JP5463667B2 - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP5463667B2 JP5463667B2 JP2008329251A JP2008329251A JP5463667B2 JP 5463667 B2 JP5463667 B2 JP 5463667B2 JP 2008329251 A JP2008329251 A JP 2008329251A JP 2008329251 A JP2008329251 A JP 2008329251A JP 5463667 B2 JP5463667 B2 JP 5463667B2
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- Prior art keywords
- extract
- skin
- acid
- plant
- cosmetic
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Landscapes
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Description
Trichosanthes dioicaの葉、Longifolia thwaitesの幹、Mimosa hexandraの全草、Premna integrifoliaの樹皮、Aphanamixis polystachyaの樹皮、Anacyclus、およびpyrethrumの根のそれぞれ100gを粉砕し、それぞれ別々の2リットル容量のガラス容器に入れ、更に50%含水エタノール溶液1000mLを加え混合し、密閉した。室温にて7日間静置した後、ろ過して不溶解物を取り除き、Trichosanthes dioica抽出液、Longifolia thwaites抽出液、Mimosa hexandra抽出液、Premna integrifolia抽出液、Aphanamixis polystachya抽出液、およびAnacyclus pyrethrum抽出液をそれぞれ得た。この抽出液を以降の試験例および実施例において植物抽出物として用いた。
植物抽出物の調製例で得られたTrichosanthes dioica、Longifolia thwaites、Mimosa hexandra、Premna integrifolia、Aphanamixis polystachya、およびAnacyclus pyrethrumの各植物抽出物について、1,1−ジフェニル−2−ピクリル−ヒドラジル(1,1−diphenyl−2−picrylhydrazyl:以下、DPPH)を用いたラジカル消去実験を以下に説明するように行った。
表2の配合成分のうち、成分(1)〜(6)を加熱混合して75℃の混合物1Aを調製し、それとは別に、成分(12)に成分(7)〜(10)を加えて加熱混合して75℃の混合物1Bを調製した。得られた混合物1Aと混合物1Bとを、ホモミキサーを用いて混合乳化し、室温まで放冷することで混合物1Cを調製した。得られた混合物1Cに、成分(11)を均一に混合して外用クリーム剤を得た。
表3の配合成分のうち、成分(1)〜(6)を室温下で混合溶解して混合物2Aを調製し、それとは別に、成分(7)〜(13)を室温下で混合溶解して混合物2Bを調製した。得られた混合物2Aと混合物2Bとを、撹拌機を用いて均一に混合することで化粧水を得た。また、Longifolia thwaites抽出物に代えて精製水を使用すること以外は、実施例7と同様にして比較例2の化粧水を製造した。
表4の配合成分のうち、成分(1)〜(8)を加熱混合して75℃の混合物3Aを調製し、それとは別に、成分(15)に成分(9)〜(13)を加えて加熱混合して75℃の混合物3Bを調製した。得られた混合物3Aと混合物3Bとを、ホモミキサーを用いて混合乳化し、室温まで放冷することで混合物3Cを調製した。得られた混合物3Cに、成分(14)を均一に混合して乳液を得た。また、Mimosa hexandra抽出物に代えて精製水を使用すること以外は、実施例8と同様にして比較例3の乳液を製造した。
表5の配合成分のうち、成分(1)〜(6)を混合しながら70℃に加熱し溶解して混合物4Aを調製し、それとは別に、成分(7)〜(10)を室温下で混合溶解して混合物4Bを調製した。得られた混合物4Aと混合物4Bとを、撹拌機を用いて混合し、室温まで放冷することでパック剤を得た。また、Premna integrifolia抽出物に代えて精製水を使用すること以外は、実施例9と同様にして比較例4のパック剤を製造した。
実施例1〜6または比較例1(実施例1の処方における本発明の植物抽出物を精製水に置換して調製したもの)に示す外用クリームについて、肌荒れ改善効果を以下に説明するように試験評価した。
肌荒れが顕著に認められる女性被験者(25〜60才)40名を半分に2つの群に分け、各群に実施例1および比較例1のそれぞれのクリームを、毎日2回(朝の洗顔の際と夜の入浴後)、3ヶ月にわたって顔に使用してもらい、使用前後の肌荒れ改善の程度を、美容専門技術者が観察し、以下の評価基準に従って評価した。得られた結果を表6に示す。なお、表6中の数字は、当該項目に該当する被験者数である。
評価ランク: 内容
A(有効): 肌荒れが改善された。
B(やや有効): 肌荒れがやや改善された。
C(無効): 肌荒れの改善がみられない。
Claims (4)
- ロンギフリア スワイテス(Longifolia thwaites)の抽出物を配合することを特徴とする抗酸化剤。
- ロンギフリア スワイテス(Longifolia thwaites)の抽出物を配合することを特徴とする皮膚外用剤。
- ロンギフリア スワイテス(Longifolia thwaites)の抽出物を配合することを特徴とする化粧料。
- 請求項3記載の化粧料を皮膚に適用することを特徴とする美容方法。
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