JP2017039706A - Hydrocolloid type adhesive composition for skin patches, and patches using the same - Google Patents
Hydrocolloid type adhesive composition for skin patches, and patches using the same Download PDFInfo
- Publication number
- JP2017039706A JP2017039706A JP2016154321A JP2016154321A JP2017039706A JP 2017039706 A JP2017039706 A JP 2017039706A JP 2016154321 A JP2016154321 A JP 2016154321A JP 2016154321 A JP2016154321 A JP 2016154321A JP 2017039706 A JP2017039706 A JP 2017039706A
- Authority
- JP
- Japan
- Prior art keywords
- adhesive composition
- hydrocolloid
- water absorption
- skin
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 84
- 239000000853 adhesive Substances 0.000 title claims abstract description 63
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 63
- 239000000416 hydrocolloid Substances 0.000 title claims abstract description 62
- 239000007933 dermal patch Substances 0.000 title abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 103
- 238000010521 absorption reaction Methods 0.000 claims abstract description 55
- 239000002245 particle Substances 0.000 claims abstract description 39
- 239000012153 distilled water Substances 0.000 claims abstract description 31
- 229920001971 elastomer Polymers 0.000 claims abstract description 25
- 229920005989 resin Polymers 0.000 claims abstract description 19
- 239000011347 resin Substances 0.000 claims abstract description 19
- 239000004014 plasticizer Substances 0.000 claims abstract description 16
- 239000000806 elastomer Substances 0.000 claims abstract description 13
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 59
- 239000000463 material Substances 0.000 claims description 30
- 239000002504 physiological saline solution Substances 0.000 claims description 26
- 239000010410 layer Substances 0.000 claims description 19
- 239000012790 adhesive layer Substances 0.000 claims description 13
- 239000005060 rubber Substances 0.000 claims description 12
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 10
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 9
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 9
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 229920006132 styrene block copolymer Polymers 0.000 claims description 6
- 239000000084 colloidal system Substances 0.000 claims description 5
- 238000006266 etherification reaction Methods 0.000 claims description 4
- 239000012266 salt solution Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 16
- 238000000034 method Methods 0.000 description 10
- 206010052428 Wound Diseases 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 229920001342 Bakelite® Polymers 0.000 description 8
- 239000004637 bakelite Substances 0.000 description 8
- 229940105329 carboxymethylcellulose Drugs 0.000 description 8
- 238000007654 immersion Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 239000000123 paper Substances 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 229920001400 block copolymer Polymers 0.000 description 4
- 238000002788 crimping Methods 0.000 description 4
- -1 fatty acid ester Chemical class 0.000 description 4
- 239000012943 hotmelt Substances 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 150000003505 terpenes Chemical class 0.000 description 4
- 235000007586 terpenes Nutrition 0.000 description 4
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000010030 laminating Methods 0.000 description 3
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- 230000035699 permeability Effects 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 229920002367 Polyisobutene Polymers 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 239000011086 glassine Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920001083 polybutene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920006264 polyurethane film Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- MSFGZHUJTJBYFA-UHFFFAOYSA-M sodium dichloroisocyanurate Chemical compound [Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O MSFGZHUJTJBYFA-UHFFFAOYSA-M 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 2
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- KPAPHODVWOVUJL-UHFFFAOYSA-N 1-benzofuran;1h-indene Chemical compound C1=CC=C2CC=CC2=C1.C1=CC=C2OC=CC2=C1 KPAPHODVWOVUJL-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 229930185605 Bisphenol Natural products 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 206010007269 Carcinogenicity Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000984084 Helianthemum nummularium subsp. grandiflorum Species 0.000 description 1
- 239000013032 Hydrocarbon resin Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 206010048629 Wound secretion Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- WMNULTDOANGXRT-UHFFFAOYSA-N bis(2-ethylhexyl) butanedioate Chemical compound CCCCC(CC)COC(=O)CCC(=O)OCC(CC)CCCC WMNULTDOANGXRT-UHFFFAOYSA-N 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 230000007670 carcinogenicity Effects 0.000 description 1
- 231100000260 carcinogenicity Toxicity 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000012897 dilution medium Substances 0.000 description 1
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- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
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- 230000007794 irritation Effects 0.000 description 1
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- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
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- 229920002742 polystyrene-block-poly(ethylene/propylene) -block-polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
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Landscapes
- Adhesive Tapes (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
本発明は、皮膚貼付用ハイドロコロイド型粘着剤組成物に関し、特に創傷用処置剤として好適な皮膚貼付用ハイドロコロイド型粘着剤組成物、及びこれを用いた貼付材に関する。 The present invention relates to a hydrocolloid pressure-sensitive adhesive composition for skin application, and more particularly, to a hydrocolloid-type pressure-sensitive adhesive composition for skin application suitable as a wound treatment agent, and a patch using the same.
ハイドロコロイド型粘着剤は、それ自体が粘着性を有し、治癒過程で滲出する創傷分泌物を吸収し、且つ湿潤状態を保持することにより、良好な創傷治癒効果を示すとして近年その重要性が増している。 Hydrocolloid adhesives are becoming more and more important in recent years as having good wound healing effects by adhering to themselves, absorbing wound secretions that exude during healing, and maintaining a moist condition. ing.
一般に、ハイドロコロイド型粘着剤は、可塑性ゴムからなる連続相（母材）に吸水性のコロイド粒子（吸水剤）が分散して存在している構造を有し、その多くは、一定時間で自重の３〜５倍程度の水又は創傷部位からの滲出液を吸収し得るように調製されている。水等を吸水してもその母材が一体性を失うことがないよう、且つ、所望の粘着性を発揮できるよう、ゴム成分を種々検討した提案がなされている（例えば特許文献１）。また、近年、環境ホルモン作用や発がん性の疑いが持たれるＤＯＰやＤＯＡ等の可塑剤を替えた場合においても、十分な吸水量・吸水速度の調整ができる、新たな可塑剤の使用を検討した提案もなされている（例えば特許文献２）。さらに、ハイドロコロイド型粘着剤を貼付材、とりわけ救急絆創膏のパッドへの適用を検討した提案もなされている（例えば特許文献３）。 In general, hydrocolloid pressure-sensitive adhesives have a structure in which water-absorbing colloidal particles (water-absorbing agent) are dispersed in a continuous phase (base material) made of plastic rubber, and many of them are self-weight in a certain time. It is prepared to absorb about 3 to 5 times as much water or exudate from a wound site. Various proposals have been made on rubber components so that the base material does not lose its integrity even when water or the like is absorbed, and the desired adhesiveness can be exhibited (for example, Patent Document 1). In addition, in recent years, even when plasticizers such as DOP and DOA, which are suspected of environmental hormone action and carcinogenicity, have been changed, the use of a new plasticizer that can adjust the amount of water absorption and absorption speed has been examined. Proposals have also been made (for example, Patent Document 2). Furthermore, proposals have also been made in which application of hydrocolloid pressure-sensitive adhesives to patches, particularly emergency adhesive bandages, is examined (for example, Patent Document 3).
これらハイドロコロイド型粘着剤や該粘着剤を用いた創傷材は、創面に貼付された際、基材との一体性や、皮膚等への実用的な粘着性能を保持するものである。しかしながら、入浴や発汗等により、水濡れや浸水した場合も、貼付性に問題が生じないことが求められている。従来のハイドロコロイド組成物は、貼付部位の湿潤環境を保つために、浸出液を吸収する能力について重点的に検討されてきた。しかし、水と浸出液の吸水性が異なることについては考えられてこなかった。 These hydrocolloid pressure-sensitive adhesives and wound materials using the pressure-sensitive adhesives maintain the integrity with the base material and the practical pressure-sensitive adhesive performance to the skin when applied to the wound surface. However, it is demanded that no problem arises in the sticking property even when wet or submerged by bathing or sweating. Conventional hydrocolloid compositions have been focused on their ability to absorb leachate in order to maintain a moist environment at the site of application. However, it has not been considered that water absorbs water and leachate.
本発明の目的は、上記の課題を解決した皮膚貼付用ハイドロコロイド型粘着剤組成物、すなわち、水濡れや浸水後であっても粘着性能の低下を抑制し、快適な貼付を可能にする皮膚貼付用ハイドロコロイド型粘着剤組成物を提供することにある。 An object of the present invention is to provide a hydrocolloid pressure-sensitive adhesive composition for skin application that solves the above-described problems, that is, skin application that suppresses a decrease in adhesive performance even after being wet or immersed, and enables comfortable application. It is to provide a hydrocolloid pressure-sensitive adhesive composition.
本発明者らは上記課題に対して鋭意研究を行なった結果、貼付材に用いられる粘着剤組成物として、単位体積当たりの蒸留水の吸水量が生理食塩水の吸水量と同等か、蒸留水よりも生理食塩水の吸水量が多いものを採用することにより、浸出液を吸収する性能を保持しつつ、所望の粘着性を有し、水に濡れた後であっても粘着性能の低下を抑制することができる貼付材を提供し得ることを見出し、本発明を完成させた。 As a result of diligent research on the above problems, the present inventors have found that the water absorption amount of distilled water per unit volume is equal to the water absorption amount of physiological saline as the pressure-sensitive adhesive composition used for the patch, or distilled water. By adopting a material that absorbs more saline than water, while maintaining the ability to absorb leachate, it has the desired adhesiveness and suppresses the deterioration of adhesive performance even after it gets wet The present inventors have found that a patch that can be used can be provided, and have completed the present invention.
本発明は、下記の構成であり、これにより本発明の上記課題が解決される。 The present invention has the following configuration, which solves the above-described problems of the present invention.
[１]
（Ａ）エラストマー、
（Ｂ）粘着付与樹脂、
（Ｃ）可塑剤、及び
（Ｄ）コロイド粒子を含有する皮膚貼付用ハイドロコロイド型粘着剤組成物であって該皮膚貼付用ハイドロコロイド型粘着剤組成物の、単位体積当たりの蒸留水の吸水量を（Ｘ）とし、単位体積当たりの生理食塩水の吸水量を（Ｙ）とした場合に、以下の式（１）を満たす皮膚貼付用ハイドロコロイド型粘着剤組成物。
式（１） 蒸留水の吸水量（Ｘ） ≦ 生理食塩水の吸水量（Ｙ）
[２]
前記（Ｄ）コロイド粒子が、コロイド粒子の単位重量当たりの蒸留水の吸水量を（Ｘｄ）とし、単位重量当たりの生理食塩水の吸水量を（Ｙｄ）とした場合に、以下の式（３）を満たすコロイド粒子である、[１]に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物。
式（３） 蒸留水の吸水量（Ｘｄ） ≦ 生理食塩水の吸水量（Ｙｄ）
[３]
前記（Ｄ）コロイド粒子が、粒径が１〜５００μｍ、エーテル化度が０．５５〜１．０５のカルボキシメチルセルロースを含む、[１]又は[２]に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物。
[４]
前記（Ｄ）コロイド粒子の含有量は、前記皮膚貼付用ハイドロコロイド型粘着剤組成物の全質量に対して１０質量％〜５０質量％である、[１]〜[３]のいずれか一項に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物。
[５]
前記（Ａ）エラストマーは、スチレン系ブロック共重合体及び液状ゴムを含む、[１]〜[４]のいずれか一項に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物。
[６]
前記（Ｃ）可塑剤の含有量は、前記皮膚貼付用ハイドロコロイド型粘着剤組成物の全質量に対して０．５質量〜６０質量％である、[１]〜[５]のいずれか一項に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物。
[７]
基材と、該基材の少なくとも一方の面に粘着剤層を有し、該粘着剤層が、[１]〜[６]のいずれか一項に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物を用いて形成された、貼付材。
[８]
基材と、粘着層と、パッド層とをこの順に有し、該パッド層が、[１]〜[６]のいずれか一項に記載の皮膚貼付用ハイドロコロイド型粘着剤組成物を含む、
貼付材。
[1]
(A) an elastomer,
(B) a tackifying resin,
(C) A hydrocolloid-type pressure-sensitive adhesive composition for skin application containing a plasticizer and (D) colloidal particles, and the water absorption of distilled water per unit volume of the hydrocolloid-type pressure-sensitive adhesive composition for skin application ( A hydrocolloid-type pressure-sensitive adhesive composition for skin application satisfying the following formula (1), where X) is the amount of physiological saline absorbed per unit volume: (Y).
Formula (1) Water absorption amount of distilled water (X) ≦ Water absorption amount of physiological saline (Y)
[2]
When the colloidal particles (D) have a water absorption amount of distilled water per unit weight of the colloidal particles as (Xd) and a water absorption amount of physiological saline per unit weight as (Yd), the following equation (3) The hydrocolloid-type pressure-sensitive adhesive composition for skin application according to [1], which is a colloidal particle satisfying 2).
Formula (3) Water absorption of distilled water (Xd) ≦ Water absorption of physiological saline (Yd)
[3]
The hydrocolloid pressure-sensitive adhesive composition for skin application according to [1] or [2], wherein the (D) colloidal particles contain carboxymethylcellulose having a particle size of 1 to 500 μm and a degree of etherification of 0.55 to 1.05. object.
[4]
Content of the said (D) colloid particle is 10 mass%-50 mass% with respect to the total mass of the said hydrocolloid type adhesive composition for skin sticking, It is any one of [1]-[3]. The hydrocolloid pressure-sensitive adhesive composition for skin application as described.
[5]
The hydrocolloid pressure-sensitive adhesive composition for skin application according to any one of [1] to [4], wherein the (A) elastomer includes a styrene block copolymer and a liquid rubber.
[6]
Content of said (C) plasticizer is 0.5 mass-60 mass% with respect to the total mass of the said hydrocolloid type adhesive composition for skin sticking, Any one of [1]-[5] A hydrocolloid pressure-sensitive adhesive composition for skin application as described in 1.
[7]
A hydrocolloid pressure-sensitive adhesive composition for skin application according to any one of [1] to [6], comprising a base material and a pressure-sensitive adhesive layer on at least one surface of the base material. A patch made of
[8]
It has a base material, an adhesive layer, and a pad layer in this order, and the pad layer contains the hydrocolloid adhesive composition for skin application according to any one of [1] to [6].
Patch material.
本発明は、浸出液を吸収する能力を持ちながら、水濡れや浸水後であっても粘着性能の低下を抑制することができる皮膚貼付用ハイドロコロイド型粘着剤組成物を提供できる。
従って、本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物（以下、単に「粘着剤組成物」と称する場合がある）を用いた貼付材は、創傷部位に貼付した場合に治癒過程で滲出する創傷分泌物を吸収し、且つ湿潤状態を保持して良好な創傷治癒効果を示す。また、シャワー等を浴びた場合の水濡れや、入浴等による浸水後であっても、ハイドロコロイドが膨潤しにくいか、又は溶出しにくいことにより、貼付材が剥がれにくいことが期待できる。
そしてこの粘着剤組成物を用いた貼付材は救急絆創膏やドレッシング材等の医療・衛生分野への展開が期待できる。
INDUSTRIAL APPLICABILITY The present invention can provide a hydrocolloid-type pressure-sensitive adhesive composition for skin application that has the ability to absorb a leachate and can suppress a decrease in pressure-sensitive adhesive performance even after being wetted or immersed.
Therefore, the patch using the hydrocolloid adhesive composition for skin application of the present invention (hereinafter sometimes simply referred to as “adhesive composition”) is a wound that exudes during the healing process when applied to a wound site. It absorbs secretions and maintains a moist state to show a good wound healing effect. In addition, it can be expected that the patch is difficult to peel off because the hydrocolloid is difficult to swell or dissolve even after being soaked in a shower or the like or after being immersed in a bath or the like.
And the adhesive material using this adhesive composition can be expected to be developed in the medical and hygiene fields such as emergency bandages and dressings.
＜皮膚貼付用ハイドロコロイド型粘着剤組成物＞
本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物は、（Ａ）エラストマー、（Ｂ）粘着付与樹脂、（Ｃ）可塑剤、及び（Ｄ）コロイド粒子を含有し、該皮膚貼付用ハイドロコロイド型粘着剤組成物の、単位体積当たりの蒸留水の吸水量を（Ｘ）とし、単位体積当たりの生理食塩水の吸水量を（Ｙ）とした場合に、以下の式（１）を満たす。
式（１） 蒸留水の吸水量（Ｘ） ≦ 生理食塩水の吸水量（Ｙ）
本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物は、所望によりその他の成分を含み得る。
<Hydrocolloid adhesive composition for skin application>
The hydrocolloid pressure-sensitive adhesive composition for skin patch of the present invention contains (A) an elastomer, (B) a tackifier resin, (C) a plasticizer, and (D) colloid particles, and the hydrocolloid-type pressure-sensitive adhesive for skin patch When the water absorption of distilled water per unit volume of the composition is (X) and the water absorption of physiological saline per unit volume is (Y), the following formula (1) is satisfied.
Formula (1) Water absorption amount of distilled water (X) ≦ Water absorption amount of physiological saline (Y)
The hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention may contain other components as desired.
［皮膚貼付用ハイドロコロイド型粘着剤組成物の吸水量］
本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物の吸水量は、皮膚貼付用ハイドロコロイド型粘着剤組成物を、温度３７℃の蒸留水又は生理食塩水中に２４時間浸漬し、その前後の質量から算出したものであり、皮膚貼付用ハイドロコロイド型粘着剤組成物を粘着剤層とした後述の貼付材を用いて算出することもできる。
本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物は、皮膚貼付用ハイドロコロイド型粘着剤組成物の、単位体積当たりの蒸留水の吸水量を（Ｘ）とし、単位体積当たりの生理食塩水の吸水量を（Ｙ）とした場合に、以下の式（１）を満たす。
式（１） 蒸留水の吸水量（Ｘ） ≦ 生理食塩水の吸水量（Ｙ）
本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物は、蒸留水の吸水量（Ｘ）よりも生理食塩水の吸水量（Ｙ）が多いことが特徴である。
単位体積当たりの蒸留水の吸水量（Ｘ）よりも生理食塩水の吸水量（Ｙ）が多いことにより、浸出液等の体液を吸収することができる一方で、シャワーなどの水については吸水量を抑えることができるために、水を含むことによるハイドロコロイドの溶解を防ぐことができる。
[Water absorption of hydrocolloid adhesive composition for skin application]
The water absorption of the hydrocolloid adhesive composition for skin application of the present invention is calculated from the mass before and after immersing the hydrocolloid adhesive composition for skin application in distilled water or physiological saline at a temperature of 37 ° C. for 24 hours. It can also be calculated using a patch described later using the hydrocolloid pressure-sensitive adhesive composition for skin patch as a pressure-sensitive adhesive layer.
The hydrocolloid pressure-sensitive adhesive composition for skin patch of the present invention has a water absorption amount of physiological saline per unit volume, wherein the water absorption amount of distilled water per unit volume of the hydrocolloid pressure-sensitive adhesive composition for skin patch is (X). (Y) is satisfied, the following formula (1) is satisfied.
Formula (1) Water absorption amount of distilled water (X) ≦ Water absorption amount of physiological saline (Y)
The hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention is characterized in that the amount of water absorbed in physiological saline (Y) is larger than the amount of water absorbed in distilled water (X).
While the amount of absorbed water (Y) in physiological saline is larger than the amount of absorbed water (X) in distilled water per unit volume, body fluids such as leachate can be absorbed. Since it can suppress, melt | dissolution of the hydrocolloid by containing water can be prevented.
また、単位重量当たりの蒸留水の吸水量≦単位重量当たりの生理食塩水の吸水量の関係式（後述の式（３））を満たす（Ｄ）コロイド粒子を含むことにより、式（１）を満たす皮膚貼付用ハイドロコロイド型粘着剤組成物とすることができる。皮膚貼付用ハイドロコロイド型粘着剤組成物の体積１ｃｍ３あたりの蒸留水の吸水量は、体積１ｃｍ３の皮膚貼付用ハイドロコロイド型粘着剤組成物を、温度３７℃の蒸留水又は生理食塩水中に２４時間浸漬し、浸漬前と浸漬後の質量から算出できる。該吸水量は、用いる（Ｄ）コロイド粒子の種類及び配合量により制御することができ、５ｇ/ｃｍ３以下であることが好ましく、３ｇ/ｃｍ３以下であることがさらに好ましい。生理食塩水の吸水量は、３〜８ｇ/ｃｍ３であることが好ましく、４．０〜６．５ｇ/ｃｍ３であることがさらに好ましい。 Further, by containing colloidal particles (D) satisfying the relational expression (absorbed amount of distilled water per unit weight) ≦ absorbed amount of physiological saline per unit weight (formula (3) described later), It can be set as the hydrocolloid type adhesive composition for skin patches which satisfy | fills. The water absorption of distilled water per volume 1 cm 3 of a skin patch for hydrocolloid adhesive composition is 24 hours for application to the skin hydrocolloid adhesive composition of the volume of 1 cm 3, in distilled water or saline water at a temperature 37 ° C. It is immersed and can be calculated from the mass before and after immersion. The amount of water absorption can be controlled by the type and blending amount of the (D) colloidal particles to be used, preferably 5 g / cm 3 or less, more preferably 3 g / cm 3 or less. The water absorption of saline is preferably 3 to 8 g / cm 3, further preferably 4.0~6.5g / cm 3.
皮膚貼付用ハイドロコロイド型粘着剤組成物の体積１ｃｍ３あたりの生理食塩水の吸水量を（Ｙ１）、皮膚貼付用ハイドロコロイド型粘着剤組成物の体積１ｃｍ３あたりの蒸留水の吸水量を（Ｘ１）とした場合に、生理食塩水と蒸留水の吸水量差は、下記式（２）により求めることができる。
式（２） 生理食塩水の吸水量（Ｙ１） ― 蒸留水の吸水量（Ｘ１）＝吸水量差（Ｚ１）
上記吸水量差（Ｚ１）は ０．５〜６ｇ/ｃｍ３であることが好ましく、１〜３.５ｇ/ｃｍ３であることがより好ましい、ここで、（Ｘ１）は５ｇ/ｃｍ３以下、特に好ましくは３ｇ/ｃｍ３以下であり、かつ（Ｙ１）が１ｇ/ｃｍ３以上好ましくは１．４ｇ/ｃｍ３以上であれば、貼付材として水の吸収量が少なく、浸出液を十分に吸収することができ、好ましい。
なお、貼付材に用いられた皮膚貼付用ハイドロコロイド型粘着剤組成物の体積は、
”粘着剤層の厚さ”×”皮膚に接触可能な粘着剤組成物の面積”
により算出できる。
以下、上記各成分について詳述する。
The amount of physiological saline water absorption per 1 cm 3 of the hydrocolloid adhesive composition for skin application (Y1), and the amount of distilled water absorption 1 cm 3 of the hydrocolloid adhesive composition for skin application (X1) In this case, the difference in water absorption between physiological saline and distilled water can be obtained by the following formula (2).
Formula (2) Water absorption amount of physiological saline (Y1) —Water absorption amount of distilled water (X1) = Water absorption difference (Z1)
Preferably the water absorption amount difference (Z1) is 0.5~6g / cm 3, more preferably 1~3.5g / cm 3, wherein, (X1) is 5 g / cm 3 or less, Particularly preferably, it is 3 g / cm 3 or less, and (Y1) is 1 g / cm 3 or more, preferably 1.4 g / cm 3 or more, the amount of water absorbed as a patch is small, and the exudate is sufficiently absorbed. Can be preferred.
The volume of the hydrocolloid pressure-sensitive adhesive composition for skin patch used for the patch is:
"Adhesive layer thickness" x "Area of adhesive composition that can contact skin"
Can be calculated.
Hereafter, each said component is explained in full detail.
［（Ａ）エラストマー］
本発明において使用するエラストマーは、従来より使用されているエラストマーであれば特に限定されないが、好適には、スチレン系ブロック共重合体及び液状ゴムを含む。
前記スチレン系ブロック共重合体としては、スチレン・ブタジエンブロック共重合体（ＳＢＳ）及びその水添ゴム（ＳＥＢＳ）、スチレン・イソプレンブロック共重合体（ＳＩＳ）及びその水添ゴム（ＳＥＰＳ）、スチレン・イソブチレンブロック共重合体（ＳＩＢＳ）などが挙げられ、これらの１種あるいは複数を組合せて使用することができる。これらの中でも、ＳＩＳ及びＳＥＢＳが更に好ましく、特に好ましくはＳＩＳが用いられる。
[(A) Elastomer]
The elastomer used in the present invention is not particularly limited as long as it is a conventionally used elastomer, but preferably includes a styrene block copolymer and a liquid rubber.
Examples of the styrenic block copolymer include styrene / butadiene block copolymer (SBS) and its hydrogenated rubber (SEBS), styrene / isoprene block copolymer (SIS) and its hydrogenated rubber (SEPS), styrene · An isobutylene block copolymer (SIBS) etc. are mentioned, These can be used 1 type or in combination. Among these, SIS and SEBS are more preferable, and SIS is particularly preferably used.
また、前記液状ゴムとしては、液状ポリイソプレン（ＬＩＲ）や液状ポリブタジエン（ＬＰＢ）、ポリイソブチレン（ＰＩＢ）、ポリブテン（ＰＢ）などの液状エラストマー成分を挙げることができる。 Examples of the liquid rubber include liquid elastomer components such as liquid polyisoprene (LIR), liquid polybutadiene (LPB), polyisobutylene (PIB), and polybutene (PB).
スチレン系ブロック共重合体と液状ゴムは、好ましくは質量比でスチレン系ブロック共重合体：液状ゴム＝２０〜８０：８０〜２０、特に好ましくは５０〜８０：５０〜２０の割合で使用することが望ましい。
本発明において、（Ａ）エラストマーの含有量は、粘着剤組成物全成分の総質量に対して、２０質量％〜６０質量％であることが好ましく、３０質量％〜４５質量％であることがより好ましい。
The styrene block copolymer and the liquid rubber are preferably used in a mass ratio of styrene block copolymer: liquid rubber = 20 to 80:80 to 20, particularly preferably 50 to 80:50 to 20. Is desirable.
In the present invention, the content of the (A) elastomer is preferably 20% by mass to 60% by mass, and preferably 30% by mass to 45% by mass with respect to the total mass of all components of the pressure-sensitive adhesive composition. More preferred.
［（Ｂ）粘着付与樹脂］
本発明において使用する粘着付与樹脂としては、一般に疎水性ゴムベース成分と相溶して粘着性を発現させる疎水性の樹脂であり、具体的にはロジン樹脂、ロジンエステル樹脂、テルペン樹脂、テルペンフェノール樹脂、Ｃ５系石油系樹脂、Ｃ５／Ｃ９系石油系樹脂、ＤＣＰＤ系石油系樹脂、クマロン・インデン樹脂、またこれらの水添物などが挙げられる。
成分（Ｂ）の粘着付与樹脂の具体例としては、例えば、脂環族飽和炭化水素樹脂のアルコン（登録商標）Ｐ−１２５（荒川化学工業）、水添テルペン樹脂のクリアロン（登録商標）Ｐ１５０（ヤスハラケミカル（株））などが挙げられる。
上記粘着付与樹脂は、剥離時の皮膚への刺激性を考慮して、例えば上記クリアロンＰ１５０であれば粘着剤組成物の全エラストマー成分の１００質量部に対して２０質量部乃至２００質量部、好ましくは５０質量部乃至１８０質量部の量で存在していることが好ましい。
[(B) Tackifying resin]
The tackifying resin used in the present invention is generally a hydrophobic resin that is compatible with a hydrophobic rubber base component and develops tackiness. Specifically, rosin resin, rosin ester resin, terpene resin, terpene phenol resins, C 5 petroleum resins, C 5 / C 9 petroleum resins, DCPD-based petroleum resins, coumarone-indene resins, also like those hydrogenated products.
Specific examples of the tackifying resin of component (B) include, for example, alicyclic saturated hydrocarbon resin Alcon (registered trademark) P-125 (Arakawa Chemical Industries), hydrogenated terpene resin Clearon (registered trademark) P150 ( Yasuhara Chemical Co., Ltd.).
In consideration of irritation to the skin at the time of peeling, the tackifier resin is, for example, Clearon P150, preferably 20 parts by mass to 200 parts by mass with respect to 100 parts by mass of all elastomer components of the adhesive composition. Is preferably present in an amount of 50 to 180 parts by weight.
［（Ｃ）可塑剤］
本発明において使用する可塑剤（軟化剤）としては、パラフィン系、ナフテン系、等の石油系プロセスオイルやひまし油、大豆油などの植物油、及び植物油由来の脂肪酸エステルなどの軟化剤を使用してもよい。また、フタル酸、イソフタル酸、テレフタル酸等の芳香族ジカルボン酸や、コハク酸、グルタル酸、アジピン酸、ピメリン酸、スベリン酸、アゼライン酸、セバシン酸等の脂肪族ジカルボン酸と、例えば炭素原子数８乃至１０程度のアルキル基を有するモノアルコールとの二塩基酸エステル系可塑剤；前記香族ジカルボン酸や脂肪族ジカルボン酸とエチレングリコール、プロピレングリコール、ブチレングリコール、ネオペンチルグリコール、ジエチレングリコール等のグリコールとの重縮合により得られるポリエステル系可塑剤；ポリエチレングリコール、クエン酸エステル等のその他の可塑剤なども使用することができる。これら２つ以上を併用することもできる。
本発明において、成分（Ｃ）の可塑剤は、粘着剤組成物全成分の総質量に対して、０．５質量％〜６０質量％であることが好ましく、１１質量％〜４５質量％であることがより好ましい。
[(C) Plasticizer]
The plasticizer (softener) used in the present invention may be a paraffinic or naphthenic petroleum process oil, a castor oil, a vegetable oil such as soybean oil, or a softener such as a fatty acid ester derived from a vegetable oil. Good. In addition, aromatic dicarboxylic acids such as phthalic acid, isophthalic acid and terephthalic acid, and aliphatic dicarboxylic acids such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid and sebacic acid, and the number of carbon atoms, for example Dibasic acid ester plasticizer with monoalcohol having about 8 to 10 alkyl groups; the above-mentioned aromatic dicarboxylic acid or aliphatic dicarboxylic acid and glycols such as ethylene glycol, propylene glycol, butylene glycol, neopentyl glycol, diethylene glycol and the like; Polyester plasticizers obtained by polycondensation of polyethylene; other plasticizers such as polyethylene glycol and citrate can also be used. Two or more of these can be used in combination.
In the present invention, the plasticizer of the component (C) is preferably 0.5% by mass to 60% by mass, and 11% by mass to 45% by mass with respect to the total mass of all components of the pressure-sensitive adhesive composition. It is more preferable.
［（Ｄ）コロイド粒子］
本発明において使用するコロイド粒子としては、特に制限はないが、例えば、コーンスターチ、グアーガム、ローカストビーンガム、デンプン、ペクチン、アルギン酸及びその塩、カラギーナン、コラーゲン、寒天、ゼラチン、キチン、キトサン、カラヤガム、アラビアゴム、キサンタンガム、デキストリン、デキストラン、カルボキシメチルセルロース、カルボキシメチルセルロース・ナトリウム、カルボキシメチルセルロース・カルシウム、ヒドロキシアルキルメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、デンプンアセテート、デンプンホスフェート、ヒドロキシエチル化デンプン、ヒドロキシプロピルデンプン、酸化デンプン、デキストリン化デンプン、デンプン・アクリル酸グラフト重合体、ポリアクリル酸及びその塩、ポリエチレンオキシド、ポリビニルアルコール、ポリ−Ｎ−ビニルピロリドン等のハイドロコロイド粒子（親水性ポリマー）を挙げることができる。
（Ｄ）コロイド粒子は、単位重量当たりの蒸留水の吸水量を（Ｘｄ）とし、単位重量当たりの生理食塩水の吸水量を（Ｙｄ）とした場合に、以下の式（３）を満たすコロイド粒子であることが好ましい。
式（３） 蒸留水の吸水量（Ｘｄ） ≦ 生理食塩水の吸水量（Ｙｄ）
上記式（３）を満たすコロイド粒子を粘着剤組成物に配合することにより、上記式（１）を満たす粘着剤組成物を得ることができる。
（Ｘｄ）、及び（Ｙｄ）は皮膚貼付用ハイドロコロイド型粘着剤組成物の吸水量と同様の方法により算出できる。
[(D) Colloidal particles]
The colloidal particles used in the present invention are not particularly limited. Gum, xanthan gum, dextrin, dextran, carboxymethylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose calcium, hydroxyalkylmethylcellulose, hydroxypropylcellulose, methylcellulose, starch acetate, starch phosphate, hydroxyethylated starch, hydroxypropyl starch, oxidized starch, dextrin Starch, starch / acrylic acid graft polymer, polyacrylic Acid and salts thereof, polyethylene oxide, polyvinyl alcohol, poly -N- vinylpyrrolidone hydrocolloid particles (hydrophilic polymer) can be mentioned.
(D) Colloidal particles are colloids satisfying the following formula (3) when the water absorption amount of distilled water per unit weight is (Xd) and the water absorption amount of physiological saline per unit weight is (Yd): Particles are preferred.
Formula (3) Water absorption of distilled water (Xd) ≦ Water absorption of physiological saline (Yd)
A pressure-sensitive adhesive composition satisfying the above formula (1) can be obtained by blending colloidal particles satisfying the above formula (3) into the pressure-sensitive adhesive composition.
(Xd) and (Yd) can be calculated by the same method as the water absorption of the hydrocolloid pressure-sensitive adhesive composition for skin application.
上記式（３）を満たすコロイド粒子としては、カルボキシメチルセルロースを挙げることができる。中でも粒径が１〜５００μｍ、エーテル化度が０．５５〜１．０５のカルボキシメチルセルロースであることが好ましい。カルボキシメチルセルロースの粒径は、より好ましくは１５乃至６０μｍである。また、カルボキシメチルセルロースのエーテル化度は、より好ましくは０．８〜１．０５である。上記式（３）を満たすカルボキシメチルセルロースの市販品としては、サンローズＦ３５０ＨＣ（日本製紙株式会社製）が挙げられる。
本発明に用いるコロイド粒子は、一種を単独で使用してもよく、２種以上を併用してもよい。例えば、上記式（３）を満たすコロイド粒子を一種を単独で使用してもよく、２種以上を併用してもよい。また、上記式（３）を満たすコロイド粒子と、上記式（３）を満たさないコロイド粒子とを併用してもよい。コロイド粒子の種類及び配合割合を選択することにより蒸留水の吸水量と生理食塩水の吸水量を制御することができる。
上記式（３）を満たすコロイド粒子と、上記式（３）を満たさないコロイド粒子とを併用する場合の配合量は、上記式（３）を満たすコロイド粒子：上記式（３）を満たさないコロイド粒子５０：５０〜９９：１であることが好ましく、２０：８０〜９９：１であることがより好ましい。
Examples of colloidal particles that satisfy the above formula (3) include carboxymethylcellulose. Among these, carboxymethylcellulose having a particle size of 1 to 500 μm and a degree of etherification of 0.55 to 1.05 is preferable. The particle size of carboxymethyl cellulose is more preferably 15 to 60 μm. Further, the degree of etherification of carboxymethylcellulose is more preferably 0.8 to 1.05. As a commercially available product of carboxymethylcellulose satisfying the above formula (3), Sunrose F350HC (manufactured by Nippon Paper Industries Co., Ltd.) can be mentioned.
The colloidal particles used in the present invention may be used alone or in combination of two or more. For example, one type of colloidal particles satisfying the above formula (3) may be used alone, or two or more types may be used in combination. Moreover, you may use together the colloidal particle which satisfy | fills said Formula (3), and the colloidal particle which does not satisfy | fill said Formula (3). By selecting the type and blending ratio of the colloidal particles, the water absorption amount of distilled water and the water absorption amount of physiological saline can be controlled.
When the colloidal particles satisfying the above formula (3) and the colloidal particles not satisfying the above formula (3) are used in combination, colloidal particles satisfying the above formula (3): colloid not satisfying the above formula (3) The particles are preferably 50:50 to 99: 1, and more preferably 20:80 to 99: 1.
これらコロイド粒子の配合量は、適度な吸水速度と吸水量を得るために、例えばカルボキシメチルセルロース・ナトリウムやカルボキシメチルセルロースであれば、粘着剤組成物全成分の総質量に対して１０質量％乃至５０質量％、好ましくは２０質量％乃至４０質量％の割合で使用することが、吸液性、特に吸水性、創傷部位との接着性、及び適度な保形性（側面からの膏体のはみだし防止性）の観点から望ましい。 In order to obtain an appropriate water absorption rate and water absorption amount, for example, carboxymethylcellulose sodium or carboxymethylcellulose is used as the amount of the colloidal particles in the range of 10% by mass to 50% by mass with respect to the total mass of all components of the pressure-sensitive adhesive composition. %, Preferably 20% to 40% by weight, is a liquid-absorbing property, especially water-absorbing property, adhesiveness to the wound site, and appropriate shape retention (preventing the sticking of the plaster from the side) Is desirable from the viewpoint of
［その他成分］
さらに本発明の粘着剤組成物には、一般的なゴム系粘着剤で使用する、酢酸トコフェロール及び／又はその誘導体、アスコルビン酸及び／又はその誘導体、亜硫酸ナトリウム、ジブチルヒドロキシトルエン等の酸化防止剤、ビスフェノール系、ヒンダードアミン系、ベンゾイミダゾール系などの老化防止剤や紫外線吸収剤、光安定剤などを１種又は複数の組合せで適宜添加してもよい。
また本発明の粘着剤組成物には、その他皮膚貼付用の粘着テープやシートに一般に用いられるようなその他の各種添加剤、例えば充填剤、脱臭剤、芳香剤などを配合してもよく、或いは内部凝集力を高めるために架橋剤を適宜配合させてもよい。
これらの任意成分の配合量は、通常、粘着剤組成物全成分の総質量に対して５質量％以下である。
[Other ingredients]
Furthermore, the pressure-sensitive adhesive composition of the present invention includes an antioxidant such as tocopherol acetate and / or a derivative thereof, ascorbic acid and / or a derivative thereof, sodium sulfite, and dibutylhydroxytoluene, which are used in a general rubber-based pressure-sensitive adhesive. Bisphenol-based, hindered amine-based, benzimidazole-based anti-aging agents, ultraviolet absorbers, light stabilizers, and the like may be appropriately added in one or more combinations.
In addition, the pressure-sensitive adhesive composition of the present invention may contain other various additives commonly used for pressure-sensitive adhesive tapes and sheets for skin application, such as fillers, deodorants, and fragrances, or In order to increase the internal cohesive force, a crosslinking agent may be appropriately added.
The compounding quantity of these arbitrary components is 5 mass% or less normally with respect to the total mass of an adhesive composition all the components.
また、既に損傷を受けた皮膚又は、損傷が予想される皮膚に対しては、皮膚の治療又は損傷の予防、美容等を目的とする薬効成分を添加してもよい。例えば、薬理学上有効な薬効成分としては、抗生物質、殺菌剤や抗菌剤（アクリノール、塩化ベンザルコニウム、銀系化合物等）、消毒剤、抗炎症剤及び皮膚保護剤などが挙げられる。また、セラミド等の保湿効果のある物質を添加することで、角質剥離でダメージを受けた皮膚の健常な皮膚への再生を助長することができ、或いは血流促進効果の高いγ−オリザノール等を添加することにより、褥瘡発生が懸念される部位において体圧によって生じる血管の閉塞を緩和し、褥瘡予防が期待できる。
これらの薬効成分は、粘着剤組成物全成分の総質量に対して通常３質量％以下、好ましくは２質量％以下の含有量とすることができる。
In addition, a medicinal component for the purpose of skin treatment or prevention of damage, beauty and the like may be added to skin that has already been damaged or skin that is expected to be damaged. For example, pharmacologically effective medicinal ingredients include antibiotics, bactericides and antibacterial agents (acrinol, benzalkonium chloride, silver compounds, etc.), disinfectants, anti-inflammatory agents and skin protection agents. Moreover, by adding a substance having a moisturizing effect such as ceramide, regeneration of healthy skin damaged by exfoliation can be promoted, or γ-oryzanol having a high blood flow promoting effect can be promoted. By adding, it can relieve the occlusion of blood vessels caused by body pressure at the site where pressure ulcers are concerned, and it can be expected to prevent pressure ulcers.
These medicinal components can be used in a content of usually 3% by mass or less, preferably 2% by mass or less, based on the total mass of all components of the pressure-sensitive adhesive composition.
＜貼付材＞
本発明の第一の態様における貼付材は、基材と、該基材の少なくとも一方の面に粘着剤層を有し、該粘着剤層が、本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物を用いて形成された貼付材である。
<Patch material>
The adhesive patch in the first aspect of the present invention has a base material and an adhesive layer on at least one surface of the base material, and the adhesive layer is a hydrocolloid adhesive composition for skin application of the present invention. It is a patch material formed using.
本発明の貼付材は、有機溶剤が不要の塗工方法であるカレンダー法やホットメルト法などによって、好適に作製することができる。
ホットメルト法は、有機溶剤などの希釈媒体を全く使用せず、高温で急激に軟化溶融するブロック共重合体の特性を利用した方法であり、乾燥工程が不要、塗工速度が速い、爆発火災の危険がないなどの利点がある。
一例として、ホットメルト法による貼付材の製造例を以下に記載する。加熱制御可能な高速回転ミキサーで、エラストマー成分、粘着付与樹脂、可塑剤及びコロイド粒子、そして適宜その他成分を、窒素雰囲気下、通常１５０〜２００℃の温度で３０〜１２０分間加熱高速撹拌して溶解物として各成分が均一となった粘着剤組成物を得ることができる。
前記方法にて得られた粘着剤組成物を、ホットメルト塗工機にて、１５０〜２００℃に温度制御したダイヘッド部分から押し出して剥離シート上に１００〜１，０００μｍの厚さに展延した後、これに、基材を積層(好ましくはラミネート)することで貼付材を作製することができる。
The patch of the present invention can be suitably produced by a calendar method, a hot melt method, or the like, which is a coating method that does not require an organic solvent.
The hot-melt method uses the characteristics of a block copolymer that softens and melts rapidly at high temperatures without using any dilution medium such as organic solvents, and does not require a drying process. There are advantages such as no danger of.
As an example, a manufacturing example of a patch by a hot melt method will be described below. Heat-controllable high-speed rotating mixer to dissolve the elastomer component, tackifier resin, plasticizer and colloidal particles, and other components as needed by heating and stirring at a temperature of 150-200 ° C for 30-120 minutes in a nitrogen atmosphere. As a product, a pressure-sensitive adhesive composition in which each component is uniform can be obtained.
The pressure-sensitive adhesive composition obtained by the above method was extruded from a die head part temperature-controlled at 150 to 200 ° C. with a hot melt coating machine and spread on a release sheet to a thickness of 100 to 1,000 μm. Thereafter, a patch can be produced by laminating (preferably laminating) a base material thereon.
ここで用いられる基材としては、適度な伸縮性、柔軟性、強度を備えるものであれば特に限定されず、適度の通気性、透湿性及び菌バリヤー性の性質を備えるものが特に好ましい。例えばポリオレフィン、ポリウレタン、ポリエステル及びポリアクリル酸等のフィルム、フォーム、不織布、織布及び編み布等が挙げられる。中でも上述の観点からポリウレタン性のフィルムが好ましい。 The substrate used here is not particularly limited as long as it has appropriate stretchability, flexibility, and strength, and those having appropriate air permeability, moisture permeability, and fungus barrier properties are particularly preferable. Examples thereof include films such as polyolefin, polyurethane, polyester and polyacrylic acid, foams, nonwoven fabrics, woven fabrics and knitted fabrics. Among these, a polyurethane film is preferable from the above viewpoint.
また、使用する剥離シートは貼付材の分野で慣用のものを用いることができる。例えばシリコーン離型処理した上質紙、グラシン紙等の紙基材やポリエステルフィルム等を用いることができる。
本発明において、剥離シートの長さは、粘着剤の流出防止、生産性、取扱性、経済性及び製法の容易性等の観点より、粘着剤の塗工領域よりも、０．２ｍｍ以上、特に１〜５ｍｍ大きくすることが好ましい。
Moreover, the release sheet used can use a thing conventionally used in the field | area of a patch. For example, a paper base material such as high-quality paper or glassine paper subjected to silicone release treatment, a polyester film, or the like can be used.
In the present invention, the length of the release sheet is 0.2 mm or more, particularly from the adhesive coating area, from the viewpoint of prevention of adhesive flow-out, productivity, handling, economy, and ease of production. It is preferable to increase it by 1 to 5 mm.
貼付材は、基材に皮膚貼付用ハイドロコロイド型粘着剤組成物を全面或いはパターンコーティングにより積層し、粘着剤層とすることで得ることもできる。
本発明の第二の態様における貼付材は、基材と、粘着層と、パッド層とをこの順に有し、該パッド層が、本発明の皮膚貼付用ハイドロコロイド型粘着剤組成物を含むものである。このとき、基材は、透湿性が高いことが好ましく、粘着層はパッド層よりも粘着力を高く設定することが好ましい。
The patch material can also be obtained by laminating the hydrocolloid pressure-sensitive adhesive composition for skin patching on the entire surface or by pattern coating to form a pressure-sensitive adhesive layer.
The patch in the second aspect of the present invention has a base, an adhesive layer, and a pad layer in this order, and the pad layer contains the hydrocolloid adhesive composition for skin patch of the present invention. At this time, it is preferable that the base material has high moisture permeability, and the adhesive layer is preferably set to have higher adhesive force than the pad layer.
本発明の貼付材の粘着剤層（ハイドロコロイド組成物層）の厚さは、特に制限されないが、皮膚への固定性を担保し、基材厚みとのバランスの点から、一定厚とする場合は、１００乃至１，２００μｍ以下が好ましい。また、例えば、貼付材の縁取り部の粘着剤の使用量を、貼付材の中央部分の粘着剤の使用量より少なく、厚みを薄くすることにより、縁取り部と衣類等とのこすれを防止し、皮膚へ適用した時に剥がれにくくなる効果が得られる。この場合、粘着剤の使用量は、中央部で、好ましくは３００〜１，２００μｍ、更に好ましくは６００〜８００μｍであり、縁取り部の粘着剤の使用量は、好ましくは５０〜３００μｍ、更に好ましくは１００〜３００μｍである。 The thickness of the pressure-sensitive adhesive layer (hydrocolloid composition layer) of the patch of the present invention is not particularly limited. However, when securing the fixation to the skin and keeping a constant thickness from the balance with the substrate thickness, 100 to 1,200 μm or less is preferable. Also, for example, the amount of adhesive used at the border of the patch is less than the amount of adhesive used at the center of the patch, and the thickness is reduced to prevent rubbing between the border and clothing, etc. The effect that it becomes difficult to peel off when applied to is obtained. In this case, the amount of the adhesive used is preferably 300 to 1,200 μm, more preferably 600 to 800 μm at the center, and the amount of the adhesive used in the border is preferably 50 to 300 μm, more preferably. 100 to 300 μm.
〔粘着剤層の粘着力〕
皮膚貼付用ハイドロコロイド型粘着剤組成物を用いて形成された粘着剤層は、創傷部位を含む貼付皮膚面に貼付されるものであり、創傷部位及び健常皮膚に損傷を与えることなく剥離できるものでなければならないこと、及び背面に配置される支持体に対する投錨性を良好に保つ必要があることから、所定の粘着力を有することが望ましい。
[Adhesive strength of adhesive layer]
The pressure-sensitive adhesive layer formed using the hydrocolloid pressure-sensitive adhesive composition for skin application is applied to the surface of the applied skin including the wound site and can be peeled without damaging the wound site and healthy skin. It is desirable to have a predetermined adhesive force because it must be maintained and the anchoring property to the support disposed on the back surface must be kept good.
粘着剤層の皮膚面に対する粘着力は、好ましく０．１〜２．０Ｎ／１５ｍｍ、より好ましくは０．２〜０．８Ｎ／１５ｍｍの範囲である。
皮膚面に対する粘着剤層の粘着力の測定方法は、以下のとおりである。まず１５ｍｍ×長さ１５ｍｍ以上、好ましくは７０ｍｍの所定の長さに裁断したハイドロコロイド組成物層を、所定人数の被験者の前腕内側部位（肘から手首方向に向かって３０〜６５％の範囲とする。）に貼付し、手のひらを１０秒間押し当てて圧着する。貼付してから１時間経過した後、ＪＩＳ Ｚ０２３７に準拠し、剥離角度９０°、剥離速度１００ｍｍ／分の条件で、粘着力を測定することができる。
The adhesive strength of the adhesive layer to the skin surface is preferably in the range of 0.1 to 2.0 N / 15 mm, more preferably 0.2 to 0.8 N / 15 mm.
The measuring method of the adhesive strength of the adhesive layer to the skin surface is as follows. First, the hydrocolloid composition layer cut into a predetermined length of 15 mm × length 15 mm or more, preferably 70 mm, is set to a range of 30 to 65% of the forearm inner part of the predetermined number of subjects (from the elbow toward the wrist). ) And press the palm for 10 seconds to crimp. After 1 hour has elapsed since the application, the adhesive strength can be measured under the conditions of a peeling angle of 90 ° and a peeling speed of 100 mm / min in accordance with JIS Z0237.
また上記貼付材における支持体に対する投錨性を良好に保つ観点から、ハイドロコロイド組成物層のベークライト板に対する粘着力は、好ましくは０．３〜８Ｎ／１５ｍｍ、より好ましくは０．４〜７Ｎ／１５ｍｍ、更に好ましくは０．５〜６Ｎ／１５ｍｍの範囲である。
ハイドロコロイド組成物層のベークライト板に対する粘着力の測定方法は、以下のとおりである。まず、ハイドロコロイド組成物層を支持テープに固定し、幅１５ｍｍ×長さ１５ｍｍ以上、好ましくは、７０ｍｍに裁断して試験片とする。試験片をベークライト板に押しつけて貼着させた後、２ｋｇのローラーで圧着速さ６００ｍｍ／分、圧着回数２往復で貼着させて試験片を調製する。貼着してから１分以内にＪＩＳ Ｚ０２３７に準拠し、剥離角度９０°、剥離速度３００ｍｍ／分の条件で、粘着力を測定する。
Moreover, from the viewpoint of keeping the anchoring property to the support in the above-mentioned patch well, the adhesive strength of the hydrocolloid composition layer to the bakelite plate is preferably 0.3 to 8 N / 15 mm, more preferably 0.4 to 7 N / 15 mm, More preferably, it is the range of 0.5-6N / 15mm.
The method for measuring the adhesive strength of the hydrocolloid composition layer to the bakelite plate is as follows. First, the hydrocolloid composition layer is fixed to a support tape and cut into a width of 15 mm × length of 15 mm or more, preferably 70 mm, to obtain a test piece. After the test piece is pressed against the bakelite plate and pasted, a test piece is prepared by sticking with a 2 kg roller at a crimping speed of 600 mm / min and a number of crimping times of two reciprocations. Within 1 minute after sticking, the adhesive strength is measured under the conditions of a peeling angle of 90 ° and a peeling speed of 300 mm / min in accordance with JIS Z0237.
本発明の貼付材の物理的・化学的性質については、国際公開第２０１３／０７７１３４号パンフレットに定義されたものを好適に適用できる。 As the physical and chemical properties of the patch of the present invention, those defined in International Publication No. 2013/077134 can be suitably applied.
以下に実施例を挙げて、本発明をさらに詳しく説明するが、本発明はこれら実施例に限定されるものではない。 EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples.
＜皮膚貼付用ハイドロコロイド型粘着剤組成物の調製＞
前記ホットメルト法で、表１に示す組成にて約１８０℃で３０〜５０分間の加熱高速撹拌を行い、均一な粘着剤組成物を調製した。
調製した粘着剤組成物をシリコーン処理したグラシン紙（厚さ１２０μｍ）上に、３００μｍの厚さに展延して粘着剤層を形成した。この粘着剤層の上に基材として３０μｍのポリエーテル系ポリウレタンフィルムをラミネートし実施例１の貼付材を作製した。
実施例２、比較例１及び２は、実施例１と同様にして貼付材を作製した。
実施例３は、基材を１５μｍ、粘着剤層を４５０μｍとした以外は実施例１と同様にして貼付材を作製した。
<Preparation of hydrocolloid adhesive composition for skin application>
A uniform pressure-sensitive adhesive composition was prepared by the hot melt method, followed by heating and stirring at about 180 ° C. for 30 to 50 minutes at the composition shown in Table 1.
The prepared adhesive composition was spread on a glassine paper (thickness 120 μm) treated with silicone to a thickness of 300 μm to form an adhesive layer. A 30 μm polyether polyurethane film was laminated as a base material on the pressure-sensitive adhesive layer to prepare a patch of Example 1.
In Example 2 and Comparative Examples 1 and 2, a patch was produced in the same manner as in Example 1.
In Example 3, a patch was prepared in the same manner as in Example 1 except that the base material was 15 μm and the pressure-sensitive adhesive layer was 450 μm.
＜吸水量評価＞
試料として各貼付材を２０ｍｍ×１１ｍｍに裁断したものを用い、これを３７℃の生理食塩水または蒸留水に浸漬した。浸漬から２４時間経過後の試料の重量増加量（ｇ）を測定し、下記式に従い、浸漬前の試料重量に対する重量増加量（ｇ）を生理食塩水または蒸留水の吸水量とした（ｇ/ｃｍ３）。
浸漬から２４時間経過後の吸水量（ｇ/ｃｍ３）＝
｛（生理食塩水または蒸留水に２４時間浸漬後の試料重量（ｇ）−浸漬前の試料重量（ｇ））｝／浸漬前の試料中のハイドロコロイド型粘着剤組成物の体積（ｃｍ３）
<Evaluation of water absorption>
A sample obtained by cutting each patch into 20 mm × 11 mm was used, and this was immersed in 37 ° C. physiological saline or distilled water. The weight increase amount (g) of the sample after 24 hours from the immersion was measured, and the weight increase amount (g) with respect to the sample weight before the immersion was defined as the water absorption amount of physiological saline or distilled water according to the following formula (g / cm 3 ).
Water absorption amount after 24 hours from immersion (g / cm 3 ) =
{(Sample weight after immersion in physiological saline or distilled water for 24 hours (g) -Sample weight before immersion (g))} / Volume of hydrocolloid pressure-sensitive adhesive composition in the sample before immersion (cm 3 )
＜ヒト皮膚粘着力＞
こうして作製した実施例と比較例の貼付材について、ヒト皮膚粘着力を評価した。なお試料として、各貼付材を１５ｍｍ幅×７０ｍｍ長さに裁断した試験片を用いた。
被験者（成人３名）の前腕内側部に貼付し、手のひらを１０秒間押し当てて圧着した。貼付してから１時間経過後に、インストロン型引張試験機で９０°の剥離角度で１００ｍｍ／分の引張速度で引き剥がして皮膚粘着力を測定し、平均値を算出した。なお、貼付材におけるヒト皮膚粘着力の好適な数値範囲は０．１０〜１［Ｎ／１５ｍｍ］であり、より好ましくは０．２〜０．７［Ｎ／１５ｍｍ］である。得られた結果を表１に示す。
<Human skin adhesion>
Human skin adhesive strength was evaluated for the patch materials of Examples and Comparative Examples thus prepared. In addition, the test piece which cut each patch material into 15 mm width x 70 mm length was used as a sample.
Affixed to the inner side of the forearm of subjects (3 adults), and pressed against the palm for 10 seconds. One hour after the application, the skin adhesive strength was measured by peeling with an Instron type tensile tester at a peeling angle of 90 ° and a tensile speed of 100 mm / min, and the average value was calculated. In addition, the suitable numerical range of the human skin adhesive force in a patch is 0.10-1 [N / 15mm], More preferably, it is 0.2-0.7 [N / 15mm]. The obtained results are shown in Table 1.
＜対ベークライト板粘着力＞
上記で作製した実施例と比較例の貼付材に対する粘着力の測定方法は、以下のとおりである。まず、各貼付材を、幅１５ｍｍ×７０ｍｍ長さに裁断して試験片とした。試験片をベークライト板に押しつけて貼着させた後、２ｋｇのローラーで圧着速さ６００ｍｍ／分、圧着回数２往復で試験片を貼着させた。貼着してから１分以内にＪＩＳ Ｚ０２３７に準拠し、剥離角度９０°、剥離速度３００ｍｍ／分の条件で、粘着力を測定し、対ベークライト板粘着力とした。
<Adhesive strength to bakelite plate>
The measuring method of the adhesive force with respect to the adhesive material of the Example produced above and a comparative example is as follows. First, each patch was cut into a width of 15 mm × 70 mm and used as a test piece. After the test piece was pressed against the bakelite plate and pasted, the test piece was pasted with a 2 kg roller at a crimping speed of 600 mm / min and with two rounds of crimping. Within 1 minute after sticking, the adhesive strength was measured under the conditions of a peeling angle of 90 ° and a peeling speed of 300 mm / min in accordance with JIS Z0237, and was defined as the adhesive strength to the bakelite plate.
＜耐浸水性試験＞
上記で作製した実施例と比較例の貼付材に対する耐浸水性試験の測定方法は、以下のとおりである。まず、各貼付材を、幅１５ｍｍ×７０ｍｍ長さに裁断して試験片とした。試験片をベークライト板に押しつけて貼付させた後、貼付してから１分以内に３８℃の湯浴中に浸漬し６０分間静置し、以下の評価方法で判定した。
〇： 貼付材の周囲から水が入らず、貼付時と変化がなかった。
×： 貼付材の周囲から水が入り、貼付材の周囲が浮いて白く濁った。
<Water immersion test>
The measurement method of the water resistance test for the patch materials of Examples and Comparative Examples prepared above is as follows. First, each patch was cut into a width of 15 mm × 70 mm and used as a test piece. After the test piece was pressed against the bakelite plate and pasted, the test piece was immersed in a 38 ° C. hot water bath within 1 minute and allowed to stand for 60 minutes, and judged by the following evaluation method.
○: Water did not enter from the periphery of the patch, and there was no change from when the patch was applied.
X: Water entered from the periphery of the patch, and the periphery of the patch floated and became cloudy.
結果を表１に示した。
また、耐浸水性試験後のベークライト板に貼付した試験片の写真を撮影し、図１に示した。図１中、左から順に、実施例１、実施例２、実施例３、比較例１、比較例２の試験片である。
The results are shown in Table 1.
Moreover, the photograph of the test piece affixed on the bakelite board after a water-resistance test was taken, and it showed in FIG. 1 are test pieces of Example 1, Example 2, Example 3, Comparative Example 1, and Comparative Example 2 in order from the left in FIG.
ＳＩＳ：クインタック３４５０、日本ゼオン社製
ＬＩＲ−３０：クラレ社製
OPANOL B15：ＢＡＳＦ社製
水添テルペン樹脂：ヤスハラケミカル社製
ロジンエステル：荒川化学社製
可塑剤：流動パラフィン、カネダ社製
コハク酸ジ２エチルヘキシル、クローダジャパン社製
アジピン酸ポリエステル、ジェイ・プラス社製
F350HC：日本製紙社製
MAC10H：日本製紙社製
F800HC：日本製紙社製
F1400MC：日本製紙社製
BHTスワノックス：精工化学社製
SIS: QUINTAC 3450, manufactured by Nippon Zeon Co., Ltd. LIR-30: manufactured by Kuraray Co., Ltd.
OPANOL B15: manufactured by BASF Hydrogenated terpene resin: manufactured by Yashara Chemical Co., Ltd. Rosin ester: manufactured by Arakawa Chemical Co., Ltd. plasticizer: liquid paraffin, manufactured by Kaneda
Di-2-ethylhexyl succinate, made by Croda Japan
Adipic acid polyester, manufactured by Jay Plus
F350HC: Nippon Paper Industries
MAC10H: Nippon Paper Industries
F800HC: Nippon Paper Industries
F1400MC: Nippon Paper Industries
BHT Swanox: Seiko Chemical Co., Ltd.
Claims (8)
式（１） 蒸留水の吸水量（Ｘ） ≦ 生理食塩水の吸水量（Ｙ） A hydrocolloid-type pressure-sensitive adhesive composition for skin application, comprising (A) an elastomer, (B) a tackifier resin, (C) a plasticizer, and (D) colloidal particles. Hydrocolloid adhesive for skin application satisfying the following formula (1), where (X) is the water absorption amount of distilled water per unit volume and (Y) is the water absorption amount of physiological saline per unit volume Composition.
Formula (1) Water absorption amount of distilled water (X) ≦ Water absorption amount of physiological saline (Y)
式（３） 蒸留水の吸水量（Ｘｄ） ≦ 生理食塩水の吸水量（Ｙｄ） When the colloidal particles (D) have a water absorption amount of distilled water per unit weight of the colloidal particles as (Xd) and a water absorption amount of physiological saline per unit weight as (Yd), the following equation (3) The hydrocolloid pressure-sensitive adhesive composition for skin application according to claim 1, which is a colloidal particle satisfying (1).
Formula (3) Water absorption of distilled water (Xd) ≦ Water absorption of physiological saline (Yd)
An adhesive material comprising a base material, an adhesive layer, and a pad layer in this order, wherein the pad layer comprises the hydrocolloid adhesive composition for skin application according to any one of claims 1 to 7.
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| WO2020121533A1 (en) * | 2018-12-14 | 2020-06-18 | ジュネル株式会社 | Adhesive sheet for nail tips |
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