E and use of a combination of vitamin C and E for preventing or treating conditions involving oxidative stress |
US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
WO2001026670A1 (fr) * | 1999-10-14 | 2001-04-19 | The Nisshin Oil Mills, Ltd. | Agents de soin de la peau, agents anti-ages pour la peau, agents de blanchiment de la peau et preparations pour la peau, a usage externe |
US6291533B1 (en) * | 1999-12-22 | 2001-09-18 | Vitamerica, Inc. | Dietary supplements for each specific blood type |
US6680070B1 (en) * | 2000-01-18 | 2004-01-20 | Albemarle Corporation | Particulate blends and compacted products formed therefrom, and the preparation thereof |
US7115297B2 (en) * | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
US7416749B2 (en) * | 2000-06-12 | 2008-08-26 | Access Business Group International Llc | Dietary supplement and related method |
AU2002218748A1 (en) * | 2000-07-10 | 2002-01-21 | The University Of Mississippi | High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity |
JP3589623B2 (ja) * | 2000-07-13 | 2004-11-17 | 独立行政法人 科学技術振興機構 | 飲食品の抗酸化成分の分離方法 |
US6444115B1 (en) * | 2000-07-14 | 2002-09-03 | Lifescan, Inc. | Electrochemical method for measuring chemical reaction rates |
AU7319701A (en) * | 2000-07-14 | 2002-01-30 | Usf Filtration & Separations | Electrochemical method for measuring chemical reaction rates |
JP2004515508A (ja) * | 2000-12-16 | 2004-05-27 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 化合物の健康促進組成物 |
US6759395B2 (en) * | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
US20040220118A1 (en) * | 2001-02-02 | 2004-11-04 | Bland Jeffrey S. | Medical composition for balancing bodily processes |
US20020192314A1 (en) * | 2001-03-06 | 2002-12-19 | Cho Suk H. | Dietary supplement compositions |
US20020182736A1 (en) | 2001-04-02 | 2002-12-05 | Trustees Of Tufts College | Methods to measure lipid antioxidant activity |
CA2401452A1 (en) * | 2001-09-04 | 2003-03-04 | Uri Saragovi | Combination of antioxidant substances for the treatment of alzheimer's disease |
WO2003074067A1 (en) * | 2002-03-01 | 2003-09-12 | Stoner Gary D | Compositions of and derived from strawberry and raspberry and therapeutic uses therefor |
US20090011048A1 (en) * | 2002-04-16 | 2009-01-08 | Coleman Henry D | Dietary Supplement For Promoting Removal Of Heavy Metals From The Body |
US7067150B2 (en) * | 2002-04-16 | 2006-06-27 | Scepter Holdings, Inc. | Delivery systems for functional ingredients |
JP2004251870A (ja) * | 2003-02-20 | 2004-09-09 | Miriona Keshohin:Kk | 化学発光法による抗酸化能の総合的評価法 |
US20040258674A1 (en) * | 2003-04-10 | 2004-12-23 | Thunder Jalili | Quercetin supplementation to treat hypertenstion |
US7999003B2 (en) * | 2003-08-26 | 2011-08-16 | Mannatech, Incorporated | Antioxidant compositions and methods thereto |
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