JP2020002058A - イソプロピルメチルフェノールを含有する水性組成物 - Google Patents
イソプロピルメチルフェノールを含有する水性組成物 Download PDFInfo
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- JP2020002058A JP2020002058A JP2018122785A JP2018122785A JP2020002058A JP 2020002058 A JP2020002058 A JP 2020002058A JP 2018122785 A JP2018122785 A JP 2018122785A JP 2018122785 A JP2018122785 A JP 2018122785A JP 2020002058 A JP2020002058 A JP 2020002058A
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- aqueous composition
- ipmp
- acid
- addition
- sodium
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- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 229960001435 sisomicin sulfate Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940068459 sodium pantothenate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 description 1
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- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
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- 229960001975 sulfisomidine Drugs 0.000 description 1
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- 229940021790 tetrahydrozoline hydrochloride Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1
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- 239000001585 thymus vulgaris Substances 0.000 description 1
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- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
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- 229960000401 tranexamic acid Drugs 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
- 229960005342 tranilast Drugs 0.000 description 1
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- WYXIGTJNYDDFFH-UHFFFAOYSA-Q triazanium;borate Chemical compound [NH4+].[NH4+].[NH4+].[O-]B([O-])[O-] WYXIGTJNYDDFFH-UHFFFAOYSA-Q 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
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- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
- 229960001128 triprolidine Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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- A61K31/05—Phenols
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract
Description
(I−1)IPMP、炭素数3〜6のジオール、及び無水ケイ酸を含有する水性組成物。
(I−2)さらに増粘剤を含有する(I−1)記載の水性組成物。
(I−3)IPMPの添加回収率が90〜110%の範囲にあることを特徴とする(I−1)または(I―2)記載の水性組成物。
(I−4)医薬品または医薬部外品である(I−1)〜(I−3)のいずれかに記載の水性組成物。
(I−5)添加回収試験用の水性組成物である(I−1)〜(I−4)のいずれかに記載の水性組成物。
(II−1)IPMP及び炭素数3〜6のジオールを含有する水性組成物についてIPMPの添加回収率を改善する方法であって、IPMP及び炭素数3〜6のジオールに加えて無水ケイ酸を配合して水性組成物を調製する工程を有する、前記方法。
(II−2)前記水性組成物がさらに増粘剤を含有するものである、(II−1)記載の添加回収率改善方法。
(II−3)前記水性組成物が医薬品または医薬部外品である(II−1)または(II−2)記載の添加回収率改善方法。
(II−4)IPMPの添加回収率が90〜110%の範囲になるようにする、(II−1)〜(II−3)のいずれかに記載の添加回収率改善方法。
(III−1)IPMP及び炭素数3〜6のジオールを含有する水性組成物におけるIPMPの添加回収試験方法であって、被験試料として規定量のIPMP、及び炭素数3〜6のジオールに加えて、無水ケイ酸を配合した水性組成物を用いることを特徴とする、添加回収試験方法。
(III−2)前記水性組成物がさらに増粘剤を含有するものである、(III−1)に記載の添加回収試験方法。
(III−3)前記水性組成物が医薬品または医薬部外品である(III−1)または(III−2)記載の添加回収試験方法。
本発明の水性組成物(以下、単に「本水性組成物」と称する。)は、IPMP、炭素数3〜6のジオール、及び無水ケイ酸を含有することを特徴とする。
IPMPは、チモールの異性体であり、化学名を3−メチル−4−イソプロピルフェノールという針状結晶形態を有する化合物である。広範囲の抗菌・抗真菌スペクトル(O−157、MRSA、セラチア、白癬菌など)を有し、各種の殺菌、酵母、カビ類に対して殺菌効果を発揮するとともに、低臭、低味性、低刺激、及び非感作性という特性を有するため、医薬品及び医薬部外品をはじめ、化粧品や日用品にも、殺菌剤、抗菌剤または防腐剤として広く使用されている。IPMPは商業的に入手することができ(例えば、大阪化成株式会社など)、また水性製品に容易に配合できる製品として販売されている「BIOSOL(登録商標)-LIQUID」(大阪化成株式会社製)を用いることもできる。
炭素数3〜6のジオール(以下、「C3−6ジオール」と称する)は、炭素数3〜6であり、鎖式脂肪族炭化水素の2つの炭素原子に1つずつ水酸基が置換している構造を持つ化合物である。具体的には、1,2−プロパンジオール、1,3−プロパンジオール、1,2−ブタンジオール、1,3−ブタンジオール、1,4−ブタンジオール、1,2−ペンタンジオール、1,5−ペンタンジオール、1,2−ヘキサンジオール、1,6−ヘキサンジオール、ジプロピレングリコールなどが挙げられる。好ましくは1,3−ブタンジオール、1,2−ペンタンジオール、ジプロピレングリコールであり、より好ましくは1,3−ブタンジオールである。これらの炭素数3〜6のジオールは、1種単独で用いても、また2種以上を任意に組み合わせて用いることもできる。
無水ケイ酸は、二酸化ケイ素またはシリカと称されるケイ素の酸化物である。その形状(球状、針状、板状、不定形状、鱗片状、紡錘状など)、粒子径(煙霧状、微粒子、顔料級など)、粒子構造(多孔質、無孔質など)は問わず、いずれのものをも使用することができる。好ましくは、粒子径7.0〜10.0μmの多孔質非中空の球状の無水ケイ酸を例示することができる。
本発明の水性組成物は、前記IPMP、C3−6ジオール、及び無水ケイ酸を水性溶媒中に溶解、分散または乳濁した状態で含有するものである。ここで水性溶媒としては水を挙げることができる。水は医薬品、医薬部外品または化粧品の調製に使用されるものであればよく、例えば精製水、蒸留水、生理食塩水、または滅菌水等を制限なく使用することができる。本水性組成物における水性溶媒の含有量としては、配合成分の安定性(溶解性や分散性など)、製剤特性(粘度、浸透圧、pHなど)、製剤形状、及び投与形態などに応じて適宜設定することができる。通常50〜99質量%、好ましくは60〜95質量%、より好ましくは70〜90質量%の範囲を例示することができる。
本水性組成物は、IPMPを可溶化する成分として前述するC3−6ジオールに加えてメチルポリシロキサンを含有していてもよい。本水性組成物におけるメチルポリシロキサンの配合割合としては、対象とする本水性組成物のIPMPの抗菌効果を妨げず、また本発明の効果を奏する範囲であればよく、例えば0.1〜20質量%の範囲から適宜選択設定することができる。好ましくは0.5〜10質量%、より好ましくは1〜5質量%の範囲を例示することができる。
本水性組成物は、IPMPの抗菌活性からpH5〜8の範囲に調整されていることが好ましい。より好ましくはpH5〜7程度である。
本水性組成物は、本発明の効果を奏すれば特に限定されないが、IPMPの抗菌作用に基づいて医薬品または医薬部外品などとして広く利用することができる。その用法は、本水性組成物の目的、製剤形態、及び投与経路に応じて、定法に従って用いることができる。また本水性組成物の形態は、水を50質量%以上配合し、液状または半固形剤(ゾル剤またはゲル剤)とすることができるが、好ましくは液剤またはゲル剤(ジェル)である。これらの製剤は常法により調製して得られ、その際、上述の成分に加えてその製剤に応じた慣用の添加剤(ゲル剤の場合は増粘剤やガム質など)を使用することができる。液剤としては、均一溶液であっても懸濁液(分散液、乳液)であっても、混合又は溶解して使用する組成物であっても良い。
本水性組成物は、前述するようにIPMP、C3−6ジオール、無水ケイ酸及び水性溶媒を配合すること以外は、公知の方法により製造できる。例えば、蒸留水又は精製水等の水性溶媒に、IPMP、C3〜6ジオール、及び無水ケイ酸を溶解または分散し、所定のpHに調整し、無菌環境下、ろ過滅菌処理し、洗浄滅菌済みの容器に無菌充填することにより製造することができる。本水性組成物の目的や製剤形態に応じて、前述する(その他の成分)を適宜配合することができる。例えば、本水性組成物をゲル剤(ジェル)として調製する場合は、前述する増粘剤を配合して定法に従ってゲル状にすることで調製することができる。
IPMPの添加回収率(%)=
(試験結果として得られたIPMP量/添加したIPMP既知量)×100
また本発明は、IPMPを含有する水性組成物についてIPMPの添加回収率を改善する方法に関する。
本発明は、IPMP含有水性組成物に対して行われる添加回収試験方法に関する。具体的には、本発明はIPMP及び炭素数3〜6のジオールを含有する水性組成物におけるIPMPの添加回収試験方法であって、当該方法は被験試料として規定量のIPMP、及び炭素数3〜6のジオールに加えて、無水ケイ酸を配合した水性組成物を用いることで実施することができる。
以下に説明するように、表1に記載する水性組成物(被験試料:実施例1及び比較例1、pH6.6)について添加回収試験を行い、被験試料中のイソプロピルメチルフェノール(IPMP)の量を分析(定量)した。
(1−1)試料の調製
(a)内標準溶液の調製
内標準物質として4−メトキシベンズアルデヒドを用いて内標準溶液を調製した。具体的には4−メトキシベンズアルデヒド7mgにエタノール(95)を加えて200mLとしたものを内標準溶液とした(0.0035w/v%)。なお、エタノール(95)とは純度(密度による)が94.8〜95.8vol%のエタノールを意味する(以下、同じ)。
(b)標準溶液の調製
定量用IPMP約40mgを精密に量り、エタノール(95)を加えて正確に100mLとしたものを標準原液とした。この標準原液5mLを正確に量り、これに内標準溶液5mLを正確に加えて、エタノール(95)を加えて正確に50mLとしたものを標準溶液とした。
(c)試料溶液の調製
表1に記載する各成分をその割合で量り取り、全成分を撹拌混合することで溶解して被験試料(実施例1、比較例1)を調製した。この被験試料をよくかき混ぜ、約2gを精密に量り、これに内標準溶液5mLを正確に加えて、エタノール(95)を加えて正確に50mLとした。これに超音波を10分間照射し、メンブランフィルター(孔径0.45μm、「ACRODISC 25mm」Pall Corporation製)で濾過したものを試料溶液とした。
試料溶液及び標準溶液のそれぞれ20μLを、下記条件の液体クロマトグラフィー(HPLC)に供して、試料溶液及び標準溶液のそれぞれについて、内標準物質のピーク面積に対するIPMPのピーク面積の比(QT、QS)を求めた。
QT:試料溶液について内標準物質のピーク面積に対するIPMPのピーク面積の比
QS:標準溶液について内標準物質のピーク面積に対するIPMPのピーク面積の比
カラム:Inertsi ODS-3(4.6mm×250nm、5μm)(ジーエルサイエンス株式会社)
カラム温度:40℃または40℃付近の一定温度
移動相:アセトニトリル/ラウリル硫酸ナトリウムの薄めた酢酸(100)(1→1000)混合液(13:12)。なお、これは酢酸(100)2mLに水を加えて2000mLとしたものに、ラウリル硫酸ナトリウム11.6gを加えて混和して調製した。
流量(流速):IPMPの保持時間が約11分になるよう調整。
注入量:20μL
分析時間:20分
溶出挙動:4−メトキシベンズアルデヒド(内標準物質)、及びIPMPの順に溶出する。
上記試料溶液について得られたHPLC分析結果から、試料溶液に含まれているIPMPの量として試験結果として得られたIPMP量(定量値)を求め、成分として実際に添加した既知量(配合値)から下式に従って、添加回収率を算出した。
[数2]
IPMPの添加回収率(%)= (定量値/配合値)×100
具体的には、添加回収率(%)は下式により算出することができる。
(QT/QS)×(定量用IPMP秤取量(mg)/試料の秤取量(g)/400/処方100g中のIPMP配合量(実施例1では0.1g)×100
結果を表1に併せて示す。
なお、添加回収率が「90%未満または110%超」である場合を不良「×」、「90%〜110%超」である場合を良「○」、その中でも特に「95%〜105%」である場合を最良「◎」として判定した。
表2に記載する水性組成物(被験試料:実施例2〜5及び比較例2、pH6.6)について、実験例1と同様に、添加回収試験を行い、被験試料中のイソプロピルメチルフェノール(IPMP)の量を分析(定量)した。結果を表2に併せて示す。
イソプロピルメチルフェノール 0.1
無水ケイ酸 0.5
メチルポリシロキサン 2.6
1,2-ペンタンジオール 3.0
1,3-ブチレングリコール 5.0
L−アスコルビン酸 2−グルコシド 2.0
グリチルリチン酸二カリウム 0.05
エリスリトール 2.0
ヘパリン類似物質 0.1
酢酸トコフェロール 0.1
カルボキシビニルポリマー 0.7
ヒドロキシプロピルメチルセルロース 0.5
(ジメチコン/ビニルジメチコン)クロスポリマー/ジメチコン 0.5
ポリソルベート80 2.0
ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル 0.5
エデト酸二ナトリウム 0.1
メチルパラベン 0.1
クエン酸 適 量
クエン酸ナトリウム 適 量
水酸化ナトリウム 適 量
精製水 残 部
合 計 100.00%
Claims (6)
- イソプロピルメチルフェノール、炭素数3〜6のジオール及び無水ケイ酸を含有する水性組成物。
- イソプロピルメチルフェノールの添加回収率が90〜110%の範囲にあることを特徴とする請求項1に記載する水性組成物。
- イソプロピルメチルフェノール及び炭素数3〜6のジオールを含有する水性組成物についてイソプロピルメチルフェノールの添加回収率を改善する方法であって、イソプロピルメチルフェノール及び炭素数3〜6のジオールに加えて無水ケイ酸を配合して水性組成物を調製する工程を有する、前記方法。
- 前記水性組成物が医薬品または医薬部外品である、請求項3に記載する添加回収率改善方法。
- イソプロピルメチルフェノール及び炭素数3〜6のジオールを含有する水性組成物におけるイソプロピルメチルフェノールの添加回収試験方法であって、被験試料として規定量のイソプロピルメチルフェノール、及び炭素数3〜6のジオールに加えて、無水ケイ酸を配合した水性組成物を用いることを特徴とする、添加回収試験方法。
- 前記水性組成物が医薬品または医薬部外品である、請求項5に記載する添加回収試験方法。
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