CA2101049A1 - Dosing apparatus for sterile and/or pharmaceutical solutions - Google Patents
Dosing apparatus for sterile and/or pharmaceutical solutionsInfo
- Publication number
- CA2101049A1 CA2101049A1 CA 2101049 CA2101049A CA2101049A1 CA 2101049 A1 CA2101049 A1 CA 2101049A1 CA 2101049 CA2101049 CA 2101049 CA 2101049 A CA2101049 A CA 2101049A CA 2101049 A1 CA2101049 A1 CA 2101049A1
- Authority
- CA
- Canada
- Prior art keywords
- nozzle
- sterile
- ring
- cup
- pharmaceutical solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/08—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type
- G01F11/082—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type of the squeeze container type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The dosing device for sterile and/or pharmaceutical solutions is comprised of a laminar body (10) which contains the solution, presenting a top neck wherein a tubular nozzle (20) may be inserted and which is covered by a cup (30) having a weakened area, with a fluted ring (40) which interconnects said parts. The device may be coupled to a rigid support (50) which has a base slidable on an axis in order to apply the solution by manually pressing on the base of said support.
Description
210104~
DOSING APPAE~ATUS FOR STERILE AND/OR
PHARMACEUTICAL SOLUTIONS
The present invention relates to a dosing apparatus ~or sterile and/or pharmaceutical solutions, comprised of a disposable container which contains the solution, provided with a nozzle with a cup, a sealing ring and a rigid support for holding the ass~mbly, which, in its turn, makes the use and handling o~ the device easy.
10The dosing apparatus of the present invention for sterile and/or pharmaceutical solutions is of medical or pharmaceutical application, for human or veterinarian use.
FIELD OF THE INVENTION
As is already known, in some situations it is an advantage to dispense fix amounts of solution on localized points, for curative or preventive purposes. These functions are performed through conventional means such as syringes or the like, working by sucking up liquids from a sterile containar through also sterile means, such as syringes, and pouring out their collected contents on specific points of the human or animal body.
This solution involves several problems, among them, the transfer from a medium to another~ since although both mediums are :sterile it usually presents problems of sterility loss, as well as certain nuisances in i~s use and :handling. ~ ~
B~CKGROUND: OF THE INVENTION
Devic~s containing pharmaceutical and veterinarian liquid ~olutions ar~ known, such as blisters, cartridges or the like, which are providèd with needles with means for their coupling, ~which allow a direct use of them in its administration.
~ A device of this kind is described in Spanish : patent No. 8801006, comprised of a container made of a flexible synthetic~material, its contents baing pourPd out through a pressure made against the walls thereof.
: More concrete antecedents of the present invention 2101G~9 :
in the sector where the latter applies are in the first place US patent No. 2,319,383 by Merck & Co., Inc and in particular the embodiment disclosed in US patent No. 3,9~9,045 by William F.Van Eck, wherein a syringe is described comprised of a containei~ and a needle, the said container being balloon-shaped and with flexible walls, having fastening ~eans on the container's neck.
The device referred to has a first disadvantage in its use, since it lacks a flat base for its physical positioning on a surface, involving that the tip of the needle comes into contact with the surface where it lies, thus, losing its sterility.
Also in the referred position, part of the solution is poured out on the flat surface where the set lies, due to capillarity.
Thirdly, it exists a high lack of precision when the container is being poured out, since the necessary flexibility of the container wall requires a substantial firm hand to dose with accuracy.
Other antecedents of the invention are found in British patent No. 1 573 514 by AB Helinos from Sweden, and German patent No~ 29 00 827 by Merc~ Patent GmbH, in which devices are described comprising a flexible closed sealed container with a solution, said container being applied against rigid elements provided with a needle that goes through it, being capable of puncturing by one of the needle : ends the referred container and fittin~ly secure i~, while : the other end of the~needle allows the exit of the contained solution.
These devices have the common disadvantage ! of : reguiring a coupling operation, situation that involves a manual (in the Merck solution) handling of the container and the rigid element for the~end to be punctured to the former, thus, losing optimai conditions of tightness of the set, and consistentIy, its sterility.
Like in abov~mentioned solutions, the lack of precision is also high when the container is being poured out, mainly in the Merck solution.
Lastly, systems of cartridges containing solutions coupled to rigid structures are al80 known, such as that described in PCT patent W0 89/02286 by Wolke, in which a device is described comprising a sealed container placed into a hollow rigid ~tructure, with one of its ends provided with a needle which punctures and connects the solution which is aontained into the container with the outside, being doseable through a plunger placed in the other end o the cited hollow rigid structure.
Although this solution has a better reliability as for precision in the pouring out of the container contents, it also requires a manual handling of the containers to be placed into the hollow rigid structure.
Another important disadvantage is the high amount of pieces involvsd in the cited device, with a high cost in its production.
SUMMARY OF THE INVENTION
The device according to the present invention eliminates the abovementioned disadvantages, succeeding in dosing and dispensing a sterile solution in optimal conditions, with an easy handling and high precision, as well as involving a low manufacturing cost~
For this aim, the present device comprises~ a container with a solution, comprising:
a- a flexlbl~ generally cylindrical laminar body with its wall bellow-shaped, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ~ing, b- a cylindrical tubular nozzle, which has a flat outer surrounding rim and having an end like a bevel edge, and its outer diameter being slightly smaller than the one o~ the orifice of the ~ylindrical tube which extends the bellows, c- a cup which covers part of the nozzle, having in its wall a surrounding weakened line, and it~ mouth being extended by a flange, lying on the surrounding rim of the nozzle, and, d- a fluted ring which comprises a circular channel capable 2~
~f perimetrally trapping the ring of the extension of the body a) with the flange of the cup, said fluted ring being laterally extended by, at least, a lug.
The coupling between t~e flexible laminar body and the tubular nozzle is achieved by inserting the end of the latter in the orifice of the cylindrical tube which extends the bellow-shaped container. Likewise, the cup covers the other end of thP nozzle, its flange lying on the out~r riny of the flexible laminar body.
~he described assembled elements are fixed by the fluted ring which perimetrally traps the ring of the flexible laminar body extension with the flange of the cup.
The described set is held on a rigid structure, as a support, comprising:
- a flat U-shaped surface with two non-contiguous and parallel ends provided with a L~shaped projection, determining two longitudinal and parallel guides, - an axis perpendicularly connected underneath said flat surface and symmetrically disposed on it, - a circular base which comprises a central recess, with a lateral extension provided with a passing hole, where $he perpendicular axis~is socketed, and with a lower extension held ~y pressure means perpendicular to said axis.
The axis perpendicular to the flat surface of the rigid structure~may ha~e a graduated scale.
The features of the aforesaid elements will be following descr~ibed in detail.
~DESCRIPTI~N OF THE DRAWINGS
The annexed drawings, only as an example, will help to better understand the invention, its characteristics and the advantages it pro~ides.
Figure 1 is a perspective view of the flexible laminar body, the tubular nozzle and the cup, with the elements uncoupled Figure 2 is a cross section view of the elements shown in the figure 1, coupled and with the fluted ring that tie~ them together, 21Dl~
Figure 3 shows two views of a valve in section and in perspective with the three elements thereof, Figure 4 is a perspective view of the support s~ructure of the set shown in the Figure 1, ~igure 5 iæ a cross section view o~ the support structure, and, Figure 6 îs a perspective view of the ~upport st,ucture holding the set shown in figure 2, The items designated with numbers on the drawings correspond to the parts pointed out below.
PREFERRED EMBODIMENT OF THE INVENTION
In Figure 1 is shown a device according to the present invention, comprised of a laminar body ~10), a nozzle (20) and a cup (30), illustrated in an uncoupled position, on a same ideal axis.
The laminar body 10, the nozzle 20 and the cup 30, preferably made of plastic material, are obtained by moulding.
The laminar body 10 in its lower part has a cylindrical general configuration, with its lateral wall 11 bellow-shaped and one of its bases blind. Its other base axially extends by a cylindrical tube 12, ending in an outer ring 13 which def ines a central orifice 14 communicating through ths tube ~2 with the hollow body 10.
The nozzle 20 is tubular, with a longitudinal passage 21j having a:cylindrical general con~iguration, with a flat outer surrounding rim 22.
The nozzle 20 of:the figure l has an upper bevelled end 23~ Such as it will be described below, this end may have several forms according to applications.
The gene~al diameters of the nozzle 20, both upper and lower with regard;to the surrounding rim 22, are slightly lower than the one o~ the central orifice 14 and the one of the cylindrical tube 12 of the laminar body 10.
Such as abovementioned, the nozzle 20 is preferably made of plastic material. However, its width must provide such a rigidness that eliminates any possible flexibility when handling.
The cup 30 is generally long-shaped, with a central cylindrical hollow section from which laterally two diametrally opponents lugs 31 and 3~ emerge, with it~ upper ends slightly inclined ending adiacent to the end of the cup.
Internally, the cup 30 is provided with a bllnd cylindrical cavity, not shown in Figure 1, with a slightly greater diameter than the one of the upper section o.~ the nozzle 20.
In the lower part, the cup 30 comprises in its outer wall a surrounding weakened line 33, its mouth being extended by a flange 34 which defines a flat ring.
The internal cavity of the cup 3Q may receive inserted the upper end of the nozzle 20, thus coinciding the upper area of the surrounding rim 22 against the lower area of the flange 34 which defines the opening of the cup 30.
In the same way, the lower section of the nozzle can be inserted through a central ori~ice 14 and penetrating into the cylindrical tube 12, thus coinciding the lower area of the surrounding rim 22 with the upper area of the outer ring 13 of the body 10.
Figure 2 shows in cross section the body 10 and the cup 30 with the nozzle 20 inserted into the cylindrical tube 12, and in its turn into the cup 30.
In the same Figure 2, the fluted ring 40 is shown, defining a circular: channel 41 perimetrally trapping the outer ring 13 of the body 10, with the flange 34 and the cup 30, and thus the surrounding rim 22 of the nozæle 20 The fluted ring 40 is laterally extended by a lu~
42 in the illustrated example.
The fluted ring 40 allows to hol~.together the body 10, the nozzle 2n and the cup 30 in a steady way.
In an industrial application o~ the device according to the present invention, it is better to first fill up the body 10 with a solution before assembl~ng the parts thereof.
once said elements are assembled on the body 10, 2101~
the fluted ring will allow, apart from interconnecting the parts, to keep tight the inside o~ the device, the set being able to be sterilized by conventional means beyond the pxesent in~ention.
~he described device consist of a disposable closed container which allows to dlspense solution~. ~o as to open the device and proceed to d~se its contents the device shall be held with one hand taking its lug 42 and the other hand holding the cup 30 in order to proceed to its tearing by an axial spin. In this operation both lugs 31 and 32 o~ the cup 30 efficiently cooperate, avoiding that the fingers may slip during the opening of ~he device.
Later, and with only one hand, the contained æolution may be dosed, by holding with two consecutive fingers of the hand the cylindrical tube 12 and pressing the blind base of the body 10 with the thumb. The lateral wall 11 of the body will give, allowing to dose by a slightly weakening of the bellows, and/or suck up by its recuperation.
The upper end 23 of the nozzle 20 shows a bevelled form, for specific applications with regard to the use of the device. Such as abovementioned, the nozzle 20 may have different upper ends 23, as the one shown in Figure 3.
Llkewise, the inner tube which goes through the nozzle 20 may be provided with elements which allow to keep an unidirectional passage~of the solutions contained into the body 10.
~ ~ , -~ ; In the Figure 3 a nozzle 20 which has in its upper part a cylindrical~end ~3 is show~.
The shown nozzle 20 is comprised of the connection of two halves, upper~and lower, having an orifice ~1 which leads to a tubular inner tube 28 that goes longitudinally through it, with a disc 29 which is placed into a cavity 27, working as a va~lve, allowing an unidirectional passage of the ; solutions. The cited valve is conventional beyond the present invention with regard to its particularities, different kinds of valves can be used.~
Such as abovementioned, the ends 23 of the nozzle :::
20 may have di~ferent shapes according to the specific application of the solution to be dosed. Independently, several valves or direct tubes can be used into the nozzle 20.
5The application of a one-way val~e as described above allows to take out the air which may be in the body 10 ~nd keep this position in a steady way. Similarly said valve stops any possible sucX, and in its turn, penetration of other liquid or gaseous material into the body 10.
10~he nozzle 20 may also have thP most convenient shape to be able to tightly secure coaxially to its outer surface conventional tubes or couplings in order to assure their retention. In all cases, the blind cavity o~ the cup 30 has a suitable shape in order to secure cited ends and in its turn to generally keep tight the device.
The fluted ring 40 is laterally extended by a lug 42. The device may have a multiple number of lugs.
This cited lug has pertinent functional applications, allowing to adhere a label with the identification of the solution which is contained into the device, such as a description, a formula, expiring date or the like.
Apart from the abovementioned function, in order to facilitate the opening of the device, the use of a lug allows to protect th~ fingers of the hand when the solution is being dcsed a~oiding the contact of them with he area receiving the solution.
Likewise, when the device is not being used, the lug prevents the device from rolling over apparently flat areas,:and in its turn helps to keep the ~nd 23 of the nozzle 20 ~part from th~ very surface where the device is placed.
The device described can be used alone or together with a rigid support.
~ he Figures 4 and 5 show a rigid support 50. In the Figure 6 is shown the rigid support 50 at which the dosing device has been socketed~
:In the rigid support 50 a flat surface 51 is 21~10~
provided with one of its edges having an inlet 54, and with two non-contiguou~ and parallel ends provided with L-shaped projections 52 and 53 which de~ine two longitudinal guides.
The rigid support 50 comprises an axis 33 perpendicularly connected underneath the flat surface 51, symmetrically arranged on cited surface.
In the lower part, the support 50 comprises a base 56 having a circular surface with a central recess 5'7 and a lateral passing hole 58.
The lateral passing hole 58 of the base 56 is slightly greater in diameter than the one of the axis 55.
The base 56 in its lower part has an extension with an inner passage 65 perpendicular to the lateral passing hole 58 and communicating with it. Pressure means constituted by a screw 59 which controls a spring 61 are located within said passage and in its turn the latter fits on the cylinder 60.
Once the base 56 is plac~d in the axis 55 through its lateral orifice 58, the cylinder 60 presses by the assistance of the cited means on the previous paragraph on the surface of the axis 55. So, the base 56 can only be slidable along the axis 55 when desired.
The base 56 on the axis 55 is in its upper part limit~d by the flat surface 51, and in its lower part by the inlet 62, which has in its last end a slight step against whiah the cylinder 60 fits.
The outer surface of the axis 55 has a graduate scale 63l whose use will be describe below.
The different parts which comprise the rigid support can be also obtained by moulding, made of plastic or metallic materials.
The dosing device is coupled to the rigid ~upport 50. For doing so, the lug 42 has to be placed on the flat surface 51 with the assistance of the L-shaped pro~ections 52 and 53 by securing the edges of the lug 42. In this position, the neck 12 of the body 10 and the ring 40 are placed into the inlet 54. Inferiorly, the blind base of the body 10 is placed on the central recess 57 of the base 56 of 2 1 ~
the rigid support. The Figure 6 illustrates the last positioning of the device in the rigid support.
The opening and handling o~ the dosing device coupled to the rigid support is identical to what described above without it.
The application of the rigid support have clear advantages allowing to dose with greater precision, since it assists with a greater rigidness of the device set, and by having a graduate scale 63 on the axis 55. So, specific amounts of solution can be dosed.
~ ~ , ! ' ' : . '
DOSING APPAE~ATUS FOR STERILE AND/OR
PHARMACEUTICAL SOLUTIONS
The present invention relates to a dosing apparatus ~or sterile and/or pharmaceutical solutions, comprised of a disposable container which contains the solution, provided with a nozzle with a cup, a sealing ring and a rigid support for holding the ass~mbly, which, in its turn, makes the use and handling o~ the device easy.
10The dosing apparatus of the present invention for sterile and/or pharmaceutical solutions is of medical or pharmaceutical application, for human or veterinarian use.
FIELD OF THE INVENTION
As is already known, in some situations it is an advantage to dispense fix amounts of solution on localized points, for curative or preventive purposes. These functions are performed through conventional means such as syringes or the like, working by sucking up liquids from a sterile containar through also sterile means, such as syringes, and pouring out their collected contents on specific points of the human or animal body.
This solution involves several problems, among them, the transfer from a medium to another~ since although both mediums are :sterile it usually presents problems of sterility loss, as well as certain nuisances in i~s use and :handling. ~ ~
B~CKGROUND: OF THE INVENTION
Devic~s containing pharmaceutical and veterinarian liquid ~olutions ar~ known, such as blisters, cartridges or the like, which are providèd with needles with means for their coupling, ~which allow a direct use of them in its administration.
~ A device of this kind is described in Spanish : patent No. 8801006, comprised of a container made of a flexible synthetic~material, its contents baing pourPd out through a pressure made against the walls thereof.
: More concrete antecedents of the present invention 2101G~9 :
in the sector where the latter applies are in the first place US patent No. 2,319,383 by Merck & Co., Inc and in particular the embodiment disclosed in US patent No. 3,9~9,045 by William F.Van Eck, wherein a syringe is described comprised of a containei~ and a needle, the said container being balloon-shaped and with flexible walls, having fastening ~eans on the container's neck.
The device referred to has a first disadvantage in its use, since it lacks a flat base for its physical positioning on a surface, involving that the tip of the needle comes into contact with the surface where it lies, thus, losing its sterility.
Also in the referred position, part of the solution is poured out on the flat surface where the set lies, due to capillarity.
Thirdly, it exists a high lack of precision when the container is being poured out, since the necessary flexibility of the container wall requires a substantial firm hand to dose with accuracy.
Other antecedents of the invention are found in British patent No. 1 573 514 by AB Helinos from Sweden, and German patent No~ 29 00 827 by Merc~ Patent GmbH, in which devices are described comprising a flexible closed sealed container with a solution, said container being applied against rigid elements provided with a needle that goes through it, being capable of puncturing by one of the needle : ends the referred container and fittin~ly secure i~, while : the other end of the~needle allows the exit of the contained solution.
These devices have the common disadvantage ! of : reguiring a coupling operation, situation that involves a manual (in the Merck solution) handling of the container and the rigid element for the~end to be punctured to the former, thus, losing optimai conditions of tightness of the set, and consistentIy, its sterility.
Like in abov~mentioned solutions, the lack of precision is also high when the container is being poured out, mainly in the Merck solution.
Lastly, systems of cartridges containing solutions coupled to rigid structures are al80 known, such as that described in PCT patent W0 89/02286 by Wolke, in which a device is described comprising a sealed container placed into a hollow rigid ~tructure, with one of its ends provided with a needle which punctures and connects the solution which is aontained into the container with the outside, being doseable through a plunger placed in the other end o the cited hollow rigid structure.
Although this solution has a better reliability as for precision in the pouring out of the container contents, it also requires a manual handling of the containers to be placed into the hollow rigid structure.
Another important disadvantage is the high amount of pieces involvsd in the cited device, with a high cost in its production.
SUMMARY OF THE INVENTION
The device according to the present invention eliminates the abovementioned disadvantages, succeeding in dosing and dispensing a sterile solution in optimal conditions, with an easy handling and high precision, as well as involving a low manufacturing cost~
For this aim, the present device comprises~ a container with a solution, comprising:
a- a flexlbl~ generally cylindrical laminar body with its wall bellow-shaped, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ~ing, b- a cylindrical tubular nozzle, which has a flat outer surrounding rim and having an end like a bevel edge, and its outer diameter being slightly smaller than the one o~ the orifice of the ~ylindrical tube which extends the bellows, c- a cup which covers part of the nozzle, having in its wall a surrounding weakened line, and it~ mouth being extended by a flange, lying on the surrounding rim of the nozzle, and, d- a fluted ring which comprises a circular channel capable 2~
~f perimetrally trapping the ring of the extension of the body a) with the flange of the cup, said fluted ring being laterally extended by, at least, a lug.
The coupling between t~e flexible laminar body and the tubular nozzle is achieved by inserting the end of the latter in the orifice of the cylindrical tube which extends the bellow-shaped container. Likewise, the cup covers the other end of thP nozzle, its flange lying on the out~r riny of the flexible laminar body.
~he described assembled elements are fixed by the fluted ring which perimetrally traps the ring of the flexible laminar body extension with the flange of the cup.
The described set is held on a rigid structure, as a support, comprising:
- a flat U-shaped surface with two non-contiguous and parallel ends provided with a L~shaped projection, determining two longitudinal and parallel guides, - an axis perpendicularly connected underneath said flat surface and symmetrically disposed on it, - a circular base which comprises a central recess, with a lateral extension provided with a passing hole, where $he perpendicular axis~is socketed, and with a lower extension held ~y pressure means perpendicular to said axis.
The axis perpendicular to the flat surface of the rigid structure~may ha~e a graduated scale.
The features of the aforesaid elements will be following descr~ibed in detail.
~DESCRIPTI~N OF THE DRAWINGS
The annexed drawings, only as an example, will help to better understand the invention, its characteristics and the advantages it pro~ides.
Figure 1 is a perspective view of the flexible laminar body, the tubular nozzle and the cup, with the elements uncoupled Figure 2 is a cross section view of the elements shown in the figure 1, coupled and with the fluted ring that tie~ them together, 21Dl~
Figure 3 shows two views of a valve in section and in perspective with the three elements thereof, Figure 4 is a perspective view of the support s~ructure of the set shown in the Figure 1, ~igure 5 iæ a cross section view o~ the support structure, and, Figure 6 îs a perspective view of the ~upport st,ucture holding the set shown in figure 2, The items designated with numbers on the drawings correspond to the parts pointed out below.
PREFERRED EMBODIMENT OF THE INVENTION
In Figure 1 is shown a device according to the present invention, comprised of a laminar body ~10), a nozzle (20) and a cup (30), illustrated in an uncoupled position, on a same ideal axis.
The laminar body 10, the nozzle 20 and the cup 30, preferably made of plastic material, are obtained by moulding.
The laminar body 10 in its lower part has a cylindrical general configuration, with its lateral wall 11 bellow-shaped and one of its bases blind. Its other base axially extends by a cylindrical tube 12, ending in an outer ring 13 which def ines a central orifice 14 communicating through ths tube ~2 with the hollow body 10.
The nozzle 20 is tubular, with a longitudinal passage 21j having a:cylindrical general con~iguration, with a flat outer surrounding rim 22.
The nozzle 20 of:the figure l has an upper bevelled end 23~ Such as it will be described below, this end may have several forms according to applications.
The gene~al diameters of the nozzle 20, both upper and lower with regard;to the surrounding rim 22, are slightly lower than the one o~ the central orifice 14 and the one of the cylindrical tube 12 of the laminar body 10.
Such as abovementioned, the nozzle 20 is preferably made of plastic material. However, its width must provide such a rigidness that eliminates any possible flexibility when handling.
The cup 30 is generally long-shaped, with a central cylindrical hollow section from which laterally two diametrally opponents lugs 31 and 3~ emerge, with it~ upper ends slightly inclined ending adiacent to the end of the cup.
Internally, the cup 30 is provided with a bllnd cylindrical cavity, not shown in Figure 1, with a slightly greater diameter than the one of the upper section o.~ the nozzle 20.
In the lower part, the cup 30 comprises in its outer wall a surrounding weakened line 33, its mouth being extended by a flange 34 which defines a flat ring.
The internal cavity of the cup 3Q may receive inserted the upper end of the nozzle 20, thus coinciding the upper area of the surrounding rim 22 against the lower area of the flange 34 which defines the opening of the cup 30.
In the same way, the lower section of the nozzle can be inserted through a central ori~ice 14 and penetrating into the cylindrical tube 12, thus coinciding the lower area of the surrounding rim 22 with the upper area of the outer ring 13 of the body 10.
Figure 2 shows in cross section the body 10 and the cup 30 with the nozzle 20 inserted into the cylindrical tube 12, and in its turn into the cup 30.
In the same Figure 2, the fluted ring 40 is shown, defining a circular: channel 41 perimetrally trapping the outer ring 13 of the body 10, with the flange 34 and the cup 30, and thus the surrounding rim 22 of the nozæle 20 The fluted ring 40 is laterally extended by a lu~
42 in the illustrated example.
The fluted ring 40 allows to hol~.together the body 10, the nozzle 2n and the cup 30 in a steady way.
In an industrial application o~ the device according to the present invention, it is better to first fill up the body 10 with a solution before assembl~ng the parts thereof.
once said elements are assembled on the body 10, 2101~
the fluted ring will allow, apart from interconnecting the parts, to keep tight the inside o~ the device, the set being able to be sterilized by conventional means beyond the pxesent in~ention.
~he described device consist of a disposable closed container which allows to dlspense solution~. ~o as to open the device and proceed to d~se its contents the device shall be held with one hand taking its lug 42 and the other hand holding the cup 30 in order to proceed to its tearing by an axial spin. In this operation both lugs 31 and 32 o~ the cup 30 efficiently cooperate, avoiding that the fingers may slip during the opening of ~he device.
Later, and with only one hand, the contained æolution may be dosed, by holding with two consecutive fingers of the hand the cylindrical tube 12 and pressing the blind base of the body 10 with the thumb. The lateral wall 11 of the body will give, allowing to dose by a slightly weakening of the bellows, and/or suck up by its recuperation.
The upper end 23 of the nozzle 20 shows a bevelled form, for specific applications with regard to the use of the device. Such as abovementioned, the nozzle 20 may have different upper ends 23, as the one shown in Figure 3.
Llkewise, the inner tube which goes through the nozzle 20 may be provided with elements which allow to keep an unidirectional passage~of the solutions contained into the body 10.
~ ~ , -~ ; In the Figure 3 a nozzle 20 which has in its upper part a cylindrical~end ~3 is show~.
The shown nozzle 20 is comprised of the connection of two halves, upper~and lower, having an orifice ~1 which leads to a tubular inner tube 28 that goes longitudinally through it, with a disc 29 which is placed into a cavity 27, working as a va~lve, allowing an unidirectional passage of the ; solutions. The cited valve is conventional beyond the present invention with regard to its particularities, different kinds of valves can be used.~
Such as abovementioned, the ends 23 of the nozzle :::
20 may have di~ferent shapes according to the specific application of the solution to be dosed. Independently, several valves or direct tubes can be used into the nozzle 20.
5The application of a one-way val~e as described above allows to take out the air which may be in the body 10 ~nd keep this position in a steady way. Similarly said valve stops any possible sucX, and in its turn, penetration of other liquid or gaseous material into the body 10.
10~he nozzle 20 may also have thP most convenient shape to be able to tightly secure coaxially to its outer surface conventional tubes or couplings in order to assure their retention. In all cases, the blind cavity o~ the cup 30 has a suitable shape in order to secure cited ends and in its turn to generally keep tight the device.
The fluted ring 40 is laterally extended by a lug 42. The device may have a multiple number of lugs.
This cited lug has pertinent functional applications, allowing to adhere a label with the identification of the solution which is contained into the device, such as a description, a formula, expiring date or the like.
Apart from the abovementioned function, in order to facilitate the opening of the device, the use of a lug allows to protect th~ fingers of the hand when the solution is being dcsed a~oiding the contact of them with he area receiving the solution.
Likewise, when the device is not being used, the lug prevents the device from rolling over apparently flat areas,:and in its turn helps to keep the ~nd 23 of the nozzle 20 ~part from th~ very surface where the device is placed.
The device described can be used alone or together with a rigid support.
~ he Figures 4 and 5 show a rigid support 50. In the Figure 6 is shown the rigid support 50 at which the dosing device has been socketed~
:In the rigid support 50 a flat surface 51 is 21~10~
provided with one of its edges having an inlet 54, and with two non-contiguou~ and parallel ends provided with L-shaped projections 52 and 53 which de~ine two longitudinal guides.
The rigid support 50 comprises an axis 33 perpendicularly connected underneath the flat surface 51, symmetrically arranged on cited surface.
In the lower part, the support 50 comprises a base 56 having a circular surface with a central recess 5'7 and a lateral passing hole 58.
The lateral passing hole 58 of the base 56 is slightly greater in diameter than the one of the axis 55.
The base 56 in its lower part has an extension with an inner passage 65 perpendicular to the lateral passing hole 58 and communicating with it. Pressure means constituted by a screw 59 which controls a spring 61 are located within said passage and in its turn the latter fits on the cylinder 60.
Once the base 56 is plac~d in the axis 55 through its lateral orifice 58, the cylinder 60 presses by the assistance of the cited means on the previous paragraph on the surface of the axis 55. So, the base 56 can only be slidable along the axis 55 when desired.
The base 56 on the axis 55 is in its upper part limit~d by the flat surface 51, and in its lower part by the inlet 62, which has in its last end a slight step against whiah the cylinder 60 fits.
The outer surface of the axis 55 has a graduate scale 63l whose use will be describe below.
The different parts which comprise the rigid support can be also obtained by moulding, made of plastic or metallic materials.
The dosing device is coupled to the rigid ~upport 50. For doing so, the lug 42 has to be placed on the flat surface 51 with the assistance of the L-shaped pro~ections 52 and 53 by securing the edges of the lug 42. In this position, the neck 12 of the body 10 and the ring 40 are placed into the inlet 54. Inferiorly, the blind base of the body 10 is placed on the central recess 57 of the base 56 of 2 1 ~
the rigid support. The Figure 6 illustrates the last positioning of the device in the rigid support.
The opening and handling o~ the dosing device coupled to the rigid support is identical to what described above without it.
The application of the rigid support have clear advantages allowing to dose with greater precision, since it assists with a greater rigidness of the device set, and by having a graduate scale 63 on the axis 55. So, specific amounts of solution can be dosed.
~ ~ , ! ' ' : . '
Claims (6)
1. Dosing device for sterile and/or pharmaceutical solutions, of the type consisting of a container which contains the solution and that is provided with outlet connecting means, and a rigid support at which the said container is coupled, characterized by having the following parts:
a) a flexible generally cylindrical tubular body with its wall bellow-shaped, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ring, b) a cylindrical tubular nozzle, which has a flat outer surrounding rim having one of its ends bevelled and its outer diameter being slightly smaller than the one of the orifice of the cylindrical tube which extends the bellows, c) a cup which covers the nozzle having in its wall a surrounding weakened line, and being its mouth extended by a flange, lying on the surrounding rim of the nozzle, and, d) a fluted ring which defines a circular channel capable of perimetrally trapping the ring of the extension of the body a) with the flange of the cup, and said fluted ring being laterally extended by at least a lug.
a) a flexible generally cylindrical tubular body with its wall bellow-shaped, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ring, b) a cylindrical tubular nozzle, which has a flat outer surrounding rim having one of its ends bevelled and its outer diameter being slightly smaller than the one of the orifice of the cylindrical tube which extends the bellows, c) a cup which covers the nozzle having in its wall a surrounding weakened line, and being its mouth extended by a flange, lying on the surrounding rim of the nozzle, and, d) a fluted ring which defines a circular channel capable of perimetrally trapping the ring of the extension of the body a) with the flange of the cup, and said fluted ring being laterally extended by at least a lug.
2. Dosing device for sterile and/or pharmaceutical solutions, according to claim 1, characterized in that it further includes a one-way valve which may be placed between the bellow-shaped body and the nozzle.
3. Dosing device for sterile and/or pharmaceutical solutions, according to claims 1 and 2, characterized in that the end of the nozzle finishes in a bevelled tip.
4. Dosing device for sterile and/or pharmaceutical solutions according to claims 1 and 2, characterized in that the very end of the nozzle is capable of ending in a conus of the 'Luer' type.
5. Dosing device for sterile and/or pharmaceutical solutions, according to aforementioned claims, characterized by having, in a second embodiment, the following parts:
a) a flexible generally cylindrical tubular body with a bellow-shaped wall, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ring, b) a cylindrical tubular nozzle, which has a flat outer surrounding rim having one of its ends bevelled and its outer diameter being slightly smaller than the one of the orifice of the cylindrical tube which extends the bellows, c) a cup which covers the nozzle, having in its wall a surrounding weakened line, and being its month extended by a flange, lying on the surrounding rim of the nozzle, and, d) a fluted ring which defines a circular channel capable of perimetrally trapping the ring of the extension of the body a) with the flange of the cup, and said fluted ring being laterally extended by at least a lug.
e) a rigid support capable of socketing the cited set, which is provided with:
- a flat U-shaped surface with two non-contiguous parallel ends provided with a L-shaped projection, defining two longitudinal parallel guides, - an axis perpendicularly connected underneath said flat surface and symmetrically disposed on it, - a circular base which comprises a central recess, with a lateral extension provided with a passing hole, where the perpendicular axis is socketed, and with a lower extension held by pressure means perpendicular to said axis.
a) a flexible generally cylindrical tubular body with a bellow-shaped wall, with one of its bases blind and the other axially extended by a cylindrical tube ending in an outer ring, b) a cylindrical tubular nozzle, which has a flat outer surrounding rim having one of its ends bevelled and its outer diameter being slightly smaller than the one of the orifice of the cylindrical tube which extends the bellows, c) a cup which covers the nozzle, having in its wall a surrounding weakened line, and being its month extended by a flange, lying on the surrounding rim of the nozzle, and, d) a fluted ring which defines a circular channel capable of perimetrally trapping the ring of the extension of the body a) with the flange of the cup, and said fluted ring being laterally extended by at least a lug.
e) a rigid support capable of socketing the cited set, which is provided with:
- a flat U-shaped surface with two non-contiguous parallel ends provided with a L-shaped projection, defining two longitudinal parallel guides, - an axis perpendicularly connected underneath said flat surface and symmetrically disposed on it, - a circular base which comprises a central recess, with a lateral extension provided with a passing hole, where the perpendicular axis is socketed, and with a lower extension held by pressure means perpendicular to said axis.
6. Dosing device for sterile and/or pharmaceutical solutions, according to claim 5, characterized in that the axis perpendicular to the base of the rigid support may have a graduate scale.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/ES1991/000081 WO1993010422A1 (en) | 1991-11-22 | 1991-11-22 | Dosing apparatus for sterile and/or pharmaceutical solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2101049A1 true CA2101049A1 (en) | 1993-05-23 |
Family
ID=8270758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2101049 Abandoned CA2101049A1 (en) | 1991-11-22 | 1991-11-22 | Dosing apparatus for sterile and/or pharmaceutical solutions |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0570378A1 (en) |
| CA (1) | CA2101049A1 (en) |
| WO (1) | WO1993010422A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7484678B2 (en) | 2003-04-24 | 2009-02-03 | Glaxo Group Limited | Nozzle for a nasal inhaler |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5819730A (en) * | 1993-06-09 | 1998-10-13 | Glaxo Wellcome Australia Ltd. | Device for administering pharmaceutical substances |
| US6820770B2 (en) * | 2002-12-06 | 2004-11-23 | The Dial Corporation | Dispenser holder for vehicles |
| CN104602737B (en) * | 2013-03-15 | 2017-09-29 | 泰尔茂株式会社 | Syringe assembly, its assemble method and its assembling device, pre-encapsulated injector and its assemble method using the syringe assembly |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1407945A (en) * | 1964-09-07 | 1965-08-06 | Behringwerke Ag | Device for the collection of body fluids under sterile conditions |
| US4244366A (en) * | 1979-10-30 | 1981-01-13 | Burron Medical, Inc. | Syringe stroke controlling mechanism |
| US4327782A (en) * | 1980-04-03 | 1982-05-04 | The Procter & Gamble Company | Dispensing apparatus having portable means for dispensing predetermined quantity of liquid from a bulk container |
| US4671330A (en) * | 1984-10-26 | 1987-06-09 | Gilbert Miles | Container with removable transfer flask |
| EP0238609A1 (en) * | 1985-10-01 | 1987-09-30 | Axipac Limited | Disposable syringe |
| US4955871A (en) * | 1987-04-29 | 1990-09-11 | Path | Single-use disposable syringe |
-
1991
- 1991-11-22 WO PCT/ES1991/000081 patent/WO1993010422A1/en not_active Application Discontinuation
- 1991-11-22 EP EP19920900409 patent/EP0570378A1/en not_active Withdrawn
- 1991-11-22 CA CA 2101049 patent/CA2101049A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7484678B2 (en) | 2003-04-24 | 2009-02-03 | Glaxo Group Limited | Nozzle for a nasal inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0570378A1 (en) | 1993-11-24 |
| WO1993010422A1 (en) | 1993-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100232689B1 (en) | Device | |
| KR100763213B1 (en) | Medicament dispenser | |
| AU682670B2 (en) | Syringe needle isolation device | |
| US6280418B1 (en) | Container for storing and dispensing injection, infusion and diagnostic preparations | |
| CA2074219C (en) | Syringe sprayer | |
| EP1015382B1 (en) | Fluid dispenser apparatus | |
| FI115956B (en) | Spraying device for storing and applying a multi-component material, as well as a method for manufacturing a spraying device | |
| US5370621A (en) | Insert device for facilitating limited aspiration of a delivery apparatus | |
| EP0713401A1 (en) | Mechanism preventing rearward movement of piston syringe | |
| LV12925B (en) | Ophthalmic package and delivery device | |
| US11203467B2 (en) | Assembly and method for delivery of micro-volume droplets from a squeeze bottle | |
| CA2101049A1 (en) | Dosing apparatus for sterile and/or pharmaceutical solutions | |
| AU7369594A (en) | Liquid dispenser having a dosage counter | |
| GB2120630A (en) | Squeezable liquid-dispensing containers | |
| GB1573514A (en) | Container and device for emptying the container | |
| GB2203345A (en) | Dispenser for vaginal creams |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |