JP4822702B2 - 造影剤 - Google Patents
造影剤 Download PDFInfo
- Publication number
- JP4822702B2 JP4822702B2 JP2004374878A JP2004374878A JP4822702B2 JP 4822702 B2 JP4822702 B2 JP 4822702B2 JP 2004374878 A JP2004374878 A JP 2004374878A JP 2004374878 A JP2004374878 A JP 2004374878A JP 4822702 B2 JP4822702 B2 JP 4822702B2
- Authority
- JP
- Japan
- Prior art keywords
- carbon nanohorn
- contrast agent
- carbon
- nanohorn aggregate
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000002872 contrast media Substances 0.000 title claims description 32
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 77
- 229910052799 carbon Inorganic materials 0.000 claims description 75
- 239000002116 nanohorn Substances 0.000 claims description 72
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 23
- 229910052742 iron Inorganic materials 0.000 claims description 23
- 229910044991 metal oxide Inorganic materials 0.000 claims description 19
- 150000004706 metal oxides Chemical class 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 10
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 35
- 229920001817 Agar Polymers 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 10
- 238000003745 diagnosis Methods 0.000 description 10
- 239000007789 gas Substances 0.000 description 10
- CMIHHWBVHJVIGI-UHFFFAOYSA-N gadolinium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[Gd+3].[Gd+3] CMIHHWBVHJVIGI-UHFFFAOYSA-N 0.000 description 9
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 8
- 229910003472 fullerene Inorganic materials 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 229910001938 gadolinium oxide Inorganic materials 0.000 description 7
- 229940075613 gadolinium oxide Drugs 0.000 description 7
- 239000008272 agar Substances 0.000 description 6
- 229910052786 argon Inorganic materials 0.000 description 6
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 231100000053 low toxicity Toxicity 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000007547 defect Effects 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- LYQGMALGKYWNIU-UHFFFAOYSA-K gadolinium(3+);triacetate Chemical compound [Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O LYQGMALGKYWNIU-UHFFFAOYSA-K 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 238000003917 TEM image Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- ZPKMIURLGRBLPQ-UHFFFAOYSA-K gadolinium(3+);triacetate;tetrahydrate Chemical compound O.O.O.O.[Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O ZPKMIURLGRBLPQ-UHFFFAOYSA-K 0.000 description 3
- 239000011261 inert gas Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 150000002736 metal compounds Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 2
- 241000722921 Tulipa gesneriana Species 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 229910002804 graphite Inorganic materials 0.000 description 2
- 239000010439 graphite Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- 150000008040 ionic compounds Chemical class 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 244000115658 Dahlia pinnata Species 0.000 description 1
- 235000012040 Dahlia pinnata Nutrition 0.000 description 1
- 239000002616 MRI contrast agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- -1 anion radical salt Chemical class 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001721 carbon Chemical class 0.000 description 1
- 239000002717 carbon nanostructure Substances 0.000 description 1
- 239000002041 carbon nanotube Substances 0.000 description 1
- 229910021393 carbon nanotube Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/189—Host-guest complexes, e.g. cyclodextrins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Description
Gd 2 O 3 などの酸化ガドリニウム(GdO x )は、それ自体ですぐれた造影効果を示す上、酸化物であるので安定性があり、さらに耐水性、耐酸性及び低毒性の要求も満足する。酸化ガドリニウムを造影剤として使用する場合、粒径は0.3〜20nm程度とすることが好ましい。
室温下、アルゴンガス雰囲気、101kPaの圧力のチャンバー内でグラファイト原料にCO2レーザーを照射し、グラファイト原料を蒸発させ、ダリア状のカーボンナノホーン集合体を作製した。各カーボンナノホーンは単層であった。
実施例1と同様にしてダリア状のカーボンナノホーン集合体を作製した。
実施例1で得られたカーボンナノホーン集合体を寒天に溶かしてチューリップと桜の型および「2004」という文字型のゲルを作り、それをカーボンナノホーン集合体を含まない寒天ゲルに埋め込んだものを作製し、MRIで撮像した。そのT2強調写真像を図6に示す。
Claims (4)
- カーボンナノホーン集合体よりなることを特徴とする造影剤。
- 前記カーボンナノホーン集合体を構成する個々のカーボンナノホーンのうち少なくとも一部がその側壁又は先端に開口部を有していることを特徴とする請求項1記載の造影剤。
- Gd又はFeの金属酸化物が内包され、あるいはカーボンナノホーン表面上にGd又はFeの金属酸化物が分散されていることを特徴とする請求項2記載の造影剤。
- 前記Gd又はFeの金属酸化物の平均粒子径が0.3〜100nmであることを特徴とする請求項3記載の造影剤。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004374878A JP4822702B2 (ja) | 2004-12-24 | 2004-12-24 | 造影剤 |
US11/793,655 US20080152593A1 (en) | 2004-12-24 | 2005-12-21 | Contrast Agent |
PCT/JP2005/024003 WO2006068294A1 (ja) | 2004-12-24 | 2005-12-21 | 造影剤 |
US13/295,621 US20120058053A1 (en) | 2004-12-24 | 2011-11-14 | Carbon nanohorn mri contrast agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004374878A JP4822702B2 (ja) | 2004-12-24 | 2004-12-24 | 造影剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006182657A JP2006182657A (ja) | 2006-07-13 |
JP4822702B2 true JP4822702B2 (ja) | 2011-11-24 |
Family
ID=36601879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004374878A Active JP4822702B2 (ja) | 2004-12-24 | 2004-12-24 | 造影剤 |
Country Status (3)
Country | Link |
---|---|
US (2) | US20080152593A1 (ja) |
JP (1) | JP4822702B2 (ja) |
WO (1) | WO2006068294A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5200474B2 (ja) * | 2007-09-25 | 2013-06-05 | 日本電気株式会社 | 薬物内包カーボンナノホーン集合体とその製造方法 |
JPWO2009041130A1 (ja) | 2007-09-25 | 2011-01-20 | 日本電気株式会社 | 物質内包カーボンナノホーン集合体、およびその製造方法 |
US11696688B2 (en) | 2017-11-17 | 2023-07-11 | Shimadzu Corporation | Semiconductor SWCNT slurry for bioimaging and method for producing the same |
WO2019097698A1 (ja) * | 2017-11-17 | 2019-05-23 | 株式会社島津製作所 | 生体イメージング用半導体swcnt分散液及びその検査方法 |
JP2023018182A (ja) * | 2021-07-27 | 2023-02-08 | 日本電気株式会社 | 親水性カーボンナノホーン集合体およびその製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264220A (en) * | 1991-11-12 | 1993-11-23 | Long David M Jr | Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents |
GB9203037D0 (en) * | 1992-02-11 | 1992-03-25 | Salutar Inc | Contrast agents |
JPH08508721A (ja) * | 1993-03-17 | 1996-09-17 | シリカゲル ゲス.エム.ビー.エイチ | 超常磁性粒子、その製法及びその用途 |
GB9808581D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to contrast agents |
JP2005281275A (ja) * | 2004-03-31 | 2005-10-13 | Terumo Corp | 磁気共鳴用造影剤およびそれを含む高分子組成物 |
US20080003182A1 (en) * | 2004-07-13 | 2008-01-03 | Wilson Lon J | Shortened Carbon Nanotubes |
-
2004
- 2004-12-24 JP JP2004374878A patent/JP4822702B2/ja active Active
-
2005
- 2005-12-21 WO PCT/JP2005/024003 patent/WO2006068294A1/ja active Application Filing
- 2005-12-21 US US11/793,655 patent/US20080152593A1/en not_active Abandoned
-
2011
- 2011-11-14 US US13/295,621 patent/US20120058053A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006182657A (ja) | 2006-07-13 |
WO2006068294A1 (ja) | 2006-06-29 |
US20120058053A1 (en) | 2012-03-08 |
US20080152593A1 (en) | 2008-06-26 |
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