JP2018002658A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2018002658A JP2018002658A JP2016131945A JP2016131945A JP2018002658A JP 2018002658 A JP2018002658 A JP 2018002658A JP 2016131945 A JP2016131945 A JP 2016131945A JP 2016131945 A JP2016131945 A JP 2016131945A JP 2018002658 A JP2018002658 A JP 2018002658A
- Authority
- JP
- Japan
- Prior art keywords
- pepper
- vitamin
- oral composition
- present
- vitamins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
本発明は、高血圧症を予防及び／又は改善することができる経口組成物に関する。 The present invention relates to an oral composition capable of preventing and / or improving hypertension.
高血圧は、わが国で多くみられる疾患であり、高齢化や食生活の欧米化等により、その患者数は増加傾向にある。血圧が上昇するにつれて、脳や心臓に係る疾患が生じやすくなることがわかっている。 Hypertension is a common disease in Japan, and the number of patients is increasing due to aging and westernization of eating habits. It has been found that as the blood pressure increases, diseases related to the brain and heart are more likely to occur.
このような血圧改善のための組成物として、例えば、特定の方法で得られた乳酸菌発酵物を有効成分とする高血圧抑制剤（特許文献１参照）や、炭素数１６以上の長鎖炭化水素を有効成分とする高血圧改善剤（特許文献２参照）が提案されている。 As such a composition for improving blood pressure, for example, an antihypertensive agent (see Patent Document 1) containing a fermented lactic acid bacterium obtained by a specific method as an active ingredient, or a long-chain hydrocarbon having 16 or more carbon atoms. An antihypertensive agent as an active ingredient (see Patent Document 2) has been proposed.
本発明の課題は、優れた高血圧症の予防及び／又は改善効果を有する組成物を提供することにある。 An object of the present invention is to provide a composition having an excellent effect of preventing and / or improving hypertension.
本発明者らは、ロングペッパー、グリーンペッパー等のペッパー植物のもつ機能について鋭意調査・研究したところ、ペッパー植物が用量依存的なＡＣＥ（アンジオテンシン変換酵素）活性阻害能を有するという知見を得た。本発明者らは、さらに研究を進めた結果、このペッパー植物にビタミン類やポリフェノールといった特定の成分を加えることにより、ＡＣＥ活性阻害能を高めることができ、非常に優れた高血圧症の予防及び／又は改善効果を得ることができることを見いだし、本発明を完成するに至った。 The present inventors diligently investigated and studied the functions of pepper plants such as long pepper and green pepper, and as a result, obtained the knowledge that pepper plants have a dose-dependent ability to inhibit ACE (angiotensin converting enzyme) activity. As a result of further research, the present inventors have been able to increase the ACE activity inhibition ability by adding specific components such as vitamins and polyphenols to this pepper plant. Alternatively, the inventors have found that an improvement effect can be obtained and have completed the present invention.
すなわち、本発明は、ペッパー植物と、ビタミン類又はポリフェノールとを含有することを特徴とする経口組成物に関する。 That is, the present invention relates to an oral composition comprising a pepper plant and vitamins or polyphenols.
本発明の経口組成物において用いられるペッパー植物は、ウォーターペッパー、ロングペッパー、グリーンペッパー、チリペッパー、及びブラックペッパーから選ばれる少なくとも１種であることが好ましい。 The pepper plant used in the oral composition of the present invention is preferably at least one selected from water pepper, long pepper, green pepper, chili pepper, and black pepper.
本発明の経口組成物において用いられるビタミン類は、ビタミンＢ１塩酸塩、ビタミンＢ２、ビタミンＢ６、ビタミンＢ１２、ニコチン酸、Ｄ−パントテン酸ナトリウム、ビオチン、葉酸、ビタミンＣ、ビタミンＡ、ビタミンＤ３、ビタミンＥ、及びビタミンＫから選ばれる少なくとも１種であることが好ましい。 The vitamins used in the oral composition of the present invention are vitamin B1 hydrochloride, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, sodium D-pantothenate, biotin, folic acid, vitamin C, vitamin A, vitamin D3, vitamin It is preferably at least one selected from E and vitamin K.
本発明の経口組成物において用いられるポリフェノールは、没食子酸、クロロゲン酸、及びカテキンから選ばれる少なくとも１種であることが好ましい。 The polyphenol used in the oral composition of the present invention is preferably at least one selected from gallic acid, chlorogenic acid, and catechin.
本発明の経口組成物は、錠状、カプセル状、粉末状、顆粒状、又は液状であることが好ましい。 The oral composition of the present invention is preferably in the form of a tablet, capsule, powder, granule, or liquid.
本発明の経口組成物は、高血圧症の予防及び／又は改善のための高血圧症予防改善用組成物であることが好ましく、例えば、機能性食品である。 The oral composition of the present invention is preferably a composition for the prevention and / or improvement of hypertension for the prevention and / or improvement of hypertension, such as a functional food.
本発明の経口組成物は、ペッパー植物を有効成分とする高血圧症予防改善用組成物であって、さらにビタミン類又はポリフェノールを配合することを特徴とする高血圧症予防改善用組成物に関する。ビタミン類又はポリフェノールは、ペッパー植物より少ない配合量であっても、優れた効果を発揮する。 The oral composition of the present invention relates to a composition for preventing and improving hypertension, which comprises a pepper plant as an active ingredient, and further contains vitamins or polyphenols. Vitamins or polyphenols exhibit excellent effects even when the amount is less than that of pepper plants.
本発明の経口組成物は、ペッパー植物を有効成分として含有することを特徴とするビタミン類又はポリフェノールを配合した高血圧症予防改善促進用組成物に関する。 The oral composition of the present invention relates to a composition for promoting the improvement and prevention of hypertension, which contains vitamins or polyphenols containing a pepper plant as an active ingredient.
本発明の経口組成物は、ペッパー植物のアンジオテンシン変換酵素の活性部位への結合を促進するビタミン類又はポリフェノールを配合した高血圧症予防改善用組成物に関する。 The oral composition of the present invention relates to a composition for improving and preventing hypertension, which contains vitamins or polyphenols that promote the binding of an angiotensin converting enzyme of a pepper plant to the active site.
本発明は、ペッパー植物を配合した経口組成物において、ビタミン類又はポリフェノールを配合することを特徴とする高血圧症予防改善用組成物の製造方法に関する。 The present invention relates to a method for producing a composition for improving and preventing hypertension, which comprises blending vitamins or polyphenols in an oral composition blended with a pepper plant.
本発明の経口組成物によれば、ＡＣＥ活性を阻害し、高血圧症の予防及び／又は改善することができる。 According to the oral composition of the present invention, ACE activity can be inhibited, and hypertension can be prevented and / or improved.
本発明の経口組成物は、ペッパー植物と、ビタミン類又はポリフェノールとを含有することを特徴とする。本発明の組成物においては、ビタミン類及びポリフェノールの両者を含有してもよく、ビタミン類及びポリフェノールの各成分は、２種以上組合せて用いてもよい。２種以上組み合せて用いる場合、ペッパー植物との相乗効果の高いビタミン類又はポリフェノール同士を組み合わせることが好ましい。 The oral composition of the present invention is characterized by containing a pepper plant and vitamins or polyphenols. In the composition of this invention, you may contain both vitamins and polyphenol, and each component of vitamins and polyphenol may be used in combination of 2 or more types. When two or more types are used in combination, it is preferable to combine vitamins or polyphenols having a high synergistic effect with the pepper plant.
本発明の組成物は、ペッパー植物及びビタミン類又はポリフェノールの組合せにより、ＡＣＥ活性阻害能を高め、優れた血圧改善効果を得ることができ、高血圧をより有効に予防、改善することができる。したがって、本発明の組成物は、ＡＣＥ活性阻害剤として用いることができる。 The composition of the present invention can enhance the ACE activity inhibitory ability by obtaining a combination of a pepper plant and vitamins or polyphenols, obtain an excellent blood pressure improving effect, and can more effectively prevent and improve hypertension. Therefore, the composition of the present invention can be used as an ACE activity inhibitor.
［ペッパー植物］
本発明の組成物に用いるペッパー植物は、地上部、根部、果実等、植物のいずれの部位であってもよく、植物そのものの他、その乾燥物、乾燥粉砕物、搾汁、抽出物、発酵物等の植物処理物を用いることができる。粉砕物としては、粉末、顆粒等が挙げられる。絞汁や抽出物は、液状であってもよいが、ペースト状や乾燥粉末として用いることもできる。抽出物は、適当な溶媒を用いて抽出することに得ることができ、溶媒としては、例えば、水（温水、熱水）、エタノール、含水エタノールを用いることができる。ペッパー植物は、市販されているものを使用してもよい。
[Pepper plant]
The pepper plant used in the composition of the present invention may be any part of the plant, such as the above-ground part, root part, fruit, etc., in addition to the plant itself, its dried product, dried pulverized product, juice, extract, fermentation Processed plant products such as products can be used. Examples of the pulverized product include powder and granules. The juice or extract may be liquid, but can also be used as a paste or dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water (hot water, hot water), ethanol, hydrous ethanol can be used. Pepper plants that are commercially available may be used.
（ロングペッパー：学名Piper longum）
ロングペッパー（long pepper）は、Piperaceae科の植物であって、蔓性の常緑木本である。その果実は、刺激的な風味や辛味を持ち、古くから果実を乾燥させて香辛料や調味料として用いられている。本発明の組成物において用いる部位としては、果実を用いることが好ましい。
(Long Pepper: Scientific name Piper longum)
Long pepper is a plant of the Piperaceae family and is a vine evergreen tree. The fruit has an irritating flavor and pungent taste, and has long been used as a spice and seasoning by drying the fruit. As a site used in the composition of the present invention, it is preferable to use a fruit.
（グリーンペッパー：学名Capsicum annuum）
グリーンペッパーは、Solanaceae科の植物であって、多年草（温帯域では一年草）または低木である。チリペッパーの甘味種で果実は独特な風味を持ち、グリーンペッパーの未熟な果実は、主に香辛料や野菜として用いられる。本発明の組成物において用いる部位としては、果実を用いることが好ましく、未熟な果実を用いることが特に好ましい。
(Green Pepper: Scientific name Capsicum annuum)
Green pepper is a plant of the Solanaceae family that is a perennial (annual in the temperate zone) or a shrub. The sweet berries of chili pepper have a unique flavor, and the unripe fruits of green pepper are mainly used as spices and vegetables. As a site used in the composition of the present invention, it is preferable to use a fruit, and it is particularly preferable to use an immature fruit.
（ウォーターペッパー：学名Persicaria hydropiper）
ウォーターペッパーは、Polygonaceae科の植物であって、水辺生、一年生であり、地下茎を引かない特徴を有する。ウォーターペッパーは、特有の香りと辛味を持ち、香辛料として薬味や刺身の添え物などに用いられる。本発明の組成物において用いる部位としては、芽部（スプラウト）を用いることが好ましい。
(Water Pepper: Scientific name Persicaria hydropiper)
Water pepper is a plant belonging to the family Polygonaceae, which is waterside and annual, and does not draw rhizomes. Water pepper has a unique scent and pungent taste, and is used as a spice in condiments and sashimi. As a site used in the composition of the present invention, it is preferable to use a sprout.
（チリペッパー：学名Capsicum annuum）
チリペッパーは、Solanaceae科の植物であって、多年草（温帯域では一年草）または低木である。果実は刺激的な辛味を持ち、果実を乾燥させて香辛料として主に用いられている。本発明の組成物において用いる部位としては、果実を用いることが好ましい。
(Chilli pepper: Scientific name Capsicum annuum)
Chili pepper is a plant of the Solanaceae family that is perennial (annual in the temperate zone) or shrub. The fruit has an pungent pungent taste and is mainly used as a spice by drying the fruit. As a site used in the composition of the present invention, it is preferable to use a fruit.
（ブラックペッパー：学名Piper nigrum）
ブラックペッパーは、Piperaceae科の植物であって、蔓性の常緑木本である。その果実は独特の風味をもち、果実を乾燥させて香辛料として主に用いられている。本発明の組成物において用いる部位としては、果実を用いることが好ましく、未熟な果実を用いることが特に好ましい。
(Black pepper: Scientific name Piper nigrum)
Black pepper is a plant of the Piperaceae family and is a vine evergreen tree. The fruit has a unique flavor and is mainly used as a spice by drying the fruit. As a site used in the composition of the present invention, it is preferable to use a fruit, and it is particularly preferable to use an immature fruit.
［ビタミン類又はポリフェノール］
（ビタミン類）
本発明の経口組成物においては、ペッパー植物と共に、ビタミン類を用いることが好ましい。ビタミン類としては、ビタミンＢ１塩酸塩、ビタミンＢ２、ビタミンＢ６、ビタミンＢ１２、ニコチン酸、Ｄ−パントテン酸ナトリウム、ビオチン、葉酸、ビタミンＣ（以上、水溶性ビタミン）、ビタミンＡ、ビタミンＤ３、ビタミンＥ、及びビタミンＫ１（以上、脂溶性ビタミン）から選ばれる少なくとも１種を用いることが好ましい。
[Vitamins or polyphenols]
(Vitamins)
In the oral composition of the present invention, vitamins are preferably used together with pepper plants. As vitamins, vitamin B1 hydrochloride, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, sodium D-pantothenate, biotin, folic acid, vitamin C (above, water-soluble vitamin), vitamin A, vitamin D3, vitamin E And at least one selected from vitamin K1 (and above, fat-soluble vitamins).
（ポリフェノール）
本発明の経口組成物においては、ペッパー植物と共に、ポリフェノールを用いることが好ましい。ポリフェノールとしては、没食子酸、クロロゲン酸、及びカテキンから選ばれる少なくとも１種を用いることが好ましい。
(Polyphenol)
In the oral composition of the present invention, it is preferable to use polyphenol together with pepper plants. As the polyphenol, it is preferable to use at least one selected from gallic acid, chlorogenic acid, and catechin.
これらビタミン類又はポリフェノールは、ペッパー植物の高血圧症の予防及び／又は改善機能の促進剤として機能する。 These vitamins or polyphenols function as promoters for preventing and / or improving hypertension in pepper plants.
本発明の経口組成物としては、例えば、医薬品（医薬部外品を含む）や、特定保健用食品、栄養機能食品、機能性表示食品等の所定機関より効能の表示が認められた機能性食品などのいわゆる健康食品や、一般的な食品、食品添加剤、飼料等を挙げることができる。本発明の経口組成物は、高血圧の人に限らず、高血圧が気になる人などが、性別や年齢に関係なく摂取することができる。 Examples of the oral composition of the present invention include, for example, pharmaceuticals (including quasi-drugs), functional foods for which indications of efficacy have been approved by predetermined institutions such as foods for specified health use, nutritional functional foods, functional labeling foods, etc. And so-called health foods, general foods, food additives, feeds and the like. The oral composition of the present invention can be taken not only by people with high blood pressure but also by people who are concerned about high blood pressure, regardless of gender or age.
本発明の経口組成物は、高血圧症の予防及び／又は改善に用いられる高血圧予防改善用組成物として用いることができ、かかる高血圧予防改善用組成物は、ペッパー植物及び所定のビタミン類又はポリフェノールを含有し、高血圧症の予防及び／又は改善に用いられる点において、製品として他の製品と区別することができるものであれば特に制限されるものではない。例えば、本発明に係る製品の本体、包装、説明書、宣伝物のいずれかに高血圧症の予防及び／又は改善機能がある旨を表示したものが本発明の範囲に含まれる。なお、本発明の高血圧予防改善用組成物は、製品の包装等に、本発明における組合せの成分（ペッパー植物及びビタミン類又はポリフェノール）が高血圧症の予防及び／又は改善効果の有効成分として表示されているものに限られない。例えば、有効成分を特定していないものであってもよく、ペッパー植物及びビタミン類又はポリフェノールを有効成分として表示したものであってもよく、ペッパー植物のみを有効成分として表示したものであってもよい。 The oral composition of the present invention can be used as a composition for improving and preventing hypertension used for the prevention and / or improvement of hypertension, and the composition for improving and preventing hypertension comprises a pepper plant and a predetermined vitamin or polyphenol. It is not particularly limited as long as it is contained and can be used for prevention and / or improvement of hypertension as a product that can be distinguished from other products. For example, it is included in the scope of the present invention that any of the main body, packaging, instructions, and promotional material of the product according to the present invention indicates that it has a function of preventing and / or improving hypertension. In the antihypertensive composition of the present invention, the combination component (pepper plant and vitamins or polyphenol) of the present invention is displayed on the product packaging or the like as an active ingredient for preventing and / or improving hypertension. It is not limited to what you have. For example, an active ingredient may not be specified, a pepper plant and vitamins or polyphenols may be displayed as active ingredients, or only a pepper plant may be displayed as an active ingredient Good.
具体的に高血圧予防改善用組成物としては、医薬品やいわゆる健康食品が挙げられ、いわゆる健康食品においては、「血圧が高めの方に」、「血圧が気になる方に」、「正常な血圧を維持するのを助ける」、「高めの血圧を下げる」、「血圧が高めの方の血圧を改善」、「血圧が高めの方の血圧を下げる」、「血圧が高めの方の血圧を下げるのを助ける」、「血圧が高めの方に適した機能」、「血圧を低下させる機能」、「血圧が高めな方の健康な血圧をサポートする」、「血圧が高めの方の健康に役立つ」等を表示したものを例示することができる。 Specifically, the composition for improving and preventing hypertension includes pharmaceuticals and so-called health foods. In so-called health foods, “for those with high blood pressure”, “for those who are concerned about blood pressure”, “normal blood pressure” ”,“ Lower blood pressure ”,“ improve blood pressure in higher blood pressure ”,“ lower blood pressure in higher blood pressure ”,“ lower blood pressure in higher blood pressure ” , "Functions suitable for people with higher blood pressure", "functions to lower blood pressure", "supports healthy blood pressure of people with higher blood pressure", "helps health of people with higher blood pressure" "Etc." can be exemplified.
本発明の経口組成物の形態としては、例えば、錠状、カプセル状、粉末状、顆粒状、液状、粒状、棒状、板状、ブロック状、固形状、丸状、ペースト状、クリーム状、カプレット状、ゲル状、チュアブル状、スティック状等を挙げることができる。これらの中でも、錠状、カプセル状、粉末状、顆粒状、液状の形態が特に好ましい。具体的には、サプリメントや、ペットボトル、缶、瓶等に充填された容器詰飲料や、水（湯）、牛乳、果汁、青汁等に溶解して飲むためのインスタント飲料や、食品添加剤を例示することができる。これらは食事の際などに手軽に飲用しやすく、また嗜好性を高めることができるという点で好ましい。 Examples of the oral composition of the present invention include tablets, capsules, powders, granules, liquids, granules, rods, plates, blocks, solids, rounds, pastes, creams, caplets , Gel, chewable, stick, and the like. Among these, a tablet, capsule, powder, granule, and liquid form are particularly preferable. Specifically, supplements, container-packed beverages filled in PET bottles, cans, bottles, instant beverages that are dissolved in water (hot water), milk, fruit juice, green juice, etc., and food additives Can be illustrated. These are preferable in that they can be easily taken at the time of eating and the like, and can enhance palatability.
本発明の経口組成物におけるペッパー植物及びビタミン類又はポリフェノール（本発明の成分）の合計含有量としては、その効果の奏する範囲で適宜含有させればよい。 The total content of pepper plants and vitamins or polyphenols (components of the present invention) in the oral composition of the present invention may be appropriately contained within the range where the effects are exerted.
一般的には、本発明の経口組成物が医薬品やサプリメントの場合には、本発明の成分が全体の０．０００１〜１００重量％含まれていることが好ましく、０．１〜８５重量％含まれていることがより好ましく、０．５〜７０重量％含まれていることがさらに好ましい。 In general, when the oral composition of the present invention is a pharmaceutical product or a supplement, the component of the present invention is preferably contained in an amount of 0.0001 to 100% by weight, preferably 0.1 to 85% by weight. More preferably, it is more preferably 0.5 to 70% by weight.
本発明の経口組成物が容器詰飲料である場合には、本発明の成分は全体の０．０００１〜１５重量％含まれていることが好ましく、０．００１〜１２．５重量％含まれていることがより好ましく、０．０１〜１０重量％含まれていることがさらに好ましい。 When the oral composition of the present invention is a packaged beverage, the components of the present invention are preferably contained in an amount of 0.0001 to 15% by weight, and 0.001 to 12.5% by weight. More preferably, it is more preferably 0.01 to 10% by weight.
また、本発明の経口組成物がインスタント飲料である場合には、本発明の成分は全体の０．００１〜８０重量％含まれていることが好ましく、０．００５〜７０重量％含まれていることがより好ましく、０．１〜６０重量％含まれていることがさらに好ましい。 Moreover, when the oral composition of this invention is an instant drink, it is preferable that the component of this invention is contained 0.001-80 weight% of the whole, and 0.005-70 weight% is contained. It is more preferable that 0.1 to 60% by weight is contained.
本発明の効果をより有効に発揮させるためには、本発明の成分は本発明の経口組成物全体の８０％以上含まれていることが好ましく、９０％以上含まれていることがより好ましく、９５％以上含まれていることがさらに好ましく、１００％であることが特に好ましい。 In order to exhibit the effect of the present invention more effectively, the component of the present invention is preferably contained in 80% or more of the whole oral composition of the present invention, more preferably 90% or more, More preferably 95% or more, and particularly preferably 100%.
本発明の経口組成物の摂取量としては特に制限はないが、本発明の効果をより顕著に発揮させる観点から、ペッパー植物が乾燥物、乾燥粉砕物の場合、成人（６５ｋｇ）の１日当たりの本発明の成分の摂取量が、１００ｍｇ／日以上となるように摂取することが好ましく、２００ｍｇ／日以上となるように摂取することがより好ましく、４００ｍｇ／日以上となるように摂取することがさらに好ましい。その上限は特に制限されないが、例えば、５０００ｍｇ／日であり、好ましくは４０００ｍｇ／日である。ペッパー植物が搾汁、抽出物の場合は、乾燥物との重量比に基づいて換算した量とすることが好ましい。 Although there is no restriction | limiting in particular as an intake amount of the oral composition of this invention, From a viewpoint of exhibiting the effect of this invention more notably, when a pepper plant is a dry matter and a dry ground material, the adult (65kg) per day The intake of the component of the present invention is preferably taken to be 100 mg / day or more, more preferably taken to be 200 mg / day or more, and taken to be 400 mg / day or more. Further preferred. Although the upper limit in particular is not restrict | limited, For example, it is 5000 mg / day, Preferably it is 4000 mg / day. When the pepper plant is squeezed juice or extract, the amount is preferably converted based on the weight ratio to the dried product.
本発明の経口組成物は、１日の摂取量が前記摂取量となるように、１つの容器に、又は例えば２〜３の複数の容器に分けて、１日分として収容することができる。 The oral composition of the present invention can be stored in one container or divided into a plurality of containers such as 2 to 3 so that the daily intake becomes the above-mentioned intake.
ペッパー植物及びビタミン類又はポリフェノールの配合重量比としては、０．５：１〜７０：１の範囲であることが好ましく、０．７５：１〜６０：１の範囲であることがより好ましく、１：１〜６０：１の範囲であることがさらに好ましく、１：１〜５０：１の範囲であることが特に好ましい。ペッパー植物及びビタミン類又はポリフェノールの配合比が、上記範囲であることにより、本発明の効果をより有効に発揮することができる。 The blending weight ratio of the pepper plant and vitamins or polyphenol is preferably in the range of 0.5: 1 to 70: 1, more preferably in the range of 0.75: 1 to 60: 1. : More preferably in the range of 1 to 60: 1, particularly preferably in the range of 1: 1 to 50: 1. The effect of this invention can be exhibited more effectively because the mixture ratio of a pepper plant and vitamins or polyphenol is the said range.
本発明の経口組成物は、必要に応じて、経口用として許容される本発明の成分以外の成分を添加して、公知の方法によって製造することができる。 The oral composition of this invention can be manufactured by a well-known method, adding components other than the component of this invention accept | permitted as oral use as needed.
本発明の経口組成物を水に溶解した場合のｐＨは、特に限定されないが、ｐＨ２．０〜７．０の範囲が好ましく、ｐＨ３．０〜６．５がより好ましく、ｐＨ４．５〜６．５であることが最も好ましい。 Although the pH at the time of dissolving the oral composition of this invention in water is not specifically limited, The range of pH2.0-7.0 is preferable, pH3.0-6.5 are more preferable, pH4.5-6. 5 is most preferred.
以下、本発明を実施例に基づき説明する。
［実施例１］
（原料）
ペッパー植物としては、ウォーターペッパーの芽部、ロングペッパーの果実、チリペッパーの果実、グリーンペッパーの果実、及びブラックペッパーの果実の乾燥物を６０％エタノールで抽出したエタノール抽出物を用いた。各抽出物を１０％ＤＭＳＯに懸濁し、１時間ボルテックスした後、遠心を行い、上清を採取した。得られた上清を、終濃度１％ＤＭＳＯとなるようにし所定の濃度に系列希釈したものをサンプル溶液（ペッパー溶液）として試験に使用した。
Hereinafter, the present invention will be described based on examples.
[Example 1]
(material)
As the pepper plant, an ethanol extract obtained by extracting 60% ethanol from a dried product of water pepper buds, long pepper fruits, chili pepper fruits, green pepper fruits, and black pepper fruits was used. Each extract was suspended in 10% DMSO, vortexed for 1 hour, centrifuged, and the supernatant was collected. The obtained supernatant was serially diluted to a predetermined concentration to a final concentration of 1% DMSO, and used as a sample solution (pepper solution) for the test.
ビタミン類又はポリフェノールとしては、ビタミンＢ１塩酸塩、ビタミンＢ２、ビタミンＢ６（ピリドキシン塩酸塩）、ビタミンＢ１２、ニコチン酸(ナイアシン)、Ｄ−パントテン酸ナトリウム、ビオチン、葉酸、ビタミンＣ（Ｌ（＋）−アスコルビン酸ナトリウム）、ビタミンＡ、ビタミンＤ３、ビタミンＥ（ＤＬ−αトコフェロール）、ビタミンＫ１、没食子酸、クロロゲン酸、カテキンについて、いずれも市販の試薬を用いた。各試薬１０％ＤＭＳＯ又は１００％ＤＭＳＯに溶解した後、終濃度１％ＤＭＳＯとなるようにし所定の濃度に希釈したものをサンプル溶液（ビタミン類又はポリフェノール溶液）として試験に使用した。 Vitamins or polyphenols include vitamin B1 hydrochloride, vitamin B2, vitamin B6 (pyridoxine hydrochloride), vitamin B12, nicotinic acid (niacin), sodium D-pantothenate, biotin, folic acid, vitamin C (L (+)- Commercially available reagents were used for sodium ascorbate), vitamin A, vitamin D3, vitamin E (DL-α tocopherol), vitamin K1, gallic acid, chlorogenic acid, and catechin. After each reagent was dissolved in 10% DMSO or 100% DMSO and diluted to a predetermined concentration so that the final concentration was 1% DMSO, a sample solution (vitamin or polyphenol solution) was used for the test.
（試験）
ＡＣＥ Ｋｉｔ-ＷＳＴ（（株）同仁化学研究所製）を用いて、3-Hydroxybutyryl-Gly-Gly-Gly(3HB-GGG) から切り出されてくる3-Hydroxybutyric acid(3HB)を酵素法により検出することにより、ＡＣＥ活性阻害を求めた。
(test)
Using ACE Kit-WST (manufactured by Dojindo Laboratories Co., Ltd.), 3-Hydroxybutyric acid (3HB) extracted from 3-Hydroxybutyryl-Gly-Gly-Gly (3HB-GGG) is detected by enzymatic method Thus, inhibition of ACE activity was determined.
各ウェルにサンプル溶液１０μＬを加えた。サンプル溶液としては、本発明の実施例に係る溶液（ペッパー溶液５μＬ＋ビタミン類又はポリフェノール溶液５μＬ）、比較例１に係る溶液（ペッパー溶液５μＬ＋１％ＤＭＳＯ５μＬ）、及び比較例２に係る溶液（ビタミン類又はポリフェノール溶液５μＬ＋１％ＤＭＳＯ５μＬ）を用いた。なお、ブランク及びテストコントロールとしては、１％ＤＭＳＯ１０μＬを用いた。
10 μL of sample solution was added to each well. Sample solutions include solutions according to examples of the present invention (
全ウェルに、Substrate Bufferを１０μＬずつ添加した。ブランクのウェルにのみ１％ＤＭＳＯを１０μＬ加え、実施例、比較例１及び２、テストコントロールのウェルにEnzyme Working Solutionを１０μＬ加えた。３７±１℃にて６０分間インキュベートした。全ウェルに、Indicator Working Solutionを１００μＬ加え、１０分間、室温静置した。光分析装置にて４５０ｎｍにおける吸光度を測定した。吸光度から、ＡＣＥ阻害活性（阻害率％）を求めた。なお、サンプルブランクとして、サンプル溶液１０μＬに、純水１２０μＬ加えたものを用いた。 10 μL of Substrate Buffer was added to all wells. 10 μL of 1% DMSO was added only to the blank wells, and 10 μL of Enzyme Working Solution was added to the wells of Examples, Comparative Examples 1 and 2 and the test control. Incubated for 60 minutes at 37 ± 1 ° C. 100 μL of Indicator Working Solution was added to all wells and allowed to stand at room temperature for 10 minutes. Absorbance at 450 nm was measured with an optical analyzer. The ACE inhibitory activity (inhibition rate%) was determined from the absorbance. In addition, what added 120 microliters of pure waters to 10 microliters of sample solutions was used as a sample blank.
ＡＣＥ阻害活性（阻害率％）
＝[１−（Ａsample−Ａsample blank）／（Ａtest control−Ａblank）］×１００
ACE inhibitory activity (inhibition rate%)
= [1- (A sample -A sample blank ) / (A test control -A blank )] × 100
test control：阻害剤（本発明の成分）なしの発色
blank：試薬の発色
sample blank：サンプルの発色
test control: Color development without inhibitors (components of the present invention)
blank: Reagent development
sample blank: Sample color
これらの結果を図１〜図５に示す。図中、ＬＰはロングペッパーを示し、ＧＰはグリーンペッパーを示し、ＷＰはウォーターペッパーを示し、ＣＰはチリペッパーを示し、ＢＰはブラックペッパーを示す。成分名の後に記載された数値は、濃度（μｇ／ｍＬ）を示す。 These results are shown in FIGS. In the figure, LP represents a long pepper, GP represents a green pepper, WP represents a water pepper, CP represents a chili pepper, and BP represents a black pepper. The numerical value described after the component name indicates the concentration (μg / mL).
図１〜図５に示すように、本発明の植物ペッパーとビタミン類又はポリフェノールとの組み合わせにより、ＡＣＥ活性阻害が増強されることが明らかとなった。特に、ビタミン類やポリフェノールは、配合量がペッパー植物よりも少ない場合であっても、ペッパー植物と組み合わせることにより、ＡＣＥ活性阻害作用を高めることができることがわかった。 As shown in FIGS. 1-5, it became clear that ACE activity inhibition is enhanced by the combination of the plant pepper of this invention, vitamins, or polyphenol. In particular, it has been found that vitamins and polyphenols can enhance the ACE activity inhibitory action by combining with pepper plants even when the blending amount is less than that of pepper plants.
［実施例２］（錠剤の製造）
下記成分からなるタブレット３錠（３６００ｍｇ）を製造した。
[Example 2] (Manufacture of tablets)
Three tablets (3600 mg) comprising the following components were produced.
ウォーターペッパー芽部乾燥粉末 ２０重量％
ビタミンＢ１塩酸塩 １重量％
葉酸 １重量％
没食子酸 １重量％
セルロース ２重量％
二酸化ケイ素 ２重量％
ステアリン酸カルシウム １重量％
シェラック １重量％
還元麦芽糖 残部
Water pepper bud dry powder 20% by weight
Vitamin B1 hydrochloride 1% by weight
1% by weight of folic acid
1% by weight of gallic acid
2% by weight of silicon dioxide
Calcium stearate 1% by weight
Shellac 1%
Reduced maltose balance
上記錠剤は一日に１回か、２〜３回に分けて水と共に服用する。 Take the tablets with water once a day or in 2 to 3 divided doses.
［実施例３］（錠剤の製造）
下記成分からなるタブレット３錠（３６００ｍｇ）を製造した。
Example 3 (Manufacture of tablets)
Three tablets (3600 mg) comprising the following components were produced.
ウォーターペッパー芽部抽出物 ６重量％
ビタミンＢ６ ２重量％
カテキン １重量％
セルロース ２重量％
二酸化ケイ素 ２重量％
ステアリン酸カルシウム １重量％
シェラック １重量％
還元麦芽糖 残部
Water pepper bud extract 6% by weight
Catechin 1% by weight
2% by weight of silicon dioxide
Calcium stearate 1% by weight
Shellac 1%
Reduced maltose balance
上記錠剤は一日に１回か、２〜３回に分けて水と共に服用する。 Take the tablets with water once a day or in 2 to 3 divided doses.
［実施例４］（カプセル剤の製造）
下記混合物をソフトカプセルに封入し、カプセル剤を製造した。
[Example 4] (Manufacture of capsules)
The following mixture was enclosed in a soft capsule to produce a capsule.
ロングペッパー果実乾燥粉末 １００ｍｇ
ニコチン酸 １０ｍｇ
クロロゲン酸 ５ｍｇ
ロイシン ２．５ｍｇ
チロシン ２．５ｍｇ
バリン ２．５ｍｇ
塩化鉄 １ｍｇ
麦芽糖 ７８．５ｍｇ
Long pepper fruit dry powder 100mg
Nicotinic acid 10mg
Chlorogenic acid 5mg
Leucine 2.5mg
Tyrosine 2.5mg
Valine 2.5mg
Iron chloride 1mg
Maltose 78.5mg
上記カプセル剤は４錠を一日に２〜４回に分けて水と共に服用する。 The above capsules should be taken with water in 4 divided doses 2-4 times a day.
［実施例５］（カプセル剤の製造）
下記混合物をソフトカプセルに封入し、カプセル剤を製造した。
[Example 5] (Manufacture of capsules)
The following mixture was enclosed in a soft capsule to produce a capsule.
ロングペッパー果実抽出物 ５０ｍｇ
ニコチン酸 １０ｍｇ
クロロゲン酸 ５ｍｇ
ロイシン ２．５ｍｇ
チロシン ２．５ｍｇ
バリン ２．５ｍｇ
塩化鉄 １ｍｇ
麦芽糖 １２８．５ｍｇ
Long pepper fruit extract 50mg
Nicotinic acid 10mg
Chlorogenic acid 5mg
Leucine 2.5mg
Tyrosine 2.5mg
Valine 2.5mg
Iron chloride 1mg
Maltose 128.5mg
上記カプセル剤は２錠を一日に１回か、２回に分けて水と共に服用する。 Take 2 capsules with water once a day or in 2 divided doses with water.
［実施例６］（顆粒剤の製造）
下記成分を混合して常法により顆粒剤（３０００ｍｇ）を製造した。
[Example 6] (Production of granules)
The following ingredients were mixed to produce granules (3000 mg) by a conventional method.
グリーンペッパー果実抽出物 ５００ｍｇ
還元パラチノース ５００ｍｇ
二酸化ケイ素 ２００ｍｇ
ショ糖脂肪酸エステル ５０ｍｇ
イノシトール ２５ｍｇ
ビタミンＡ １０ｍｇ
グルコン酸亜鉛 １０ｍｇ
塩化マグネシウム ５ｍｇ
トレオニン ５ｍｇ
トリプトファン ２．５ｍｇ
デンプン 残部
Green pepper fruit extract 500mg
Reduced palatinose 500mg
200 mg silicon dioxide
Sucrose fatty acid ester 50mg
Inositol 25mg
Vitamin A 10mg
Zinc gluconate 10mg
Magnesium chloride 5mg
Threonine 5mg
Tryptophan 2.5mg
Starch balance
［実施例７］（インスタント粉末剤の製造）
下記成分を混合して常法によりインスタント粉末（１０ｇ）を製造した。
[Example 7] (Production of instant powder)
The following components were mixed to produce an instant powder (10 g) by a conventional method.
豆乳粉末 ５ｇ
チリペッパー果実抽出物 ０．２５ｇ
シトルリン １ｇ
ビタミンＥ ０．０２ｇ
ビタミンＫ１ ０．０２ｇ
グルタミン ０．０１ｇ
グルコン酸亜鉛 ０．００１ｇ
塩化鉄 ０．００１ｇ
還元パラチノース ０．１ｇ
ステアリン酸カルシウム ２ｇ
難消化性デキストリン 残部
5g soymilk powder
Chili pepper fruit extract 0.25g
Citrulline 1g
Vitamin E 0.02g
Vitamin K1 0.02g
Glutamine 0.01g
Zinc gluconate 0.001g
0.001 g of iron chloride
Reduced palatinose 0.1g
Calcium stearate 2g
Indigestible dextrin balance
［実施例８］（液剤の製造）
下記成分からなる液剤（５００ｍＬ）を製造した。
[Example 8] (Production of liquid agent)
A liquid (500 mL) comprising the following components was produced.
ブラックペッパー果実抽出物 １０ｍｇ
トレハロース ５００ｍｇ
塩化カルシウム ５０ｍｇ
バリン ２５ｍｇ
ロイシン ２５ｍｇ
イソロイシン ２５ｍｇ
フェニルアラニン １０ｍｇ
プロリン １０ｍｇ
Ｄ−パントテン酸ナトリウム ３００ｍｇ
ビタミンＫ１ １５０ｍｇ
ビタミンＣ ５０ｍｇ
水 残量
Black pepper fruit extract 10mg
Trehalose 500mg
Calcium chloride 50mg
Valine 25mg
Leucine 25mg
Isoleucine 25mg
Phenylalanine 10mg
Proline 10mg
D-Sodium pantothenate 300mg
Vitamin K1 150mg
Vitamin C 50mg
Water remaining
本発明の経口組成物は、高血圧症を予防及び／又は改善する効果を有し、いわゆる健康食品等として用いることができることから、本発明の産業上の有用性は高い。
Since the oral composition of the present invention has an effect of preventing and / or improving hypertension and can be used as a so-called health food, the industrial utility of the present invention is high.
Claims (9)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016131945A JP6934150B2 (en) | 2016-07-01 | 2016-07-01 | Oral composition |
| JP2021127963A JP2021168703A (en) | 2016-07-01 | 2021-08-04 | Oral composition |
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| JP2016131945A JP6934150B2 (en) | 2016-07-01 | 2016-07-01 | Oral composition |
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| JP2021127963A Division JP2021168703A (en) | 2016-07-01 | 2021-08-04 | Oral composition |
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| JP2016131945A Active JP6934150B2 (en) | 2016-07-01 | 2016-07-01 | Oral composition |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005162745A (en) * | 2003-11-13 | 2005-06-23 | Taisho Pharmaceut Co Ltd | Ameliorating agent for hypertension |
| JP2006212021A (en) * | 2005-08-05 | 2006-08-17 | Ajinomoto Co Inc | Food composition |
| JP2007119373A (en) * | 2005-10-26 | 2007-05-17 | Arkray Inc | Maillard reaction product-decomposing agent and drink or food using the same |
| JP2010110283A (en) * | 2008-11-07 | 2010-05-20 | Kobayashi Pharmaceut Co Ltd | Food/drink composition containing piper longum extract, and method for ameliorating taste of the composition |
-
2016
- 2016-07-01 JP JP2016131945A patent/JP6934150B2/en active Active
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- 2021-08-04 JP JP2021127963A patent/JP2021168703A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005162745A (en) * | 2003-11-13 | 2005-06-23 | Taisho Pharmaceut Co Ltd | Ameliorating agent for hypertension |
| JP2006212021A (en) * | 2005-08-05 | 2006-08-17 | Ajinomoto Co Inc | Food composition |
| JP2007119373A (en) * | 2005-10-26 | 2007-05-17 | Arkray Inc | Maillard reaction product-decomposing agent and drink or food using the same |
| JP2010110283A (en) * | 2008-11-07 | 2010-05-20 | Kobayashi Pharmaceut Co Ltd | Food/drink composition containing piper longum extract, and method for ameliorating taste of the composition |
Non-Patent Citations (1)
| Title |
|---|
| 薬理と治療, (2015), 43, [8], P.1127-1139, JPN6021017632, ISSN: 0004521859 * |
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