JP4593558B2 - 鼻吸入器用ノズル - Google Patents
鼻吸入器用ノズル Download PDFInfo
- Publication number
- JP4593558B2 JP4593558B2 JP2006505222A JP2006505222A JP4593558B2 JP 4593558 B2 JP4593558 B2 JP 4593558B2 JP 2006505222 A JP2006505222 A JP 2006505222A JP 2006505222 A JP2006505222 A JP 2006505222A JP 4593558 B2 JP4593558 B2 JP 4593558B2
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- thread
- nozzle
- nasal
- insert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 description 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 description 1
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- 229960002052 salbutamol Drugs 0.000 description 1
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- 238000007789 sealing Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
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- 229960000278 theophylline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
- 229940110309 tiotropium Drugs 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229950000339 xinafoate Drugs 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3447—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a cylinder having the same axis as the outlet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3442—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a cone having the same axis as the outlet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
- B05B11/0032—Manually actuated means located downstream the discharge nozzle for closing or covering it, e.g. shutters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1052—Actuation means
- B05B11/1056—Actuation means comprising rotatable or articulated levers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coating Apparatus (AREA)
- Massaging Devices (AREA)
- Percussion Or Vibration Massage (AREA)
Description
流体流路を画定する本体;
前記流路への入口を画定する投入口であって、前記放出口がはめ込まれて前記流路に前記ポンプ送りされる流体医薬を送ることができる形状を有する投入口;および
前記流路からの出口を画定する排出口であって、ユーザーが鼻腔に挿入することで、前記ポンプ送りされる流体医薬を鼻腔に投与できるような形状を有する排出口
を有し;
ネジ山通路が、前記入口と前記出口との間の流路に設けられて、前記ポンプ送りされる流体医薬に角運動量が与えられることを特徴とする鼻投薬ノズルが提供される。
Claims (18)
- ポンプ送りされる流体医薬(35)の放出のための放出口(31;431)を有する流体医薬放出ポンプ装置(30;430)で用いられる鼻投薬ノズル(50;450)において、
流体流路(156;256)を画定する本体;
前記流路への入口を画定する投入口(57;457)であって、前記放出口を収容するための、前記流路に前記ポンプ送りされる流体医薬を送ることを可能にする投入口;
前記流路からの出口(58;458)を画定する排出口であって、ユーザーが鼻腔に挿入することで、前記ポンプ送りされる流体医薬を鼻腔に投与できるような形状を有する排出口;および
本体と該本体上のネジ山とを備える挿入物(160;260)であって、該ネジ山は、該挿入物に、一定の直径(A)を有するネジ山外側表面(162;262)を付与し、該挿入物は、該ネジ山が前記流路の壁(155;255)に係合することにより、前記入口と前記出口との間の流路に螺旋状のネジ山通路(164;264)を付与するように前記流路内に位置付けられている、該挿入物
を有し;
前記ネジ山通路の断面積が、進入口からそれへの出口にかけて小さくなるように、前記流路の前記壁および前記挿入物の前記本体の一方がテーパ状の輪郭を有し、他方が一定の直径を有する、鼻投薬ノズル。 - 前記本体がさらに、前記ネジ山通路と前記排出口との間に位置する中空チャンバ(59;459)を画定する請求項1に記載の鼻投薬ノズル。
- 前記ネジ山通路が少なくとも3回の完全ネジ回数を画定する請求項1または2のいずれかに記載の鼻投薬ノズル。
- 前記螺旋状のネジ山通路がネジ山軸(T)を中心として対称形に延在している請求項1〜3のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山軸が前記流体医薬放出ポンプ装置のポンプ送り軸(P)に対応している請求項4に記載の鼻投薬ノズル。
- 前記流体流路が前記ネジ山軸を中心として対称である請求項4または5に記載の鼻投薬ノズル。
- 前記ノズルの前記本体が前記ネジ山軸を中心として対称である請求項4〜6のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路が複数のネジ切りされた経路を有する請求項1〜7のいずれかに記載の鼻投薬ノズル。
- 各ネジ切りされた経路が共通のネジ山軸を中心として配置されている請求項8に記載の鼻投薬ノズル。
- 前記ネジ山通路が2〜8個のネジ切りされた経路を有する請求項8または9のいずれかに記載の鼻投薬ノズル。
- 前記流路(156)が一定の直径を有し、前記流路の前記壁(155)が平滑であり、前記挿入物の前記本体がテーパ形状である、請求項1〜10のいずれかに記載の鼻投薬ノズル。
- 前記流路の前記壁(255)がテーパ形状であり、且つ、該壁に画定された、前記挿入物(260)のネジ山を収容するネジ山表面(253)を有しており、前記挿入物の前記本体は一定の直径を有している、請求項1〜10のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路の深さ(C)が、前記進入口から前記出口にかけて徐々に小さくなる請求項1〜12のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路の幅またはピッチ(D)が、前記進入口から前記出口にかけて徐々に小さくなる請求項1〜13のいずれかに記載の鼻投薬ノズル。
- 流体医薬を鼻腔内に噴霧する流体医薬放出装置の可逆的収容を行うための筐体アセンブリにおいて、空洞部を画定する本体;ならびに前記本体と係合可能な請求項1〜14のいずれかに記載の投薬ノズルを有する筐体アセンブリ。
- 請求項15に記載の筐体アセンブリおよび該アセンブリによって収容される流体医薬放出ポンプ装置を有する流体医薬投薬装置。
- 前記流体医薬放出ポンプ装置が所定体積の流体医薬を入れるための貯留部を画定する中空ケーシング(34;430)と該中空ケーシング内に延在する吸引口(32;432)を持ったポンプ(29;249)を有し;前記ポンプが、前記投薬ノズルと共動して前記貯留部から前記投薬ノズルまでの流体のポンプ送りを可能とするための、前記中空ケーシングの第1の端部から延在する放出口(31;431)を有する請求項16に記載の流体医薬投薬装置。
- 前記貯留部が所定体積の流体医薬製剤を含む請求項17に記載の流体医薬投薬装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0309354.9A GB0309354D0 (en) | 2003-04-24 | 2003-04-24 | Nozzle for a nasal inhaler |
PCT/EP2004/004243 WO2004094068A2 (en) | 2003-04-24 | 2004-04-21 | Nozzle for a nasal inhaler |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006525049A JP2006525049A (ja) | 2006-11-09 |
JP4593558B2 true JP4593558B2 (ja) | 2010-12-08 |
Family
ID=9957190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006505222A Expired - Lifetime JP4593558B2 (ja) | 2003-04-24 | 2004-04-21 | 鼻吸入器用ノズル |
Country Status (7)
Country | Link |
---|---|
US (1) | US7484678B2 (ja) |
EP (1) | EP1615724B1 (ja) |
JP (1) | JP4593558B2 (ja) |
AT (1) | ATE413229T1 (ja) |
DE (1) | DE602004017594D1 (ja) |
GB (1) | GB0309354D0 (ja) |
WO (1) | WO2004094068A2 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030180351A1 (en) * | 1998-11-06 | 2003-09-25 | Reinhard Gluck | Pharmaceutically active composition and dispensing device |
GB0312007D0 (en) * | 2003-05-24 | 2003-07-02 | Innovata Biomed Ltd | Container |
FR2887232B1 (fr) * | 2005-06-21 | 2010-11-05 | Rexam Dispensing Sys | Embout poussoir pour distributeur de produit liquide |
SE529956C2 (sv) * | 2005-07-12 | 2008-01-15 | Medux Ab | Sprejanordning, metod för sprejning samt sätt för tillverkning av anordning |
GB0515592D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Nozzle for a nasal inhaler |
EP1792660A1 (en) * | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
SE529863C2 (sv) * | 2006-05-02 | 2007-12-18 | Medux Ab | Sprayanordning med munstycksförslutning |
EP2247330B1 (en) * | 2008-02-07 | 2017-09-20 | The University of Washington | Circumferential aerosol device |
BR112013022249B8 (pt) | 2011-03-03 | 2022-10-25 | Impel Neuropharma Inc | Dispositivo de distribuição de droga nasal |
BR112013028572B8 (pt) | 2011-05-09 | 2022-10-25 | Impel Neuropharma Inc | Bocais para distribuição de droga nasal |
US9681932B2 (en) * | 2013-04-25 | 2017-06-20 | Hankookin, Inc. | Intraoral biofilm control apparatus |
EP2991713B1 (en) | 2013-04-28 | 2019-06-19 | Impel Neuropharma Inc. | Medical unit dose container |
GB201308679D0 (en) | 2013-05-14 | 2013-06-26 | 3M Innovative Properties Co | Actuator for an inhaler |
CN103623951B (zh) * | 2013-11-13 | 2017-02-22 | 浙江工业大学 | 气雾剂喷头 |
JP6753927B2 (ja) | 2015-09-10 | 2020-09-09 | インペル ニューロファーマ インコーポレイテッド | 直列形経鼻送達デバイス |
US10482365B1 (en) * | 2017-11-21 | 2019-11-19 | Wells Fargo Bank, N.A. | Transaction instrument containing metal inclusions |
JP2021503988A (ja) | 2017-11-21 | 2021-02-15 | インペル ニューロファーマ インコーポレイテッド | インレットインターフェースを用いた鼻腔内装置 |
EP3713628A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH DIVER TUBE |
ES2937440T3 (es) | 2018-01-05 | 2023-03-28 | Impel Pharmaceuticals Inc | Administración intranasal de dihidroergotamina mediante un dispositivo olfativo de precisión |
CN111836615A (zh) | 2018-01-05 | 2020-10-27 | 英倍尔药业股份有限公司 | 通过精密鼻装置的奥氮平的鼻内递送 |
KR20210034047A (ko) | 2018-07-19 | 2021-03-29 | 임펠 뉴로파마 인코포레이티드 | 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달 |
EA202191856A1 (ru) | 2019-01-03 | 2021-09-02 | Импел Ньюрофарма, Инк. | Устройство для назальной доставки лекарственных средств |
EP3969085A4 (en) | 2019-05-17 | 2023-06-21 | Impel Pharmaceuticals Inc. | DISPOSABLE NASAL DELIVERY DEVICE |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1506722A (en) | 1919-10-16 | 1924-08-26 | Allis Chalmers Mfg Co | Method of producing spray nozzles |
US2435605A (en) * | 1944-03-31 | 1948-02-10 | Herman L Rowell | Spray nozzle |
DE960777C (de) * | 1953-03-27 | 1957-03-28 | Pumpindustri Ab | Fluessigkeitsduese fuer Schaumstrahlrohre fuer Feuerloeschzwecke |
FR1340235A (fr) * | 1962-08-13 | 1963-10-18 | Anciens Etablissements E Rober | Appareil pulvérisateur à pompe |
GB1318462A (en) | 1969-08-21 | 1973-05-31 | Wimmer Kg | Drop dispenser for bottles or the like containers |
US3692243A (en) * | 1970-02-02 | 1972-09-19 | Spirolet Corp | Nozzle |
BE788194A (fr) | 1971-08-31 | 1973-02-28 | Thomae Gmbh Dr K | Dispositif pour l'administration de quantites mecaniquement dosees de medicaments liquides ou en solution |
US3949939A (en) | 1975-03-26 | 1976-04-13 | Smithkline Corporation | Metered spray device |
US4513891A (en) | 1982-04-15 | 1985-04-30 | Sterling Drug Inc. | Spray dispensing container and valve therefor |
US4515315A (en) | 1983-06-08 | 1985-05-07 | Corsette Douglas Frank | Nozzle insert for a fluid dispenser |
FR2547737B1 (fr) | 1983-06-24 | 1988-04-08 | Valois Sa | Embout-poussoir pour pulverisateur medical |
US4706888A (en) | 1986-07-11 | 1987-11-17 | Calmar, Inc. | Multi-purpose nozzle assembly |
DE3712894A1 (de) | 1987-04-16 | 1988-11-03 | Hans Heinlein | Sprueheinsatz fuer elastisch deformierbare fluessigkeitsbehaelter |
DE3731464A1 (de) | 1987-09-18 | 1989-04-06 | Rotring Werke Riepe Kg | In eine spritzpistole einsetzbarer behaelter |
DE3734306A1 (de) | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
US4961727A (en) * | 1988-11-16 | 1990-10-09 | Beard Walter C | Dispensing package |
JP2922935B2 (ja) | 1989-08-11 | 1999-07-26 | 東興薬品工業株式会社 | 粘稠液用鼻孔内噴霧容器の使捨てアダプタ |
DE4016126A1 (de) | 1990-04-17 | 1991-10-24 | Coster Tecnologie Speciali Spa | Vorrichtung zur transnasalen oder oralen verabreichung von medikamenten o. dgl. |
CA2101049A1 (en) | 1991-11-22 | 1993-05-23 | Pedro Casamira Camps | Dosing apparatus for sterile and/or pharmaceutical solutions |
JP2934912B2 (ja) | 1992-12-05 | 1999-08-16 | インクロ リミテッド | 自己清浄式/閉塞防止式スプレーノズル |
AR001305A1 (es) | 1996-11-29 | 1997-10-08 | Daniel Osvaldo Portugues | Mejoras en boquillas, de salida de un fluido a presión que incluye una membrana flexible, obturadoradel canal de salida de dicha boquilla. |
DE19723133A1 (de) | 1997-06-03 | 1998-12-10 | Caideil M P Teoranta Tourmakea | Austragvorrichtung für Medien |
FR2771296B1 (fr) | 1997-11-25 | 2000-03-10 | Sofab | Embout nasal avec fermeture d'extremite |
FR2782024B1 (fr) | 1998-08-04 | 2000-10-13 | Valois Sa | Tete de distribution et dispositif de distribution de produit fluide comportant une telle tete |
US6245278B1 (en) | 1999-06-03 | 2001-06-12 | Husky Injection Molding Systems Ltd. | Injection nozzle and method |
DE60007593T2 (de) | 1999-10-14 | 2004-11-11 | Becton, Dickinson And Co. | Nasales Verabreichungsgerät mit Zerstäuberdüse |
US6644305B2 (en) | 2000-04-14 | 2003-11-11 | Trudell Medical International | Nasal inhaler |
GB2372782B (en) | 2000-09-29 | 2004-09-22 | Pharmacure Ab | Nasal sprays |
FR2815611B1 (fr) | 2000-10-23 | 2003-04-11 | Valois Sa | Tete de distribution et distributeur de produit fluide comportant une telle tete de distribution |
RU2184619C1 (ru) | 2001-03-22 | 2002-07-10 | Душкин Андрей Леонидович | Распылитель жидкости (варианты) |
US6745760B2 (en) | 2001-05-15 | 2004-06-08 | Trudell Medical International | Medicament applicator |
FR2832079B1 (fr) | 2001-11-14 | 2004-07-30 | Valois Sa | Tete de distribution et distributeur de produit fluide comportant une telle tete de distribution |
WO2003045573A1 (en) | 2001-11-27 | 2003-06-05 | Incro Limited | Nozzle |
EP1331036A1 (en) | 2002-01-24 | 2003-07-30 | Daniel Osvaldo Portugués | A flexible membrane as an outlet channel stopper |
FR2837179B1 (fr) | 2002-03-15 | 2004-07-09 | Valois Sa | Dispositif de distribution de produit fluide |
ITMI20022299A1 (it) * | 2002-10-29 | 2004-04-30 | St Microelectronics Srl | Dispositivo per il pilotaggio di un transitor di potenza |
-
2003
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- 2004-04-21 WO PCT/EP2004/004243 patent/WO2004094068A2/en active Application Filing
- 2004-04-21 DE DE602004017594T patent/DE602004017594D1/de not_active Expired - Lifetime
- 2004-04-21 AT AT04728551T patent/ATE413229T1/de not_active IP Right Cessation
- 2004-04-21 US US10/553,688 patent/US7484678B2/en active Active
- 2004-04-21 EP EP04728551A patent/EP1615724B1/en not_active Expired - Lifetime
- 2004-04-21 JP JP2006505222A patent/JP4593558B2/ja not_active Expired - Lifetime
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ATE413229T1 (de) | 2008-11-15 |
US20060219813A1 (en) | 2006-10-05 |
WO2004094068A2 (en) | 2004-11-04 |
JP2006525049A (ja) | 2006-11-09 |
EP1615724B1 (en) | 2008-11-05 |
EP1615724A2 (en) | 2006-01-18 |
DE602004017594D1 (de) | 2008-12-18 |
WO2004094068A3 (en) | 2004-12-02 |
GB0309354D0 (en) | 2003-06-04 |
US7484678B2 (en) | 2009-02-03 |
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