JP2021526211A - 媒質中の三次元粒子分布の特定方法 - Google Patents
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Abstract
Description
Claims (10)
- 媒質(M)における三次元粒子分布(6)、好ましくはバクテリア分布を特定する方法であって、
上記粒子(P)を含む上記媒質(M)の試料(3)を提供する工程と、
光源(2)を用いて、コヒーレント光ビーム(9)を放射し、試料(3)に上記光ビーム(9)を照射し、光ビーム(9)の第一の部分が粒子(P)に散乱され散乱光ビーム(10)となる工程と、
散乱光ビーム(10)と、上記光ビームの散乱されていない第二の部分(11)との干渉画像(12)を、カメラ(5)によって記録する工程と、
上記試料(3)内に位置する複数の仮想平面(13i)のそれぞれについて、その仮想平面(13i)における上記試料(3)の再構成画像(14i)であって、強度値(I)と位相値(Φ)とを有する複数の画素(15)を有する再構成画像(14i)を、プロセッサ(7)によって上記干渉画像(12)から計算する工程と、
上記再構成画像(14i)のそれぞれについて、画素(17)のレイアウトが上記再構成画像(14i)と同じである存在画像(16i)であって、各画素(17)について、上記再構成画像(14i)における対応する画素(15)の強度値(I)が所定の閾値(TH)を超え、かつ、上記再構成画像(14i)における対応する画素(15)の位相値(Φ)が所定の符号(SG)を有する場合に、該画素(17)に値が与えられ、上記二つの条件のうちの少なくとも一つが満たされない場合に、該画素(17)に値が与えられない存在画像(16i)を、上記プロセッサ(7)によって生成する工程と、
存在画像(16i)において値が与えられている画素(17)から、上記三次元粒子分布(6)を特定する工程と、を含む方法。 - 上記試料(3)の外に位置する焦点(F)を有する光学デバイス(4)によって、上記散乱光ビーム(10)を、散乱後、かつ、記録前に、上記カメラ(5)上に向けることを特徴とする、請求項1に記載の方法。
- 上記所定の符号(SG)は、上記焦点(F)が、上記光ビーム(9)の方向において上記試料(3)を基準としたときに位置する側と、上記粒子(P)の屈折率に対する上記媒質(M)の屈折率とに依存することを特徴とする、請求項2に記載の方法。
- 上記仮想平面(13i)のそれぞれは、所定の間隔(IV)で離間しており、上記試料(3)の全体をカバーする、請求項1〜3の何れか一項に記載の方法。
- 上記光源(2)と、上記試料(3)と、上記カメラ(5)とを含むインライン干渉計(1)が設けられていることを特徴とする、請求項1〜4の何れか一項に記載の方法。
- 上記カメラ(5)として、デジタルカメラ、好ましくは相補型金属酸化膜半導体または電荷結合素子が設けられていることを特徴とする、請求項1〜5の何れか一項に記載の方法。
- 上記干渉画像(12)の平面に対応する二次元の平面に、上記三次元粒子分布(6)を投影することを特徴とする、請求項1〜6の何れか一項に記載の方法。
- 少なくとも一つの上記再構成画像(14i)の各画素(15)について、上記閾値(TH)を、その画素(15)からの所定の範囲内に位置する画素の強度値の代表値の所定のパーセンテージとして計算する、請求項1〜7の何れか一項に記載の方法。
- 上記閾値(TH)を、基準の強度分布(18)の第二の最大強度値(M2)と第三の最大強度値(M3)との間となるように決定することを特徴とする、請求項1〜8の何れか一項に記載の方法。
- 放射、照射、記録、生成、および特定を繰り返すことにより第一および第二の粒子分布(6)を特定し、上記第一の粒子分布(6)における少なくとも一つの粒子(P)を、第二の粒子分布(6)における同じ粒子(P)と対応付けて、上記粒子(P)の移動を追跡することを特徴とする、請求項1〜9の何れか一項に記載の方法。
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EP18174605.8A EP3575773A1 (en) | 2018-05-28 | 2018-05-28 | A method for determining a three-dimensional particle distribution in a medium |
EP18174605.8 | 2018-05-28 | ||
PCT/EP2019/061615 WO2019228763A1 (en) | 2018-05-28 | 2019-05-07 | A method for determining a three-dimensional particle distribution in a medium |
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EP (2) | EP3575773A1 (ja) |
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CN107152970B (zh) * | 2017-04-21 | 2018-11-09 | 中国科学院苏州生物医学工程技术研究所 | 基于干涉阵列光场的高分辨并行显微成像仪 |
CN106908942A (zh) * | 2017-04-21 | 2017-06-30 | 中国科学院苏州生物医学工程技术研究所 | 基于微透镜阵列的高分辨并行显微成像仪 |
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JP2002526815A (ja) * | 1998-10-07 | 2002-08-20 | エコール ポリテクニーク フェデラル ドゥ ローザンヌ(エーペーエフエル) | ディジタル・ホログラムを数値的に再構成することにより、振幅コントラスト画像と定量的位相コントラスト画像を同時に形成する方法と装置 |
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JP2016206061A (ja) * | 2015-04-24 | 2016-12-08 | 株式会社東洋精機製作所 | 微粒子を含む薄膜の状態変化を解析する解析装置及び解析方法 |
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CN112219104A (zh) | 2021-01-12 |
CN112219104B (zh) | 2024-03-26 |
EP3575773A1 (en) | 2019-12-04 |
US20210199552A1 (en) | 2021-07-01 |
KR20210016382A (ko) | 2021-02-15 |
US11852574B2 (en) | 2023-12-26 |
EP3803331A1 (en) | 2021-04-14 |
EP3803331B1 (en) | 2022-07-27 |
WO2019228763A1 (en) | 2019-12-05 |
JP7338882B2 (ja) | 2023-09-05 |
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