JP2023517529A - ナノファイバーを使用して皮膚を修復するための方法 - Google Patents
ナノファイバーを使用して皮膚を修復するための方法 Download PDFInfo
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Abstract
Description
実施例1:
本発明によるナノファイバーパッチの効果を評価するための非限定的な臨床研究を実施した。研究は、カフェイン(活性成分)の有無別のナノファイバーパッチを用いた目の処置の効果を評価した。研究はまた、インライフ(in-life)視覚的等級付け及び3Dフリンジイメージング(fringe imaging)技術を使用して、目の下の腫れの外観及び特性を評価した。インライフ視覚的等級付けを使用して、目の下のしわを評価した。
・18~19歳の女性
・Fitzpatrick皮膚タイプI~IV
・目の下の腫れの等級3~6
・LGスコア分布:[2,3]=3;[3,4]=7;[4,5]=8;[5,6]=3;[6,7]=2。
MatTek皮膚(人工的にしわがある)を使用してナノファイバーパッチの硬化効果の影響を評価するためのエクスビボ試験を行った。以下の材料を試験した:MatTek皮膚;PVPオリジナルパッチ、厚さ(面密度)3gsm;PVPパッチ、厚さ(面密度)3gsm;活性物質を含むPVP/HAパッチ、厚さ(面密度)3gsm;HA/PEO、厚さ(面密度)3gsm;及びプルラン、厚さ(面密度)10gsm。
Claims (20)
- 対象の皮膚の眼窩周囲領域における腫れの外観を低減する方法であって、それを必要とする前記対象の皮膚に電界紡糸繊維を含む組成物を局所的に適用することを含む、方法。
- 前記対象の前記眼窩周囲領域の周りで前記皮膚の硬化又は引き締めを更に引き起こす、請求項1に記載の方法。
- 前記組成物が、活性成分を実質的に含まない、請求項1に記載の方法。
- 前記組成物が、活性成分を欠いている、請求項1に記載の方法。
- 前記組成物が、化粧用として許容可能な担体を更に含む、請求項1に記載の方法。
- 前記組成物が、酸化防止剤又は保湿剤又は軟化剤又は防腐剤を更に含む、請求項1に記載の方法。
- 前記組成物が、約0.1~約50gsmの範囲の厚さを有するパッチ又はマスクである、請求項1に記載の方法。
- 前記電界紡糸繊維が、親水性ポリマーを含む、請求項1に記載の方法。
- 対象の皮膚の視覚的外観を改善するための方法であって、前記皮膚を湿潤させるための溶液を対象に提供することと、組成物を前記皮膚に局所的に投与することと、を含み、前記組成物が、電界紡糸繊維を含む、方法。
- 前記組成物が、活性成分を実質的に含まない、請求項9に記載の方法。
- 前記組成物が、活性成分を欠いている、請求項9に記載の方法。
- 溶液を噴霧することによって、又は噴霧を通して皮膚を湿潤させる、請求項9に記載の方法。
- 前記方法が、静脈の拡張、目の下のたるみ、目の下のクマ、及び目の周りの腫脹、リフティング、硬化、前記皮膚の平滑化、小じわ、しわ、又は前記皮膚の引き締めを改善する、請求項9に記載の方法。
- 前記電界紡糸繊維が、2分未満の湿潤で溶解する1つ以上の親水性ポリマーを含む、請求項9に記載の方法。
- 親水性電界紡糸繊維を含む化粧用パッチであって、前記パッチが、活性成分を実質的に含まない、化粧用パッチ。
- 1つ以上の接着剤層を更に含む、請求項15に記載の化粧用パッチ。
- 活性成分を欠いている、請求項15に記載の化粧用パッチ。
- 予備湿潤用溶液と、親水性電界紡糸ポリマー繊維を含む化粧用パッチと、を含む、キット。
- 前記パッチが、マスクである、請求項18に記載のキット。
- 前記パッチが、フィルムである、請求項18に記載のキット。
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AU2021230481A1 (en) | 2022-09-29 |
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