JP5542665B2 - マトリックス型経皮投与剤およびその製造方法 - Google Patents
マトリックス型経皮投与剤およびその製造方法 Download PDFInfo
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- JP5542665B2 JP5542665B2 JP2010511118A JP2010511118A JP5542665B2 JP 5542665 B2 JP5542665 B2 JP 5542665B2 JP 2010511118 A JP2010511118 A JP 2010511118A JP 2010511118 A JP2010511118 A JP 2010511118A JP 5542665 B2 JP5542665 B2 JP 5542665B2
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- JP
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- Prior art keywords
- layer
- capsaicin
- matrix
- weight
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Description
<実施例1〜11>
Claims (10)
- 薬物保護層;
第1粘着層、薬物含有層、および第2粘着層のそれぞれの層の全成分を合わせた総重量を基準に、非水溶性アクリル系高分子を含む粘着剤20〜75重量%、非イオン性界面活性剤0〜19.9重量%、600ダルトン以下の分子量を有するアルコール0〜29重量%、および親水性高分子を含む溶解補助剤0〜19.9重量%を含み、カプサイシンまたはカプサイシン誘導体を含まない、前記薬物保護層上に形成される第1粘着層;
カプサイシンまたはカプサイシン誘導体0.1〜25重量%、非イオン性界面活性剤0〜15重量%、600ダルトン以下の分子量を有するアルコール0〜30重量%、および親水性高分子を含む溶解補助剤0〜20重量%を含み、前記第1粘着層上に形成される薬物含有層;
非水溶性アクリル系高分子を含む粘着剤20〜75重量%、非イオン性界面活性剤0〜20重量%、600ダルトン以下の分子量を有するアルコール0〜29重量%、および親水性高分子を含む溶解補助剤0〜19.9重量%を含み、カプサイシンまたはカプサイシン誘導体を含まない、前記薬物含有層上に形成される第2粘着層;および
前記第2粘着層上に形成される剥離層;を含み、
前記カプサイシンまたはカプサイシン誘導体が、カプサイシン、ジヒドロカプサイシン、ノルジヒドロカプサイシン、ホモジヒドロカプサイシン、ホモカプサイシン、カプサゼピン、N−バニリルノナンアミド、(Z)−カプサイシン、(E)−カプサイシン、および6−ヨードノルジヒドロカプサイシンからなる群より選択される一つの物質または二つ以上の混合物であり、
前記非水溶性アクリル系高分子が、2−エチルヘキシルアクリレート、ビニルアクリレート、およびビニルアクリル酸からなる群より選択される一つ以上の単量体が重合した単一重合体または共重合体を含むものであり、
前記アルコールが、プロピレングリコールであり、
前記非イオン性界面活性剤が、ソルビタンモノラウレート、およびソルビタンモノオレエート、からなる群より選択される一つの物質または二つの混合物であり、
前記親水性高分子が、ポリビニルピロリドン、およびコロイド状二酸化ケイ素、からなる群より選択される一つの物質または二つの混合物である、
ことを特徴とする、マトリックス型経皮投与剤。 - 前記薬物保護層は、ポリエステル、ポリウレタン、ポリエチレン、もしくはレーヨンからなるフィルムまたは不織布を含むことを特徴とする、請求項1に記載のマトリックス型経皮投与剤。
- 前記アルコールは、第1粘着層:薬物含有層:第2粘着層に1:1〜6:0.5〜3の重量比で含まれることを特徴とする、請求項1に記載のマトリックス型経皮投与剤。
- 前記非イオン性界面活性剤は、第1粘着層:薬物含有層:第2粘着層に1:0〜1:0.5〜2の重量比で含まれることを特徴とする、請求項1に記載のマトリックス型経皮投与剤。
- 前記溶解補助剤は、第1粘着層:薬物含有層:第2粘着層に1:0〜1:0.2〜5の重量比で含まれることを特徴とする、請求項1に記載のマトリックス型経皮投与剤。
- 薬物保護層および剥離層上にそれぞれ非水溶性アクリル系高分子を含む粘着剤を含む粘着溶液を塗布する工程;
塗布された粘着溶液を乾燥する工程;
前記薬物保護層または剥離層上に塗布された粘着溶液上に、カプサイシンまたはカプサイシン誘導体、親水性高分子を含む溶解補助剤、および600ダルトン以下の分子量を有するアルコールを塗布する工程;および
前記粘着溶液が塗布された面が互いに向き合うように前記薬物保護層と剥離層を接着する工程;を含むことを特徴とする、請求項1に記載のマトリックス型経皮投与剤の製造方法。 - 前記薬物保護層または剥離層の少なくとも一つの層上に、非イオン性界面活性剤、600ダルトン以下の分子量を有するアルコール、またはこれらの混合物をさらに含む粘着溶液を塗布することを特徴とする、請求項6に記載のマトリックス型経皮投与剤の製造方法。
- 前記薬物保護層または剥離層の少なくとも一つの層上に、親水性高分子を含む溶解補助剤をさらに含む粘着溶液を塗布することを特徴とする、請求項6または7に記載のマトリックス型経皮投与剤の製造方法。
- 前記剥離層上に、前記粘着剤、前記非イオン性界面活性剤、前記アルコール、および前記溶解補助剤を含む粘着溶液を塗布することを特徴とする、請求項8に記載のマトリックス型経皮投与剤の製造方法。
- 前記薬物保護層上に、前記粘着剤、前記非イオン性界面活性剤、前記アルコール、および前記溶解補助剤を含む粘着溶液を塗布することを特徴とする、請求項9に記載のマトリックス型経皮投与剤の製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2007-0056299 | 2007-06-08 | ||
KR20070056299 | 2007-06-08 | ||
PCT/KR2008/003166 WO2008150120A1 (en) | 2007-06-08 | 2008-06-05 | Matrix-type transdermal drug delivery system and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010529116A JP2010529116A (ja) | 2010-08-26 |
JP5542665B2 true JP5542665B2 (ja) | 2014-07-09 |
Family
ID=40093869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010511118A Expired - Fee Related JP5542665B2 (ja) | 2007-06-08 | 2008-06-05 | マトリックス型経皮投与剤およびその製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8404277B2 (ja) |
EP (1) | EP2155175B1 (ja) |
JP (1) | JP5542665B2 (ja) |
KR (1) | KR101000945B1 (ja) |
CN (1) | CN101677969B (ja) |
AU (1) | AU2008260774B2 (ja) |
BR (1) | BRPI0812368A2 (ja) |
CA (1) | CA2688294C (ja) |
WO (1) | WO2008150120A1 (ja) |
Families Citing this family (13)
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EP2671578A4 (en) * | 2011-01-31 | 2014-04-02 | Nippon Zoki Pharmaceutical Co | PROPHYLACTIC OR THERAPEUTIC MEDICINE FOR PERIPHERAL NEUROPATHY CAUSED BY AN ANTICANCER AGENT |
ES2592530T3 (es) | 2011-06-17 | 2016-11-30 | Fiberweb, Llc | Artículo de múltiples capas permeable al vapor, sustancialmente impermeable al agua |
US10369769B2 (en) | 2011-06-23 | 2019-08-06 | Fiberweb, Inc. | Vapor-permeable, substantially water-impermeable multilayer article |
EP2723568B1 (en) | 2011-06-23 | 2017-09-27 | Fiberweb, LLC | Vapor permeable, substantially water impermeable multilayer article |
WO2012178011A2 (en) | 2011-06-24 | 2012-12-27 | Fiberweb, Inc. | Vapor-permeable, substantially water-impermeable multilayer article |
CN102670566B (zh) * | 2012-01-12 | 2013-08-07 | 河南科技大学 | 一种环糊精衍生物透皮复合膜剂及其制备方法 |
EP3297620A4 (en) * | 2015-06-27 | 2019-01-09 | Shenox Pharmaceuticals, LLC | TRANSDERMAL DELIVERY SYSTEM FOR KETAMINE |
KR101621945B1 (ko) | 2015-07-02 | 2016-05-17 | 주식회사 엘지생활건강 | 이층 구조의 나노 크기 구멍을 가진 마이크로니들 및 이의 제조 방법 |
EA039732B1 (ru) * | 2016-06-27 | 2022-03-04 | Юничарм Корпорейшн | Лист, вызывающий ощущение тепла |
KR101883737B1 (ko) * | 2016-12-26 | 2018-07-31 | (주) 태광직물 | 캡사이신 오일 캡슐을 포함하는 밴딩용 점착제 조성물 및 그를 포함하는 스포츠테이핑용 기능성 밴드 |
KR101880442B1 (ko) * | 2017-02-02 | 2018-07-23 | 대구한의대학교산학협력단 | 혈압 강하용 패치 조성물 |
EP3572141B1 (en) * | 2017-03-17 | 2022-06-22 | Sumitomo Chemical Company, Limited | Gas separation membrane element, gas separation membrane module, and gas separation device |
CN115006379B (zh) * | 2021-12-28 | 2023-12-15 | 南京清普生物科技有限公司 | 一种trpv1激动剂原位膜剂组合物,及其制备方法和用途 |
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-
2008
- 2008-06-05 WO PCT/KR2008/003166 patent/WO2008150120A1/en active Application Filing
- 2008-06-05 AU AU2008260774A patent/AU2008260774B2/en not_active Ceased
- 2008-06-05 CA CA2688294A patent/CA2688294C/en not_active Expired - Fee Related
- 2008-06-05 EP EP08766128.6A patent/EP2155175B1/en not_active Not-in-force
- 2008-06-05 KR KR1020080053294A patent/KR101000945B1/ko not_active IP Right Cessation
- 2008-06-05 JP JP2010511118A patent/JP5542665B2/ja not_active Expired - Fee Related
- 2008-06-05 BR BRPI0812368-3A2A patent/BRPI0812368A2/pt active Search and Examination
- 2008-06-05 US US12/602,256 patent/US8404277B2/en active Active
- 2008-06-05 CN CN2008800193098A patent/CN101677969B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20080108050A (ko) | 2008-12-11 |
US8404277B2 (en) | 2013-03-26 |
CN101677969B (zh) | 2011-12-28 |
KR101000945B1 (ko) | 2010-12-13 |
AU2008260774B2 (en) | 2011-01-06 |
WO2008150120A1 (en) | 2008-12-11 |
EP2155175A4 (en) | 2013-01-23 |
BRPI0812368A2 (pt) | 2015-02-03 |
AU2008260774A1 (en) | 2008-12-11 |
CA2688294A1 (en) | 2008-12-11 |
CN101677969A (zh) | 2010-03-24 |
CA2688294C (en) | 2012-08-07 |
JP2010529116A (ja) | 2010-08-26 |
US20100172946A1 (en) | 2010-07-08 |
EP2155175B1 (en) | 2014-03-12 |
EP2155175A1 (en) | 2010-02-24 |
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