JP2017509901A - 高速試料分析方法及び高速試料分析システム - Google Patents
高速試料分析方法及び高速試料分析システム Download PDFInfo
- Publication number
- JP2017509901A JP2017509901A JP2017501084A JP2017501084A JP2017509901A JP 2017509901 A JP2017509901 A JP 2017509901A JP 2017501084 A JP2017501084 A JP 2017501084A JP 2017501084 A JP2017501084 A JP 2017501084A JP 2017509901 A JP2017509901 A JP 2017509901A
- Authority
- JP
- Japan
- Prior art keywords
- sample
- sample cell
- cell
- components
- spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 88
- 238000012284 sample analysis method Methods 0.000 title claims description 9
- 238000000034 method Methods 0.000 claims abstract description 103
- 230000003287 optical effect Effects 0.000 claims abstract description 47
- 238000001514 detection method Methods 0.000 claims abstract description 32
- 238000004821 distillation Methods 0.000 claims abstract description 29
- 238000011002 quantification Methods 0.000 claims abstract description 9
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 192
- 238000001228 spectrum Methods 0.000 claims description 140
- 230000003595 spectral effect Effects 0.000 claims description 83
- 239000002904 solvent Substances 0.000 claims description 53
- 230000004044 response Effects 0.000 claims description 46
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims description 42
- 238000000862 absorption spectrum Methods 0.000 claims description 25
- 238000004817 gas chromatography Methods 0.000 claims description 23
- 238000005259 measurement Methods 0.000 claims description 23
- 230000010354 integration Effects 0.000 claims description 15
- 238000003795 desorption Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 10
- 238000002411 thermogravimetry Methods 0.000 claims description 5
- 238000001042 affinity chromatography Methods 0.000 claims description 4
- 238000004508 fractional distillation Methods 0.000 claims description 4
- 238000004255 ion exchange chromatography Methods 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- 238000010183 spectrum analysis Methods 0.000 claims description 4
- 238000004808 supercritical fluid chromatography Methods 0.000 claims description 4
- 230000032258 transport Effects 0.000 claims description 4
- 238000001069 Raman spectroscopy Methods 0.000 claims description 3
- 238000000295 emission spectrum Methods 0.000 claims description 3
- 238000000197 pyrolysis Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 238000000642 dynamic headspace extraction Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000003705 background correction Methods 0.000 claims 1
- 238000004442 gravimetric analysis Methods 0.000 claims 1
- 238000004422 calculation algorithm Methods 0.000 abstract description 17
- 238000010521 absorption reaction Methods 0.000 abstract description 15
- 238000004611 spectroscopical analysis Methods 0.000 abstract description 8
- 238000003672 processing method Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 276
- 239000007789 gas Substances 0.000 description 142
- 230000014759 maintenance of location Effects 0.000 description 38
- 238000000926 separation method Methods 0.000 description 31
- 239000007924 injection Substances 0.000 description 29
- 238000002347 injection Methods 0.000 description 29
- 239000000463 material Substances 0.000 description 20
- 238000010828 elution Methods 0.000 description 19
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 18
- 239000012159 carrier gas Substances 0.000 description 17
- 238000010438 heat treatment Methods 0.000 description 17
- 238000004949 mass spectrometry Methods 0.000 description 16
- 239000000126 substance Substances 0.000 description 16
- 230000008901 benefit Effects 0.000 description 15
- 238000004587 chromatography analysis Methods 0.000 description 15
- 230000009102 absorption Effects 0.000 description 14
- 238000012935 Averaging Methods 0.000 description 13
- 230000008859 change Effects 0.000 description 13
- 238000013461 design Methods 0.000 description 13
- 230000002829 reductive effect Effects 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 238000000576 coating method Methods 0.000 description 11
- 230000035945 sensitivity Effects 0.000 description 11
- 230000005526 G1 to G0 transition Effects 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 10
- 239000011248 coating agent Substances 0.000 description 10
- 238000013480 data collection Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000012855 volatile organic compound Substances 0.000 description 10
- 229910000661 Mercury cadmium telluride Inorganic materials 0.000 description 9
- MCMSPRNYOJJPIZ-UHFFFAOYSA-N cadmium;mercury;tellurium Chemical compound [Cd]=[Te]=[Hg] MCMSPRNYOJJPIZ-UHFFFAOYSA-N 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 230000006872 improvement Effects 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 238000009835 boiling Methods 0.000 description 7
- 239000013626 chemical specie Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 238000004445 quantitative analysis Methods 0.000 description 7
- GWHJZXXIDMPWGX-UHFFFAOYSA-N 1,2,4-trimethylbenzene Chemical compound CC1=CC=C(C)C(C)=C1 GWHJZXXIDMPWGX-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 238000002329 infrared spectrum Methods 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 238000005457 optimization Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000012491 analyte Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 238000007405 data analysis Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000001307 helium Substances 0.000 description 4
- 229910052734 helium Inorganic materials 0.000 description 4
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000002452 interceptive effect Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000002310 reflectometry Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000000451 chemical ionisation Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910052732 germanium Inorganic materials 0.000 description 3
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 3
- 239000004009 herbicide Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- PFNQVRZLDWYSCW-UHFFFAOYSA-N (fluoren-9-ylideneamino) n-naphthalen-1-ylcarbamate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1=NOC(=O)NC1=CC=CC2=CC=CC=C12 PFNQVRZLDWYSCW-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000005083 Zinc sulfide Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 239000000538 analytical sample Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- XQPRBTXUXXVTKB-UHFFFAOYSA-M caesium iodide Chemical compound [I-].[Cs+] XQPRBTXUXXVTKB-UHFFFAOYSA-M 0.000 description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 2
- 229910001634 calcium fluoride Inorganic materials 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 239000012468 concentrated sample Substances 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- WPYVAWXEWQSOGY-UHFFFAOYSA-N indium antimonide Chemical compound [Sb]#[In] WPYVAWXEWQSOGY-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000491 multivariate analysis Methods 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- 229960002715 nicotine Drugs 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000000611 regression analysis Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000012306 spectroscopic technique Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005979 thermal decomposition reaction Methods 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- 230000008016 vaporization Effects 0.000 description 2
- 229910052984 zinc sulfide Inorganic materials 0.000 description 2
- YBNMDCCMCLUHBL-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-pyren-1-ylbutanoate Chemical compound C=1C=C(C2=C34)C=CC3=CC=CC4=CC=C2C=1CCCC(=O)ON1C(=O)CCC1=O YBNMDCCMCLUHBL-UHFFFAOYSA-N 0.000 description 1
- OTDJAMXESTUWLO-UUOKFMHZSA-N 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-3H-purine-6-thione Chemical compound C12=NC(N)=NC(S)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OTDJAMXESTUWLO-UUOKFMHZSA-N 0.000 description 1
- -1 AlInGaAs Inorganic materials 0.000 description 1
- 229910016036 BaF 2 Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229910000530 Gallium indium arsenide Inorganic materials 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- YUWBVKYVJWNVLE-UHFFFAOYSA-N [N].[P] Chemical compound [N].[P] YUWBVKYVJWNVLE-UHFFFAOYSA-N 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- OYLGJCQECKOTOL-UHFFFAOYSA-L barium fluoride Chemical compound [F-].[F-].[Ba+2] OYLGJCQECKOTOL-UHFFFAOYSA-L 0.000 description 1
- 229910001632 barium fluoride Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 238000000170 chemical ionisation mass spectrum Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 150000002013 dioxins Chemical class 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000005264 electron capture Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 238000009615 fourier-transform spectroscopy Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 238000000186 gas chromatography-infrared spectroscopy Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 229910001872 inorganic gas Inorganic materials 0.000 description 1
- CBEQRNSPHCCXSH-UHFFFAOYSA-N iodine monobromide Chemical compound IBr CBEQRNSPHCCXSH-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 238000010223 real-time analysis Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012419 revalidation Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- PGAPATLGJSQQBU-UHFFFAOYSA-M thallium(i) bromide Chemical compound [Tl]Br PGAPATLGJSQQBU-UHFFFAOYSA-M 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- GZXOHHPYODFEGO-UHFFFAOYSA-N triglycine sulfate Chemical class NCC(O)=O.NCC(O)=O.NCC(O)=O.OS(O)(=O)=O GZXOHHPYODFEGO-UHFFFAOYSA-N 0.000 description 1
- FYGHSUNMUKGBRK-UHFFFAOYSA-N trimethylbenzene Natural products CC1=CC=CC(C)=C1C FYGHSUNMUKGBRK-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/031—Multipass arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8603—Signal analysis with integration or differentiation
- G01N30/8606—Integration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8624—Detection of slopes or peaks; baseline correction
- G01N30/8641—Baseline
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N2030/0075—Separation due to differential desorption
- G01N2030/008—Thermal desorption
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/025—Gas chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
- G01N2030/743—FTIR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pure & Applied Mathematics (AREA)
- Mathematical Optimization (AREA)
- Mathematical Analysis (AREA)
- Algebra (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Optical Measuring Cells (AREA)
Abstract
Description
気相状態にある。この放出物は、試料(ここではガスともいう)セル14に向けられ、これは通常、排気可能で、ガス圧を周囲の圧(大気圧、常圧)よりも低くできるように構成された容器である。特定の実施形態では、試料セルの圧力は約0.001〜約1.0気圧の間にある。例えば、1mL/分の流量、200mLの試料セル容量、セルの初期ガス圧1/2気圧で、100分のデータ採取を行うことができる。これは、ほとんどのガスクロ試料分析に対して、充分なタイムウィンドウであると考慮される。一例では、窒素キャリア、外径0.53mmのカラムに対し、約1.5mL/mmの流量が最適の分解度をもたらすことがわかった。また、低圧への切り替えにより、個々の分析処理(ラン)の間のセルの浄化をより早く行うことができることがわかった。例示的実施形態では、圧力は、約0.1気圧〜約0.01気圧に低下される。
パス長と容積の比を考慮すると、光路長5mの、多くのFTIRガス分析計で容積が10倍となれば、ピークが1/10に小さくなる。ガスセルを200mLまたはそれ以下に保ちながら、光路長を最大値にすると、限界感度が得られる。これは、ミラー表面のカッティングに起因する、反射率と収差に基づいている。公知の被覆を用い、128から256のパスが可能である。キャビティリングダウン法とレーザ技術に基づき、1000パスが可能であろう。その際、反射率は0.999またはそれ以上が可能であり、これは他の実施形態でも実施できる。32パスを有し、5m(本発明の構成を実証するために用いられる試料セルの一種)を与える試料(ガス)セルと対比すると、128パスのガスセルは、吸収性が4倍となる。高反射性ミラー被覆があれば、全体で顕著なロスは生じない。理論上、反射率0.999、1000パスを使用すると信号ロスを50%のみとすることができる。これは5mセルに比し、吸収率が31倍となり、MDLは、15.5倍低くなる(15.5分の1となる)。
・ガスクロの保持時間(RT)をモニタする;
・ガスセルを特定の真空圧まで排気し、必要に応じ、これを封止する;
・セルを加圧せず、ガスクロに影響を与えずに全てのガスをガスセルに集めるに必要な真空度を決定する;
・ガスセルの圧力が測定結果に影響を与えないよう、絶対モードで測定を行う;
・ガスクロの排出口とFTIRのガスセルを直接連結する;
・ガスセルの圧力を断続的に、または好ましくは連続的にモニタする;
・ピーク信号を積算し、現行の技術に対し、顕著なSN比の向上を得る;
・化合物がガスクロから出るのが終わったのち、化合物を繰り返し測定し、そのピーク信号を平均する;
・出力データストリームを制御するため、FTIRスペクトルデータを管理する。
・得られたデータのいずれが試料データであり、いずれがバックグラウンドデータであるかを決定する。
・干渉が生じて測定の信頼度が低下するまでに、化合物を分析しうる時間の長さを決定する;
・出てくる化合物に応じ、データベースを検索する;
・出てくる化合物を定量する;
・内部標準データを用い、濃度を補正する;
・各化合物について、較正ファイルを作成する;
・化合物が干渉の補正のため出てきた場合に、データを分析する手法(プロトコル)を開発する;
・いつ新たな化合物がガスクロから溶出するかを決定する;
・いつ化合物がガスクロから出なくなるかを決定する。
・化合物がGCを出た後、例えば、測定誤差を用いながら、どれだけ長く化合物を定量できるかを決定する。
・異なる化合物について、多数回(複数回)分析を同時に行う;
・最適結果を得るため、各化合物について多数回分析を行う;
・場合によって干渉に基づき、利用するスペクトル領域を変化させる;
・測定時のMDLを予測する;
・以後の分析または設定された分析のため、保持時間および/またはリテンションインデックスを決定する。
(農薬、除草剤、尿中の薬物、ニコチンなど)準揮発性物質の分析、医学試験、例えば、製薬工業における薬品の純度試験、その他に使用または適用することができる。特定の応用では、ここで記載したシステムは、TDT、液体、固体、パージ−トラップ装置または他の装置などの試料採集装置と接続される。
従来型のGC−FTIRの構成において、ガスはGCを出てFTIRガスセル(通常光管で、一般的におよそ10〜20cmの長さを持つ)を数秒で通過する。化学化合物の濃度が十分に高ければ、他の検出器でも典型的に見られるように、上昇し、下降するピークが観察される。これに対し、図2A、2Bに示されるようなシステムを用いると、ガスはガスセルに集積され、GCから溶出する各ピークを積算できる。
ここで記載する技術のスペクトル上の構成を示すため、実験を行った。ここで記載するポストプロセシングの後にどのようにスペクトルが変化するかを実証するため、550〜1250cm−1のIRスペクトルの指紋領域の二つのスクリーンショットを採取した。
12 ガスクロマトグラフ(分離器)
14 試料セル
16 FTIR(分光器)
18 ポンプ
22 検出器
24、26A、26B バルブ
30A、30B、32、43、45、47 反射器
34 コンピュータシステム
36 ヒータ
39 ホワイトセル
41 光源
50 蒸留分離器(分離器)
Claims (30)
- 試料分析システムであって、
試料の成分を経時的に供給する分離器と、
前記成分が集積される試料セルと、
前記試料セル中の前記成分のスペクトル応答を取得する分光システムとを備えた、
システム。 - 請求項1に記載のシステムであって、
前記分光システムが、前記試料セル中の前記成分の前記スペクトル応答を測定するスペクトル領域が、ミリ波、マイクロ波、テラヘルツ波、赤外線(近赤外、中赤外、遠赤外を含む)、可視光、紫外線(UV)(真空紫外線(VUV)を含む)、x線、および/またはγ線から選択される一または二以上のスペクトル領域から選択される、システム。 - 請求項1に記載のシステムであって、前記分光システムが前記試料セル中の前記成分の、吸収スペクトル、発光スペクトル(黒体、または蛍光を含む)、弾性散乱および反射スペクトル、インピーダンス(例えば、屈折率)スペクトル、および/または非弾性散乱(例えば、ラマン散乱およびコンプトン散乱)スペクトルを測定する、システム。
- 請求項1記載のシステムであって、前記分離器が、ガスクロマトグラフィシステム、液体クロマトグラフィシステム、親和クロマトグラフィシステム、超臨界流体クロマトグラフィシステム、イオン交換クロマトグラフィシステム、蒸留システム、分別蒸留システム、加熱脱離システム、疑似蒸留装置、熱重量分析装置、または熱分解装置である、システム。
- 請求項1に記載のシステムであって、前記分離器は、別の検出システムを要しない、ガスクロマトグラフィシステムである、システム。
- 請求項1に記載のシステムであって、前記分光システムは、フーリエ変換型赤外分光計である、システム。
- 請求項1に記載のシステムであって、前記試料セル中の光路長は、多重光路光学配置によって延長されている、システム。
- 請求項1に記載のシステムであって、前記試料セルが、ホワイトセルまたは変形ホワイトセルタイプの光学配置を有する、システム。
- 請求項1に記載のシステムであって、前記試料セルを部分的または全体的に排気する真空ポンプ装置をさらに備える、システム。
- 請求項1に記載のシステムであって、前記試料セルをポンピング装置から隔離するバルブ、前記分離器からの放出物を前記試料セルから逸流させるバルブ、試料セルの圧力制御装置、またはこれらのいずれかの組み合わせをさらに備える、システム。
- 請求項1に記載のシステムであって、さらに試料採集のための試料濃集装置を備えるシステム。
- 請求項11に記載のシステムであって、前記試料濃集装置が、TDT、パージおよびトラップ、または溶媒濃縮装置である、システム。
- 請求項1に記載のシステムであって、さらに自動化された装置制御を備えるシステム。
- 請求項13に記載のシステムであって、前記装置制御は、既知の化合物に関する情報へのアクセス、積算プロセス、バックグラウンド補正プロセス、化合物情報ライブラリ、較正、内部標準試料、またはこれらの任意の組み合わせを含むシステム。
- 試料の分析法であって、
経時的に試料の成分を供給するステップと、
試料セル中に前記成分を収集するステップと、
前記試料セル中の前記成分からのスペクトル応答を得るステップとを含む、方法。 - 請求項15に記載の方法であって、
前記試料セル中の前記成分のスペクトル応答の測定において、応答を採取するスペクトル領域が、ミリ波、マイクロ波、テラヘルツ波、赤外線(近赤外、中赤外、遠赤外を含む)、可視光、紫外線(UV)(真空紫外線(VUV)を含む)、x線、および/またはγ線から選択される一または二以上のスペクトル領域から選択される、方法。 - 請求項15に記載の方法であって、
前記スペクトル応答の採取が、前記試料セル中の前記成分からの、吸収スペクトル、発光スペクトル(黒体または蛍光を含む)、弾性散乱および反射スペクトル、インピーダンス(例えば、屈折率)スぺクトル、および/または非弾性散乱(例えば、ラマン散乱およびコンプトン散乱)スペクトルの採取を含む、方法。 - 請求項15に記載の方法であって、前記成分はガスクロマトグラフィシステム、液体クロマトグラフィシステム、親和クロマトグラフィシステム、超臨界流体クロマトグラフィシステム、イオン交換クロマトグラフィシステム、蒸留、分別蒸留、加熱脱離、疑似蒸留、熱重量分析、または熱分解を利用して供給される、方法。
- 請求項15に記載の方法であって、さらに電磁照射を多重光路に沿って、前記試料セルに加えるステップを含む、方法。
- 請求項15に記載の方法であって、前記試料セルを少なくとも部分的に排気し、該試料セルを封止して前記成分を集積するステップを含む、方法。
- 試料セルシステムであって、
成分を集積する試料セルと、
分離器からの成分を前記試料セルへ取り入れる、取入口と、
該試料セル中でエネルギーを輸送し、前記セル中の前記成分のスペクトル応答の測定を可能とするスペクトル分析経路とを
有する、システム。 - 請求項21に記載の試料セルシステムであって、前記試料セルが少なくとも部分的に排気されるシステム。
- 試料セルの使用方法であって、
成分を前記試料セルに集積するステップと、
前記セル中の前記成分からのスペクトル応答を周期的に測定するステップと、
前記スペクトル応答の一部をバックグラウンドとして用いて、より新しいスペクトル応答を分析し、前記成分を同定するステップを含む方法。 - 試料を分析するシステムであって、
成分を集積し、試料を分析するための試料セルと、
前記試料セル中の前記成分のスペクトル応答を経時的に測定する分光システムと、
前記スペクトル応答を対比して前記試料セル中の前記成分を同定および/または定量するコンピュータシステムとを備える、システム。 - 試料の分析方法であって、
前記試料から溶出した成分を試料セル中に集積するステップと、
前記試料セル中の前記成分のスペクトル応答を経時的に決定するステップと、
前記スペクトル応答を対比して、前記試料セル中の前記成分を同定および/または定量するステップとを有する、
方法。 - 試料を分析するシステムであって。
試料の成分を溶出するガスクロマトグラフィシステムと、
前記成分を収集し、集積する試料セルと、
前記ガススクロマトグラフィシステムと前記試料セルとの間において、周期的に開放され、溶出物の塊を前記試料セルへ放出するバルブ装置と、
前記試料セル中の前記成分のスペクトル応答を測定する、分光システムとを有するシステム。 - 請求項26に記載のシステムであって、前記バルブ装置は、マスフローコントローラである、システム。
- 試料分析方法であって、
分離器から試料の成分を溶出させるステップと、
前記試料セル中に前記成分を収集し集積するステップと、
前記分離器からの溶出物を周期的に前記試料セルに放出するステップと、
前記試料セル中の前記成分のスペクトル応答を測定するステップとを有する
方法。 - 試料を分析するコンピュータシステムであって、
試料からの成分の生成と該成分の試料セルへの収集を制御し、
分光システムから成分のスペクトル応答を受信し、
該スペクトル応答を、以前に生成されたスペクトル応答と対比して、前記試料セル中の
前記成分を同定および/または定量する、コンピュータシステム。 - 試料の分析方法であって、
試料からの成分の生成を制御し、前記成分のスペクトル応答を経時的に取得するステップと、前記スペクトル応答を先に生成されたスペクトル応答と対比して、新たに生成された成分の同定および/または定量を行う、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461954054P | 2014-03-17 | 2014-03-17 | |
US61/954,054 | 2014-03-17 | ||
PCT/US2015/021046 WO2015142906A1 (en) | 2014-03-17 | 2015-03-17 | Process and system for rapid sample analysis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017509901A true JP2017509901A (ja) | 2017-04-06 |
JP2017509901A5 JP2017509901A5 (ja) | 2018-04-05 |
Family
ID=52824555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017501084A Pending JP2017509901A (ja) | 2014-03-17 | 2015-03-17 | 高速試料分析方法及び高速試料分析システム |
Country Status (8)
Country | Link |
---|---|
US (3) | US9606088B2 (ja) |
EP (1) | EP3120141A1 (ja) |
JP (1) | JP2017509901A (ja) |
KR (1) | KR20160132467A (ja) |
CN (1) | CN106461542A (ja) |
AU (1) | AU2015231494A1 (ja) |
CA (1) | CA2940429A1 (ja) |
WO (1) | WO2015142906A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021009031A (ja) * | 2019-06-28 | 2021-01-28 | 株式会社堀場製作所 | 分析装置及び分析方法 |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2820580A4 (en) * | 2012-02-28 | 2015-07-29 | Univ Wayne State | USE OF IONIC CURRENT SIGNAL FOR MOTOR PERFORMANCE AND EMISSION MEASUREMENT TECHNIQUES AND METHODS FOR REALIZING THE SAME |
GB2517187B (en) | 2013-08-14 | 2016-09-14 | Duvas Tech Ltd | Multipass spectroscopic absorption cell |
CN105518454B (zh) * | 2013-09-02 | 2018-04-10 | 株式会社岛津制作所 | 色谱仪用数据处理装置以及方法 |
US9250175B1 (en) * | 2014-12-16 | 2016-02-02 | Aerodyne Research, Inc. | Optical multi-pass cell for long path-length spectroscopy |
WO2017060853A1 (en) | 2015-10-07 | 2017-04-13 | Duvas Technologies Limited | Systems for detecting gas and vapor species using a multi-pass absorption cell |
EP3368892B1 (en) | 2015-10-31 | 2024-04-03 | Mls Acq, Inc. D/B/A Max Analytical Technologies | Analysis system for analyzing samples from a sample source, and analysis method |
CN107024442A (zh) * | 2015-12-15 | 2017-08-08 | 株式会社堀场制作所 | 多重反射型单元、分析装置、排气分析装置和光的射入方法 |
US11029292B2 (en) | 2016-04-08 | 2021-06-08 | Mls Acq, Inc. | Method for identification and quantification of siloxanes in gaseous stream |
US10024749B2 (en) | 2016-04-13 | 2018-07-17 | Max Analytical Technologies, Inc. | Method and system for leak rate testing of pressurized containers |
US10656128B2 (en) | 2016-04-15 | 2020-05-19 | Mls Acq, Inc. | System and method for gas sample analysis |
JP6584366B2 (ja) * | 2016-05-20 | 2019-10-02 | 三菱電機株式会社 | ガス分析装置およびガス分析方法 |
US20170341056A1 (en) * | 2016-05-24 | 2017-11-30 | Max Analytical Technologies, Inc. | GC-FTIR and Mode of Operation to Address Water Interference |
JP2019520557A (ja) * | 2016-05-27 | 2019-07-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ ネイビー | センシング用途での反射率に基づくカラー変化の分析 |
WO2017210557A1 (en) | 2016-06-02 | 2017-12-07 | Max Analytical Technologies, Inc. | Analysis system and method employing thermal desorption and spectrometric analysis |
WO2017218821A1 (en) * | 2016-06-16 | 2017-12-21 | Valisure Llc | Methods and systems for spectroscopic analysis |
US10041926B2 (en) * | 2016-07-14 | 2018-08-07 | Chevron U.S.A. Inc. | Method for predicting total petroleum hydrocarbon concentration in soils |
US10802004B2 (en) | 2016-08-10 | 2020-10-13 | Mls Acq, Inc. | Analytics system and user interface therefor |
US11788995B2 (en) | 2016-08-10 | 2023-10-17 | Mls Acq, Inc. | System and method for background removal in spectrometry system |
US10401336B2 (en) | 2016-12-22 | 2019-09-03 | Mls Acq, Inc. | Method and system for low temperature detection of semi volatile organic compounds |
EP3570728A1 (en) * | 2017-01-23 | 2019-11-27 | Koninklijke Philips N.V. | Alignment of breath sample data for database comparisons |
US10408746B2 (en) | 2017-03-03 | 2019-09-10 | Mls Acq, Inc. | System and method for impurity detection in beverage grade gases |
CN107064373A (zh) * | 2017-05-08 | 2017-08-18 | 浙江大学 | 一种超临界流体色谱和质谱的联用***及测定方法 |
US11215590B2 (en) | 2017-08-29 | 2022-01-04 | Mls Acq, Inc. | Large volume gas chromatography injection port |
US11300503B2 (en) * | 2017-08-30 | 2022-04-12 | Mls Acq, Inc. | Carbon ladder calibration |
WO2019087201A1 (en) * | 2017-11-06 | 2019-05-09 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Interferometer system and application thereof |
US11125664B2 (en) * | 2017-12-04 | 2021-09-21 | Montana Instruments Corporation | Analytical instruments, methods, and components |
US10804562B2 (en) * | 2017-12-06 | 2020-10-13 | Tesla Motors Canada ULC | Method and system for determining concentration of electrolyte components for lithium-ion cells |
WO2019114239A1 (zh) * | 2017-12-13 | 2019-06-20 | 清华大学 | 基于太赫兹的探测大气高危化学品的方法和*** |
CN108279277B (zh) * | 2018-02-11 | 2019-08-09 | 西北大学 | 一种检测辐射气体产物的制样装置及其检测方法 |
WO2019169121A1 (en) | 2018-02-28 | 2019-09-06 | Mls Acq, Inc. D/B/A Max Analytical Technologies | Thermal desorption tube collection system and method |
US11953433B2 (en) | 2018-03-20 | 2024-04-09 | Hte Gmbh The High Throughput Experimentation Company | Method for analysing process streams |
US20210302340A1 (en) * | 2018-08-08 | 2021-09-30 | Justin L. Neill | Methods and Apparatus for Low-Volatility Sampling |
CN109142316A (zh) * | 2018-08-27 | 2019-01-04 | 裴世铀 | 一种高灵敏激光光谱气体分析仪 |
US11187585B2 (en) * | 2018-10-12 | 2021-11-30 | Mls Acq, Inc. | FTIR spectrometer with optical filter for low level gas detection such as formaldehyde and ethylene oxide |
US10684219B2 (en) | 2018-10-30 | 2020-06-16 | Chevron U.S.A. Inc. | Method for determining hydrocarbon concentration in drilled solids using near infrared spectroscopy |
KR102214705B1 (ko) * | 2019-02-11 | 2021-02-09 | 한양대학교 에리카산학협력단 | 공정 환경 내에 존재하는 물질의 분석 방법 및 이를 위한 장치 |
DE102019104481A1 (de) * | 2019-02-21 | 2020-08-27 | Laser-Laboratorium Göttingen e.V. | Verfahren und Vorrichtung zum Identifizieren von flüchtigen Substanzen mit resonatorverstärkter Raman-Spektroskopie bei reduziertem Druck |
US11150130B2 (en) * | 2019-03-04 | 2021-10-19 | Si-Ware Systems | Compact multi-pass gas cell for multi-gas spectral sensors |
US11143589B2 (en) * | 2019-03-15 | 2021-10-12 | Mls Acq, Inc. | FTIR spectrometer with cut-off filter for hydrogen sulfide detection |
CN110132885A (zh) * | 2019-05-22 | 2019-08-16 | 清华大学 | 气体太赫兹光谱探测装置和方法 |
KR102260274B1 (ko) | 2019-06-07 | 2021-06-04 | 켐아이넷(주) | Gc/ms 및 lc/ms 기반 법독성데이터 처리 통합 플랫폼 |
FI20195572A1 (en) | 2019-06-27 | 2020-12-28 | Gasmet Tech Oy | Back-to-back spectrometer arrangement |
CA3087945A1 (en) * | 2019-07-24 | 2021-01-24 | Institut National De La Recherche Scientifique | Method and system for determination of photothermal properties of particles |
CN114674859A (zh) * | 2019-07-24 | 2022-06-28 | 北京科技大学 | 一种用于测量表面偏聚挥发量的试样架及其使用方法 |
CN110530764A (zh) * | 2019-10-15 | 2019-12-03 | 北京大学深圳研究生院 | Pm2.5中有机碳和元素碳的稳定同位素测定方法 |
US20210178352A1 (en) * | 2019-12-11 | 2021-06-17 | Mls Acq, Inc. D/B/A Max Analytical Technologies | Method and system for generating interference spectra for low detection limits using reactor |
CN111103255A (zh) * | 2019-12-31 | 2020-05-05 | 深圳市太赫兹科技创新研究院 | 一种光谱仪 |
CN111721739B (zh) * | 2020-05-21 | 2023-05-16 | 中国地质科学院水文地质环境地质研究所 | 一种油页岩热解气体分析装置 |
US11977024B2 (en) | 2020-12-16 | 2024-05-07 | Mls Acq, Inc. | Method and system for low detection limit EO using pressure, chiller and reactor |
KR102557499B1 (ko) * | 2021-12-16 | 2023-07-21 | 가천대학교 산학협력단 | 열중량분석-적외선 분광분석을 이용한 약물이 로딩된 약물전달체의 분석 장치 및 방법 |
CN114414686B (zh) * | 2022-01-11 | 2023-05-16 | 宜宾五粮液股份有限公司 | 一种监测浓香型大曲制曲过程微生物生长代谢的方法 |
CN115144499A (zh) * | 2022-07-04 | 2022-10-04 | 华润化学材料科技股份有限公司 | 一种甄别可降解塑料及其制品的方法与应用 |
WO2024013240A1 (en) | 2022-07-13 | 2024-01-18 | Roche Diagnostics Gmbh | A method for quality check of at least one lc-ms measurement |
CN116106165A (zh) * | 2023-03-23 | 2023-05-12 | 哈尔滨工业大学 | 一种镁合金砂型铸造热解气氛检测装置及检测方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62115143U (ja) * | 1985-12-13 | 1987-07-22 | ||
JPS63175842U (ja) * | 1987-05-06 | 1988-11-15 | ||
JPH07270316A (ja) * | 1994-03-31 | 1995-10-20 | Shimadzu Corp | 赤外線ガス分析装置 |
US20070273882A1 (en) * | 2006-05-26 | 2007-11-29 | Spectrasensors, Inc. | Measuring trace components of complex gases using gas chromatography/absorption spectrometry |
JP2009204397A (ja) * | 2008-02-27 | 2009-09-10 | Shimadzu Corp | クロマトグラフ用データ処理装置 |
JP2012230011A (ja) * | 2011-04-26 | 2012-11-22 | Iwata Dengyo Kk | ガス分析装置、及び当該ガス分析装置を用いたガスセルの圧力又は流量の制御方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470676A (en) * | 1967-05-15 | 1969-10-07 | Perkin Elmer Corp | Elution chromatographic apparatus and method |
US3735565A (en) * | 1971-05-06 | 1973-05-29 | Wilks Scientific Corp | Enrichment of chromatograph output |
US4587835A (en) | 1985-01-09 | 1986-05-13 | International Business Machines Corp. | Light pipe and heater apparatus |
FR2587507B1 (fr) | 1985-09-16 | 1987-12-11 | Regma | Station d'exposition et appareil de reproduction d'originaux par diazocopie comportant ladite station |
JPS63175842A (ja) | 1987-01-17 | 1988-07-20 | Asahi Denki Seisakusho:Kk | カメラ |
US5039614A (en) | 1988-06-16 | 1991-08-13 | Armenag Dekmezian | Method and apparatus for collecting samples for analysis of chemical composition |
WO1993003493A1 (en) | 1991-08-01 | 1993-02-18 | The Dow Chemical Company | Interfacing liquid chromatograph and fourier transform |
JP2003014635A (ja) | 2001-06-28 | 2003-01-15 | Ishikawajima Harima Heavy Ind Co Ltd | So3,nh3同時連続濃度計 |
WO2005070291A1 (en) * | 2004-01-08 | 2005-08-04 | Inlight Solutions, Inc. | Noninvasive determination of alcohol in tissue |
EP1719958B1 (en) | 2004-02-13 | 2016-04-20 | GL Sciences Incorporated | Direct heating tube and method of heating fluid using the same |
CA2616164A1 (en) * | 2005-07-25 | 2007-02-01 | Metanomics Gmbh | Means and methods for analyzing a sample by means of chromatography-mass spectrometry |
CN100471445C (zh) * | 2005-08-01 | 2009-03-25 | 周常安 | 贴片式生理监测装置 |
KR20090094377A (ko) * | 2006-12-19 | 2009-09-04 | 바스프 코팅스 악티엔게젤샤프트 | 높은 내스크래치성 및 풍화 안정성을 갖는 코팅제 |
FR2910966B1 (fr) * | 2006-12-28 | 2009-04-17 | Commissariat Energie Atomique | Dispositif de mesures couplees permettant un suivi global et en continu de traces de goudrons presentes dans un flux gazeux |
US20100285446A1 (en) * | 2007-07-20 | 2010-11-11 | Akos Vertes | Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry |
US7884318B2 (en) * | 2008-01-16 | 2011-02-08 | Metabolon, Inc. | Systems, methods, and computer-readable medium for determining composition of chemical constituents in a complex mixture |
US20100050737A1 (en) * | 2008-09-01 | 2010-03-04 | Andrew Mark Wolters | Separation technology method and identification of error |
EP2322922B1 (en) | 2009-08-26 | 2015-02-25 | Thermo Fisher Scientific (Bremen) GmbH | Method of improving the resolution of compounds eluted from a chromatography device |
JP2011237311A (ja) * | 2010-05-12 | 2011-11-24 | Shimadzu Corp | クロマトグラフ質量分析用データ処理装置 |
US8645082B2 (en) * | 2010-09-13 | 2014-02-04 | Mks Instruments, Inc. | Monitoring, detecting and quantifying chemical compounds in a sample |
WO2013022771A1 (en) * | 2011-08-05 | 2013-02-14 | Smiths Detection Inc. | Chemical identification using a chromatography retention index |
US9594063B2 (en) * | 2012-03-16 | 2017-03-14 | National Research Council Of Canada | Retention index standards for liquid chromatography |
WO2014144074A1 (en) * | 2013-03-15 | 2014-09-18 | Smiths Detection Inc. | Mass spectrometry (ms) identification algorithm |
JP2014206510A (ja) * | 2013-04-15 | 2014-10-30 | 株式会社堀場エステック | ガスクロマトグラフ用データ処理装置、データ処理方法、及び、データ処理用プログラム |
FR3008797A1 (fr) * | 2013-07-19 | 2015-01-23 | Total Sa | Procede d'identification de composes d'un melange organique et kit pour la mise en oeuvre de ce procede |
-
2015
- 2015-03-17 KR KR1020167028518A patent/KR20160132467A/ko unknown
- 2015-03-17 AU AU2015231494A patent/AU2015231494A1/en not_active Abandoned
- 2015-03-17 EP EP15715892.4A patent/EP3120141A1/en not_active Withdrawn
- 2015-03-17 CA CA2940429A patent/CA2940429A1/en not_active Abandoned
- 2015-03-17 US US14/660,574 patent/US9606088B2/en active Active
- 2015-03-17 WO PCT/US2015/021046 patent/WO2015142906A1/en active Application Filing
- 2015-03-17 CN CN201580014461.7A patent/CN106461542A/zh active Pending
- 2015-03-17 JP JP2017501084A patent/JP2017509901A/ja active Pending
-
2017
- 2017-02-15 US US15/433,016 patent/US10054486B2/en active Active
-
2018
- 2018-08-01 US US16/051,904 patent/US10551249B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62115143U (ja) * | 1985-12-13 | 1987-07-22 | ||
JPS63175842U (ja) * | 1987-05-06 | 1988-11-15 | ||
JPH07270316A (ja) * | 1994-03-31 | 1995-10-20 | Shimadzu Corp | 赤外線ガス分析装置 |
US20070273882A1 (en) * | 2006-05-26 | 2007-11-29 | Spectrasensors, Inc. | Measuring trace components of complex gases using gas chromatography/absorption spectrometry |
JP2009204397A (ja) * | 2008-02-27 | 2009-09-10 | Shimadzu Corp | クロマトグラフ用データ処理装置 |
JP2012230011A (ja) * | 2011-04-26 | 2012-11-22 | Iwata Dengyo Kk | ガス分析装置、及び当該ガス分析装置を用いたガスセルの圧力又は流量の制御方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021009031A (ja) * | 2019-06-28 | 2021-01-28 | 株式会社堀場製作所 | 分析装置及び分析方法 |
Also Published As
Publication number | Publication date |
---|---|
US10551249B2 (en) | 2020-02-04 |
US20170160136A1 (en) | 2017-06-08 |
KR20160132467A (ko) | 2016-11-18 |
US10054486B2 (en) | 2018-08-21 |
WO2015142906A1 (en) | 2015-09-24 |
AU2015231494A1 (en) | 2016-09-01 |
CA2940429A1 (en) | 2015-09-24 |
CN106461542A (zh) | 2017-02-22 |
US20150260695A1 (en) | 2015-09-17 |
EP3120141A1 (en) | 2017-01-25 |
US20190017873A1 (en) | 2019-01-17 |
US9606088B2 (en) | 2017-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10551249B2 (en) | Process and system for sample analysis | |
US10401336B2 (en) | Method and system for low temperature detection of semi volatile organic compounds | |
US11852617B2 (en) | Thermal desorption tube collection system and method | |
EP2909600B1 (en) | Vacuum ultraviolet absorption spectroscopy system | |
US11733159B2 (en) | Analysis system and method employing thermal desorption and spectrometric analysis | |
US11680894B2 (en) | Local and global peak matching | |
US11828739B2 (en) | Large volume gas chromatography injection port | |
US20170341056A1 (en) | GC-FTIR and Mode of Operation to Address Water Interference | |
RU160148U1 (ru) | Ик-спектрометрическая ячейка для определения легколетучих органических жидкостей в смесях с водой | |
US10677767B2 (en) | Vacuum ultraviolet absorption spectroscopy system and method | |
US10802004B2 (en) | Analytics system and user interface therefor | |
Yoon et al. | Detachable Trap Preconcentrator with a Gas Chromatograph–Mass Spectrometer for the Analysis of Trace Halogenated Greenhouse Gases | |
Graham et al. | Solubility of pt-butylcalixarenes in supercritical carbon dioxide: a comparison of static and dynamic measurement techniques | |
Gocan et al. | Compound identification in thin-layer chromatography using spectrometric methods | |
Tarleton | Analytic Methods fo the Bioactive Compounds in Waste | |
Lancaster et al. | Quantitation of trace components in liquid process streams by direct liquid sampling mass spectrometry | |
Mengali et al. | GC-QEPAS: A Mems-Enabled Portable Trace Chemical Sensor for Safety & Security Applications | |
Griffiths | Automated Measurements of Infrared Spectra of Chromatographically Separated Fractions | |
Heaven | NN1 3BH, UK; Tel/Fax:(0) 1604 250221; e-mail |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161118 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180223 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180223 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190129 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190219 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190516 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190701 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20190725 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20190725 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190910 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191112 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20200804 |