JP4669228B2 - 皮膚外用剤組成物 - Google Patents
皮膚外用剤組成物 Download PDFInfo
- Publication number
- JP4669228B2 JP4669228B2 JP2004013917A JP2004013917A JP4669228B2 JP 4669228 B2 JP4669228 B2 JP 4669228B2 JP 2004013917 A JP2004013917 A JP 2004013917A JP 2004013917 A JP2004013917 A JP 2004013917A JP 4669228 B2 JP4669228 B2 JP 4669228B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- extract
- acid
- methylcyclopentadecanone
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 19
- ALHUZKCOMYUFRB-UHFFFAOYSA-N 3-methylcyclopentadecan-1-one Chemical compound CC1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-UHFFFAOYSA-N 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 21
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 20
- 229920002674 hyaluronan Polymers 0.000 claims description 20
- 229960003160 hyaluronic acid Drugs 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 244000124209 Crocus sativus Species 0.000 claims description 13
- 235000015655 Crocus sativus Nutrition 0.000 claims description 10
- PSFABYLDRXJYID-VKHMYHEASA-N N-Methylserine Chemical compound CN[C@@H](CO)C(O)=O PSFABYLDRXJYID-VKHMYHEASA-N 0.000 claims description 10
- PSFABYLDRXJYID-UHFFFAOYSA-N N-methyl-DL-serine Natural products CNC(CO)C(O)=O PSFABYLDRXJYID-UHFFFAOYSA-N 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 9
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 9
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 9
- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 9
- 230000002500 effect on skin Effects 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 description 43
- -1 acetone Chemical compound 0.000 description 26
- 230000000694 effects Effects 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- 230000037303 wrinkles Effects 0.000 description 14
- 235000002639 sodium chloride Nutrition 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- ALHUZKCOMYUFRB-OAHLLOKOSA-N Muscone Chemical compound C[C@@H]1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-OAHLLOKOSA-N 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 5
- 230000032683 aging Effects 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 150000005846 sugar alcohols Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000001599 crocus sativus l. flower extract Substances 0.000 description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229940076591 saffron extract Drugs 0.000 description 4
- 229940032094 squalane Drugs 0.000 description 4
- ALHUZKCOMYUFRB-HNNXBMFYSA-N (3s)-3-methylcyclopentadecan-1-one Chemical compound C[C@H]1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-HNNXBMFYSA-N 0.000 description 3
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 3
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000013040 bath agent Substances 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229960000541 cetyl alcohol Drugs 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000037393 skin firmness Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000238557 Decapoda Species 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 2
- 240000000912 Macadamia tetraphylla Species 0.000 description 2
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 239000004115 Sodium Silicate Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000019486 Sunflower oil Nutrition 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 210000002469 basement membrane Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229940067596 butylparaben Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
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- 239000000843 powder Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 230000004215 skin function Effects 0.000 description 2
- 235000019795 sodium metasilicate Nutrition 0.000 description 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 2
- 229910052911 sodium silicate Inorganic materials 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- QKHBMQWPOUUMQZ-BDQAORGHSA-M sodium;hydron;(2s)-2-(octadecanoylamino)pentanedioate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC([O-])=O QKHBMQWPOUUMQZ-BDQAORGHSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
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- 230000002194 synthesizing effect Effects 0.000 description 2
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- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 description 1
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- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- JPWUIQIFCDAWQX-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(O)CO JPWUIQIFCDAWQX-UHFFFAOYSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
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- Compositions Of Macromolecular Compounds (AREA)
Description
カノン、又はアヤメ科クロッカス属サフラン(Crocus sativus)から得られる抽出物若しくは精油を含有する皮膚外用剤組成物において、(A)3-メチルシクロペンタデカノン、N−メチル−L−セリンまたはその塩から選択される1種以上の真皮ヒアルロン酸産生促進剤と、(B)アヤメ科クロッカス属サフラン(Crocus sativus)から得られる抽出物又は精油、N−アセチルグルコサミンから選択される1種以上の表皮ヒアルロン酸産生促進剤とを組み合わせて配合することにより、相乗的に優れた皮膚のハリや潤いを維持して皺、乾燥肌、日焼け肌、老化肌を予防又は改善する効果を得ることができることを見出し、本発明を完成するに至った。
きる。
体、硬化油等の加工油類、ステアリン酸、ミリスチン酸、イソステアリン酸、オレイン酸、イソ型長鎖脂肪酸、アンテイソ型長鎖脂肪酸等の高級脂肪酸、リモネン、水素添加ビサボロール等のテルペン類、トリカプリル・カプリン酸グリセリル、2−エチルヘキサン酸グリセリル、トリイソ型長鎖脂肪酸グリセリル、トリパルミチン酸グリセリル等のトリグリセリド、セチル硫酸ナトリウム、N−ステアロイル−L−グルタミン酸塩等の陰イオン性界面活性剤、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレン多価アルコール脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、多価アルコール脂肪酸エステル、ポリグリセリン脂肪酸エステル、変性シリコン、蔗糖エステル等の非イオン性界面活性剤、テトラアルキルアンモニウム塩等の陽イオン性界面活性剤、ベタイン型、スルホベタイン型、スルホアミノ酸型等の両性界面活性剤、レシチン、リゾフォスファチジルコリン、セラミド、セレブロシド等の天然系界面活性剤、酸化チタン、酸化亜鉛等の顔料、ジブチルヒドロキシトルエン等の抗酸化剤、塩化ナトリウム、塩化マグネシウム、硫酸ナトリウム、硝酸カリウム、硫酸ナトリウム、メタ珪酸ナトリウム、塩化カルシウム等の無機塩類、クエン酸ナトリウム、酢酸カリウム、琥珀酸ナトリウム、アスパラギン酸ナトリウム、乳酸ナトリウム、ジクロロ酢酸、メバロン酸、グリチルリチン酸等の有機酸及びその塩、塩酸エタノールアミン、硝酸アンモニウム、塩酸アルギニン、ジイソプロピルアミン塩、尿素、デカルボキシカルノシン等の有機アミン類及びその塩、エデト酸等のキレート剤、キサンタンガム、カルボキシビニルポリマー、カラギーナン、ペクチン、アルキル変性カルボキシビニルポリマー、寒天等の増粘剤、水酸化カリウム、ジイソプロパノールアミン、トリエタノールアミン等の中和剤、ヒドロキシメトキシベンゾフェノンスルフォン酸塩等の紫外線吸収剤、ジプロピレングリコール、1,3−ブチレングリコール、グリセリン、プロピレングリコール、ソルビトール、マルビトール、ジグリセリン、ラフィノース等の多価アルコール、各種アミノ酸、アスコルビン酸、ビオチン、トコフェロール等のビタミン類及びアスコルビン酸硫酸エステル塩、アスコルビン酸燐酸エステル塩、ニコチン酸トコフェロール等のビタミン誘導体等を本発明の目的を達成する範囲内で適宜配合することができる。
表1に示す各組成の乳化型化粧料を常法により調製した。40−60代の女性被験者10名を対象として、コントロールを片方の前腕部に、各実施例・比較例の化粧料をもう片方の前腕部に、1日2回塗布し、2週間連用を行った。コントロール塗布側の張り感及び柔軟性改善度に比べたときの各実施例・比較例の張り感及び柔軟性改善度を、表2に示す評価基準に従って、パネラー自身が評価し、全パネラーの合計点数を以って評価結果とした。したがって、点数が高いほどコントロールに対する張り感・柔軟性改善効果に優れていることを示す。結果を表3に示す。
試験例1で用いた乳化型化粧料を使用した。40−60代の女性被験者10名を一群として、コントロールを片方の目尻に、各実施例・比較例のいずれかの化粧料をもう片方の目尻に、1日2回塗布し、1ヶ月間連用を行った。コントロール塗布側のシワ改善度に比べたときの各実施例・比較例のシワ改善度を、表2に示す評価基準に従って、パネラー自身が評価し、全パネラーの合計点数を以って評価結果とした。したがって、点数が高いほどコントロールに対するシワ改善効果に優れていることを示す。結果を表3に示す。
試験例1で用いた乳化型化粧料を使用した。下肢外側部に荒れ肌を実感しているパネラー10名を対象として、コントロールを片方の足の下肢外側部に、各実施例・比較例の乳化物をもう片方の足の下肢外側部に、1日2回塗布し、1週間連用を行なった。コントロール塗布側の荒れ肌改善度に比べたときの各実施例・比較例の荒れ肌改善度を、表2に示す評価基準に従って、パネラー自身が評価し、全パネラーの合計点数を以って評価結果とした。したがって、点数が高いほどコントロールに対する荒れ肌改善効果に優れていることを示す。結果を表3に示す。
件を満たさない比較例1〜4の皮膚外用剤組成物と比較して、張り感・柔軟性改善効果、皺改善効果、及び荒れ肌改善効果に優れていることがわかる。
下記に示す組成の乳液を常法により調製した。上記試験により評価したところ、張り感・柔軟性改善効果、皺改善効果、及び荒れ肌改善効果に優れていることが確認された。
エタノール 10.0
ポリオキシエチレン硬化ヒマシ油(60E.O.) 1.0
グリセリン 3.0
1,3−ブチレングリコール 2.0
ジプロピレングリコール 3.0
ポリエチレングリコール1500 1.0
ポリオキシエチレン(10)メチルグルコシド 1.0
リン酸水素ナトリウム 0.05
リン酸二水素カリウム 0.05
エデト酸二ナトリウム 0.05
メチルパラベン 0.1
(R)-(−)-3-メチルシクロペンタデカノン 0.0005
(S)-(+)-3-メチルシクロペンタデカノン 0.0005
サフラン抽出物 0.001
N−メチル−L−セリン 0.1
N−アセチルグルコサミン 1.0
リボフラビン 0.01
アスコルビン酸グルコシド 0.1
アラントイン 0.1
エンメイソウ抽出液 1.0
精製水 総量を100とする残量
下記に示す組成の乳液を常法により調製した。上記試験により評価したところ、張り感・柔軟性改善効果、皺改善効果、及び荒れ肌改善効果に優れたものであった。
ステアリン酸 1.0
モノステアリン酸グリセリル 2.0
セタノール 1.0
コレステロール 0.5
ワセリン 2.0
スクワラン 5.0
流動パラフィン 5.0
ジメチルポリシロキサン 1.0
ブチルパラベン 0.1
メチルパラベン 0.1
N−ステアロイルグルタミン酸ナトリウム 1.0
ポリエチレングリコール4000 1.0
ポリオキシエチレン(20)メチルグルコシド 2.0
アルキル変性カルボキシビニルポリマー 0.2
ジェランガム 0.2
グリセリン 2.0
ジプロピレングリコール 3.0
(R)-(−)-3-メチルシクロペンタデカノン 0.001
サフラン抽出物 0.001
N−メチル−L−セリン 0.1
N−アセチルグルコサミン 2.0
ショウブ抽出液 1.0
ワイルドタイム抽出液 0.5
アロエ抽出液 1.0
ウイキョウ抽出液 0.5
精製水 総量を100とする残量
下記に示す組成のクリームを常法により調製した。上記試験により評価したところ、張り感・柔軟性改善効果、皺改善効果、及び荒れ肌改善効果に優れたものであった。
ステアリン酸 2.0
モノステアリン酸グリセリル 2.0
セタノール 3.0
コレステロール 0.5
ワセリン 2.0
スクワラン 5.0
流動パラフィン 10.0
ジメチルポリシロキサン 1.0
ブチルパラベン 0.1
メチルパラベン 0.1
N−ステアロイルグルタミン酸ナトリウム 1.0
ポリエチレングリコール6000 1.0
ポリオキシエチレン(20)メチルグルコシド 1.0
カルボキシビニルポリマー 0.15
アルキル変性カルボキシビニルポリマー 0.15
アルギン酸 0.1
ヒアルロン酸 0.05
グリセリン 5.0
ジプロピレングリコール 3.0
グリチルリチン酸ジカリウム 0.1
乳酸菌培養液 0.5
酵母抽出液 1.0
(R)-(−)-3-メチルシクロペンタデカノン 0.0005
(S)-(+)-3-メチルシクロペンタデカノン 0.0005
サフラン抽出物 0.001
N−メチル−L−セリン 0.1
N−アセチルグルコサミン 0.1
レチノール 0.5
海藻抽出液 1.0
ヨクイニン抽出液 1.0
精製水 総量を100とする残量
Claims (1)
- (A)3-メチルシクロペンタデカノン、N−メチル−L−セリンまたはその塩から選択される1種以上の真皮ヒアルロン酸産生促進剤と、(B)アヤメ科クロッカス属サフラン(Crocus sativus)から得られる抽出物若しくは精油、N−アセチルグルコサミンから選択される1種以上の表皮ヒアルロン酸産生促進剤とを含有し、且つ3-メチルシクロペンタデカノン、又はアヤメ科クロッカス属サフラン(Crocus sativus)から得られる抽出物若しくは精油を必須の成分とすることを特徴とする皮膚外用剤組成物。
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