JP5461629B2 - 製剤 - Google Patents
製剤 Download PDFInfo
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- JP5461629B2 JP5461629B2 JP2012166843A JP2012166843A JP5461629B2 JP 5461629 B2 JP5461629 B2 JP 5461629B2 JP 2012166843 A JP2012166843 A JP 2012166843A JP 2012166843 A JP2012166843 A JP 2012166843A JP 5461629 B2 JP5461629 B2 JP 5461629B2
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- JP
- Japan
- Prior art keywords
- capsule
- diphenhydramine
- salt
- active ingredient
- hydroxocobalamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 17
- 238000009472 formulation Methods 0.000 title claims description 9
- 239000007901 soft capsule Substances 0.000 claims description 25
- 239000002775 capsule Substances 0.000 claims description 22
- 239000004480 active ingredient Substances 0.000 claims description 16
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 15
- 229920006037 cross link polymer Polymers 0.000 claims description 15
- BTNNPSLJPBRMLZ-LGMDPLHJSA-N benfotiamine Chemical group C=1C=CC=CC=1C(=O)SC(/CCOP(O)(O)=O)=C(/C)N(C=O)CC1=CN=C(C)N=C1N BTNNPSLJPBRMLZ-LGMDPLHJSA-N 0.000 claims description 11
- 229960002873 benfotiamine Drugs 0.000 claims description 11
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 8
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 claims description 8
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 6
- 229960002477 riboflavin Drugs 0.000 claims description 6
- 235000019192 riboflavin Nutrition 0.000 claims description 6
- 239000002151 riboflavin Substances 0.000 claims description 6
- 239000008157 edible vegetable oil Substances 0.000 claims description 5
- LVFFZQQWIZURIO-UHFFFAOYSA-N 2-phenylbutanedioic acid Chemical compound OC(=O)CC(C(O)=O)C1=CC=CC=C1 LVFFZQQWIZURIO-UHFFFAOYSA-N 0.000 claims description 4
- OHSHFZJLPYLRIP-BMZHGHOISA-M Riboflavin sodium phosphate Chemical compound [Na+].OP(=O)([O-])OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O OHSHFZJLPYLRIP-BMZHGHOISA-M 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 4
- 239000011666 cyanocobalamin Substances 0.000 claims description 4
- 229960002104 cyanocobalamin Drugs 0.000 claims description 4
- 229960001103 hydroxocobalamin Drugs 0.000 claims description 4
- 235000004867 hydroxocobalamin Nutrition 0.000 claims description 4
- 239000011704 hydroxocobalamin Substances 0.000 claims description 4
- 229960005469 hydroxocobalamin acetate Drugs 0.000 claims description 4
- DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 claims description 4
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 claims description 4
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 claims description 4
- 229960001327 pyridoxal phosphate Drugs 0.000 claims description 4
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 4
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 4
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 4
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 4
- MJNIWUJSIGSWKK-BBANNHEPSA-N Riboflavin butyrate Chemical compound CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-BBANNHEPSA-N 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical class C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 28
- 230000000052 comparative effect Effects 0.000 description 19
- 230000004580 weight loss Effects 0.000 description 9
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 8
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 8
- -1 riboflavin butyric acid ester Chemical class 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 235000010724 Wisteria floribunda Nutrition 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000004040 coloring Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229960000520 diphenhydramine Drugs 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000007902 hard capsule Substances 0.000 description 3
- 150000004667 medium chain fatty acids Chemical class 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 201000003152 motion sickness Diseases 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 229940082483 carnauba wax Drugs 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000008162 cooking oil Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 229960002887 deanol Drugs 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical compound C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 108010013480 succinylated gelatin Proteins 0.000 description 1
- 229940007079 succinylated gelatin Drugs 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Description
表1に示した比較例1及び参考例1に示す処方に基づき、各成分をガラス製シャーレーに取り、均一に攪拌混和したものに、耐光試験機(Heraeus社製)を用いて光照射(1000ルクス、1、2、4週間相当)した後に評価した。光照射中の耐光試験機内の最大温度は36℃であった。
表2に示した比較例2及び参考例2〜3に示す処方に基づき、ジフェンヒドラミン塩酸塩以外の各成分をビーカーに量り取り、約70〜80℃の湯せんで加温溶解し、冷後ジフェンヒドラミン塩酸塩を加え、均一に攪拌混和したものに、皮膜シート(基剤としてコハク化ゼラチン、グリセリンを使用)を入れ、それを恒温槽(40℃)に入れ1ヶ月後に皮膜シート状態を評価した。
表3に示した比較例3及び参考例4〜5に示す処方に基づき、ジフェンヒドラミン塩酸塩以外の各成分をビーカーに量り取り、約70〜80℃の湯せんで加温溶解し、冷後ジフェンヒドラミン塩酸塩を加え、均一に攪拌混和したものに、内容物として中鎖脂肪酸トリグリセリドを封入した軟カプセル(基剤としてゼラチン、グリセリンを使用)を入れ、それを恒温槽(40℃)に入れ1ヶ月後に軟カプセルの状態を評価した。
表4に示した比較例4及び参考例6〜7に示す処方に基づき、ジフェンヒドラミン塩以外の各成分をアジホモミクサーM型(特殊機化工業(株)製)に量り取り、約80℃で加温溶解し、冷後ジフェンヒドラミン塩を加え、−0.05MPa以下に減圧しながら均一に攪拌混和したものをソフトカプセル充填機(富士カプセル(株)製)を用い軟カプセル剤を得、それを恒温恒湿庫(40℃、75%RH)に入れ3ヶ月後に評価した。
表5に示した比較例5及び実施例1に示す処方に基づき、ベンフォチアミン、有効成分(X)以外の各成分をアジホモミクサーM型(特殊機化工業(株)製)に量り取り、約80℃で加温溶解し、冷後ベンフォチアミン、有効成分(X)を加え、−0.05MPa以下に減圧しながら均一に攪拌混和したものをソフトカプセル充填機(富士カプセル(株)製)を用い軟カプセル剤を得、それを恒温恒湿庫(40℃、75%RH)に入れ6ヶ月後に評価した。
有効成分(X)は本例では、リボフラビン酪酸エステル、ピリドキシン塩酸塩、d−α−トコフェノール、γ−オリザノール、加工大蒜、シアノコバラミンの6成分からなる混合物である。本実施例が適用される軟カプセル剤等のカプセル剤に充填できる有効成分(X)は、上述の6成分に限らず、dl−α−トコフェロール、dl−α−トコフェロール酢酸エステル等のビタミンEエステル類、リボフラビン、リン酸リボフラビンナトリウム、リン酸ピリドキサール、ヒドロキソコバラミン、ヒドロキソコバラミン酢酸塩、ヒドロキソコバラミン塩酸塩等であっても良く、またそれらの混合物に限らず、それらの単一成分からなるものでも良い。
表6に示した比較例6及び実施例2〜3に示す処方に基づき、ベンフォチアミン、有効成分(X)以外の各成分をアジホモミクサーM型(特殊機化工業(株)製)に量り取り、約80℃で加温溶解し、冷後ベンフォチアミン、有効成分(X)を加え、−0.05MPa以下に減圧しながら均一に攪拌混和したものをソフトカプセル充填機(富士カプセル(株)製)を用い軟カプセル剤を得、それを恒温恒湿庫(40℃、75%RH)に入れ1ヶ月、6ヶ月後に評価した。
有効成分(X)は表5におけると同一であり、本例では表5におけると同様の6成分からなる混合物である。ビニルピロリドンの架橋重合物(S)は粒子径が約10μmであり、ビニルピロリドンの架橋重合物(L)は粒子径が約100μmである。
Claims (2)
- 有効成分と、ビニルピロリドンの架橋重合物及び食用油を含有し、カプセル剤の内容物として用いられることを特徴とする製剤であって、前記有効成分が、ベンフォチアミン、リボフラビン、リボフラビン酪酸エステル、リン酸リボフラビンナトリウム、ピリドキシン塩酸塩、リン酸ピリドキサール、加工大蒜、シアノコバラミン、ヒドロキソコバラミン、ヒドロキソコバラミン酢酸塩、ヒドロキソコバラミン塩酸塩、アスコルビン酸からなる群から選ばれる1種以上である、カプセル剤の内容物として用いられる製剤。
- 請求項1に記載の製剤を内容物として用いた軟カプセル剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012166843A JP5461629B2 (ja) | 2006-07-14 | 2012-07-27 | 製剤 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006194740 | 2006-07-14 | ||
JP2006194740 | 2006-07-14 | ||
JP2012166843A JP5461629B2 (ja) | 2006-07-14 | 2012-07-27 | 製剤 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006283111A Division JP5110848B2 (ja) | 2006-07-14 | 2006-10-17 | ジフェンヒドラミン塩含有製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012211187A JP2012211187A (ja) | 2012-11-01 |
JP5461629B2 true JP5461629B2 (ja) | 2014-04-02 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012166843A Active JP5461629B2 (ja) | 2006-07-14 | 2012-07-27 | 製剤 |
Country Status (1)
Country | Link |
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JP (1) | JP5461629B2 (ja) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01186815A (ja) * | 1988-01-21 | 1989-07-26 | Tokai Kapuseru Kk | 軟カプセル剤およびその製造法 |
JP3535471B2 (ja) * | 2001-04-02 | 2004-06-07 | 株式会社ファンケル | ソフトカプセル剤およびその製造方法 |
JP4755353B2 (ja) * | 2001-04-02 | 2011-08-24 | 興和株式会社 | ビタミンb1製剤 |
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