JP2021522957A - 血液脳関門の透過性を向上させるための交流電界の使用 - Google Patents
血液脳関門の透過性を向上させるための交流電界の使用 Download PDFInfo
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Abstract
Description
本出願は、その全体が参照により本明細書に組み込まれる、2018年8月23日出願の米国仮出願第62/722,100号の利益を主張する。
対象の身体への取付け向けに構成された電極のセット;及び
AC電圧ジェネレーターの出力を電極のセットに接続する配線、
を更に含む。
がんを治療するためにBBBを通っての化学療法剤を送達すること(これに関連して、脳への薬物の透過性の向上に基づいて、身体の他の部分において重篤な副作用を有する、脳腫瘍及び転移を治療するための薬物の投与量を減らすことができる可能性がある);免疫療法のためにBBBを通って抗体及び又は細胞ベースの療法を送達すること;診断目的のために及び研究のために(例えば、脳活動のモニター)、BBBを通って造影剤染料、レポーター、及びマーカーを送達すること;感染症を治療するためにBBBを通って抗菌剤を送達すること;ウイルス感染症を治療するために、BBBを通って抗ウイルス剤又はウイルス中和抗体を送達すること;寄生虫を治療するためにBBBを通って抗寄生虫剤を送達すること;BBBを通って神経変性疾患及び自己免疫疾患を治療する薬剤を送達すること;精神病薬を送達すること;抗てんかん薬を送達すること;水頭症薬を送達すること;脳卒中介入薬及び回復薬を送達すること;脳に不足している化合物をBBBを通って送達して、それらの化合物が不足している状態を治療すること(例えば、パーキンソン病の治療等)。
42 コントローラー
44 AC電圧ジェネレーター
Claims (44)
- 対象の脳の血液脳関門を通って物質を送達する方法であって、
ある時間期間の間、対象の脳に交流電界を印加する工程であって、ある時間期間の間での対象の脳への交流電界の印加は対象の脳において血液脳関門の透過性を向上させる、工程;及び
ある時間期間が経過した後に対象に物質を投与する工程であって、血液脳関門の透過性の向上によって物質が血液脳関門を通ることが可能となる、工程、
を含む、方法。 - 交流電界が、75kHzから125kHzの間の周波数において印加される、請求項1に記載の方法。
- ある時間期間が少なくとも24時間である、請求項1に記載の方法。
- ある時間期間が少なくとも48時間である、請求項1に記載の方法。
- 交流電界が、対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項1に記載の方法。
- 交流電界が75kHzから125kHzの間の周波数において印加され、ある時間期間が少なくとも24時間であり、交流電界が対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項1に記載の方法。
- 物質を投与する工程が静脈内で行われる、請求項1に記載の方法。
- 物質を投与する工程が経口で行われる、請求項1に記載の方法。
- 対象の脳が腫瘍を有しない、請求項1に記載の方法。
- 物質が疾患を治療するための薬物を含む、請求項1に記載の方法。
- 薬物が、がん治療薬、感染症治療薬、神経変性疾患治療薬、自己免疫疾患治療薬、抗てんかん薬、水頭症薬、脳卒中介入薬、又は精神病薬を含む、請求項10に記載の方法。
- 物質が脳活動をモニターするのに使用される、請求項1に記載の方法。
- 物質が脳染料、レポーター、又はマーカーである、請求項12に記載の方法。
- 交流電界の印加を停止して、血液脳関門を回復させる工程を更に含む、請求項1に記載の方法。
- 対象の脳の血液脳関門を通って物質を送達する方法であって、
ある時間期間の間、対象の脳に第1の周波数において交流電界を印加する工程であって、第1の周波数は190kHz未満であり、ある時間期間は少なくとも24時間であり、ある時間期間の間での対象の脳への第1の周波数においての交流電界の印加は対象の脳において血液脳関門の透過性を向上させる、工程;及び
ある時間期間が経過した後に対象に物質を投与する工程であって、血液脳関門の透過性の向上によって物質が血液脳関門を通ることが可能となる、工程、
を含む、方法。 - 交流電界が、75kHzから125kHzの間の周波数において印加される、請求項15に記載の方法。
- ある時間期間が少なくとも48時間である、請求項15に記載の方法。
- 交流電界が、対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項15に記載の方法。
- 交流電界が75kHzから125kHzの間の周波数において印加され、交流電界が対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項15に記載の方法。
- 対象の脳の血液脳関門を通って物質を送達する方法であって、
ある時間期間の間、対象の脳に第1の周波数において交流電界を印加する工程であって、対象の脳は腫瘍を有さず、ある時間期間の間での対象の脳への第1の周波数においての交流電界の印加は対象の脳において血液脳関門の透過性を向上させる、工程;及び
ある時間期間が経過した後に対象に物質を投与する工程であって、血液脳関門の透過性の向上によって物質が血液脳関門を通ることが可能となる、工程、
を含む、方法。 - 交流電界が、75kHzから125kHzの間の周波数において印加される、請求項20に記載の方法。
- ある時間期間が少なくとも24時間である、請求項20に記載の方法。
- ある時間期間が少なくとも48時間である、請求項20に記載の方法。
- 交流電界が、対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項20に記載の方法。
- 交流電界が75kHzから125kHzの間の周波数において印加され、ある時間期間が少なくとも24時間であり、交流電界が対象の脳の少なくとも一部において少なくとも1V/cmの電界強度を有する、請求項20に記載の方法。
- 対象の脳内の腫瘍を治療し、対象の脳の血液脳関門を通って物質を送達する方法であって、
第1の時間期間の間、対象の脳に第1の周波数において第1の交流電界を印加する工程であって、第1の時間期間の間での対象の脳への第1の周波数においての第1の交流電界の印加は対象の脳において血液脳関門の透過性を向上させる、工程;
第1の時間期間が経過した後に対象に物質を投与する工程であって、血液脳関門の透過性の向上によって物質が血液脳関門を通ることが可能となる、工程;及び、
少なくとも1週間の長さである第2の時間期間の間、対象の脳に第2の周波数においての第2の交流電界を印加する工程であって、第2の周波数は第1の周波数とは異なり、第2の周波数においての第2の交流電界は腫瘍を阻害するのに十分大きい強度を有する、工程、
を含む、方法。 - 第1の周波数が75kHzから125kHzの間である、請求項26に記載の方法。
- 第1の周波数が50kHzから190kHzの間である、請求項26に記載の方法。
- 第2の周波数が190kHzから210kHzの間である、請求項28に記載の方法。
- 第1の時間期間が少なくとも24時間である、請求項26に記載の方法。
- 第2の時間期間が、少なくとも1週間の長さである単回の非中断の時間区間を含む、請求項26に記載の方法。
- 第2の時間期間が、第2の周波数における第2の交流電界が対象の脳に印加される複数の不連続の時間区間を含み、複数の不連続の時間区間はまとめると合計少なくとも1週間となる、請求項26に記載の方法。
- 物質が少なくとも4kDaの分子量を有する、請求項1から33のいずれかに一項に記載の方法。
- 物質が少なくとも69kDaの分子量を有する、請求項1から33のいずれかに一項に記載の方法。
- 物質が、物質が非漏出性のBBBを通るのを通常は妨害する少なくとも1つの特徴を有する、請求項1から33のいずれかに一項に記載の方法。
- 対象の身体の腫瘍を治療し、対象の身体の血液脳関門を通る物質の送達を促進するための装置であって、
50から190kHzの間の第1の周波数及び50から500kHzの間の第2の周波数で作動できるAC電圧ジェネレーターであって、第2の周波数は第1の周波数と異なり、AC電圧ジェネレーターは制御入力を有し、制御入力が第1の状態にある場合に第1の周波数を出力し、制御入力が第2の状態にある場合に第2の周波数を出力するように構成されている、AC電圧ジェネレーター;及び
(a) AC電圧ジェネレーターが第2の周波数を出力するように制御入力を第2の状態に置き、(b)第1の周波数に切り替える要求を受け取り、(c)要求を受け取り次第、AC電圧ジェネレーターがある時間区間の間第1の周波数を出力するように、制御入力を第1の状態に置き、及び、(d)ある時間区間が経過した後、AC電圧ジェネレーターが第2の周波数を出力するように、制御入力を第2の状態に置くようにプログラムされたコントローラー、
を含む、装置。 - 対象の身体への取付け向けに構成された電極のセット;及び
AC電圧ジェネレーターの出力を電極のセットに接続する配線、
を更に含む、請求項36に記載の装置。 - 第1の周波数が75kHzから125kHzの間であり、第2の周波数が150kHzから250kHzの間である、請求項36に記載の装置。
- ある時間区間が少なくとも24時間である、請求項36に記載の装置。
- ある時間区間が少なくとも72時間である、請求項36に記載の装置。
- コントローラーが、要求の受取りに続いて、第1の状態と第2の状態との間で制御入力を交互に切り替えるように更にプログラムされている、請求項36に記載の装置。
- AC電圧ジェネレーターが、50から500kHzの間の少なくとも1つの追加の周波数において作動することができ、AC電圧ジェネレーターが、制御入力が少なくとも1つの追加の状態にある場合、少なくとも1つの追加の周波数を出力するように構成されており、
コントローラーが、要求の受取りの前に、制御入力に、第2の状態及び少なくとも1つの追加の状態を周期的に繰り返させ、ある時間区間が経過した後に、制御入力に、第2の状態及び少なくとも1つの追加の状態を周期的に繰り返させるようにプログラムされている、
請求項36に記載の装置。 - ユーザーインターフェースを更に含み、要求がユーザーインターフェースを介して受け入れられる、請求項36に記載の装置。
- 要求がRFを介して受け入れられる、請求項36に記載の装置。
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JP2021150228A JP2021192835A (ja) | 2018-08-23 | 2021-09-15 | 血液脳関門の透過性を向上させるための交流電界の使用 |
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