JP4972707B2 - 光計測装置 - Google Patents
光計測装置 Download PDFInfo
- Publication number
- JP4972707B2 JP4972707B2 JP2010519706A JP2010519706A JP4972707B2 JP 4972707 B2 JP4972707 B2 JP 4972707B2 JP 2010519706 A JP2010519706 A JP 2010519706A JP 2010519706 A JP2010519706 A JP 2010519706A JP 4972707 B2 JP4972707 B2 JP 4972707B2
- Authority
- JP
- Japan
- Prior art keywords
- light
- subject
- incident
- wavelength
- optical measurement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003287 optical effect Effects 0.000 title claims description 20
- 238000001514 detection method Methods 0.000 claims description 23
- 238000005259 measurement Methods 0.000 claims description 16
- 239000003550 marker Substances 0.000 claims description 14
- 230000007246 mechanism Effects 0.000 claims description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 31
- 238000003384 imaging method Methods 0.000 description 9
- 210000003128 head Anatomy 0.000 description 6
- 239000013307 optical fiber Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000004065 semiconductor Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000004847 absorption spectroscopy Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000001061 forehead Anatomy 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000004761 scalp Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000005284 excitation Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000003710 cerebral cortex Anatomy 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001917 fluorescence detection Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3144—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Physiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Description
Claims (7)
- 被検体に波長200nmから1500nmの光を入射する1個または複数個の光入射手段と、
前記被検体上の前記光が入射された入射位置から離れた位置に配置され、入射された前記光の波長で励起される発光体と、
前記発光体から発せられる光を検出する光検出手段とを備えることを特徴とする光計測装置。 - 請求項1に記載の光計測装置において、前記発光体を配置する位置に応じて、当該発光体から発せられる光の波長が異なるようにしたことを特徴とする光計測装置。
- 請求項1に記載の光計測装置において、前記発光体の前記被検体に接する面以外の面を、前記入射光波長の光を遮蔽する部材で覆ったことを特徴とする光計測装置。
- 請求項1に記載の光計測装置において、前記発光体の形状が三角形であることを特徴とする光計測装置。
- 請求項1に記載の光計測装置において、前記光検出手段は撮像器であることを特徴とする光計測装置。
- 請求項1に記載の光計測装置において、前記光入射手段による光の入射位置にマーカが配置され、前記被検体から離れた位置から前記マーカに向けて光を照射し、前記被検体が動いても前記マーカを追跡する機構を有することを特徴とする光計測装置。
- 請求項1に記載の光計測装置において、前記光検出手段または前記光入射手段と、前記被検体との位置関係により、検出発光強度を補正する機構を有することを特徴とする光計測装置。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010519706A JP4972707B2 (ja) | 2008-07-08 | 2009-06-15 | 光計測装置 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008177483 | 2008-07-08 | ||
JP2008177483 | 2008-07-08 | ||
PCT/JP2009/060876 WO2010004835A1 (ja) | 2008-07-08 | 2009-06-15 | 光計測装置 |
JP2010519706A JP4972707B2 (ja) | 2008-07-08 | 2009-06-15 | 光計測装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2010004835A1 JPWO2010004835A1 (ja) | 2011-12-22 |
JP4972707B2 true JP4972707B2 (ja) | 2012-07-11 |
Family
ID=41506956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010519706A Active JP4972707B2 (ja) | 2008-07-08 | 2009-06-15 | 光計測装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US9339191B2 (ja) |
EP (1) | EP2322101A4 (ja) |
JP (1) | JP4972707B2 (ja) |
CN (1) | CN102076267B (ja) |
WO (1) | WO2010004835A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5829501B2 (ja) * | 2011-12-01 | 2015-12-09 | 富士機械製造株式会社 | 半導体素子画像認識装置及び半導体素子画像認識方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006102110A (ja) * | 2004-10-05 | 2006-04-20 | Matsushita Electric Ind Co Ltd | 血管位置提示装置 |
JP2007082769A (ja) * | 2005-09-22 | 2007-04-05 | Fujifilm Corp | 試料分析装置 |
JP2008149154A (ja) * | 2000-11-27 | 2008-07-03 | General Hospital Corp | 蛍光媒介式分子断層撮影法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2687360A (en) * | 1951-01-18 | 1954-08-24 | Rauland Corp | Process for making a multicolor fluorescent screen |
US4215275A (en) * | 1977-12-07 | 1980-07-29 | Luxtron Corporation | Optical temperature measurement technique utilizing phosphors |
JPS57115232A (en) | 1980-07-09 | 1982-07-17 | Deyuuku Univ Inc | Apparatus for measuring metabolic action in internal organ |
JPS63260532A (ja) | 1987-04-17 | 1988-10-27 | 株式会社島津製作所 | 近赤外線無侵襲生体計測装置 |
JPS63275323A (ja) | 1987-05-08 | 1988-11-14 | Hamamatsu Photonics Kk | 診断装置 |
US5200838A (en) * | 1988-05-27 | 1993-04-06 | The University Of Connecticut | Lateral effect imaging system |
GB9000740D0 (en) * | 1990-01-12 | 1990-03-14 | Univ Salford | Measurement of luminescence |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US6399397B1 (en) * | 1992-09-14 | 2002-06-04 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5304809A (en) * | 1992-09-15 | 1994-04-19 | Luxtron Corporation | Luminescent decay time measurements by use of a CCD camera |
US5593899A (en) * | 1993-02-25 | 1997-01-14 | Trustees Of The University Of Pennsylvania | Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence |
CN1136815C (zh) | 1993-08-24 | 2004-02-04 | 松下电器产业株式会社 | 医用激光机和使用该激光机的诊断/治疗机 |
US7328059B2 (en) * | 1996-08-23 | 2008-02-05 | The Texas A & M University System | Imaging of light scattering tissues with fluorescent contrast agents |
JP3593764B2 (ja) | 1995-11-29 | 2004-11-24 | 株式会社日立製作所 | 生体光計測装置 |
US5760406A (en) * | 1996-06-03 | 1998-06-02 | Powers; Linda | Method and apparatus for sensing the presence of microbes |
US6123455A (en) * | 1997-05-02 | 2000-09-26 | American Iron And Steel Institute | Phosphor thermometry system |
US20030205681A1 (en) * | 1998-07-22 | 2003-11-06 | Ljl Biosystems, Inc. | Evanescent field illumination devices and methods |
DE10026435A1 (de) * | 2000-05-29 | 2002-04-18 | Osram Opto Semiconductors Gmbh | Kalzium-Magnesium-Chlorosilikat-Leuchtstoff und seine Anwendung bei Lumineszenz-Konversions-LED |
US7383076B2 (en) | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
JP4057422B2 (ja) * | 2001-01-25 | 2008-03-05 | プレシジョン・システム・サイエンス株式会社 | 微小物識別装置およびその識別方法 |
US20020155589A1 (en) * | 2001-03-30 | 2002-10-24 | Fuji Photo Film Co., Ltd. | Biochemical analysis unit and biochemical analyzing method using the same |
US20020150944A1 (en) * | 2001-04-06 | 2002-10-17 | Fuji Photo Film Co., Ltd. | Biochemical analysis unit and method for exposing stimulable phosphor sheet using the same |
EP1256794A2 (en) * | 2001-05-11 | 2002-11-13 | Fuji Photo Film Co., Ltd. | Biochemical analysis data producing method and scanner used thereof |
JP2003339677A (ja) | 2002-05-24 | 2003-12-02 | Communication Research Laboratory | 非拘束生体活動計測装置 |
US7599731B2 (en) * | 2002-07-16 | 2009-10-06 | Xenogen Corporation | Fluorescent light tomography |
JP4365824B2 (ja) * | 2003-11-04 | 2009-11-18 | 株式会社日立製作所 | 生体光計測装置 |
US8190231B2 (en) | 2003-11-20 | 2012-05-29 | Hamamatsu Photonics K.K. | Lymph node detecting apparatus |
JP4379150B2 (ja) * | 2004-02-26 | 2009-12-09 | 株式会社日立製作所 | 生体光計測装置および信号処理方法 |
JP4812393B2 (ja) * | 2005-03-04 | 2011-11-09 | 株式会社日立ハイテクノロジーズ | 蛍光分子計測システム |
JP5289768B2 (ja) * | 2005-09-29 | 2013-09-11 | オリンパス株式会社 | 焦点位置決定方法、焦点位置決定装置、微弱光検出装置及び微弱光検出方法 |
NZ569818A (en) | 2005-12-16 | 2012-07-27 | Catherine M Shachaf | Diagnostic system for the detection and diagnosis of skin cancer |
JP4702107B2 (ja) * | 2006-03-03 | 2011-06-15 | 株式会社日立製作所 | 生体光計測装置 |
FR2900043B1 (fr) * | 2006-04-24 | 2008-07-04 | Commissariat Energie Atomique | Procede d'imagerie optique par fluorescence de tissus biologiques, notamment pour delimiter des regions d'interet des tissus a analyser par tomographie |
US10335038B2 (en) * | 2006-08-24 | 2019-07-02 | Xenogen Corporation | Spectral unmixing for in-vivo imaging |
EP2083675A2 (en) * | 2006-11-17 | 2009-08-05 | Koninklijke Philips Electronics N.V. | Diffuse optical tomography with markers containing fluorescent material |
CA2673386A1 (en) * | 2006-12-22 | 2008-07-03 | Washington University | High performance imaging system for diffuse optical tomography and associated method of use |
-
2009
- 2009-06-15 JP JP2010519706A patent/JP4972707B2/ja active Active
- 2009-06-15 CN CN2009801250088A patent/CN102076267B/zh not_active Expired - Fee Related
- 2009-06-15 WO PCT/JP2009/060876 patent/WO2010004835A1/ja active Application Filing
- 2009-06-15 US US13/002,411 patent/US9339191B2/en not_active Expired - Fee Related
- 2009-06-15 EP EP09794282.5A patent/EP2322101A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008149154A (ja) * | 2000-11-27 | 2008-07-03 | General Hospital Corp | 蛍光媒介式分子断層撮影法 |
JP2006102110A (ja) * | 2004-10-05 | 2006-04-20 | Matsushita Electric Ind Co Ltd | 血管位置提示装置 |
JP2007082769A (ja) * | 2005-09-22 | 2007-04-05 | Fujifilm Corp | 試料分析装置 |
Also Published As
Publication number | Publication date |
---|---|
CN102076267A (zh) | 2011-05-25 |
US9339191B2 (en) | 2016-05-17 |
EP2322101A1 (en) | 2011-05-18 |
JPWO2010004835A1 (ja) | 2011-12-22 |
CN102076267B (zh) | 2013-02-06 |
WO2010004835A1 (ja) | 2010-01-14 |
EP2322101A4 (en) | 2013-04-10 |
US20110260065A1 (en) | 2011-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5658993B2 (ja) | 生体計測装置 | |
US10912504B2 (en) | Near-infrared spectroscopy and diffuse correlation spectroscopy device and methods | |
US8428674B2 (en) | Apparatus for spectrometric based oximetry | |
EP1013219B1 (en) | Living body information measuring apparatus, living body information measuring method, body fat measuring apparatus, body fat measuring method, and program recording medium | |
JP5944511B2 (ja) | 生体光計測装置およびそれを用いる生体光計測方法 | |
US9279763B2 (en) | Apparatus and method for measuring an analyte such as bilirubin, using light | |
JP2010214087A (ja) | 脳状態測定装置 | |
US20120057164A1 (en) | Biological information measuring apparatus | |
US8597208B2 (en) | Method and apparatus for measuring analytes | |
JP6285576B2 (ja) | 生体光計測装置 | |
US20070293766A1 (en) | Transmission Based Imaging for Spectroscopic Analysis | |
Kekkonen et al. | Chemical imaging of human teeth by a time-resolved Raman spectrometer based on a CMOS single-photon avalanche diode line sensor | |
US20100076319A1 (en) | Pathlength-Corrected Medical Spectroscopy | |
JP4972707B2 (ja) | 光計測装置 | |
US7544503B2 (en) | Apparatus for the pH determination of blood and method therefor | |
JP2015173920A (ja) | 生体検査装置および生体検査方法 | |
JP6412956B2 (ja) | 生体光計測装置、解析装置、及び方法 | |
JP6850257B2 (ja) | 共焦点分光測定装置を介して生理的パラメータを測定するための非侵襲的方法 | |
Funane et al. | Noncontact optical brain activity measurement system using phosphor placed on skin | |
EP3777680A1 (en) | Active miniaturized sensing system and method | |
JP5060268B2 (ja) | 生体計測装置および校正治具 | |
JP2004174126A (ja) | 生体情報計測装置 | |
JP2014174140A (ja) | 光学プローブ保持具、および、検出装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120313 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120409 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150413 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4972707 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |