JP5273683B2 - 化粧料的に又は医薬的に活性な化合物を与えられている多孔性粒子 - Google Patents
化粧料的に又は医薬的に活性な化合物を与えられている多孔性粒子 Download PDFInfo
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- JP5273683B2 JP5273683B2 JP2010121953A JP2010121953A JP5273683B2 JP 5273683 B2 JP5273683 B2 JP 5273683B2 JP 2010121953 A JP2010121953 A JP 2010121953A JP 2010121953 A JP2010121953 A JP 2010121953A JP 5273683 B2 JP5273683 B2 JP 5273683B2
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- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 1
- 229960000249 pregnenolone Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229950006862 rilopirox Drugs 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-N trans-4-coumaric acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Images
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Description
該方法は、個人の皮膚の表面に、集合体又は凝集体の形で集合化されていない多孔性粒子であって、10μm以下の体積平均直径、及び1m2/g以上の比表面積を有する前記多孔性粒子を含む組成物を局所的に施与する工程を少なくとも含み、
該有機多孔性粒子は、ナイロン6、ナイロン6−6、ナイロン12、及びナイロン6−12の粒子から選択され、かつ少なくとも1の化粧的に又は医薬的に活性な化合物を含み、
該化合物は、少なくとも5−n−オクタノイルサリチル酸であり、かつ該化合物は、予め、含浸により該多孔性粒子により含められている、
前記方法に関する。
を有し得る。
− シリカ粒子例えばアサヒガラスにより“サンスフィアHシリーズ”の名前で販売されるもの、及び鈴木油脂により“ゴッドボール”の名前で販売されるもの、
− ハイドロキシアパタイト粒子、例えばMERCK社により販売されるもの(製品番号1051990010、平均粒子サイズ15μm)、さもなければLABORATORY SKIN CARE又はアサヒガラス及びセキスイによりそれぞれ“ヒドロキシゾーム”(LSC及びアサヒガラス)、AP20C及びAP12C(セキスイ)の名前で販売されるもの、及びセキスイプラスチック社による“ASP(商標)”
− アルミナ−シリカ粒子、例えば3Mにより“Zeeosphere(商標)”の名前で販売されるもの
− 酸化チタン粒子、例えば石原産業により販売されるもの
− これらの鉱物の混合物からなる粒子
から選択されることができる。
− 抗生剤、例えばトリクロサン、IPBC(ヨウ化−3−プロピニル−2−ブチルカーバメート)、ベンズアルコニウムクロライド、クロロヘキシジン、トタロール(商標)(トタラ−8,11,13−トリエン−13−オールを含む植物抽出物)等、
− 抗菌剤、例えばピロクトンオラミン、ジンクピリチオン、クリムバゾール、リロピロックス、ケトコナゾール、イトラコナゾール等、
− 皮脂調節剤、例えばイミノジベンジル又は米国特許第6355687号に記載されるフルオレン誘導体、米国特許第6355686号に記載される置換された2級アミン誘導体、欧州特許出願公開第1219296号に記載されるグルクロン酸及びグルコサミン誘導体及びその塩、又は国際特許出願公開第02/067889号に記載されるニアシンナミドと、サリチル酸のC11〜C30アルキル又はアルケニルエステルとの組み合わせ、
− 皮脂刺激剤、例えばDHEA及びその合成又は天然誘導体、ビタミンD1のα−ヒドロキシ化誘導体例えば米国特許第6369099号に記載されるもの、
− 角質溶解剤、例えばサリチル酸及びその誘導体、例えばより詳細には5−n−オクタノイルサリチル酸、アルファ−ヒドロキシ酸、例えばグリコール酸、乳酸又はリンゴ酸、及びレゾルシノール、
− ニキビ治療剤、例えばレチノール及びその誘導体、レチノン酸及びそのオールトランス又は13−シス異性体、過酸化ベンゾイル、米国特許第6399774号に記載されているチトクロームP450阻害剤及びそれらの誘導体及びアゼライン酸、
− マクロライド構造を有してもよいし、あるいは有しなくてもよいところの抗生物質、米国特許第6399652号に記載されているアベルメクチン化合物、国際特許出願公開第01/56556号に記載されているクロロエステリル及びワックスエステル合成の阻害剤としての、[(2,4,6−トリイソプロピルフェニル)−アセチル]スルファミン酸2,6−ジイソプロピルフェニルエステル又はその塩、
− 脱毛阻害剤及びまた育毛刺激剤例えばミノキシジル、ビオチン、フィナステリド、2,4ジピリミジンN−オキサイド、パンテノール及びそれらの誘導体、フラバノンT、又はより一般的にアンチ−5−アルファ−レダクターゼのタイプI又はIIの活性を有する任意の植物抽出物、
− 頭髪又は体毛の成長を阻害する剤、例えば米国特許第6407056号に記載されているセリンプロテアーゼ、カフェイン酸、ケルセチン、プロピルガレート、ノルジヒドログアイアレチック酸又はNDGA、インドメタシン、塩酸エフロルニチン、米国特許第6171595号に記載されている植物抽出物、例えばクローブ、ローズヒップ、ワレモコウ、ガンビール等、米国特許第6075052号に記載されている化合物、米国特許第6020006号に記載されているテトラミゾール、オルトバナジン酸ナトリウム、レバミゾール、クロモグリケート2ナトリウム、硝酸バナジウム、及び硝酸ガリウム、また米国特許第4885289号、第4720489号,第5132293号、第5096911号、第5095007号、第5143925号、第5328686号、第5440090号、第5364885号、第5411991号、第5648394号、第5468476号、第5475763号、第5455608号、第5674477号、第5728736号、及び第5652273号、
及び国際特許出願公開第94/27586号、第94/27563号及び第98/03149号に記載されている化合物。また以下のものも使用され得る。米国特許第6375948号に記載されているセイヨウネズの抽出物、
− 抗フケ剤例えばジンクピリチオン、
− 抗酸化剤、例えばブチルヒドロキシトルエン(BHT)、カロテノイド例えばβカロテン、リコペン、カンサキサンチン、ユビキノン、ジブチルペンタエリスリチルヒドロキシシンナメート、ビタミンE、トロロックス、ビタミンC及びその誘導体、
− アストリンゼント及び毛穴収縮剤、例えば国際特許出願公開第02/32392号に記載されているもの
− 制汗剤、例えばアルミニウム塩及びジルコニウム塩、
− 上に述べられた以外のビタミン、例えばビタミンB3、ビタミンK、ビタミンH,ビタミンPP、ビタミンD、ビタミンB6、及びそれらの誘導体、及び
− 抗炎症剤、例えばα−ビサボロール、グリチルリジン酸2カリウム、グリチルレチン酸およびその誘導体、エラグ酸、ウルソル酸、イブプロフェン、ナプロキセン、フェノプロフェン、カルプロフェン、ケトプロフェン、ステロイド系抗炎症剤、例えばコーチゾン、プレグネノロン、デソナイド、及びアルコルアミン及びチロシンの混合物、例えば欧州特許出願公開第1192939号に記載されているもの。
− 基本的に毛嚢脂腺単位の外で作用することを意図された少なくとも1の化粧料的に又は医薬的に活性な化合物、及び/又は
− 少なくとも1の化粧料的に又は医薬的に許容できる添加物及び/又は
− 生薬の担体、任意の適切のタイプでよい、
もまた含みうる。
20gのサリチル酸、1lのアセトン及び200gの多孔性シリカ(サンスフィアH33)の溶液が調整された。この溶液が攪拌下、活性剤が完全に溶解されるまで環境温度に保たれた。溶液は次に丸底フラスコに移され、アセトンは40℃においてロータリーエバポレーター中で蒸発除去された、溶媒の完全な蒸発後、多孔性シリカ粒子からなる粉末がこのようにして得られ、その孔は固体状態のサリチル酸を含む。得られた粒子の重量組成は、粒子の合計重量に対して10重量%のサリチル酸及び90重量%のシリカである。
粒子組成物
2.5gのトリクロサンが50mlのアセトン中に溶解される。7.5gの“Orgasol(商標)”がこの混合物に導入される。分散物は次にロータリーエバポレーターに導びかれ、アセトンを除去する。するとトリクロサンを与えられている粉末が得られる。
Claims (11)
- 油性の皮膚を予防する及び/又は処置するための化粧的方法において、
該方法は、個人の皮膚の表面に、集合体又は凝集体の形で集合化されていない多孔性粒子であって、10μm以下の体積平均直径、及び1m2/g以上の比表面積を有する前記多孔性粒子を含む組成物を局所的に施与する工程を少なくとも含み、
該有機多孔性粒子は、ナイロン6、ナイロン6−6、ナイロン12、及びナイロン6−12の粒子から選択され、かつ少なくとも1の化粧的に又は医薬的に活性な化合物を含み、
該化合物は、少なくとも5−n−オクタノイルサリチル酸であり、かつ該化合物は、予め、含浸により該多孔性粒子により含められている、
前記方法。 - 該粒子が、3〜750m2/gの範囲の比表面積を有することを特徴とする、請求項1に記載の方法。
- 該粒子が、0.2〜5g/cm3の範囲の体積当たりの質量を有することを特徴とする請求項1又は2に記載の方法。
- 該粒子が、0.5〜8μmの範囲の体積平均直径を有することを特徴とする、請求項1〜3のいずれか1項に記載の方法。
- 該粒子が、0.5〜10μmの範囲の数平均直径を有することを特徴とする、請求項1〜4のいずれか1項に記載の方法。
- 該粒子が、3以下の分散度を有することを特徴とする、請求項1〜5のいずれか1項に記載の方法。
- 該粒子が、粉末の形で提供されることを特徴とする、請求項1〜6のいずれか1項に記載の方法。
- 活性化合物:活性化合物を除く多孔性粒子の重量比が、1/100〜1/1であることを特徴とする、請求項1〜7のいずれか1項に記載の方法。
- 該粒子が、
トリクロサン、IPBC(ヨウ化−3−プロピニル−2−ブチルカーバメート)、ベンズアルコニウムクロライド、クロロヘキシジン、トタロール(商標)(トタラ−8,11,13−トリエン−13−オールを含む植物抽出物)から選択される抗生剤;
過酸化ベンゾイル;
α−ビサボロール、グリチルリジン酸2カリウム、グリチルレチン酸、エラグ酸、ウルソル酸、並びにそれらの混合物から選択される抗炎症剤;
から選択される、別の化粧的に活性な化合物をさらに含むことを特徴とする、請求項1〜8のいずれか1項に記載の方法。 - 該別の化粧的に活性な化合物がトタロール(商標) (トタラ−8,11,13−トリエン−13−オールを含む植物抽出物)、グリチルレチン酸、及びそれらの混合物から選択される、請求項9に記載の方法。
- 活性化合物が、活性化合物と粒子との合計重量に対して5〜30重量%の範囲の活性剤の量において該多孔性粒子中に存在することを特徴とする、請求項1〜10のいずれか1項に記載の方法。
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EP1493433A1 (fr) | 2005-01-05 |
FR2856594A1 (fr) | 2004-12-31 |
JP4060828B2 (ja) | 2008-03-12 |
JP2005047893A (ja) | 2005-02-24 |
JP5032859B2 (ja) | 2012-09-26 |
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