JP4588324B2 - 組織測定用プローブ - Google Patents

組織測定用プローブ Download PDF

Info

Publication number
JP4588324B2
JP4588324B2 JP2003584690A JP2003584690A JP4588324B2 JP 4588324 B2 JP4588324 B2 JP 4588324B2 JP 2003584690 A JP2003584690 A JP 2003584690A JP 2003584690 A JP2003584690 A JP 2003584690A JP 4588324 B2 JP4588324 B2 JP 4588324B2
Authority
JP
Japan
Prior art keywords
raman
tissue
spectrum
probe
fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003584690A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005522293A5 (de
JP2005522293A (ja
Inventor
モツツ,ジエイソン・テイ
ガリンド,ルイス・エイチ
ハンター,マーテイン
ハカ,アビゲイル・エス
ガンデイ,ソーミル
ダサリ,ラマチヤンドラ
フエルド,マイケル・エス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/178,062 external-priority patent/US7647092B2/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of JP2005522293A publication Critical patent/JP2005522293A/ja
Publication of JP2005522293A5 publication Critical patent/JP2005522293A5/ja
Application granted granted Critical
Publication of JP4588324B2 publication Critical patent/JP4588324B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519Muscles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4742Details of optical heads therefor, e.g. using optical fibres comprising optical fibres
    • G01N2021/4745Fused bundle, i.e. for backscatter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4752Geometry
    • G01N2021/4759Annular illumination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
JP2003584690A 2002-04-05 2003-04-04 組織測定用プローブ Expired - Fee Related JP4588324B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37019702P 2002-04-05 2002-04-05
US10/178,062 US7647092B2 (en) 2002-04-05 2002-06-21 Systems and methods for spectroscopy of biological tissue
PCT/US2003/010307 WO2003087793A1 (en) 2002-04-05 2003-04-04 Systems and methods for spectroscopy of biological tissue

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010136655A Division JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Publications (3)

Publication Number Publication Date
JP2005522293A JP2005522293A (ja) 2005-07-28
JP2005522293A5 JP2005522293A5 (de) 2006-05-25
JP4588324B2 true JP4588324B2 (ja) 2010-12-01

Family

ID=28677945

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003584690A Expired - Fee Related JP4588324B2 (ja) 2002-04-05 2003-04-04 組織測定用プローブ
JP2010136655A Pending JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010136655A Pending JP2010249835A (ja) 2002-04-05 2010-06-15 生物学的組織の分光法のための系および方法

Country Status (3)

Country Link
EP (1) EP1495309A1 (de)
JP (2) JP4588324B2 (de)
AU (1) AU2003230799A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013075027A (ja) * 2011-09-30 2013-04-25 Fujifilm Corp 内視鏡用照明光学系及び照明装置

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4041421B2 (ja) * 2003-03-25 2008-01-30 独立行政法人理化学研究所 ラマンプローブ及びそれを用いたラマン散乱計測装置
GB0426993D0 (en) * 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
EP1726256A1 (de) * 2005-05-27 2006-11-29 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Phantomvorrichtung
DE102005045088B4 (de) * 2005-09-21 2007-05-16 Siemens Ag Optisches Kohärenztomographie-System
GB0611981D0 (en) * 2006-06-16 2006-07-26 Renishaw Plc Spectroscopic analysis methods
JP4920507B2 (ja) * 2007-06-27 2012-04-18 オリンパス株式会社 画像処理装置および画像処理プログラム
JP5201920B2 (ja) * 2007-09-12 2013-06-05 キヤノン株式会社 測定装置
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
EP2425785A1 (de) * 2009-03-13 2012-03-07 Kyoto Prefectural Public University Corporation Bilddarstellung von körpergewebe mit raman-streulicht
AU2010333666A1 (en) * 2009-12-17 2012-07-12 British Columbia Cancer Agency Branch Apparatus and methods for in vivo tissue characterization by Raman spectroscopy
US8223443B2 (en) * 2010-09-01 2012-07-17 Kla-Tencor Corporation Collection optics
EP2633796A4 (de) * 2010-10-26 2016-12-14 Konica Minolta Inc Sonde
EP2653090A4 (de) * 2010-12-16 2016-11-16 Konica Minolta Inc Sonde
JP2012189322A (ja) * 2011-03-08 2012-10-04 Olympus Corp 液状生体ファントム及び液状生体ファントムの作製方法
JP5814635B2 (ja) * 2011-06-07 2015-11-17 シャープ株式会社 検出装置
JPWO2013061590A1 (ja) * 2011-10-25 2015-04-02 コニカミノルタ株式会社 光学プローブ及びその製造方法
JP5733163B2 (ja) * 2011-11-10 2015-06-10 コニカミノルタ株式会社 プローブの製造方法
EP2790580A4 (de) 2011-12-14 2015-08-12 Univ Pennsylvania Glasfaserfluss- und oxygenierungsüberwachung mit diffuser korrelation und reflexion
WO2013136664A1 (ja) 2012-03-13 2013-09-19 コニカミノルタ株式会社 プローブ
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
US20150216417A1 (en) * 2012-08-16 2015-08-06 National University Of Singapore Diagnostic instrument and methods relating to raman spectroscopy
JP6006036B2 (ja) * 2012-08-17 2016-10-12 オリンパス株式会社 分光スペクトル解析方法
JP6082273B2 (ja) * 2013-02-25 2017-02-15 日本板硝子株式会社 蛍光検出装置
JP6294614B2 (ja) * 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
JP6273470B2 (ja) * 2013-05-10 2018-02-07 ナノフォトン株式会社 分子振動の表示方法
JP6103700B2 (ja) * 2013-05-15 2017-03-29 京都府公立大学法人 ラマン散乱を用いた心臓組織の識別方法及び装置
JP2014224771A (ja) * 2013-05-16 2014-12-04 三菱重工業株式会社 燃料ガス計測装置及び方法
WO2015128946A1 (ja) 2014-02-25 2015-09-03 オリンパス株式会社 分光スペクトル解析方法
CN103932680A (zh) * 2014-04-15 2014-07-23 广州玖玖伍捌信息科技有限公司 一种人体肿瘤复发监测及热疗一体***
FR3024546B1 (fr) * 2014-07-29 2018-08-24 Universite De Reims Champagne-Ardenne Procede de detection et de quantification de la fibrose
WO2016121811A1 (ja) * 2015-01-29 2016-08-04 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6336949B2 (ja) * 2015-01-29 2018-06-06 富士フイルム株式会社 画像処理装置及び画像処理方法、並びに内視鏡システム
JP6630944B2 (ja) * 2016-01-19 2020-01-15 国立大学法人島根大学 ラマン散乱光の観測方法、ラマン散乱光の観測装置及びプログラム
WO2018116363A1 (ja) * 2016-12-19 2018-06-28 オリンパス株式会社 ラマンプローブおよびラマンスペクトル測定装置
GB201701355D0 (en) * 2017-01-27 2017-03-15 Renishaw Plc Direct laser writing and chemical etching
JP6428825B2 (ja) * 2017-03-29 2018-11-28 セイコーエプソン株式会社 検出装置
US11672425B2 (en) 2018-02-15 2023-06-13 Speclipse, Inc. Stand-alone apparatus and methods for in vivo detection of tissue malignancy using laser spectroscopy
KR102279688B1 (ko) 2019-03-22 2021-07-20 스페클립스 주식회사 레이저 유도 붕괴 스펙트럼 분석을 이용하는 진단 방법 및 이를 수행하는 진단 장치

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230679B1 (de) * 1986-01-30 1990-08-08 The Dow Chemical Company Faseroptische Sonde
DK130586A (da) * 1985-03-22 1986-09-23 Massachusetts Inst Technology Laser-kateter til indfoering i arterier
WO1989002718A1 (en) * 1987-09-24 1989-04-06 Massachusetts Institute Of Technology Catheter system for imaging
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
CA2264870C (en) * 1996-08-02 2005-07-26 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
JPH10267846A (ja) * 1997-03-27 1998-10-09 Jeol Ltd レーザ照射/取り込み光学装置
JP4486743B2 (ja) * 2000-10-31 2010-06-23 株式会社町田製作所 血管内壁の付着物質の分析システム

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013075027A (ja) * 2011-09-30 2013-04-25 Fujifilm Corp 内視鏡用照明光学系及び照明装置

Also Published As

Publication number Publication date
EP1495309A1 (de) 2005-01-12
AU2003230799A1 (en) 2003-10-27
JP2010249835A (ja) 2010-11-04
JP2005522293A (ja) 2005-07-28

Similar Documents

Publication Publication Date Title
JP4588324B2 (ja) 組織測定用プローブ
US20170202462A1 (en) Systems and methods for spectroscopy of biological tissue
EP2325623A2 (de) Vorrichtung und Verfahren zur Spektroskopie von biologischem Gewebe
CA2658811C (en) Multi modal spectroscopy
JP4870356B2 (ja) 組織を測定するための高波数ラマン分光法の使用
Austin et al. Raman technologies in cancer diagnostics
US8243269B2 (en) Raman spectral analysis of sub-surface tissues and fluids
US20120302892A1 (en) Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis
US20060281068A1 (en) Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US20090326385A1 (en) Obtaining optical tissue properties
KR20170039168A (ko) 비정상적 성장하는 표본 또는 조직의 유형 또는 특성을 분석하는 라만 분광 시스템, 장치 및 방법
JP3923080B2 (ja) 光学的微細プローベ及び材料のスペクトル分析方法
US20120200850A1 (en) Cytological methods for detecting a condition such as transplant efficiency by raman spectroscopic imaging
Vasquez et al. Multimodal scanning microscope combining optical coherence tomography, Raman spectroscopy and fluorescence lifetime microscopy for mesoscale label-free imaging of tissue
Kandurova et al. Optical fine-needle biopsy approach for intraoperative multimodal diagnostics in minimally invasive abdominal surgery
Uckermann et al. Optical biochemical imaging: potential new applications in neuro-oncology
RU2184486C2 (ru) Способ диагностики онкологических заболеваний и устройство для его осуществления
WO2012127378A1 (en) An apparatus for optical analysis of an associated tissue sample
Bandzeviciute et al. Fast and label-free intraoperative discrimination of malignant pancreatic tissue by attenuated total reflection infrared spectroscopy
Motz Development of in vivo Raman spectroscopy of atherosclerosis
Baria et al. Label-free spectroscopic diagnosis of urothelial carcinoma
Curtis Comparing coherent and spontaneous Raman modalities for the investigation of gastrointestinal cancers.
Desroches Sonde de biopsie optique afin d'améliorer la sécurité et la précision de diagnostic des biopsies neurochirurgicales
Krafft et al. Raman Spectroscopy to Solve Unmet Needs in Histopathology
Chau Development of an intracoronary Raman spectroscopy

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060403

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060403

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20081101

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090407

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090707

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090714

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091006

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100315

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100323

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100615

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100817

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100908

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130917

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees