HUE056950T2 - Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére - Google Patents

Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére

Info

Publication number
HUE056950T2
HUE056950T2 HUE19780002A HUE19780002A HUE056950T2 HU E056950 T2 HUE056950 T2 HU E056950T2 HU E19780002 A HUE19780002 A HU E19780002A HU E19780002 A HUE19780002 A HU E19780002A HU E056950 T2 HUE056950 T2 HU E056950T2
Authority
HU
Hungary
Prior art keywords
electric fields
brain barrier
blood brain
alternating electric
increase permeability
Prior art date
Application number
HUE19780002A
Other languages
English (en)
Inventor
Carsten Hagemann
Mario Lohr
Almuth Kessler
Malgorzata Burek
Carola Forster
Catherine BRAMI
Hadas Hershkovich
Tali VOLOSHIN-SELA
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of HUE056950T2 publication Critical patent/HUE056950T2/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Microbiology (AREA)
  • Social Psychology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
HUE19780002A 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére HUE056950T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862722100P 2018-08-23 2018-08-23

Publications (1)

Publication Number Publication Date
HUE056950T2 true HUE056950T2 (hu) 2022-03-28

Family

ID=68104708

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE21170598A HUE059062T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
HUE20212126A HUE058160T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére
HUE19780002A HUE056950T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HUE21170598A HUE059062T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
HUE20212126A HUE058160T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére

Country Status (16)

Country Link
US (4) US11400269B2 (hu)
EP (5) EP3878389A1 (hu)
JP (1) JP6974671B2 (hu)
KR (2) KR20240042240A (hu)
CN (6) CN113908433A (hu)
AU (2) AU2019324585C1 (hu)
BR (1) BR112020025422A2 (hu)
CA (2) CA3100817A1 (hu)
DK (3) DK3892219T3 (hu)
ES (3) ES2911526T3 (hu)
HU (3) HUE059062T2 (hu)
IL (1) IL279466A (hu)
MX (1) MX2020013519A (hu)
PL (3) PL3892219T3 (hu)
SG (1) SG11202012592WA (hu)
WO (1) WO2020039390A1 (hu)

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WO2021214693A1 (en) * 2020-04-24 2021-10-28 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
EP4251261A1 (en) 2020-11-25 2023-10-04 Novocure Gmbh Increasing the efficacy of tumor treating fields (ttfields) by applying the ttfields at peak intensity less than half the time
WO2022130183A2 (en) * 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
CN113008403B (zh) * 2021-02-08 2022-08-12 清华大学 电场发生装置及测温电极装置
US20220323753A1 (en) * 2021-04-08 2022-10-13 Novocure Gmbh Methods of Treating Neurodegenerative Disorders with Alternating Electric Fields
CN113509641A (zh) * 2021-06-29 2021-10-19 北京康源嘉成生物科技有限公司 一种非药物且非侵入性开放血脑屏障的装置和方法
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WO2023053044A1 (en) * 2021-09-30 2023-04-06 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields
TW202333820A (zh) 2021-12-29 2023-09-01 瑞士商諾沃庫勒有限責任公司 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺
US20230218912A1 (en) 2021-12-30 2023-07-13 Novocure Gmbh Selecting Values of Parameters for Treatment Using Tumor Treating Fields (TTFields)
TW202404658A (zh) 2022-03-30 2024-02-01 瑞士商諾沃庫勒有限責任公司 使用交錯的冷卻週期來增加腫瘤治療場的峰值強度
US20230310877A1 (en) * 2022-03-30 2023-10-05 Novocure Gmbh Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Pairing Transducer Arrays Together
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KR102637878B1 (ko) * 2022-09-02 2024-02-19 주식회사 뉴로스피어 대뇌병변 산화철의 전자-펜톤효과를 이용한 전기장 대뇌자극치료기기
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WO2024069321A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for reducing electrosensation and/or skin irritation
WO2024069503A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing electrosensation while treating a subject using alternating electric fields by deactivating selected electrode elements
WO2024069504A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing electrosensation while treating a subject using alternating electric fields by controlling ramp-up characteristics
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US20240216684A1 (en) 2022-12-29 2024-07-04 Novocure Gmbh Reducing Electrosensation While Treating a Subject Using Alternating Electric Fields by Increasing the Number of Steps in a Ramp-Up Portion of a Waveform

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