JP2024015465A - Topical skin preparation - Google Patents
Topical skin preparation Download PDFInfo
- Publication number
- JP2024015465A JP2024015465A JP2022117613A JP2022117613A JP2024015465A JP 2024015465 A JP2024015465 A JP 2024015465A JP 2022117613 A JP2022117613 A JP 2022117613A JP 2022117613 A JP2022117613 A JP 2022117613A JP 2024015465 A JP2024015465 A JP 2024015465A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- acid
- production example
- derivatives
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000000699 topical effect Effects 0.000 title abstract 3
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Landscapes
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Abstract
Description
本発明は、複数の成分を組み合わせて配合することで、より高い有効性を発揮する皮膚外用剤に関するものである。 The present invention relates to an external skin preparation that exhibits higher effectiveness by combining a plurality of ingredients.
従来、皮膚外用剤の配合可能な成分として、種々の化合物の使用が提案され、それらを配合した皮膚外用剤(外用医薬品、医薬部外品及び化粧品等)が上市されている。例えば、ビタミンC、ビタミンE、スーパーオキシドジスムターゼ等の抗酸化剤;グリチルリチン酸等の抗炎症剤;各種紫外線吸収剤;α-ヒドロキシカルボン酸、胎盤抽出液、γ-アミノ-β-ヒドロキシ酪酸等の細胞賦活成分;コラーゲン、エラスチン、ヒアルロン酸等の細胞外マトリックス成分;尿素等の保湿剤が提案されている。一方で、安全性を考慮して、様々な植物由来成分を配合した皮膚外用剤が提案されている。しかし、植物由来成分はそれら単独では有効性の点で十分と言えず、高い有効性を発揮する成分の組み合わせが求められている。 BACKGROUND ART Conventionally, the use of various compounds has been proposed as ingredients that can be incorporated into external skin preparations, and external skin preparations (external drugs, quasi-drugs, cosmetics, etc.) containing these compounds have been put on the market. For example, antioxidants such as vitamin C, vitamin E, and superoxide dismutase; anti-inflammatory agents such as glycyrrhizinic acid; various ultraviolet absorbers; Cell activation components; extracellular matrix components such as collagen, elastin, and hyaluronic acid; and moisturizing agents such as urea have been proposed. On the other hand, in consideration of safety, external skin preparations containing various plant-derived ingredients have been proposed. However, plant-derived ingredients alone cannot be said to be sufficiently effective in terms of effectiveness, and there is a need for a combination of ingredients that exhibits high effectiveness.
本発明者らは、上記従来技術の問題点に鑑みて、皮膚外用剤の有効成分として有効性の高い化合物及び植物由来成分の組み合わせについて鋭意研究を行った。その結果、ナイアシンアミド(別名:ニコチン酸アミド)と、ゲンチアナ抽出物、ヘチマ抽出物及びグレープフルーツ抽出物のいずれか2以上の抽出物との組み合わせが、皮膚外用剤の配合成分として高い有効性を発揮することを見出した。従来、ナイアシンアミド、ゲンチアナ抽出物、ヘチマ抽出物及びグレープフルーツ抽出物をそれぞれ単独又はアスコルビン酸誘導体等の組み合わせで皮膚外用剤の成分として使用する技術については、特許文献1~6により知られているが、ナイアシンアミド、ゲンチアナ抽出物、ヘチマ抽出物及びグレープフルーツ抽出物うちの2以上の抽出物を組み合わせることで、シミ、ソバカス等の色素沈着の予防又は改善、肌荒れ改善並びにシワ改善等の効果を相乗的に発揮することについては知られていなかった。
本発明は、ナイアシンアミドと、ゲンチアナ抽出物、ヘチマ抽出物及びグレープフルーツ抽出物のうちのいずれか2以上の抽出物とを含む皮膚外用剤である。 The present invention is an external skin preparation containing niacinamide and any two or more extracts of gentian extract, loofah extract, and grapefruit extract.
本発明は、ナイアシンアミドと、ゲンチアナ抽出物、ヘチマ抽出物及びグレープフルーツ抽出物のうちのいずれか2以上の抽出物とを組み合わせることで相乗的なシミ、ソバカス等の色素沈着の予防及び改善、肌荒れ改善、並びにシワ改善の効果を相乗的に発揮することから、有効性の高い皮膚外用剤を提供することができる。 The present invention provides synergistic prevention and improvement of pigmentation such as age spots and freckles by combining niacinamide and any two or more extracts of gentian extract, loofah extract, and grapefruit extract. Since it synergistically exhibits the effects of wrinkle improvement and wrinkle improvement, it is possible to provide a highly effective skin preparation for external use.
本発明において、「ゲンチアナ」とは、リンドウ科リンドウ属のゲンチアナ(Gentiana lutea)である。使用部位としては、全草、花、茎、葉、根等を用いることができる。 In the present invention, "Gentiana" refers to Gentiana lutea, which belongs to the Gentiana family and Gentiana genus. As the parts used, the whole plant, flowers, stems, leaves, roots, etc. can be used.
また、本発明において、「ヘチマ」とは、ウリ科(Cucurbitaceae)ヘチマ属(Luffa)のヘチマ(Luffa aegyptiaca)である。使用可能な部位としては、その全草、果実、花、種子、葉、茎及び根等が挙げられる。 Moreover, in the present invention, "loofah" means loofah (Luffa aegyptiaca) of the cucurbitaceae (Cucurbitaceae) genus (Luffa). Parts that can be used include the whole plant, fruits, flowers, seeds, leaves, stems, roots, etc.
また、本発明において、「グレープフルーツ」とは、ミカン科(Rutaceae)ミカン属(Citrus)のグレープフルーツ(Citrus paradisi Macfadyen[Rutaceae]))である。使用可能な部位としては、果皮、果肉、種子などが挙げられる。また、本発明においては、未成熟果実(果皮及び果肉を含む)を使用することも可能である。「未成熟」とは、食用に適する成熟期前のものをいい、成熟期のものより、ヘスペリジンやナリンギン等のフラボノイドが多く含まれるものが好ましい。例えば、グレープフルーツの果実の栽培において、収穫期よりも前に間引きする摘果果実を使用することができる。 In the present invention, "grapefruit" refers to grapefruit (Citrus paradisi Macfadyen [Rutaceae]) belonging to the family Rutaceae and the genus Citrus. Parts that can be used include pericarp, pulp, and seeds. Further, in the present invention, it is also possible to use immature fruit (including pericarp and pulp). "Imature" refers to a product that is not yet ripe enough to be eaten, and preferably contains more flavonoids such as hesperidin and naringin than a mature product. For example, in the cultivation of grapefruit fruits, thinned fruits can be used that are thinned out before the harvest period.
本発明においては、ゲンチアナ、ヘチマ及びグレープフルーツの使用可能部位から抽出物を調製する際には、当該使用部位を乾燥し、又細切もしくは粉砕した上で、浸漬法、向流抽出法、水蒸気蒸留法、亜臨界抽出法、超臨界抽出法等の常法によって抽出溶媒に接触させることで行うことができる。 In the present invention, when preparing extracts from usable parts of gentian, loofah, and grapefruit, the parts to be used are dried, chopped or crushed, and then processed by immersion method, countercurrent extraction method, steam distillation method, etc. This can be carried out by contacting with an extraction solvent by a conventional method such as a method, a subcritical extraction method, a supercritical extraction method, or the like.
抽出溶媒としては、水;メタノール、エタノール、プロパノール等の低級アルコール類;エチレングリコール、プロピレングリコール、1,3-ブチレングリコール、グリセリン等の多価アルコール類;酢酸エチル、酢酸ブチル、プロピオン酸メチル等のエステル類;アセトン、メチルエチルケトン等のケトン類;エチルエーテル、イソプロピルエーテル等のエーテル類;n-ヘキサン、トルエン、クロロホルム等の炭化水素系溶媒等が挙げられ、それらは単独で又は二種以上混合して用いられる。 Extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; ethyl acetate, butyl acetate, methyl propionate, etc. Esters; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene, and chloroform; these may be used alone or in combination of two or more. used.
それら抽出溶媒のうちでも、皮膚外用剤(化粧料又は医薬部外品)への幅広い適用が可能であるという点からも、本発明においては水或いは水と低級アルコール類又は水と多価アルコール類との混合溶媒の使用が好ましい。 Among these extraction solvents, water, water and lower alcohols, or water and polyhydric alcohols are preferred in the present invention because they can be widely applied to external skin preparations (cosmetics or quasi-drugs). It is preferable to use a mixed solvent with
本発明において、抽出物溶液を調製する際は、適宜、アルカリ調整剤又は酸性調整剤を用いてpHを調製することが好ましい。アルカリ調製剤としては、例えば、水酸化ナトリウム、炭酸ナトリウム等のナトリウム塩、水酸化カリウム等のカリウム塩等が挙げられる。それらの中でも、水酸化ナトリウム、炭酸ナトリウムが好ましい。また、酸性調整剤としては、塩酸、硫酸、燐酸等の無機酸、又は酢酸、乳酸、リンゴ酸、クエン酸等の有機酸等が挙げられる。 In the present invention, when preparing an extract solution, it is preferable to adjust the pH using an alkaline regulator or an acidic regulator as appropriate. Examples of the alkali preparation include sodium salts such as sodium hydroxide and sodium carbonate, potassium salts such as potassium hydroxide, and the like. Among them, sodium hydroxide and sodium carbonate are preferred. Further, examples of the acidity regulator include inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid, and organic acids such as acetic acid, lactic acid, malic acid, and citric acid.
抽出温度、抽出時間等の抽出条件は、用いる溶媒の種類やpHによっても異なるが、例えば、水又は水と低級アルコール若しくは多価アルコールの混合溶媒を抽出溶媒とする浸漬法の場合であれば、抽出温度は一般的には1~90℃、好ましくは40℃から80℃の範囲であり、抽出時間は、抽出温度が40℃の場合であれば、一般的には0.5~24時間、好ましくは0.5~6時間の範囲である。 Extraction conditions such as extraction temperature and extraction time vary depending on the type and pH of the solvent used, but for example, in the case of an immersion method using water or a mixed solvent of water and lower alcohol or polyhydric alcohol as the extraction solvent, The extraction temperature is generally in the range of 1 to 90°C, preferably 40°C to 80°C, and the extraction time is generally 0.5 to 24 hours when the extraction temperature is 40°C. Preferably it is in the range of 0.5 to 6 hours.
本発明は、以上の植物抽出物に加えて、ナイアシンアミドと併用することがより好ましい。ナイアシンアミドと併用することで、シミ、ソバカス等の色素沈着の予防及び改善、肌荒れ改善並びにシワ改善の効果が相乗的に発揮されることから、より有効性が高い皮膚外用剤を提供することができる。 In the present invention, in addition to the above-mentioned plant extracts, it is more preferable to use niacinamide in combination. When used in combination with niacinamide, the effects of preventing and improving pigmentation such as spots and freckles, improving rough skin, and improving wrinkles are exhibited synergistically, so it is possible to provide a more effective skin preparation for external use. can.
本発明に係る成分を皮膚外用剤に配合する場合、上記必須構成成分のほかに、皮膚外用剤に用いられる成分、例えば油性成分、界面活性剤(合成系、天然物系)、保湿剤、増粘剤、乳化剤又は乳化助剤、防腐・殺菌剤、粉体成分、紫外線吸収剤、抗酸化剤、色素、香料、抗シワ剤、その他の生理活性成分等を必要に応じて適宜配合することができる。 When the ingredients according to the present invention are incorporated into a skin preparation for external use, in addition to the above-mentioned essential constituents, ingredients used in the skin preparation for external use, such as oily components, surfactants (synthetic type, natural product type), moisturizers, Adhesives, emulsifiers or emulsifying aids, preservatives/sterilizers, powder components, ultraviolet absorbers, antioxidants, pigments, fragrances, anti-wrinkle agents, and other physiologically active ingredients may be added as necessary. can.
ここで、油性成分としては、例えば、オリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米胚芽油、ヤシ油、パーム油、カカオ油、メドウフォーム油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、ベルガモット油、ラベンダー油、バラ油、ベルガモット油、カミツレ油等の植物由来の油脂類;ビタミンA油;ミンク油、タートル油等の動物由来の油脂類;ミツロウ、カルナウバロウ、ライスワックス、ラノリン等のロウ類;流動パラフィン、ワセリン、パラフィンワックス、スクワラン(例えば、シュガースクワラン、オリーブスクワラン)等の炭化水素類;ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、cis-11-エイコセン酸等の脂肪酸類;ラウリルアルコール、セタノール、パントテニルアルコール、ステアリルアルコール等の高級アルコール類;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、2-エチルヘキシルグリセライド、トリ2-エチルヘキサン酸グリセリル、トリ2-エチルヘキサン酸トリメチルプロパン、トリ(カプリル酸・カプリン酸)グリセリル、トリ(カプリル酸・カプリン酸・ミリスチン・ステアリン酸)グリセリル、高級脂肪酸オクチルドデシル(ステアリン酸オクチルドデシル等)等の合成エステル類及び合成トリグリセライド類、シクロペンタシロキサン、ジメチコール、ジメチコン(メチルポリシロキサン)等のシリコーンが挙げられる。 Here, examples of oily ingredients include olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadowfoam oil, shea butter, tea tree oil, avocado oil. , plant-based oils such as macadamia nut oil, bergamot oil, lavender oil, rose oil, bergamot oil, and chamomile oil; vitamin A oil; animal-based oils and fats such as mink oil and turtle oil; beeswax, carnauba wax, rice wax, Waxes such as lanolin; hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, squalane (e.g. sugar squalane, olive squalane); myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosene Fatty acids such as acids; Higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, stearyl alcohol; isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, glyceryl tri-2-ethylhexanoate, tri-2 - Synthetic esters and synthesis of trimethylpropane ethylhexanoate, glyceryl tri(caprylic acid/capric acid), glyceryl tri(caprylic acid/capric acid/myristic acid/stearic acid), higher fatty acid octyldodecyl (octyldodecyl stearate, etc.) Examples include silicones such as triglycerides, cyclopentasiloxane, dimethicol, and dimethicone (methylpolysiloxane).
界面活性剤としては、例えば、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステル等の非イオン界面活性剤;脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α-スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩等のアニオン界面活性剤;第四級アンモニウム塩、第一級~第三級脂肪アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、2-アルキル-1-アルキル-1-ヒドロキシエチルイミダゾリニウム塩、N、N-ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩等のカチオン界面活性剤;N、N-ジメチル-N-アルキル-N-カルボキシメチルアンモニオベタイン、N、N、N-トリアルキル-N-アルキレンアンモニオカルボキシベタイン、N-アシルアミドプロピル-N′、N′-ジメチル-N′-β-ヒドロキシプロピルアンモニオスルホベタイン等の両性界面活性剤等を使用することができる。 Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Nonionic surfactants such as polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates , polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate, and other anionic surfactants; quaternary ammonium salts, primary to tertiary fatty amine salts, Cationic surfactants such as trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts; N , N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N', N'-dimethyl-N' -Ampholytic surfactants such as β-hydroxypropylammoniosulfobetaine and the like can be used.
乳化剤及び/又は乳化助剤としては、酵素処理ステビア等のステビア誘導体、サポニン又はその誘導体、カゼイン又はその塩(ナトリウム等)、糖と蛋白質の複合体、ショ糖又はそのエステル、ラクトース、大豆由来の水溶性多糖、大豆由来蛋白質と多糖の複合体、ラノリン又はその誘導体、コレステロール、ステビア誘導体(ステビア酵素処理物等)、ケイ酸塩(アルミニウム、マグネシウム等)、炭酸塩(カルシウム、ナトリウム等)サポニン及びその誘導体、レシチン及びその誘導体(水素添加レシチン等)、乳酸菌醗酵米、乳酸菌醗酵発芽米、乳酸菌醗酵穀類(麦類、豆類、雑穀等)等を配合することもできる。 Examples of emulsifiers and/or emulsification aids include stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), sugar and protein complexes, sucrose or its esters, lactose, soybean-derived Water-soluble polysaccharides, complexes of soybean-derived protein and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (stevia enzyme-treated products, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins, Derivatives thereof, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, millet, etc.), etc. can also be blended.
保湿剤としては、保湿剤としては、例えば、グリセリン、プロピレングリコール、ジプロピレングリコール、1、3-ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム等があり、さらにトレハロース、ラフィノース等の糖類、ムコ多糖類(例えば、ヒアルロン酸及びその誘導体、ヒアルロン酸発酵液、コンドロイチン及びその誘導体、ヘパリン及びその誘導体等)、エラスチン及びその誘導体、コラーゲン及びその誘導体、コラーゲンペプチド、NMF関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、海藻抽出物、エストラジオール、各種アミノ酸及びそれらの誘導体が挙げられる。 Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and saccharides such as trehalose and raffinose. , mucopolysaccharides (e.g., hyaluronic acid and its derivatives, hyaluronic acid fermentation liquid, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea , higher fatty acid octyldodecyl, seaweed extract, estradiol, various amino acids and their derivatives.
増粘剤としては、例えばアルギン酸、寒天、カラギーナン、フコイダン等の褐藻、緑藻又は紅藻由来成分;ペクチン、アロエ多糖体等の多糖類;トラガントガム、ローカストビーンガム、キサンタンガム、グアーガム等のガム類;カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース等のセルロース誘導体;カルボシキビニルポリマー、アルキル変性カルボキシビニルポリマー、ポリビニルアルコール、ポリビニルピロリドン、アクリル酸・メタクリル酸共重合体等の合成高分子類;ヒアルロン酸及びその誘導体;ポリグルタミン酸及びその誘導体、ポリアクリル酸等が挙げられる。 Examples of thickeners include components derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin and aloe polysaccharide; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum; Cellulose derivatives such as methylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose; Synthetic polymers such as carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid/methacrylic acid copolymer; Hyaluronic acid and its derivatives ; Examples include polyglutamic acid and its derivatives, polyacrylic acid, and the like.
消炎剤としては、アラントイン、グリチルリチン酸ジカリウム、グリチルリチン酸モノアンモニウム、β-グリチルレチン酸、グリチルレチン酸ステアリル、ε-アミノカプロン酸、d-カンフル、dl-カンフル、酸化亜鉛、パンテノール、ピリドキシン塩酸塩、及びリボフラビン又はその誘導体等がある。 Anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, and riboflavin. or its derivatives.
防腐・殺菌剤としては、例えば尿素;安息香酸又はその塩、パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル等のパラオキシ安息香酸エステル類;フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、サリチル酸ナトリウム、ピリチオン亜鉛、塩化ベンザルコニウム、エタノール、ウンデシレン酸、フェノール類、臭化アルキルイソキノリニウム、レゾルシン、ジャマール(イミダゾデイニールウレア)、イソプロピルメチルフェノール、トリクロサン、トリクロロカルバニド、トリクロロヒドロキシジフェノールエーテル、ヒノキチオール、1、2-ペンタンジオール、プロパンジオール、濃ベンザルコニウム塩化物液50、ハッカ油、ユーカリ油等の精油類、樹皮乾留物、大根発酵液、サトウキビ、トウモロコシ等の植物由来のエタノール又は1、3-ブチレングリコール等がある。 Examples of preservatives and disinfectants include urea; benzoic acid or its salts, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, and hexachlorophene. , chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, alkylisoquinolinium bromide, resorcin, jamal (imidazodeinyl urea), isopropylmethyl Phenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil, eucalyptus oil, bark dry distillate, radish Examples include fermentation liquid, ethanol derived from plants such as sugarcane and corn, and 1,3-butylene glycol.
細胞賦活剤としては、パントテニルアルコール、メントール、dl-メントール、及びγ-オリザノール等がある。 Examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol.
抗アクネ剤としては、イオウ、サリチル酸又はその塩、感光素201号、ジカプリル酸ピリドキシン等がある。 Anti-acne agents include sulfur, salicylic acid or its salts, Photosensor No. 201, pyridoxine dicaprylate, and the like.
粉体成分しては、例えばセリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類(米、麦、トウモロコシ、キビ等)のパウダー、豆類(大豆、アズキ等)のパウダー等がある。 Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, There are cellulose powders, grain powders (rice, barley, corn, millet, etc.), legume powders (soybean, adzuki beans, etc.), etc.
紫外線吸収剤としては、例えばパラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミル及びその誘導体、パラメトキシ桂皮酸2-エチルヘキシル、桂皮酸オクチル、オキシベンゾン、2、4-ジヒドロキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸塩、4-ターシャリーブチル-4-メトキシベンゾイルメタン、2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等がある。 Examples of ultraviolet absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .
抗酸化剤としては、例えばブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、アスタキサンチン等のカロテノイド、ビタミンE及びその誘導体(例えば、トコフェロール酢酸エステル、トコフェロールニコチン酸エステル)、ビタミンA又はその誘導体(パルミチン酸レチノール等)等がある。 Antioxidants include, for example, carotenoids such as butylated hydroxyanisole, butylated hydroxytoluene, propyl gallate, astaxanthin, vitamin E and its derivatives (for example, tocopherol acetate, tocopherol nicotinate), vitamin A or its derivatives (palmitic acid, retinol, etc.).
また、美白剤として、コウジ酸又はその誘導体、アスコルビン酸又はその誘導体、トラネキサム酸又はその誘導体、エラグ酸及びその誘導体、レゾルシノール誘導体(例えば、4-n-ブチルレゾルシノール、4-イソアミルレゾルシノール等)、4-メトキシサリチル酸カリウム塩、2、5-ジヒドロキシ安息香酸誘導体(例えば、2、5-ジアセトキシ安息香酸、2-アセトキシ-5-ヒドロキシ安息香酸、2-ヒドロキシ-5-プロピオニルオキシ安息香酸等)、マグノリグナン(5、5'-ジプロピル-ビフェニル-2、2’-ジオール)、ヒドロキシ安息香酸及びその誘導体、ビタミンE及びその誘導体、α-ヒドロキシ酸(例えば、乳酸、リンゴ酸、コハク酸、クエン酸、α-ヒドロキシオクタン酸等)、AMP(アデノシンモノホスフェイト、アデノシン1リン酸)、t-シクロアミノ酸誘導体、ソウハクヒ抽出物、カミツレ抽出物、米糠抽出物の加水分解物、ユキノシタ抽出物及び白芥子抽出物又はその加水分解物から選択される1以上のものが挙げられる。 In addition, as whitening agents, kojic acid or its derivatives, ascorbic acid or its derivatives, tranexamic acid or its derivatives, ellagic acid and its derivatives, resorcinol derivatives (for example, 4-n-butylresorcinol, 4-isoamylresorcinol, etc.), 4 - Methoxysalicylic acid potassium salt, 2,5-dihydroxybenzoic acid derivatives (e.g., 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, etc.), magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acids (e.g. lactic acid, malic acid, succinic acid, citric acid, α -Hydroxyoctanoic acid, etc.), AMP (adenosine monophosphate, adenosine monophosphate), t-cycloamino acid derivatives, sorghum extract, chamomile extract, hydrolyzate of rice bran extract, saxifrage extract, and white mustard extract or one or more selected from hydrolyzates thereof.
また、抗シワ剤として、ビタミンA又はその誘導体、ビタミンE又はその誘導体、パントテニルアルコール、アラントイン等が挙げられる。 Further, anti-wrinkle agents include vitamin A or its derivatives, vitamin E or its derivatives, pantothenyl alcohol, allantoin, and the like.
上記コウジ酸誘導体としては、例えば、コウジ酸モノブチレート、コウジ酸モノカプレート、コウジ酸モノパルミテート、コウジ酸ジブチレート等のコウジ酸エステル類、コウジ酸エーテル類、コウジ酸グルコシド等のコウジ酸糖誘導体等が、上記アスコルビン酸誘導体としては、例えばL-アスコルビン酸-2-リン酸エステルナトリウム、L-アスコルビン酸-2-リン酸エステルマグネシウム、L-アスコルビン酸-2-硫酸エステルナトリウム、L-アスコルビン酸-2-硫酸エステルマグネシウム等のアスコルビン酸エステル塩類、L-アスコルビン酸-2-グルコシド、L-アスコルビン酸-5-グルコシド、アスコルビルトコフェリルマレイン酸、アスコルビルトコフェリルリン酸K、ミリスチル3-グリセリルアスコルビン酸、カプリリル2-グリセリルアスコルビン酸等のアスコルビン酸糖誘導体、それらアスコルビン酸糖誘導体の6位アシル化物(アシル基は、ヘキサノイル基、オクタノイル基、デカノイル基等)、L-アスコルビン酸テトライソパルミチン酸エステル、L-アスコルビン酸テトララウリン酸エステル等のL-アスコルビン酸テトラ脂肪酸エステル類、3-O-エチルアスコルビン酸、L-アスコルビン酸-2-リン酸-6-O-パルミテートナトリウム、グリセリルアスコルビン酸又はそのアシル化誘導体、ビスグリセリルアスコルビン酸等のアスコルビン酸グルセリン誘導体、L-アスコルビン酸リン酸アミノプロピル、L-アスコルビン酸のヒアルロン酸誘導体、3-O-Dラクトース-L-アスコルビン酸、イソステアリルアスコルビルリン酸塩等が、上記ハイドロキノン誘導体としては、アルブチン(ハイドロキノン-β-D-グルコピラノシド)、α-アルブチン(ハイドロキノン-α-D-グルコピラノシド)等が、上記トラネキサム酸誘導体としては、トラネキサム酸エステル(例えば、トラネキサム酸ラウリルエステル、トラネキサム酸ヘキサデシルエステル、トラネキサム酸セチルエステル又はその塩)、トラネキサム酸のアミド体(例えば、トラネキサム酸メチルアミド)等が挙げられる。また、ビタミンE誘導体としては、α-トコフェリルリン酸ナトリウム、酢酸トコフェロール等が挙げられる。 Examples of the above-mentioned kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, kojic acid ethers, and kojic acid sugar derivatives such as kojic acid glucoside. However, examples of the above-mentioned ascorbic acid derivatives include sodium L-ascorbic acid-2-phosphate, magnesium L-ascorbic acid-2-phosphate, sodium L-ascorbic acid-2-sulfate, and sodium L-ascorbic acid-2-phosphate. Ascorbic acid ester salts such as magnesium 2-sulfate ester, L-ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorbyl tocopheryl maleate, ascorbyl tocopheryl potassium phosphate, myristyl 3-glyceryl ascorbic acid, Ascorbic acid sugar derivatives such as caprylyl 2-glyceryl ascorbic acid, 6-position acylated products of these ascorbic acid sugar derivatives (acyl group is hexanoyl group, octanoyl group, decanoyl group, etc.), L-ascorbic acid tetraisopalmitate ester, L -L-ascorbic acid tetrafatty acid esters such as ascorbic acid tetralaurate, 3-O-ethyl ascorbic acid, sodium L-ascorbic acid-2-phosphate-6-O-palmitate, glyceryl ascorbic acid or its acyl derivatives, ascorbic acid glycerin derivatives such as bisglyceryl ascorbic acid, aminopropyl L-ascorbic acid phosphate, hyaluronic acid derivatives of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, isostearyl ascorbyl phosphate Examples of the hydroquinone derivatives include arbutin (hydroquinone-β-D-glucopyranoside) and α-arbutin (hydroquinone-α-D-glucopyranoside), and examples of the tranexamic acid derivatives include tranexamic acid esters (e.g. tranexamic acid). lauryl ester, tranexamic acid hexadecyl ester, tranexamic acid cetyl ester or a salt thereof), an amide form of tranexamic acid (for example, tranexamic acid methylamide), and the like. Further, examples of vitamin E derivatives include sodium α-tocopheryl phosphate, tocopherol acetate, and the like.
さらに、以下の植物又は微生物等の天然物由来の成分を併用することも可能である。例えば、コラーゲン又はその加水分解物、酵母抽出物又は加水分解物、乳酸菌培養物、イネ科植物、アブラナ科植物、ツバキ科植物、バラ科植物、ボタン科植物、ミカン科植物、ヒユ科植物、アマモ科植物、マメ科植物、キク科植物、マメ科植物、アオイ科植物、シソ科植物、ハス科植物、ウコギ科植物、ナス科植物、ノウゼンカズラ科植物、マタタビ科植物、クワ科植物、アヤメ科植物、キキョウ科植物、モクセイ科植物、マタタビ科植物、クワ科植物、クロウメモドキ科植物、ラン科植物、ウルシ科植物、フクギ科植物、バレンシ科植物、ミカン科植物、フトモモ科植物、ユリ科植物、ベンケイソウ科植物、ヒノキ科植物、ヒルガオ科の植物及びキジカクシ科のいずれかから選択される1以上の植物の抽出物又はその加水分解物或いは発酵物、コンブ科、ミリン科及びアオサ科のいずれかから選択される1以上の海藻の抽出物又はその加水分解物或いは発酵物、クラゲ(ミズクラゲ、エチゼンクラゲ等の自己消化物)、ヒアルロン酸の加水分解物又は発酵物等挙げられる。 Furthermore, it is also possible to use together the following components derived from natural products such as plants or microorganisms. For example, collagen or its hydrolyzate, yeast extract or hydrolyzate, lactic acid bacteria culture, grass, cruciferous, camellia, rose, peony, rutaceae, amaranth, eelgrass. Family plants, Legumes, Asteraceae, Legumes, Malvaceae, Lamiaceae, Lotus family, Araliaceae, Solanaceae, Trumpetaceae, Actinaceae, Moraceae, Iridaceae , Campanulaceae, Oleaceae, Actinaceae, Moraceae, Buckthorn, Orchidaceae, Anadicaceae, Fucaceae, Valenciaceae, Rutaceae, Myrtaceae, Liliaceae, Crassulaceae Extracts of one or more plants selected from plants of the family Cupressaceae, plants of the family Convolvulaceae, and plants of the family Acanthaceae, or hydrolysates or fermented products thereof; Examples include extracts of one or more seaweeds or their hydrolysates or ferments, jellyfish (autolysates of moon jellyfish, Echizen jellyfish, etc.), hydrolysates or ferments of hyaluronic acid, and the like.
イネ科の植物由来成分としては、特に、イネ葉加水分解物、米抽出物加水分解物、米糠抽出物加水分解物、発芽玄米加水分解物、米発酵液、清酒由来の酒粕抽出物、マダケ又はモウソウチクのタケノコ皮抽出物、ハトムギ種子発酵物が好ましい。また、アブラナ科植物としては、特に、ハクガイ、オウガイ又はコクガイの種子の抽出物又はその加水分解物或いは発酵物が好ましい。また、ツバキ科植物由来成分としては、特に、緑茶(やぶきた、さみどり、あさひ、ごこう、うじみどり、きょうみどり、うじひかり、さみどり、べにふうき等)及び紅茶(ダージリン、アッサム、セーロン、アールグレイ、蜜香紅茶等)が好ましい。バラ科植物由来成分としては、ダマスクバラの花の抽出物、モモの花、葉又は未成熟果実の抽出物、イチゴの花抽出物、サクラの花又は葉の抽出物が好ましい。また、ボタン科植物由来成分としては、ボタンの根又は花、シャクヤクの花の抽出物が好ましい。また、ヒユ科植物由来成分としては、特に、アッケシソウ抽出物が好ましい。また、アマモ科植物由来成分としては、特に、アマモ又はコアマモの抽出物が好ましい。マメ科植物由来成分としては、特に、白大豆又は黒大豆の抽出物又はその加水分解物或いは豆乳発酵液、アズキ抽出物、アカツメクサ抽出物、クズ根抽出物が好ましい。また、キク科植物由来成分としては、特に、ゴボウ根抽出物、ヒマワリ新芽抽出物、ハゴロモソウ抽出物、アルニカ抽出物又はカミツレ花抽出物が好ましい。アオイ科植物由来成分としては、ハイビスカス、ムクゲ又はフヨウの発酵物が好ましい。また、シソ科植物としては、シソ(紫蘇)抽出物が好ましい。ハス科植物由来成分としては、特に、ハスの花又はハス種子抽出物或いはハス種子発酵物が好ましい。ウコギ科植物由来成分としては、オタネニンジンの抽出物又は発酵物が好ましい。ナス科植物由来成分としては、ナス(長ナス、水ナス、米ナス、賀茂ナス等)の抽出物が挙げられる。ノウゼンカズラ科植物由来成分としては、パウダルコ樹皮抽出物が好ましい。マタタビ科植物由来成分としては、未成熟のキウイ抽出物が好ましい。クワ科植物由来成分としては、ソウハクヒ抽出物、マルベリー果実抽出物、イチジクの果実又は樹皮の抽出物が好ましい。また、アヤメ科植物由来成分としてはサフランが好ましい。キキョウ科植物由来成分としては、ヒカゲノツルニンジンの根の抽出物又は加水分解物が好ましい。ウルシ科植物由来成分としては、特に、マンゴ果実抽出物が好ましい。フクギ科植物由来成分としては、特に、マンゴスチン果実抽出物が好ましい。また、バレンシ科植物由来成分としては、チェリモヤ果実抽出物が好ましい。ミカン科植物由来成分として、温州ミカン、ベルガモット果実抽出物、晩白柚の果実(未成熟果実も含む)の抽出物、ミカン科植物に含まれるフラボノイド及びその配糖体を含む抽出物、或いはサンショウ種子抽出物が好ましい。ユリ科植物由来成分としては、カサブランカ、マドンナリリー、又はササユリの抽出物が好ましい。ベンケイソウ科植物由来成分としては、特に、イワベンケイ(紅景天)の抽出物又は発酵物が好ましい。モクセイ科植物由来成分としては、特に、ジャスミンの花抽出物が好ましい。ヒノキ科植物としては、特に、セイヨウネズ果実抽出物が好ましい。フトモモ科植物由来成分としては、特に、グアバ葉抽出物が好ましい。ラン科植物としては、特に、シランの根(白及)の抽出物が好ましい。ヒルガオ科植物由来成分としては、サツマイモの抽出物又はその発酵物或いは甘藷焼酎粕の抽出物又はその発酵物が好ましい。コンブ科海藻由来成分としては、特に、コンブ抽出物が好ましく、ミリン科海藻由来成分としてはカタメンキリンサイ抽出物が好ましく、特に、アオサ科海藻由来成分としてはアナアオサ抽出物が好ましい。フノリ科海藻由来成分としては、特に、フノリ抽出物が好ましい。 In particular, ingredients derived from plants of the Poaceae family include rice leaf hydrolyzate, rice extract hydrolyzate, rice bran extract hydrolyzate, germinated brown rice hydrolyzate, fermented rice liquid, sake lees extract derived from sake, Madake mushroom or Bamboo shoot skin extract and fermented pearl barley seeds are preferred. In addition, as the cruciferous plant, extracts of seeds of Chinese snail, Japanese snail or Japanese snail, or hydrolyzed or fermented products thereof are particularly preferable. In addition, components derived from plants of the Camellia family include green tea (Yabukita, Samidori, Asahi, Goku, Ujimidori, Kyomidori, Ujihikari, Samidori, Benifuki, etc.) and black tea (Darjeeling, Assam, Ceylon, Earl). Gray, honey-scented black tea, etc.) are preferred. As the ingredient derived from the Rosaceae plant, an extract of Damask rose flowers, an extract of peach flowers, leaves or immature fruit, a strawberry flower extract, and an extract of cherry blossoms or leaves are preferable. Moreover, as the component derived from a plant belonging to the family Peony, extracts of roots or flowers of peonies, and flowers of peonies are preferable. Furthermore, as the component derived from the Amaranthaceae plant, Salicornia extract is particularly preferable. In addition, as the component derived from a plant belonging to the Elaceae family, an extract of eelgrass or red eelgrass is particularly preferable. Particularly preferred legume-derived components are white soybean or black soybean extracts or their hydrolysates, fermented soybean milk, azuki bean extracts, red clover extracts, and kudzu root extracts. In addition, as the component derived from the Asteraceae plant, particularly preferred are burdock root extract, sunflower shoot extract, blackberry extract, arnica extract, or chamomile flower extract. As the component derived from a plant belonging to the mallow family, a fermented product of hibiscus, rose of Sharon, or rose of the sun is preferable. Moreover, as the plant of the Lamiaceae family, perilla (perilla) extract is preferable. As the component derived from the lotus family plant, lotus flower or lotus seed extracts or lotus seed fermented products are particularly preferred. As the component derived from the Araliaceae plant, extracts or fermented products of Panax ginseng are preferred. Examples of components derived from plants of the Solanaceae family include extracts of eggplants (long eggplant, water eggplant, rice eggplant, Kamo eggplant, etc.). As the component derived from a plant of the family Trifoliaceae, pau d'arco bark extract is preferred. As the component derived from the Actinaceae plant, an immature kiwifruit extract is preferred. As the component derived from a plant belonging to the Moraceae family, it is preferable to use a mulberry fruit extract, a mulberry fruit extract, and a fig fruit or bark extract. Moreover, saffron is preferable as the component derived from the Iridaceae plant. As the component derived from the Campanulaceae plant, an extract or hydrolyzate of the roots of Ginseng ginseng is preferred. Mango fruit extract is particularly preferred as the component derived from the Anamondaceae plant. Mangosteen fruit extract is particularly preferred as the component derived from the Fukugaceae plant. Furthermore, as the component derived from a plant belonging to the family Valenciaceae, cherimoya fruit extract is preferable. Ingredients derived from Rutaceae plants include unshiu mandarin, bergamot fruit extract, Banpeiyu fruit extract (including immature fruits), extracts containing flavonoids and their glycosides contained in Rutaceae plants, or Showa seed extract is preferred. As the component derived from the Liliaceae plant, extracts of Casablanca, Madonna lily, or Spanish lily are preferred. As the component derived from the Crassulaceae plant, an extract or a fermented product of Rhodiola rosea (Rhodia japonica) is particularly preferable. Particularly preferred as the component derived from the Oleaceae plant is a jasmine flower extract. As the plant of the Cupressaceae family, juniper fruit extract is particularly preferred. As the component derived from the Myrtaceae plant, guava leaf extract is particularly preferred. As the Orchidaceae plant, extracts of the roots of Silangea (white radish) are particularly preferred. The component derived from the Convolvulaceae plant is preferably an extract of sweet potato or a fermented product thereof, or an extract of sweet potato shochu lees or a fermented product thereof. As the component derived from the seaweed of the family Ulva family, a kelp extract is particularly preferred, as the component derived from the seaweed of the family Myrinaceae, an extract of Catamen orchid is particularly preferred, and as the component derived from the seaweed of the Ulva family, a Ulva extract is particularly preferred. As the component derived from seaweeds belonging to the Family Funoriaceae, a Funori extract is particularly preferred.
本発明に係る発酵物の組み合わせを含む皮膚外用剤(化粧品、医薬部外品、外用医薬品を含む)適用部位としては、頭皮を含む皮膚全般が挙げられ、特に制限はない。従って、剤形としては、例えば、乳液、クリーム、ローション、エッセンス、パック、口紅、ファンデーション、リクイドファンデーション、メイクアッププレスパウダー、ほほ紅、白粉、洗顔料、ボディシャンプー、石けん、マスク用製剤、及び浴剤等が挙げられるが、本発明はそれらに限定されるものではない。 The application site for external skin preparations (including cosmetics, quasi-drugs, and external drugs) containing the combination of fermented products according to the present invention includes the skin in general, including the scalp, and is not particularly limited. Therefore, the dosage forms include milky lotions, creams, lotions, essences, packs, lipsticks, foundations, liquid foundations, makeup press powders, blushers, whitening powders, facial cleansers, body shampoos, soaps, mask preparations, and baths. agents, but the present invention is not limited thereto.
次に、製造例、処方例、実施例及び試験例によって本発明をさらに具体的に説明するが、本発明はそれらに限定されるものではない。なお、以下において、部はすべて重量部を、また%はすべて重量%を意味する。 Next, the present invention will be explained in more detail with reference to production examples, formulation examples, working examples, and test examples, but the present invention is not limited thereto. In addition, in the following, all parts mean parts by weight, and all percentages mean weight %.
製造例1.ゲンチアナ抽出物の調整(1)
ゲンチアナ根(茎を含んでいてもよい)を乾燥して調製したゲンチアナ粉末14gを精製水1000gに加え、4℃で18時間抽出した。これを濾過して、ゲンチアナ抽出物(固形分濃度2.05%)903gを得た。
Manufacturing example 1. Preparation of gentian extract (1)
14 g of gentian powder prepared by drying gentian roots (which may include stems) was added to 1000 g of purified water and extracted at 4° C. for 18 hours. This was filtered to obtain 903 g of gentian extract (solid content concentration 2.05%).
製造例2.ヘチマ抽出物の調製(1)
ヘチマの生果実200gを裁断後、搾汁し、得られた溶液を40℃で1時間加熱した。加熱後、ろ過し、120gを得た(固形物濃度4.50%)。精製水で2倍希釈し、ヘチマ圧搾抽出物溶液とした。
Production example 2. Preparation of loofah extract (1)
After cutting 200 g of raw loofah fruit, the juice was squeezed, and the resulting solution was heated at 40° C. for 1 hour. After heating, it was filtered to obtain 120 g (solid concentration 4.50%). It was diluted twice with purified water to obtain a pressed loofah extract solution.
製造例3.ヘチマ抽出物の調製(2)
ヘチマの果実および茎・葉の乾燥物10gに精製水100gを加え、40℃で3時間抽出した。得られた溶液をろ過して、褐色透明の溶液74.0g(固形分濃度2.65%)を得た。これをヘチマ抽出物溶液とした。
Manufacturing example 3. Preparation of loofah extract (2)
100 g of purified water was added to 10 g of dried loofah fruits, stems, and leaves, and extracted at 40° C. for 3 hours. The obtained solution was filtered to obtain 74.0 g of a brown transparent solution (solid content concentration 2.65%). This was used as a loofah extract solution.
製造例4.グレープフルーツ抽出物の調製(1)
グレープフルーツの未成熟果実を粉砕して得られた粉砕物300gに1,3-ブチレングリコールを450g添加した後、80℃、2時間抽出を行った。抽出後、濾過して黄褐色透明の抽出物溶液540gを得た(固形分濃度3.70%)。
Manufacturing example 4. Preparation of grapefruit extract (1)
After adding 450 g of 1,3-butylene glycol to 300 g of a crushed product obtained by crushing an immature grapefruit fruit, extraction was performed at 80° C. for 2 hours. After the extraction, it was filtered to obtain 540 g of a yellowish brown transparent extract solution (solid content concentration 3.70%).
製造例5.グレープフルーツ抽出物の調製(2)
グレープフルーツの未成熟果実を粉砕して得られた粉砕物300gに1,3-プロパンジオールを450g添加した後、80℃、2時間抽出を行った。抽出後、濾過して黄褐色透明の抽出物溶液532gを得た(固形分濃度3.52%)。
Manufacturing example 5. Preparation of grapefruit extract (2)
After adding 450 g of 1,3-propanediol to 300 g of a crushed product obtained by crushing an immature grapefruit fruit, extraction was performed at 80° C. for 2 hours. After extraction, it was filtered to obtain 532 g of a yellowish brown transparent extract solution (solid content concentration 3.52%).
試験例1.チロシナーゼ活性抑制効果の評価試験
正常メラノサイトNHEMを、DermaLife培地(クラボウ社社製)を入れた96穴マイクロプレートに1×104個/穴播種し、37℃,5.0%CO2の条件下に1日間プレ培養した後、ナイアシンアミド(2mM)と製造例1又は製造例2の抽出物の組み合わせを試料溶液として添加した。ここで、製造例1又は製造例2の抽出物については、溶液としての最終濃度が培地量に対して1.0%又は2.0%となるように添加した。3日間培養後上清を捨て、PBS(-)で1回洗浄後、界面活性剤(Triton X-100)と5mM L-ドーパ溶液を添加して37℃で反応を行った後、マイクロプレートリーダー(Model 450、バイオラッド社製)を用い、波長490nmでドーパ値を測定した。なお、比較のために、上記試料溶液に代えてPBS(-)を培養培地に2.0%となるような濃度で添加したコントロール区を設定した。試験結果の値は、コントロール区のドーパ値を100としたときの各試料添加区でのドーパ値の相対値を求め、各値をチロシナーゼ活性率(%)とした。
Test example 1. Evaluation test for inhibitory effect on tyrosinase activity Normal melanocytes NHEM were seeded at 1 × 10 cells/well in a 96-well microplate containing DermaLife medium (manufactured by Kurabo Industries), and incubated at 37°C and 5.0% CO 2 . After pre-culturing for one day, a combination of niacinamide (2mM) and the extract of Production Example 1 or Production Example 2 was added as a sample solution. Here, the extract of Production Example 1 or Production Example 2 was added so that the final concentration as a solution was 1.0% or 2.0% based on the amount of the medium. After culturing for 3 days, discard the supernatant, wash once with PBS(-), add surfactant (Triton (Model 450, manufactured by Bio-Rad), the dopa value was measured at a wavelength of 490 nm. For comparison, a control group was set up in which PBS(-) was added to the culture medium at a concentration of 2.0% instead of the sample solution. The test result values were obtained by calculating the relative value of the dopa value in each sample-added group when the dopa value in the control group was set as 100, and each value was taken as the tyrosinase activity rate (%).
ナイアシンアミドと製造例1の抽出物の組み合わせの結果を図1に示し、ナイアシンアミドと製造例2の抽出物の組み合わせの結果を図2に示す。なお、図1,2においてナイアシンアミドは「NA」と表示する。図1、2に示すように、ナイアシンアミド単独でのチロシナーゼ活性抑制効果と比較して、ナイアシンアミドと製造例1又は製造例2の抽出物を組み合わせることでチロシナーゼ活性抑制効果が向上することが確認された。これにより、ナイアシンアミドと製造例1又は製造例2の抽出物を組み合わせることで皮膚におけるメラニンの合成が抑えられ、日焼けによる色素沈着やシミの抑制、加齢によるシミの抑制の効果が示唆される。また、ナイアシンアミドと製造例1の抽出物及び製造例2の抽出物を併用することで、さらに、チロシナーゼ活性抑制効果が向上することも示唆される。 The results of the combination of niacinamide and the extract of Production Example 1 are shown in FIG. 1, and the results of the combination of niacinamide and the extract of Production Example 2 are shown in FIG. In addition, in FIGS. 1 and 2, niacinamide is indicated as "NA". As shown in Figures 1 and 2, it was confirmed that the combination of niacinamide and the extract of Production Example 1 or Production Example 2 improved the tyrosinase activity inhibition effect compared to the tyrosinase activity inhibition effect of niacinamide alone. It was done. This suggests that the combination of niacinamide and the extract of Production Example 1 or Production Example 2 suppresses the synthesis of melanin in the skin, and is effective in suppressing pigmentation and age spots caused by sunburn and age spots. . It is also suggested that the combined use of niacinamide and the extract of Production Example 1 and the extract of Production Example 2 further improves the tyrosinase activity inhibiting effect.
また、製造例4又は製造例5の抽出物であるグレープフルーツ抽出物は抗酸化等を有することから、製造例4又は製造例5の抽出物をさらに併用することで、チロシナーゼ活性抑制効果が向上することが示唆される。 In addition, since the grapefruit extract, which is the extract of Production Example 4 or Production Example 5, has antioxidant properties, the effect of suppressing tyrosinase activity is improved by further using the extract of Production Example 4 or Production Example 5 in combination. This suggests that.
次に、表1に示す通り、ナイアシンアミド(成分1)、製造例1の抽出物(成分2)、製造例2の抽出物(成分3)、及び製造例4の抽出物(成分4)の組み合わせについて、透明感、潤い感及びキメを評価した。 Next, as shown in Table 1, niacinamide (component 1), the extract of Production Example 1 (component 2), the extract of Production Example 2 (component 3), and the extract of Production Example 4 (component 4) were added. The combination was evaluated for transparency, moisture, and texture.
[表1]
[Table 1]
試験例2.モニターテスト
無作為に抽出した年齢25~60歳の男女7名を被験者として各被験者の前腕部に組成物1~2と、コントロールを塗布する試験区を設け、それぞれ1日2回(朝、晩)14日間塗布した際の(イ)透明感、(ロ)潤い感、(ハ)キメについて、A:非常に良い、B:良い、C:普通、D:やや悪い、という4段階で自己評価した。
Test example 2. Monitor test Seven randomly selected male and female subjects aged 25 to 60 years old were set up in a test area where compositions 1 to 2 and a control were applied to each subject's forearm twice a day (morning and evening). ) Self-evaluation of (a) transparency, (b) moisturizing feeling, and (c) texture when applied for 14 days on a four-point scale: A: very good, B: good, C: average, D: somewhat poor. did.
試験例の結果を表2に示す。なお、表2中の数字は、回答した人数を示す。
[表2]
The results of the test examples are shown in Table 2. Note that the numbers in Table 2 indicate the number of respondents.
[Table 2]
表1に示すように、本発明に係る組成物1及び組成物2は、コントロールと比較して、皮膚に透明感、潤い感及びキメを与えるが向上したことが確認された。これにより、肌荒れの改善し、シワを改善する効果が示唆される。 As shown in Table 1, it was confirmed that Composition 1 and Composition 2 according to the present invention provided improved transparency, moisture, and texture to the skin compared to the control. This suggests the effect of improving rough skin and improving wrinkles.
以下に、本発明に係る皮膚外用剤(処方例)を示すが、本発明はこれに限るものではない。例えば、適宜、製造例2の抽出物を製造例3の抽出物に置き換え、また、製造例4の抽出物を製造例5の抽出物に置き換えてもよい。 External skin preparations (formulation examples) according to the present invention are shown below, but the present invention is not limited thereto. For example, the extract of Production Example 2 may be replaced with the extract of Production Example 3, and the extract of Production Example 4 may be replaced with the extract of Production Example 5, as appropriate.
処方例1.化粧水
[成分] 部
シュガースクワラン 1.0
ナイアシンアミド 5.0
グリチルリチン酸ジカリウム 0.1
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
グリセリン 1.0
1,3-ブチレングリコール 5.0
1,2-ペンタンジオール 3.0
クエン酸ナトリウム 適量
精製水 全量が100部となる量
Prescription example 1. Lotion [Ingredients] Part Sugar Squalane 1.0
Niacinamide 5.0
Dipotassium glycyrrhizinate 0.1
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Glycerin 1.0
1,3-butylene glycol 5.0
1,2-pentanediol 3.0
Sodium citrate Appropriate amount Purified water Amount to make 100 parts
処方例2.化粧水
[成分] 部
カプリル酸グリセリル 3.0
ラウリン酸ポリグリセリル-10 3.0
セタノール 2.0
ベヘニルアルコール 2.0
メチルパラベン 0.1
ナイアシンアミド 5.0
アスコルビン酸 3.0
トコフェロールニコチン酸エステル 0.1
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
グリセリン 2.0
1,3-ブチレングリコール 5.0
ヘキサンジオール 3.0
水酸化カリウム 適量
精製水 全量が100部となる量
Prescription example 2. Lotion [Ingredients] Part Glyceryl caprylate 3.0
Polyglyceryl laurate-10 3.0
Setanol 2.0
Behenyl alcohol 2.0
Methylparaben 0.1
Niacinamide 5.0
Ascorbic acid 3.0
Tocopherol nicotinic acid ester 0.1
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Glycerin 2.0
1,3-butylene glycol 5.0
Hexanediol 3.0
Potassium hydroxide (appropriate amount) Purified water (amount to make 100 parts)
処方例3.化粧水
[成分] 部
ホホバ油 1.0
イソステアリルアルコール 3.0
ナイアシンアミド 5.0
アスコルビン酸グルコシド 2.0
トラネキサム酸 2.0
ε-アミノカプロン酸 0.1
エストラジオール 0.1
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
フェノキシエタノール 0.3
グリセリン 3.0
1,3-ブチレングリコール 5.0
ピロ亜硫酸ナトリウム 0.1
クエン酸ナトリウム 適量
精製水 全量が100部となる量
Prescription example 3. Lotion [Ingredients] Part Jojoba oil 1.0
Isostearyl alcohol 3.0
Niacinamide 5.0
Ascorbic acid glucoside 2.0
Tranexamic acid 2.0
ε-Aminocaproic acid 0.1
Estradiol 0.1
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Phenoxyethanol 0.3
Glycerin 3.0
1,3-butylene glycol 5.0
Sodium pyrosulfite 0.1
Sodium citrate Appropriate amount Purified water Amount to make 100 parts
処方例4.乳液
[成分] 部
シュガースクワラン 5.0
シクロペンタンシロキサン 1.0
ヘキサラン 3.0
イソステアリン酸ヘキシルデシル 1.0
トリ(カプリル酸/カプリン酸)グリセリル 1.0
ラウリン酸ポリグリセリル-10 5.0
イソステアリン酸ポリグリセリル-10 5.0
ジパルミチン酸アスコルビル 15.0
水添大豆レシチン 1.5
ナイアシンアミド 5.0
アスコルビン酸グルコシド 2.0
アルブチン 3.0
製造例1の抽出物 1.0
製造例3の抽出物 1.0
製造例5の抽出物 1.0
グリセリン 3.0
1,3-ブチレングリコール 2.0
プロパンジオール 3.0
カルボキシメチルセルロース 0.3
キサンタンガム 0.2
シロキクラゲ多糖体 0.2
トコフェロール酢酸エステル 0.3
グリチルリチン酸ジカリウム 0.1
イソプロピルメチルフェノール 0.1
トリ2-エチルヘキサン酸グリセリル 1.0
水溶性コラーゲン 0.01
加水分解コラーゲン 0.01
ヒアルロン酸ナトリウム 0.01
水酸化カリウム 適量
精製水 全量が100部となる量
Prescription example 4. Emulsion [Ingredients] Part Sugar Squalane 5.0
Cyclopentane siloxane 1.0
Hexalan 3.0
Hexyldecyl isostearate 1.0
Caprylic/capric triglyceride 1.0
Polyglyceryl laurate-10 5.0
Polyglyceryl-10 isostearate 5.0
Ascorbyl dipalmitate 15.0
Hydrogenated soy lecithin 1.5
Niacinamide 5.0
Ascorbic acid glucoside 2.0
Arbutin 3.0
Extract of Production Example 1 1.0
Extract of Production Example 3 1.0
Extract of Production Example 5 1.0
Glycerin 3.0
1,3-butylene glycol 2.0
Propanediol 3.0
Carboxymethyl cellulose 0.3
Xanthan gum 0.2
White fungus polysaccharide 0.2
Tocopherol acetate 0.3
Dipotassium glycyrrhizinate 0.1
Isopropylmethylphenol 0.1
Glyceryl tri-2-ethylhexanoate 1.0
Water-soluble collagen 0.01
Hydrolyzed collagen 0.01
Sodium hyaluronate 0.01
Potassium hydroxide (appropriate amount) Purified water (amount to make 100 parts)
処方例5.乳液
処方例4の成分中、アスコルビン酸グルコシド2.0部に代えてリン酸L-アスコルビルマグネシウム2.0部を用いるほかは処方例4を同様にして乳液を得た。
Prescription example 5. Emulsion A milky lotion was obtained in the same manner as in Prescription Example 4 except that 2.0 parts of L-ascorbyl magnesium phosphate was used in place of 2.0 parts of ascorbic acid glucoside.
処方例6.乳液
処方例4の成分中、アスコルビン酸グルコシド2.0部に代えて3-O-エチルアスコルビン酸2.0部を用いるほかは処方例4と同様にして乳液を得た。
Prescription example 6. Emulsion A milky lotion was obtained in the same manner as in Formulation Example 4, except that 2.0 parts of 3-O-ethyl ascorbic acid was used in place of 2.0 parts of ascorbic acid glucoside among the ingredients in Formulation Example 4.
処方例7.クリーム
[成分] 部
オリーブ油 5.0
ホホバ油 5.0
シュガースクワラン 5.0
イソステアリン酸ヘキシルデシル 5.0
ラウロイルグルタミン酸ジ(オクチルドデシル/フィトステリル/ベヘニル) 5.0
カプリル酸グリセリル 1.0
ステアリン酸グリセリル 1.0
イソステアリルグリセリル 3.0
ナイアシンアミド 5.0
γ-オリザノール 0.1
ベヘニルアルコール 2.0
パルミチン酸 2.5
D-パントテニルアルコール 3.0
アラントイン 0.1
リボフラビン 0.01
レゾルシン 0.1
塩化ベンザルコニウム 0.05
尿素 3.0
β-グリチルレチン酸 0.1
グリチルレチン酸ステアリル 0.1
グリチルリチン酸アンモニウム 0.1
トリ2-エチルヘキサン酸グリセリル 1.0
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
乳酸菌発酵米 2.0
水添レシチン 0.5
水添リゾレシチン 0.5
油溶性オタネニンジンエキス 2.0
キサンタンガム 1.0
酸化亜鉛 0.5
dl-カンフル 0.3
l-メントール 0.5
フェノキシエタノール 0.3
1,2-ペンタンジオール 2.0
精製水 全量が100部となる量
Prescription example 7. Cream [Ingredients] Part Olive oil 5.0
Jojoba oil 5.0
Sugar Squalane 5.0
Hexyldecyl isostearate 5.0
Di(octyldodecyl/phytosteryl/behenyl) lauroylglutamate 5.0
Glyceryl caprylate 1.0
Glyceryl stearate 1.0
Isostearylglyceryl 3.0
Niacinamide 5.0
γ-oryzanol 0.1
Behenyl alcohol 2.0
Palmitic acid 2.5
D-pantothenyl alcohol 3.0
Allantoin 0.1
Riboflavin 0.01
Resorcinol 0.1
Benzalkonium chloride 0.05
Urea 3.0
β-Glycyrrhetinic acid 0.1
Stearyl glycyrrhetinate 0.1
Ammonium glycyrrhizinate 0.1
Glyceryl tri-2-ethylhexanoate 1.0
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Lactic acid bacteria fermented rice 2.0
Hydrogenated lecithin 0.5
Hydrogenated lysolecithin 0.5
Oil-soluble Panax ginseng extract 2.0
Xanthan gum 1.0
Zinc oxide 0.5
dl-camphor 0.3
l-menthol 0.5
Phenoxyethanol 0.3
1,2-pentanediol 2.0
Purified water Amount that makes the total amount 100 parts
処方例8.パック
[成分] 部
ジプロピレングリコール 5.0
ポリオキシエチレン(60)硬化ヒマシ油 5.0
セタノール 3.0
ベヘニルアルコール 3.0
アラントイン 0.1
グリチルリチン酸ジカリウム 0.1
グリチルリチン酸アンモニウム 0.1
β-グリチルレチン酸 0.1
グリチルレチン酸ステアリル 0.1
サリチル酸 0.1
トコフェロール酢酸エステル 0.5
トコフェロールニコチン酸エステル 0.1
D-パントテニルアルコール 0.3
レゾルシン 0.1
イオウ 2.0
エストラジオール 0.002
ナイアシンアミド 5.0
キサンタンガム 2.0
ミリスチン酸ポリグリセリル-6 1.0
ココイルグルタミン酸カリウム 1.0
水添レシチン 3.0
水酸化レシチン 3.0
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
1,2-ペンタンジオール 2.0
フェノキシエタノール 0.3
精製水 全量が100部となる量
Prescription example 8. Pack [Ingredients] Part Dipropylene glycol 5.0
Polyoxyethylene (60) hydrogenated castor oil 5.0
Setanol 3.0
Behenyl alcohol 3.0
Allantoin 0.1
Dipotassium glycyrrhizinate 0.1
Ammonium glycyrrhizinate 0.1
β-Glycyrrhetinic acid 0.1
Stearyl glycyrrhetinate 0.1
Salicylic acid 0.1
Tocopherol acetate 0.5
Tocopherol nicotinic acid ester 0.1
D-pantothenyl alcohol 0.3
Resorcinol 0.1
Sulfur 2.0
Estradiol 0.002
Niacinamide 5.0
Xanthan gum 2.0
Polyglyceryl-6 myristate 1.0
Potassium cocoyl glutamate 1.0
Hydrogenated lecithin 3.0
Hydroxylated lecithin 3.0
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
1,2-pentanediol 2.0
Phenoxyethanol 0.3
Purified water Amount that makes the total amount 100 parts
処方例9.ヘアシャンプー
[成分] 部
ラウレス硫酸ナトリウム 10.0
モノステアリン酸グリセリル 1.0
ヤシ油脂肪酸ジエタノールアミド 2.0
ポリオキシエチレン(40)硬化ヒマシ油 0.5
塩化ベンザルコニウム 1.0
ステアリルアルコール 2.0
ベヘニルアルコール 2.0
ジメチコン 3.0
ナイアシンアミド 5.0
アラントイン 0.1
グリチルリチン酸ジカリウム 0.1
サリチル酸 0.1
サリチル酸ナトリウム 0.1
トコフェロール酢酸エステル 0.1
ピリチオン亜鉛 0.3
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
安息香酸 0.2
トリクロサン 0.2
クエン酸 0.1
プロピレングリコール 2.0
1,2-ペンタンジオール 2.0
精製水 全量が100部となる量
Prescription example 9. Hair shampoo [Ingredients] Part Sodium laureth sulfate 10.0
Glyceryl monostearate 1.0
Coconut oil fatty acid diethanolamide 2.0
Polyoxyethylene (40) hydrogenated castor oil 0.5
Benzalkonium chloride 1.0
Stearyl alcohol 2.0
Behenyl alcohol 2.0
Dimethicone 3.0
Niacinamide 5.0
Allantoin 0.1
Dipotassium glycyrrhizinate 0.1
Salicylic acid 0.1
Sodium salicylate 0.1
Tocopherol acetate 0.1
Pyrithione zinc 0.3
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Benzoic acid 0.2
Triclosan 0.2
Citric acid 0.1
Propylene glycol 2.0
1,2-pentanediol 2.0
Purified water Amount that makes the total amount 100 parts
処方例10.ヘアコンディショナー
[成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
トリ2-エチルヘキサン酸グリセリル 1.0
塩化ベンザルコニウム 1.0
セタノール 3.0
ステアリルアルコール 1.0
ナイアシンアミド 5.0
アラントイン 0.1
イソプロピルメチルフェノール 0.1
グリチルリチン酸ジカリウム 0.1
サリチル酸 0.1
イオウ 0.5
臭化アルキルイソキノリニウム液(75%) 0.06
ピリチオン亜鉛 0.3
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
メチルパラベン 0.1
トリクロサン 0.2
レゾルシン 0.1
フェノキシエタノール 0.1
精製水 全量が100部となる量
Prescription example 10. Hair conditioner [Ingredients] Part Polyoxyethylene (10) Hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl tri-2-ethylhexanoate 1.0
Benzalkonium chloride 1.0
Setanol 3.0
Stearyl alcohol 1.0
Niacinamide 5.0
Allantoin 0.1
Isopropylmethylphenol 0.1
Dipotassium glycyrrhizinate 0.1
Salicylic acid 0.1
Sulfur 0.5
Alkylisoquinolinium bromide liquid (75%) 0.06
Pyrithione zinc 0.3
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Methylparaben 0.1
Triclosan 0.2
Resorcinol 0.1
Phenoxyethanol 0.1
Purified water Amount that makes the total amount 100 parts
処方例11.洗浄用化粧料
[成分] 部
ココイルグリシンカリウム 5.0
グリセリン 10.0
カプリル酸グリセリル 1.0
ラウロイルアスパラギン酸ナトリウム 10.0
ナイアシンアミド 5.0
セタノール 3.0
ミリスチルアルコール 3.0
イソプロピルメチルアルコール 0.1
アラントイン 0.1
イオウ 0.5
グリチルリチン酸 0.1
グリチルリチン酸ジカリウム 0.1
グリチルリチン酸モノアンモニウム 0.1
β-グリチルレチン酸 0.05
グリチルレチン酸ステアリル 0.1
サリチル酸 0.2
トコフェロール酢酸エステル 0.2
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
トリクロサン 0.1
トリクロロカルバニド 0.5
トリクロロヒドロキシジフェニルエーテル 0.2
濃ベンザルコニウム塩化物液50 0.2
ベンザルコニウム塩化物 0.1
1,2-ペンタンジオール 1.0
1,3-ブチレングリコール 3.0
プロパンジオール 1.0
精製水 全量が100部となる量
Prescription example 11. Cleansing cosmetics [Ingredients] Part Cocoylglycine potassium 5.0
Glycerin 10.0
Glyceryl caprylate 1.0
Sodium lauroyl aspartate 10.0
Niacinamide 5.0
Setanol 3.0
Myristyl alcohol 3.0
Isopropyl methyl alcohol 0.1
Allantoin 0.1
Sulfur 0.5
Glycyrrhizic acid 0.1
Dipotassium glycyrrhizinate 0.1
Monoammonium glycyrrhizinate 0.1
β-Glycyrrhetinic acid 0.05
Stearyl glycyrrhetinate 0.1
Salicylic acid 0.2
Tocopherol acetate 0.2
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Triclosan 0.1
Trichlorocarbanide 0.5
Trichlorohydroxydiphenyl ether 0.2
Concentrated benzalkonium chloride solution 50 0.2
Benzalkonium chloride 0.1
1,2-pentanediol 1.0
1,3-butylene glycol 3.0
Propanediol 1.0
Purified water Amount that makes the total amount 100 parts
処方例12.シートマスク
不織布に下記の成分を含浸させてシートマスクを得る。
[成分] 部
グリセリン 3.0
1、3-ブチレングリコール 2.0
L-アスコルビン酸 2-グルコシド 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
キサンタンガム 1.0
水溶性コラーゲン 1.0
ヒアルロン酸ナトリウム 1.0
アマモ抽出物 1.0
ナイアシンアミド 5.0
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
水酸化カリウム 適量
精製水 全量が100部となる量
Prescription example 12. Sheet mask A sheet mask is obtained by impregnating a nonwoven fabric with the following ingredients.
[Ingredients] Part Glycerin 3.0
1,3-butylene glycol 2.0
L-ascorbic acid 2-glucoside 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Xanthan gum 1.0
Water-soluble collagen 1.0
Sodium hyaluronate 1.0
Eelgrass extract 1.0
Niacinamide 5.0
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Potassium hydroxide (appropriate amount) Purified water (amount to make 100 parts)
処方例13.美容液
[成分] 部
エタノール 2.0
グリセリン 5.0
1、3-ブチレングリコール 5.0
メチルパラベン 0.1
ヒアルロン酸加水分解物 1.0
乳酸菌培養物 1.0
ナイアシンアミド 5.0
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
クエン酸ナトリウム 適量
精製水 全量が100部となる量
Prescription example 13. Beauty serum [Ingredients] Part Ethanol 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Hyaluronic acid hydrolyzate 1.0
Lactic acid bacteria culture 1.0
Niacinamide 5.0
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Sodium citrate Appropriate amount Purified water Amount to make 100 parts
処方例14.シワ改善用クリーム
[成分] 部
オリーブ油 5.0
シュガースクワラン 5.0
ホホバ油 5.0
ホホバワックス 1.0
べヘニルアルコール 1.0
ステアリルアルコール 1.5
キャンデリラワックス 0.5
ナイアシンアミド 5.0
トリ2-エチルヘキサン酸グリセリル 1.0
乳酸菌発酵米 3.0
製造例1の抽出物 1.0
製造例2の抽出物 1.0
製造例4の抽出物 1.0
水添レシチン 2.0
カルボキシビニルポリマー 0.3
アルギン酸ナトリウム 0.2
グリセリン 3.0
水酸化カリウム 適 量
精製水 全量が100部となる量
Prescription example 14. Wrinkle improvement cream [Ingredients] Part Olive oil 5.0
Sugar Squalane 5.0
Jojoba oil 5.0
Jojoba wax 1.0
Behenyl alcohol 1.0
Stearyl alcohol 1.5
Candelilla wax 0.5
Niacinamide 5.0
Glyceryl tri-2-ethylhexanoate 1.0
Lactic acid bacteria fermented rice 3.0
Extract of Production Example 1 1.0
Extract of Production Example 2 1.0
Extract of Production Example 4 1.0
Hydrogenated lecithin 2.0
Carboxyvinyl polymer 0.3
Sodium alginate 0.2
Glycerin 3.0
Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts
Claims (1)
Priority Applications (1)
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JP2022117613A JP2024015465A (en) | 2022-07-23 | 2022-07-23 | Topical skin preparation |
Applications Claiming Priority (1)
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JP2022117613A JP2024015465A (en) | 2022-07-23 | 2022-07-23 | Topical skin preparation |
Publications (1)
Publication Number | Publication Date |
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JP2024015465A true JP2024015465A (en) | 2024-02-02 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2022117613A Pending JP2024015465A (en) | 2022-07-23 | 2022-07-23 | Topical skin preparation |
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JP (1) | JP2024015465A (en) |
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2022
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