JP2018532562A - 調節型眼内レンズおよび製造する方法 - Google Patents
調節型眼内レンズおよび製造する方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1601—Lens body having features to facilitate aqueous fluid flow across the intraocular lens, e.g. for pressure equalization or nutrient delivery
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
- A61F2/164—Aspheric lenses
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- G—PHYSICS
- G02—OPTICS
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- G02B3/00—Simple or compound lenses
- G02B3/12—Fluid-filled or evacuated lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/167—Instruments for inserting intraocular lenses into the eye with pushable plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16901—Supporting structure conforms to shape of capsular bag
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B3/00—Simple or compound lenses
- G02B3/02—Simple or compound lenses with non-spherical faces
- G02B3/04—Simple or compound lenses with non-spherical faces with continuous faces that are rotationally symmetrical but deviate from a true sphere, e.g. so called "aspheric" lenses
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Abstract
Description
本出願は、2015年11月6日に出願された米国仮特許出願第62/252,260号、2016年4月12日に出願された米国仮特許出願第62/321,678号、2016年7月1日に出願された米国仮特許出願第62/357,785号、2016年4月12日に出願された米国仮特許出願第62/321,704号、2016年4月12日に出願された米国仮特許出願第62/321,666号、2016年4月2日に出願された米国仮特許出願第62/321,665号、2016年4月12日に出願された米国仮特許出願第62/321,705号、2016年4月12日に出願された米国仮特許出願第62/321,684号、2016年4月12日に出願された米国仮特許出願第62/321,670号、および2016年8月19日に出願された米国仮特許出願第62/377,402号への優先権を主張し、これらの開示は、すべて本明細書において参照により援用されている。
本明細書において言及されているすべての出版物および特許出願は、各々個別の出版物および特許出願が参照により援用されるように明確に個々に示されているかのように、本明細書において同じ度合いまで参照により援用されている。
11 径方向内側部分
12 光学部分
13 径方向外側部分
14 ハプティック
15 開口部
17 第1の端領域
18 前要素
19 第2の端領域、閉じた端
20 後要素
22 ハプティック流体室、流体通路、ハプティック室
23 経路、空間
24 光学部流体室、光学室
28 周辺表面
29 バットレス部分
30 斜めの表面
31 表面
32 流体通路
33、35 湾曲表面
36 第1のハプティック
37、39 先端
38 第2のハプティック
40 径方向内側本体部分
41 最大厚さ寸法
42 径方向外側部分
43 径方向内側の壁
45 径方向外側の壁
46、48 ハプティック
46a、46b、48a、48b 周囲隆条部
50 ハプティック
54 径方向外側部分
60 ハプティック
61 第1の領域
62 開口部
64 径方向外側部分
70 眼内レンズ
72 光学部
86 後要素
90 最も後の部分
98 調節型眼内レンズ
100 光学本体、光学部
120 前要素
140 後要素
160、180 ハプティック
170、190 ハプティック流体室
210 流体通路
220 表面
230 境界面、第1の端領域
240 流体開口
250 第2の端領域
292 間隔
300 調節型眼内レンズ
301 光学本体、光学部
303 突起
304 後要素
305 周辺表面
306 径方向周辺表面、外面
308 流体通路
309 周辺表面、外側縁表面、周縁
310 ハプティック
311 結合領域、第1の部分
312 表面、径方向内面
313 径方向内側の壁部分
315 第2の部分、遠位端先端
316 流体室
360 カートリッジ
401 カートリッジ
405 近位開口部
410 ルーメン
410a 第1の直径
410b 第2の直径
411 遠位先端
491 第1の部分
492 第2の部分
493 第3の部分
510 光学部分
510b 不透明周辺部
516、518 ハプティック
600 装着運搬装置
610 基礎部
630 押し部材、装着部材
640 IOL
641 前ハプティック
642 後ハプティック、近位ハプティック
643 光学部分、光学部
650 カバー、蓋
655 開口部
660 カートリッジ
680 粘弾性材料
690 プランジャ組立体
695 排出通気口
A 軸
AA 遠位端
B 中心線
B 部分的に傾斜した表面
BB 交差部
CB 水晶体嚢
CC 交差部
CM 毛様筋
OA 光学軸
H、H1、H2、H3 最大高さ
R 径方向外向きの力、嚢再形成力、径方向内向きの力
R 隆条部
T 方向
to、ti 厚さ
W1、W2 幅
X 第1の軸
Y 第2の軸
Z 毛様小体
Claims (40)
- 非球形のレンズ表面を有するように調節型眼内レンズの光学部を製造する方法であって、
光学部流体室を少なくとも部分的に定める前要素および後要素を備える光学部を提供するステップであって、前記前要素および前記後要素の少なくとも一方は球形である外部面を有する、ステップと、
前記調節型眼内レンズを目に挿入する前に、前記前要素および前記後要素の前記少なくとも一方の形を、前記球形構成から非球形構成へと変更するステップと
を含む方法。 - 前記前要素および前記後要素の前記少なくとも一方の形を、前記球形構成から非球形構成へと変更するステップは、前記光学部流体室内の流体圧力を高くし、前記前要素および前記後要素の前記少なくとも一方を前記球形構成から前記非球形構成へと変形させるように、前記光学部流体室に流体を加えるステップを含む、請求項1に記載の方法。
- 流体を加えるステップの前に、前記光学部に少なくとも1つのハプティックを固定するステップをさらに含む、請求項2に記載の方法。
- 前記光学部を提供するステップは、前記前要素を前記後要素に接合するステップを含む、請求項1に記載の方法。
- 前記前要素および前記後要素の少なくとも一方を機械加工するステップをさらに含む、請求項1に記載の方法。
- 前記前要素および前記後要素の前記少なくとも一方の形を、前記球形構成から非球形構成へと変更するステップの前は、前記光学部は10D〜15Dの基底状態を有する、請求項1に記載の方法。
- 前光学表面を有する前要素と、後光学表面を有する後要素とを備える光学部分であって、前記前要素および前記後要素は光学部流体室を定める、光学部分を備え、
前記前光学表面および前記後光学表面の少なくとも一方が、目への挿入の前、製造されている状態において、非球形構成を有する、流体充填された眼内レンズ。 - 光学部分と、
周辺流体室を備える周辺部分であって、前記周辺部分は、前記光学部分の光学軸を横切る平面において断面を有し、前記周辺流体室が前記周辺部分の径方向外側部分に配置され、前記周辺流体室の径方向内側部分には流体がない、周辺部分と
を備える眼内レンズ。 - 光学部分と、
周辺流体室を備える周辺部分であって、前記光学部分の光学軸を横切る平面の断面において、前記周辺部分の中間点を貫く前記光学部分の光学軸に対して直交する方向に、径方向外側の流体室の壁厚の厚さの4倍から20倍までの間である径方向内側の流体室の壁厚を有する周辺部分と
を備える眼内レンズ。 - 光学部分と、
周辺流体室を備える周辺部分であって、前記光学部分の光学軸を横切る平面の断面において、前記周辺部分を貫いて前記光学部分の光学軸と平行なすべての軸の周りで対称ではない外面を有する周辺部分と
を備え、
前記周辺部分は、前記周辺部分の中間点を貫く前記光学部分の光学軸に対して直交する方向において、径方向外側の流体室の壁厚より大きい径方向内側の流体室の壁厚を有する、眼内レンズ。 - 光学部分と、
周辺流体室を備える周辺部分であって、前記光学部分の光学軸を横切る平面の断面において、前後方向に測定される高さ寸法を有する周辺部分と
を備え、
前記周辺部分の径方向外側半分における前記周辺部分の最も大きい高さは、前記周辺部分の径方向内側半分における前記周辺部分の最も大きい高さより大きい、眼内レンズ。 - 結合部において周辺部分に結合される光学部分を備え、前記結合部は、前記光学部分の径方向外側の周縁とつながる前記周辺部分の径方向内面を備える、眼内レンズ。
- 前記周辺部分の前記径方向内面は、前記径方向内面の第2の端と異なる構成を有する第1の端を有する、請求項12に記載の眼内レンズ。
- 前記周辺部分は、結合端と自由端とを有するハプティックを備え、前記第1の端は、前記ハプティックの前記結合端より前記自由端に近い、請求項13に記載の眼内レンズ。
- 前記ハプティックは、前記ハプティックの前記結合端から前記自由端まで、前記光学部分の径方向外側の周辺の湾曲に追従する構成を有する、請求項14に記載の眼内レンズ。
- 前記第1の端は、前記径方向内面の前記第2の端より大きい表面積を有する、請求項13に記載の眼内レンズ。
- 前記第1の端は、先細りした端構成を有し、前記先細りは、前記周辺部分の自由端に向かっている、請求項16に記載の眼内レンズ。
- 前記周辺部分の前記径方向内面は周辺部分流体ポートを定める、請求項12に記載の眼内レンズ。
- 光学本体と、前記光学本体の周辺表面から径方向外向きに延びる突起と、前記突起に固定される第1の部分を有する周辺非光学本体とを備える眼内レンズ。
- 前記周辺非光学本体の前記第1の部分の径方向内面が前記突起の径方向周辺表面に追従する、請求項1に記載の眼内レンズ。
- 前記突起と前記第1の部分とは、突き合わせ継手において、任意選択で平坦または湾曲の相対的な表面同士で境界面接合する、請求項1に記載の眼内レンズ。
- 前記突起の径方向周辺表面は、平坦な表面、任意選択で全体的に平坦である表面を備える、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体の前記第1の部分の径方向内面が、平坦な表面、任意選択で全体的に平坦である表面を備える、請求項22に記載の眼内レンズ。
- 前記突起の径方向周辺表面は、湾曲した表面、任意選択で全体的に湾曲している表面を備える、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体の前記第1の部分の径方向内面が、湾曲した表面、任意選択で全体的に湾曲している表面を備える、請求項27に記載の眼内レンズ。
- 前記突起の径方向周辺表面が、前記光学本体の前記周辺表面より、10ミクロンから1mmまでの間で、任意選択で10ミクロンから500ミクロンまでの間で、前記光学本体の中心から径方向に離れている、請求項1に記載の眼内レンズ。
- 前記突起は、前記光学本体の前記周辺表面から、10ミクロンから1mmまでの間で、任意選択で10ミクロンから500ミクロンまでの間で延びる、請求項1に記載の眼内レンズ。
- 前記光学本体と前記突起とは単一の一体の物体である、請求項1に記載の眼内レンズ。
- 前記突起は前記光学本体に付着される、請求項1に記載の眼内レンズ。
- 前記光学本体は、流体室を任意選択で間に定める後要素と前要素とを備える、請求項1に記載の眼内レンズ。
- 前記後要素は前記突起を備える、請求項30に記載の眼内レンズ。
- 前記前要素は前記突起を備える、請求項30に記載の眼内レンズ。
- 前記周辺非光学本体は、前記第1の部分から離して配置される自由な第2の部分をさらに備える、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体は周辺流体室を備える、請求項1に記載の眼内レンズ。
- 前記突起は、前記周辺非光学本体において周辺流体室と流体連通している少なくとも1つの通路、任意選択で、少なくとも2つの通路を備える、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体は、任意選択で若干湾曲した、前記突起に結合される径方向内面を有し、前記突起は前記光学本体の径方向外側周縁に配置される、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体は、毛様筋の動きによって前記周辺非光学本体における力に応じて変形し、それによって、前記周辺非光学本体における周辺流体室と前記光学本体における光学部流体室との間で流体を移動させて、前記眼内レンズの光学パラメータを変化させるように適合される、請求項1に記載の眼内レンズ。
- 前記周辺非光学本体は前記突起と境界面接合するように構成される開口部を備える、請求項1に記載の眼内レンズ。
- 前記突起は、前記周辺非光学本体における開口部内に配置されると共に前記開口部と境界面接合する大きさおよび構成とされる、請求項1に記載の眼内レンズ。
- 光学本体と周辺非光学本体とを備え、
前記光学本体は、上面視において、少なくとも一部分が円弧である外側縁を有し、前記周辺非光学本体は、前記円弧の湾曲に対して径方向外向きの場所において前記光学本体突起に結合される、眼内レンズ。
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AU2021269283B2 (en) | 2023-12-21 |
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AU2021269283A1 (en) | 2021-12-09 |
EP3370647B1 (en) | 2021-05-26 |
CN111407464A (zh) | 2020-07-14 |
AU2016349532B2 (en) | 2021-08-26 |
EP3370647B8 (en) | 2021-06-30 |
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