JP5241510B2 - 固形製剤 - Google Patents

固形製剤 Download PDF

Info

Publication number: JP5241510B2
Authority: JP; Japan
Prior art keywords: solid preparation; layer; azelnidipine; olmesartan medoxomil; acid
Prior art date: 2006-12-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2008551104A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2008078726A1 (ja

Inventor

健司濱浦

育正大野

良一早川

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Daiichi Sankyo Co Ltd

Original Assignee

Daiichi Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-26

Filing date

2007-12-25

Publication date

2013-07-17

2007-12-25 Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd

2007-12-25 Priority to JP2008551104A priority Critical patent/JP5241510B2/ja

2010-04-30 Publication of JPWO2008078726A1 publication Critical patent/JPWO2008078726A1/ja

2013-07-17 Application granted granted Critical

2013-07-17 Publication of JP5241510B2 publication Critical patent/JP5241510B2/ja

Status Active legal-status Critical Current

2027-12-25 Anticipated expiration legal-status Critical

Links

239000007787 solid Substances 0.000 title claims description 60
238000002360 preparation method Methods 0.000 title claims description 58
UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims description 56
229960001199 olmesartan medoxomil Drugs 0.000 claims description 56
ZKFQEACEUNWPMT-UHFFFAOYSA-N Azelnidipine Chemical compound CC(C)OC(=O)C1=C(C)NC(N)=C(C(=O)OC2CN(C2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZKFQEACEUNWPMT-UHFFFAOYSA-N 0.000 claims description 55
229950004646 azelnidipine Drugs 0.000 claims description 54
239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims description 53
239000004480 active ingredient Substances 0.000 claims description 23
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239000001913 cellulose Substances 0.000 claims description 17
238000000034 method Methods 0.000 claims description 16
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VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 claims description 14
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 14
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FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
229920000084 Gum arabic Polymers 0.000 description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
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MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- A—HUMAN NECESSITIES
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP5824222B2 (ja) *	2010-03-31	2015-11-25	第一三共株式会社	固形製剤の製造方法
JP5917034B2 (ja) *	2011-07-15	2016-05-11	ニプロ株式会社	カルシウムブロッカーを含有する固形医薬組成物
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