JP2020502172A - 漢方薬抽出物を有効成分として含む化粧料組成物 - Google Patents
漢方薬抽出物を有効成分として含む化粧料組成物 Download PDFInfo
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Abstract
Description
竜眼肉、蔓荊子、沈香を乾燥させて細切りしておき、乾燥重量100gをフラスコに入れて抽出溶媒(蒸留水)1000gに3日間冷浸して抽出した。冷浸した抽出物を、0.2μmの気孔サイズを有するフィルターで濾過してそれぞれ竜眼肉、蔓荊子、沈香抽出物を作製した。
実施例1〜7の抽出物を含むエッセンスを作製した。エッセンスを構成する詳細な組成(重量%)を表2に示す。
作製例1で得られた7種の抽出物をヒト由来の線維芽細胞の培養液に添加して細胞レベルでの1型コラーゲン合成促進効果を確認した。合成されたコラーゲンの測定は、PICP EIA kit(Procollagen Type I C-Peptide Enzyme Immuno Assay KIT)を用いて定量した。コラーゲン合成量を測定するために、実施例1〜7の抽出物をそれぞれ最終濃度1000ppm、10000ppmで線維芽細胞の培養培地(DMEM培地)に添加して48時間培養し、その後培養液を採取してPICP EIAキットにより各濃度における1型コラーゲン合成の程度を分光光度計で450nmにて測定した。
作製例1で得られた7種の抽出物が、エラスチン(elastin)を分解する酵素であるエラスターゼ(elastase)の活性を阻害する効果を奏するか否かを確認した。
エラスターゼ阻害率(%)
=(対照群の傾き−試料の傾き)/対照群の傾き×100
作製例2で作製した竜眼肉、蔓荊子及び/又は沈香抽出物を含むエッセンスの皮膚保湿力を評価するために、前記エッセンスをそれぞれ皮膚に定量塗布して角質層の水分保有量を測定し、それを評価する方法を用いた。
作製例1で得られた7種の抽出物の抗炎症効果及び皮膚トラブル改善効果を確認するために、RAW264.7細胞株(ATCC number: CRL-2278)を用いたGRIESS法により一酸化窒素(NO)産生抑制実験を行った。
NO産生阻害率(%)
={(陰性対照群の吸光度−各抽出物の吸光度)/陰性対照群の吸光度}×100
Claims (10)
- 竜眼肉、蔓荊子及び沈香からなる群から選択される少なくとも1種の抽出物又はその分画物を有効成分として含む化粧料組成物。
- 皮膚弾力増進又はシワ改善用である、請求項1に記載の化粧料組成物。
- 皮膚保湿用である、請求項1に記載の化粧料組成物。
- 皮膚トラブル改善用である、請求項1に記載の化粧料組成物。
- コラーゲン合成促進、エラスターゼ活性抑制、保湿又は抗炎症効果を有するものである、請求項1〜4のいずれか一項に記載の化粧料組成物。
- 溶液、外用軟膏、クリーム、フォーム、栄養化粧水、柔軟化粧水、パック、柔軟水、乳液、メイクアップベース、エッセンス、石鹸、液体洗浄料、入浴剤、サンスクリーンクリーム、サンオイル、懸濁液、乳濁液、ペースト、ゲル、ローション、パウダー、界面活性剤含有クレンジング、オイル、粉末ファンデーション、乳濁液ファンデーション、ワックスファンデーション、パッチ及びスプレーからなる群から選択される剤形である、請求項1〜4のいずれか一項に記載の化粧料組成物。
- 竜眼肉、蔓荊子及び沈香からなる群から選択される少なくとも1種の抽出物又はその分画物を有効成分として含む食品組成物。
- 皮膚弾力増進もしくはシワ改善用、皮膚保湿用、又は皮膚トラブル改善用である、請求項7に記載の食品組成物。
- 竜眼肉、蔓荊子及び沈香からなる群から選択される少なくとも1種の抽出物又はその分画物を有効成分として含む医薬部外品組成物。
- 皮膚弾力増進もしくはシワ改善用、皮膚保湿用、又は皮膚トラブル改善用である、請求項9に記載の医薬部外品組成物。
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KR1020160171797A KR102008485B1 (ko) | 2016-12-15 | 2016-12-15 | 침향 추출물을 포함하는 피부 보습용 화장료 조성물 |
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KR1020160171796A KR20180069529A (ko) | 2016-12-15 | 2016-12-15 | 만형자 추출물을 포함하는 피부 보습용 화장료 조성물 |
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PCT/KR2017/014863 WO2018111042A2 (ko) | 2016-12-15 | 2017-12-15 | 한약재 추출물을 유효성분으로 포함하는 화장료 조성물 |
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KR102567187B1 (ko) * | 2022-03-31 | 2023-08-16 | 주식회사 아미코스메틱 | 순비기나무 추출물을 포함하는 화장료 조성물 |
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JP2023517118A (ja) * | 2020-03-13 | 2023-04-21 | メディヘルプライン カンパニー,リミテッド | Tlsp抑制および皮膚炎症性疾患の治療または改善のための龍眼肉含有混合生薬抽出物を含む局所用組成物およびその使用 |
CN113491648A (zh) * | 2020-04-01 | 2021-10-12 | 北京悠悦百仕科技发展有限公司 | 一种具有祛痘和祛痘印功效的精华乳及其制备方法 |
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KR20100045691A (ko) * | 2008-10-24 | 2010-05-04 | 주식회사 코리아나화장품 | 용안 추출물을 유효성분으로 포함하는 피부 염증 완화용 화장료 조성물 |
JP2011207816A (ja) * | 2010-03-30 | 2011-10-20 | Cci Corp | コラーゲン産生促進剤 |
KR20120129576A (ko) * | 2011-05-20 | 2012-11-28 | 인하대학교 산학협력단 | 용안육 추출물을 포함하는 백반증 치료 또는 예방용 조성물 |
JP2015531353A (ja) * | 2012-09-28 | 2015-11-02 | 喬本生医股▲ふん▼有限公司 | リュウガン種子アルコール抽出物の使用 |
CN103393575A (zh) * | 2013-08-07 | 2013-11-20 | 伽蓝(集团)股份有限公司 | 一种桂圆提取物及其应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102567187B1 (ko) * | 2022-03-31 | 2023-08-16 | 주식회사 아미코스메틱 | 순비기나무 추출물을 포함하는 화장료 조성물 |
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WO2018111042A2 (ko) | 2018-06-21 |
CN110072516A (zh) | 2019-07-30 |
WO2018111042A3 (ko) | 2018-08-09 |
CN110072516B (zh) | 2022-12-02 |
US20200078290A1 (en) | 2020-03-12 |
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