JP2022546938A - 局所用組成物 - Google Patents
局所用組成物 Download PDFInfo
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- JP2022546938A JP2022546938A JP2022510129A JP2022510129A JP2022546938A JP 2022546938 A JP2022546938 A JP 2022546938A JP 2022510129 A JP2022510129 A JP 2022510129A JP 2022510129 A JP2022510129 A JP 2022510129A JP 2022546938 A JP2022546938 A JP 2022546938A
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- benzoxazol
- benzene
- composition
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 59
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Abstract
Description
(i)本明細書において与えられる全ての定義及び優先度を有する微粉化された1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンを、水性分散体の総質量を基準として、25~60質量%、好ましくは25~50質量%と;
(ii)C8~16アルキルポリグルコシドを、水性分散体の総質量を基準として、5~15質量%、好ましくは7~12.5質量%と;
(iii)増粘剤、湿潤剤、及び/又は消泡剤の群から選択される少なくとも1種の添加剤を、水性分散体の総質量を基準として、0~3質量%、好ましくは0~2.5質量%と;
(iv)水を、水性分散体の総質量を基準として、全体が100質量%となる量と;
から基本的になる。
の末端基を有する、ドデセニルコハク酸無水物、ジイソプロパノールアミン、ビスジメチルアミノプロピルアミンのモノマーの超分岐などを含まない。
[1.1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの調製]
ポリリン酸702g及びメタンスルホン酸4.28mlの混合物を90℃に加熱した。テレフタル酸65g及び2-アミノフェノール107gを加えた。この混合物を不活性雰囲気下に180℃で8時間撹拌した後、氷水に移した。析出物を濾過し、水及び酢酸で洗浄した。析出物を水中に分散させ、pHを水酸化ナトリウムで8.0に調整し、濾過して水で洗浄した。粗生成物をトルエン及び1-ブタノールの3.3:1混合物中に懸濁させ、85℃で1時間撹拌し、濾過してジエチルエーテルで洗浄し、乾燥させることにより、固体非晶質1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの粗い粒子を得た(以下、DBOと称する)。
次いで、粗い粒子175g、水324g、及びGreen APG 0 810を65gの懸濁液を調製し、この懸濁液をLabStar実験室用粉砕機でイットリウム安定化酸化ジルコニウム粉砕用ビーズ(0.3mm、東ソー・セラミックス株式会社(Tosoh Ceramic)、日本国)を使用して2時間粉砕し、粉砕チャンバ内で冷却した(-12℃の飽和食塩水)。粉砕ビーズを除去することにより、微粉化された1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの30%水性分散体(以下、DBO aq.と称する)を得、これを以下に概説する抗微生物試験及び処方に使用した。
抗微生物効果を、規制に従う保存効力試験方法(regulatory challenge test)(NF EN ISO11930)に類似した方法で評価した。これに従い、以下に概説する各活性物質とNaCl濃度0.85質量%の生理食塩水(physiological serum)との混合物を無菌条件下で調製する。対照も同様に無菌条件下で調製した。次いで、対照及び混合物を96ディープウェルプレート(1.6ml/well)に排除した。以下に概説するように、ウェルを各細菌又は真菌株で、細菌の場合は2.5×105~5.6×105cfu/mlになるように、真菌の場合は1×104~2.5×104cfu/mlになるように汚染することにより、初期汚染を行った。汚染後、各ウェルを十分に混合して、微生物を確実に均一に分布させた。次いで、各プレートを22℃で24時間インキュベートした。汚染から24時間後に(生残)菌数の測定を行う。次いで、平均対数減少値を求める[-log10{(接種菌数)/(サンプルの菌数)}]。これらを表1~5に示す。
Claims (15)
- 1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンと、ヒドロキシアセトフェノン、アルカンジオール、及び安息香酸又はその塩の群から選択される少なくとも1種の化合物とを含むを含む、局所用組成物。
- 1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンの量は、前記組成物の総質量を基準として、1~20質量%の範囲、より好ましくは0.25~15質量%の範囲、最も好ましくは約0.3~10質量%の範囲において選択される、請求項1に記載の局所用組成物。
- 前記ヒドロキシアセトフェノンの量は、前記組成物の総質量を基準として、0.001~5質量%の範囲、好ましくは0.01~4質量%の範囲、最も好ましくは0.1~3質量%の範囲において選択される、請求項1又は2に記載の局所用組成物。
- 前記アルカンジオールの量は、前記組成物の総質量を基準として、0.01~5質量%の範囲、好ましくは0.1~4質量%の範囲、最も好ましくは0.5~3質量%の範囲において選択される、請求項1~3のいずれか一項に記載の局所用組成物。
- 前記安息香酸又はその塩の量は、前記組成物の総質量を基準として、0.001~6質量%の範囲、好ましくは0.01~4質量%の範囲、最も好ましくは0.1~3質量%の範囲において選択される、請求項1~4のいずれか一項に記載の局所用組成物。
- 前記1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼン対ヒドロキシアセトフェノン、アルカンジオール、及び安息香酸又はその塩の群から選択される前記少なくとも1種の化合物の質量比は、50:1~1:10、好ましくは40:1~1:5、最も好ましくは30:1~1:1の範囲から選択される、請求項1~5のいずれか一項に記載の局所用組成物。
- 前記ヒドロキシアセトフェノンはp-ヒドロキシアセトフェノンであり、前記アルカンジオールは1,3-プロパンジオールであり、前記安息香酸又はその塩は安息香酸ナトリウムである、請求項1~6のいずれか一項に記載の局所用組成物。
- 前記組成物は、O/Wエマルション、W/Oエマルション、又はゲルである、請求項1~7のいずれか一項に記載の局所用組成物。
- 前記組成物は、水と、界面活性剤、乳化剤、増粘剤、及び油からなる群から選択される少なくとも1種の薬剤とを含む、請求項1~8のいずれか一項に記載の局所用組成物。
- 皮膚及び/又は頭皮を処置する局所的方法であって、前記方法は、前記皮膚及び/又は頭皮を、請求項1~9のいずれか一項に記載の化粧用組成物と接触させるステップを含む、方法。
- 健康な皮膚恒常性を維持するため及び/又は皮膚微生物叢のバランスを維持するための、請求項10に記載の方法。
- 1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンと、ヒドロキシアセトフェノン、アルカンジオール、及び安息香酸又はその塩の群から選択される少なくとも1種の化合物との混合物の、相乗的抗微生物剤混合物としての使用。
- 前記ヒドロキシアセトフェノンはp-ヒドロキシアセトフェノンであり、前記アルカンジオールは1,3-プロパンジオールであり、前記安息香酸又はその塩は安息香酸ナトリウムである、請求項12に記載の使用。
- 局所用組成物の貯蔵寿命及び/又は貯蔵安定性を高めるための、請求項12又は13に記載の使用。
- 微生物による局所用組成物の分解を阻害するか又は遅延する方法であって、前記方法は、前記化粧用組成物に、有効量の1,4-ジ(ベンゾオキサゾール-2’-イル)ベンゼンと、ヒドロキシアセトフェノン、アルカンジオール、及び安息香酸又はその塩の群から選択される少なくとも1種の化合物とを添加するステップを含む、方法。
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WO2023224401A1 (ko) | 2022-05-19 | 2023-11-23 | 주식회사 엘지에너지솔루션 | 리튬 이차 전지용 전극의 제조 방법 및 전극을 포함하는 리튬 이차 전지 |
WO2023242008A1 (en) * | 2022-06-15 | 2023-12-21 | Dsm Ip Assets B.V. | Sunscreen composition for lactobacillus and s. epidermidis protection on skin |
WO2024049114A1 (ko) * | 2022-09-01 | 2024-03-07 | 주식회사 엑티브온 | 1,3-프로판디올을 유효성분으로 포함하는 피부의 마이크로바이옴 균형 유지용 피부 외용제 조성물 |
WO2024117424A1 (ko) * | 2022-12-02 | 2024-06-06 | 주식회사 엑티브온 | 맥주효모 추출물 및 1,3-프로판디올을 포함하는 피부의 마이크로바이옴 균형 유지용 화장료 조성물 |
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GB9403451D0 (en) | 1994-02-23 | 1994-04-13 | Ciba Geigy Ag | Sunscreen compositions |
GB9515048D0 (en) | 1995-07-22 | 1995-09-20 | Ciba Geigy Ag | Sunscreen compositions |
ATE220318T1 (de) * | 1996-02-21 | 2002-07-15 | Stoa Sa | Kosmetische, dermopharmazeutische oder tierärztliche zusammensetzungen zur antiseptischen behandlung von menschlicher oder tierischer haut |
US6177574B1 (en) * | 2000-03-02 | 2001-01-23 | Eastman Chemical Company | Preparation of mixtures of benzoxazolyl-stilbene compounds |
FR2816842B1 (fr) * | 2000-11-17 | 2005-03-11 | Oreal | Filtres uv organiques insolubles et leur utilisation en cosmetique |
CN1531530A (zh) * | 2001-02-05 | 2004-09-22 | 罗奇维生素股份公司 | 新的2-苯并噁唑基苯衍生物及其用作紫外线掩蔽剂的用途 |
WO2008041966A2 (en) * | 2005-08-12 | 2008-04-10 | United States Government As Represented By The Secretary Of The United States Army And The U.S. Army Medical Research & Materiel Command | Broad spectrum antibacterial compounds |
DE102006047618B3 (de) * | 2006-10-09 | 2007-11-15 | Clariant International Limited | Verfahren zur Herstellung von Bisbenzoxazolen |
WO2008083974A1 (en) * | 2007-01-12 | 2008-07-17 | Isdin S.A. | Active substance combination |
ES2390008T3 (es) * | 2008-07-16 | 2012-11-05 | Dsm Ip Assets B.V. | Uso de (etilendiamina)tetrametilenfosfonato pentasódico para suprimir la decoloración en composiciones tópicas |
EP2717833A2 (en) * | 2011-06-08 | 2014-04-16 | DSM IP Assets B.V. | Cosmetic compositions |
US20130101530A1 (en) * | 2011-10-25 | 2013-04-25 | Galaxy Surfactants Ltd. | Antimicrobial preservative compositions for personal care products |
CN111902126A (zh) * | 2018-03-20 | 2020-11-06 | 帝斯曼知识产权资产管理有限公司 | 微粉化1,4-二(苯并噁唑-2‘-基)苯 |
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US20220346377A1 (en) | 2022-11-03 |
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