JP2021085879A - Ra−226からAc−225を製造する方法 - Google Patents
Ra−226からAc−225を製造する方法 Download PDFInfo
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/12—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by electromagnetic irradiation, e.g. with gamma or X-rays
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
- B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
- B25J21/00—Chambers provided with manipulation devices
- B25J21/02—Glove-boxes, i.e. chambers in which manipulations are performed by the human hands in gloves built into the chamber walls; Gloves therefor
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25C—PROCESSES FOR THE ELECTROLYTIC PRODUCTION, RECOVERY OR REFINING OF METALS; APPARATUS THEREFOR
- C25C1/00—Electrolytic production, recovery or refining of metals by electrolysis of solutions
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25C—PROCESSES FOR THE ELECTROLYTIC PRODUCTION, RECOVERY OR REFINING OF METALS; APPARATUS THEREFOR
- C25C1/00—Electrolytic production, recovery or refining of metals by electrolysis of solutions
- C25C1/22—Electrolytic production, recovery or refining of metals by electrolysis of solutions of metals not provided for in groups C25C1/02 - C25C1/20
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0089—Actinium
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
Abstract
Description
・カソード表面の電流密度が高い程、Ac−225の堆積はより素早く起こる。
・pHが低い程、堆積速度は速くなる。6未満のpH、より詳細には1〜4の範囲内のpHが好ましい。
・電流密度が低い程、溶液のpH変化がより低くなる。至適電流密度は20mA/cm2〜300mA/cm2の範囲内である。
・試料容量とカソード表面積との間の比率が小さい程、堆積収量はより高くなる。
・電流密度が高い程、溶液の温度はより高まる。温度増加は堆積速度に大きな影響を及ぼす。
a.断続的な(回分式の)製造方式
b.半オンライン式の製造方式
c.連続的な製造方式
を適用する事ができる。
Claims (10)
- Ra−226を、Ra−226(γ,n)の照射によりRa−225が生成された後にRa−225がAc−225へと崩壊する光核過程に供する事で、受容器(2)内に液体溶液として存在するRa−226からAc−225を製造する方法であって、形成されたAc−225を、前記受容器内に存在するカソード(5)上でのAc−225の電気化学的析出によって収集し、ここで、前記カソードは、前記析出が起こった後に前記受容器から取り出され、前記Ac−225が前記カソードから抽出されるホットセル環境(4)へと導入される事を特徴とする、方法。
- 前記Ra−226に、6.4MeVより高いエネルギーを有する電子線から制動放射として発生する少なくとも6.4MeVのエネルギーを有する光子を照射する事を特徴とする、請求項1に記載の方法。
- 前記Ac−225が析出されるカソードは、化学的に不活性な金属、好ましくはAu、Ta、W、Nb、Rh、Pt若しくはIr又はそれらの合金でできている事を特徴とする、請求項1又は2に記載の方法。
- 前記カソードから抽出された前記Ac−225を化学的に精製する事で、微量の共沈したRa−226及びRa−225を除去する事を特徴とする、請求項1〜3のいずれか一項に記載の方法。
- Ra−226が存在する前記液体溶液は、6未満のpH、好ましくは1から4の間のpHを有するHNO3溶液である事を特徴とする、請求項1〜4のいずれか一項に記載の方法。
- 前記受容器は、Ra−226溶液が第1の受容器から第3の受容器へと循環する事ができる様に互いに連結されている第1の受容器(2)及び第3の受容器を備え、ここで、前記第3の受容器内に前記カソードが配置されている事を特徴とする、請求項1〜5のいずれか一項に記載の方法。
- 形成されたAc−225の電気化学的析出を、Ra−226の照射の間に実施する事を特徴とする、請求項1〜6のいずれか一項に記載の方法。
- 形成されたAc−225の電気化学的析出を実施する為に、複数の別個の第1の受容器を使用する事を特徴とする、請求項1〜7のいずれか一項に記載の方法。
- 電気化学的析出を回分式に実施し、カソードがホットセル環境へと導入されたときに照射を中断する事を特徴とする、請求項1〜8のいずれか一項に記載の方法。
- 前記液体溶液を、不活性ガス流、特にHe流でパージする事を特徴とする、請求項1〜9のいずれか一項に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19212438 | 2019-11-29 | ||
EP19212438.6A EP3828899B1 (en) | 2019-11-29 | 2019-11-29 | A method for producing ac-225 from ra-226 |
Publications (2)
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JP6845371B1 JP6845371B1 (ja) | 2021-03-17 |
JP2021085879A true JP2021085879A (ja) | 2021-06-03 |
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JP2020189063A Active JP6845371B1 (ja) | 2019-11-29 | 2020-11-13 | Ra−226からAc−225を製造する方法 |
Country Status (8)
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US (1) | US11594345B2 (ja) |
EP (1) | EP3828899B1 (ja) |
JP (1) | JP6845371B1 (ja) |
KR (1) | KR20210068310A (ja) |
CN (1) | CN112885495B (ja) |
AU (1) | AU2020277276B1 (ja) |
CA (1) | CA3097866C (ja) |
RU (1) | RU2756621C1 (ja) |
Cited By (2)
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WO2023100428A1 (ja) * | 2021-12-01 | 2023-06-08 | 株式会社日立製作所 | 放射性核種製造システムおよび放射性核種製造方法 |
WO2023203826A1 (ja) * | 2022-04-19 | 2023-10-26 | 株式会社日立製作所 | 放射性核種製造システムおよび放射性核種製造方法 |
Families Citing this family (3)
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JP2024514336A (ja) * | 2021-04-15 | 2024-04-01 | エスユー-エヌ エナジー ホールディングス リミテッド | 放射性同位体を作製、分離、精製する方法、装置及びシステム |
JP2022169069A (ja) * | 2021-04-27 | 2022-11-09 | 株式会社日立製作所 | 放射性核種製造システムおよび放射性核種製造方法 |
WO2023086762A2 (en) * | 2021-11-10 | 2023-05-19 | Westinghouse Electric Company Llc | Producing ac-225 using gamma radiation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0752710A1 (de) * | 1995-07-03 | 1997-01-08 | Europäische Atomgemeinschaft (Euratom) | Verfahren zur Erzeugung von Actinium-225 aus Radium-226 |
JP2002517734A (ja) * | 1998-06-02 | 2002-06-18 | ユーロピーアン コンミュニティ (エセ) | Ra−226への陽子の照射によるAc−225の製法 |
US20020094056A1 (en) * | 1999-11-30 | 2002-07-18 | Stanley Satz | Method of producing actinium-225 and daughters |
JP2007508531A (ja) * | 2003-10-13 | 2007-04-05 | アクチニウム ファーマシューティカルズ,インコーポレイティド | ラジウム標的及びその製造法 |
US20090162278A1 (en) * | 2005-01-14 | 2009-06-25 | Helge Leif Ravn | Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU88636A1 (de) * | 1995-07-03 | 1997-01-03 | Euratom | Verfahren zur Erzeugung von Actinium-225 |
US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
EP1122325A3 (en) * | 2000-02-01 | 2001-09-12 | Euratom | Electrorefining of americium |
US6758957B1 (en) * | 2001-04-17 | 2004-07-06 | University Of Central Florida | Electrochemical deposition of carbon nanoparticles from organic solutions |
JP3549865B2 (ja) * | 2001-11-28 | 2004-08-04 | 核燃料サイクル開発機構 | 使用済核燃料中の希少元素fpの分離回収方法およびこれを利用した原子力発電−燃料電池発電共生システム |
EP1455364A1 (en) * | 2003-03-06 | 2004-09-08 | European Community | Method for producing actinium-225 |
DE102004022200B4 (de) * | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
FR2885370B1 (fr) * | 2005-05-03 | 2007-09-28 | Commissariat Energie Atomique | Procede de depot electrochimique, source de rayonnements alpha et x, fabriquee par ce procede, et dispositif d'analyse pixe-xrf, utilisant cette source. |
US20070092051A1 (en) * | 2005-09-19 | 2007-04-26 | Adelman Stuart L | Method of producing radium-225 and decay products thereof |
JP2007134061A (ja) * | 2005-11-08 | 2007-05-31 | Nec Tokin Corp | 非水電解液二次電池 |
DE102006008023B4 (de) * | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
EP1933330A1 (en) * | 2006-12-11 | 2008-06-18 | Trasis S.A. | Electrochemical 18F extraction, concentration and reformulation method for radiolabeling |
DE102009023544A1 (de) * | 2009-05-30 | 2010-12-09 | Forschungszentrum Jülich GmbH | Elektrochemische Zelle und Verfahren zur Abtrennung von trägerfreiem 18F-aus einer Lösung an einer Elektrode |
JP5211022B2 (ja) * | 2009-11-30 | 2013-06-12 | 株式会社日立製作所 | リチウムイオン二次電池 |
CN101866701B (zh) * | 2010-05-18 | 2012-07-04 | 四川大学 | 一种新的制取放射性核素98Tc的方法 |
KR101256620B1 (ko) * | 2010-12-28 | 2013-04-19 | 재단법인 포항산업과학연구원 | 나트륨유황 전지 |
KR101351515B1 (ko) * | 2011-09-23 | 2014-01-15 | 전북대학교산학협력단 | 방사성 핵종이 표지되고 약물이 담지된 고분자 하이드로겔 및 이의 제조방법, 및 이를 유효성분으로 함유하는 암 치료용 약학 조성물 |
AU2013274040B2 (en) * | 2012-06-15 | 2017-01-12 | Dent International Research, Inc. | Apparatus and methods for transmutation of elements |
CN103337270A (zh) * | 2013-07-09 | 2013-10-02 | 四川大学 | 制取放射性核素95m,97mTC的方法 |
RU2601554C2 (ru) * | 2014-06-09 | 2016-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Диамиды 4,7-дизамещенных 1,10-фенантролин-2,9-дикарбоновых кислот, способ их получения и экстракционная смесь на их основе |
KR101572763B1 (ko) * | 2014-09-23 | 2015-11-30 | 한국원자력연구원 | 핵분열 생성물로부터 유용 핵종을 생산하기 위한 종합공정설비 |
US10930407B2 (en) * | 2014-11-21 | 2021-02-23 | Gary M. Sandquist | Productions of radioisotopes |
WO2017076961A1 (en) * | 2015-11-06 | 2017-05-11 | Asml Netherlands B.V. | Radioisotope production |
RU2624636C1 (ru) * | 2016-06-03 | 2017-07-05 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Способ получения радионуклида лютеций-177 |
CA2995658A1 (en) * | 2017-02-17 | 2018-08-17 | Huys Industries Limited | Controlled environment processing apparatus and method |
CN109468665A (zh) * | 2018-12-27 | 2019-03-15 | 中核四0四有限公司 | 一种适用于手套箱内的电沉积装置及方法 |
WO2020260210A1 (en) * | 2019-06-25 | 2020-12-30 | The European Union, Represented By The European Commission | Method for producing 225actinium from 226radium |
KR20230016250A (ko) * | 2019-07-02 | 2023-02-01 | 니혼 메디피직스 가부시키가이샤 | 226Ra 함유 용액의 정제 방법, 226Ra 타깃의 제조 방법, 및 225Ac의 제조 방법 |
CN110473645B (zh) * | 2019-08-20 | 2024-03-01 | 西安迈斯拓扑科技有限公司 | 基于韧致辐射和光核反应双功能靶的99Mo生产方法及设备 |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0752710A1 (de) * | 1995-07-03 | 1997-01-08 | Europäische Atomgemeinschaft (Euratom) | Verfahren zur Erzeugung von Actinium-225 aus Radium-226 |
JP2002517734A (ja) * | 1998-06-02 | 2002-06-18 | ユーロピーアン コンミュニティ (エセ) | Ra−226への陽子の照射によるAc−225の製法 |
US20020094056A1 (en) * | 1999-11-30 | 2002-07-18 | Stanley Satz | Method of producing actinium-225 and daughters |
JP2007508531A (ja) * | 2003-10-13 | 2007-04-05 | アクチニウム ファーマシューティカルズ,インコーポレイティド | ラジウム標的及びその製造法 |
US20090162278A1 (en) * | 2005-01-14 | 2009-06-25 | Helge Leif Ravn | Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023100428A1 (ja) * | 2021-12-01 | 2023-06-08 | 株式会社日立製作所 | 放射性核種製造システムおよび放射性核種製造方法 |
WO2023203826A1 (ja) * | 2022-04-19 | 2023-10-26 | 株式会社日立製作所 | 放射性核種製造システムおよび放射性核種製造方法 |
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CN112885495A (zh) | 2021-06-01 |
US20210210245A1 (en) | 2021-07-08 |
CA3097866C (en) | 2024-01-02 |
RU2756621C1 (ru) | 2021-10-04 |
CN112885495B (zh) | 2022-09-13 |
JP6845371B1 (ja) | 2021-03-17 |
KR20210068310A (ko) | 2021-06-09 |
AU2020277276B1 (en) | 2021-02-04 |
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US11594345B2 (en) | 2023-02-28 |
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