JP2017014120A - Cosmetic - Google Patents
Cosmetic Download PDFInfo
- Publication number
- JP2017014120A JP2017014120A JP2015129525A JP2015129525A JP2017014120A JP 2017014120 A JP2017014120 A JP 2017014120A JP 2015129525 A JP2015129525 A JP 2015129525A JP 2015129525 A JP2015129525 A JP 2015129525A JP 2017014120 A JP2017014120 A JP 2017014120A
- Authority
- JP
- Japan
- Prior art keywords
- feeling
- tripropylene glycol
- mass
- skin
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、使用感に優れた保湿化粧料に関する。 The present invention relates to a moisturizing cosmetic material with excellent usability.
化粧品の使用目的の一つは、皮膚の乾燥を防ぎ、皮膚表面の水分を調節し、皮膚にしっとり感を与えることである。このため、化粧品には保湿剤として種々の成分が添加される。保湿剤として通常用いられるものとしては、グリセリンや1,3−ブチレングリコール、ソルビトールなどの多価アルコール、アミノ酸や有機酸、ヒアルロン酸などの生体系保湿成分がある。これらの保湿剤は、保湿効果と同時に皮膚にべたつくような不快な感触を与える。このため、これらの保湿剤を配合する場合、べたついた使用感とならないように様々な技術が提案されている。また、保湿剤は、べたつき感以外にもぬるつき感やきしみ感など不快な使用感を与えることも指摘されている。
例えば、特許文献1には、一般的な保湿剤を、外用組成物に多量に配合すると、得られる外用組成物は、皮膚の保湿効果に優れるものの、べたついた使用感を生じるが、炭素原子数が4〜6の糖アルコールとシリコーン油とを配合すると、得られる水中油型の外用組成物は、一般的な保湿剤やムコ多糖類を単に配合して得た外用組成物よりも、皮膚に対する保湿効果に優れ、べたついた使用感のない外用組成物となることが開示されている。
また、特許文献2には、低級アルコールとカチオン性殺菌剤と湿潤剤とを含有する消毒用組成物において、特定の構造を有する環状または鎖状シリコーンおよび/またはIOB値(無機性値及び有機性値の比)が0.22〜0.85の多価アルコール脂肪酸エステルを配合すると、グリセリンのべたつきが抑えられることが開示されている。
One of the uses of cosmetics is to prevent skin dryness, adjust the moisture on the skin surface, and give the skin a moist feeling. For this reason, various components are added as a moisturizing agent to cosmetics. Examples of the humectant usually used include polyhydric alcohols such as glycerin, 1,3-butylene glycol, and sorbitol, and biological humectants such as amino acids, organic acids, and hyaluronic acid. These moisturizing agents give an unpleasant feel that is sticky to the skin at the same time as the moisturizing effect. For this reason, when blending these moisturizers, various techniques have been proposed so as not to give a sticky feeling. It has also been pointed out that moisturizers give an unpleasant feeling of use other than a sticky feeling, such as a slimy feeling and a squeaky feeling.
For example, in Patent Document 1, when a large amount of a general moisturizing agent is added to an external composition, the resulting external composition is excellent in skin moisturizing effect, but produces a sticky feeling of use. When the 4 to 6 sugar alcohol and silicone oil are blended, the resulting oil-in-water external composition is more effective against the skin than the external composition obtained by simply blending a general moisturizer or mucopolysaccharide. It is disclosed that the composition for external use has an excellent moisturizing effect and does not have a sticky feeling.
Patent Document 2 discloses a cyclic or chain silicone having a specific structure and / or an IOB value (inorganic value and organic property) in a disinfecting composition containing a lower alcohol, a cationic fungicide, and a wetting agent. It is disclosed that stickiness of glycerin can be suppressed when a polyhydric alcohol fatty acid ester having a value ratio of 0.22 to 0.85 is blended.
本発明は、保湿効果が高く、べたつき感やぬるつき感、きしみ感のない、使用感に優れた保湿化粧料を提供することを課題とする。 It is an object of the present invention to provide a moisturizing cosmetic that has a high moisturizing effect and does not have a sticky, slimy, or squeaky feeling and is excellent in use.
本発明者は、保湿剤を含む化粧料にトリプロピレングリコールを配合すると、保湿剤に起因するべたつき感やきしみ感等の不快な使用感を低減した優れた化粧料が得られることを見いだした。また、一般に保湿剤の配合量を減らしてべたつき感を抑制すると保湿効果が低下するが、トリプロピレングリコールの添加によって保湿効果の低下を引き起こすことなく、保湿剤に由来する特有のべたつき感、ぬるつき感、きしみ感が抑制されることを見いだした。本発明は、これらの知見に基づき、新たな化粧料を提案するものである。 The present inventor has found that when tripropylene glycol is blended with a cosmetic containing a humectant, an excellent cosmetic with reduced unpleasant feeling of use such as stickiness and squeak due to the humectant can be obtained. In general, reducing the amount of moisturizing agent to reduce stickiness reduces the moisturizing effect, but the addition of tripropylene glycol does not cause a decrease in moisturizing effect. It was found that the feeling and squeakiness were suppressed. The present invention proposes a new cosmetic based on these findings.
本発明の主な構成は、次のとおりである。
(1)保湿剤とトリプロピレングリコールを含有する化粧料。
(2)保湿剤が多価アルコール、糖アルコール、単糖、ムコ多糖類、コラーゲン、有機酸、アミノ酸から選ばれる一種以上である(1)に記載の化粧料。
(3)多価アルコールがグリセリン、ジグリセリン、ポリグリセリン、1,3−ブチレングリコールから選択されるいずれか1種以上の物質であり、糖アルコールがソルビトール、マルチトール、マンニトールから選択されるいずれか1種以上の物質であり、単糖がブドウ糖である(2)に記載の化粧料。
(4)保湿剤とトリプロピレングリコールの合計量が10〜30質量%である(1)に記載の化粧料。
(5)保湿剤とトリプロピレングリコールの配合比率が1:1〜10:1である(1)に記載の化粧料。
(6)グリセリン、ジグリセリン、ポリグリセリン及び1,3−ブチレングリコールから選ばれる1種以上とトリプロピレングリコールを含有する保湿化粧料。
The main configuration of the present invention is as follows.
(1) A cosmetic containing a humectant and tripropylene glycol.
(2) The cosmetic according to (1), wherein the humectant is at least one selected from polyhydric alcohol, sugar alcohol, monosaccharide, mucopolysaccharide, collagen, organic acid, and amino acid.
(3) The polyhydric alcohol is any one or more substances selected from glycerin, diglycerin, polyglycerin, and 1,3-butylene glycol, and the sugar alcohol is any one selected from sorbitol, maltitol, and mannitol. The cosmetic according to (2), which is one or more substances and the monosaccharide is glucose.
(4) The cosmetic according to (1), wherein the total amount of the humectant and tripropylene glycol is 10 to 30% by mass.
(5) The cosmetic according to (1), wherein the mixing ratio of the humectant and tripropylene glycol is 1: 1 to 10: 1.
(6) A moisturizing cosmetic containing at least one selected from glycerin, diglycerin, polyglycerin and 1,3-butylene glycol and tripropylene glycol.
本発明の構成をとることで、保湿剤に起因するべたつき感やぬるつき感、きしみ感を低減し、使用感の優れた、保湿化粧料を提供できる。 By adopting the configuration of the present invention, it is possible to provide a moisturizing cosmetic that has a feeling of stickiness, a slimy feeling, and a squeaky feeling due to the moisturizing agent and has an excellent feeling of use.
本発明は、保湿剤とトリプロピレングリコールを含有する化粧料に関する。
本発明の化粧料の成分について説明する。
<保湿剤>
本発明に用いる保湿剤とは、化粧品として必要な皮膚の保湿機能(湿潤機能)を有する物質であればよい。このような物質としては、多価アルコールや保湿効果を有する各種物質が利用可能である。また、多価アルコール以外の保湿効果を有する物質としては、糖アルコール、単糖、ムコ多糖類、コラーゲン、有機酸、アミノ酸を例示できる。
多価アルコールとしては、グリセリン、ジグリセリン、ポリグリセリン、メチルグルセス、トレハロース、1,3−ブチレングリコール、1,2−ペンタンジオール等、糖アルコールとしてはソルビトール、マルチトール、マンニトール等、単糖としてはブドウ糖が例示できる。
中でもグリセリンは、化粧品の原料として広く普及している。グリセリンは、ミヨシ油脂(株)社製の化粧品用濃グリセリン、新日本理化(株)社製の局方濃グリセリン、花王(株)社製の濃グリセリン等を使用することができる。ジグリセリンは、日油(株)社製のユニグリーG−2、坂本薬品工業(株)社製のジグリセリン801を使用することができる。ポリグリセリンは、坂本薬品工業(株)社製のPGL#250、PGL#350等を使用できる。ポリグリセリンPGL#250は、トリグリセリンを35〜55質量%含有するポリグリセリンであり、ポリグリセリンPGL#350は、テトラグリセリンを20〜40質量%含有するポリグリセリンである。ソルビトールは、三菱商事フードテック(株)社製のソルビットD−70等を使用できる。ソルビットD−70は、ソルビトール70質量%と水30質量%から成る混合原料である。1,3−ブチレングリコールは、ダイセル化学工業(株)社製の1,3−ブチレングリコール、KHネオケム(株)社製の1,3−ブチレングリコールを使用することができる。
ムコ多糖類としては、ヒアルロン酸、ヒアルロン酸ナトリウム、アセチル化ヒアルロン酸が使用できる。
有機酸としては、乳酸、乳酸ナトリウム、クエン酸、クエン酸ナトリウムを使用することができる。
アミノ酸としては、バリン、ロイシン、イソロイシン、トレオニン、メチオニン、フェニルアラニン、トリプトファン、リジン、グリシン、アラニン、アスパラギン、グルタミン、セリン、システイン、シスチン、チロシン、プロリン、ヒドロキシプロリン、アスパラギン酸、グルタミン酸、ヒドロキシリジン、アルギニン、オルニチン、ヒスチジンを例示できる。
また、ここには例示しないが、上記以外の保湿機能を有する物質についても、化粧品原料として提供されているものや、化粧品としての成分規格や安全性が満たされているものであれば本発明に使用できる。
The present invention relates to a cosmetic containing a humectant and tripropylene glycol.
The ingredients of the cosmetic of the present invention will be described.
<Humectant>
The moisturizing agent used in the present invention may be a substance having a skin moisturizing function (wetting function) necessary for cosmetics. As such a substance, polyhydric alcohol and various substances having a moisturizing effect can be used. Examples of substances having a moisturizing effect other than polyhydric alcohols include sugar alcohols, monosaccharides, mucopolysaccharides, collagen, organic acids, and amino acids.
Examples of polyhydric alcohols include glycerin, diglycerin, polyglycerin, methylgluces, trehalose, 1,3-butylene glycol, 1,2-pentanediol, sugar alcohols such as sorbitol, maltitol, mannitol, etc., monosaccharides such as glucose Can be illustrated.
Among them, glycerin is widely used as a raw material for cosmetics. As the glycerin, there can be used concentrated glycerin for cosmetics manufactured by Miyoshi Oil Co., Ltd., pharmacopoeia concentrated glycerin manufactured by Shin Nippon Rika Co., Ltd., concentrated glycerin manufactured by Kao Corporation. Diglycerin can use Unigre G-2 by NOF Corporation and diglycerin 801 by Sakamoto Pharmaceutical Co., Ltd. As the polyglycerin, PGL # 250, PGL # 350, etc. manufactured by Sakamoto Pharmaceutical Co., Ltd. can be used. Polyglycerin PGL # 250 is a polyglycerin containing 35 to 55% by mass of triglycerin, and polyglycerin PGL # 350 is a polyglycerin containing 20 to 40% by mass of tetraglycerin. As sorbitol, Sorbit D-70 manufactured by Mitsubishi Corporation Food Tech Co., Ltd. can be used. Sorbit D-70 is a mixed raw material composed of 70% by mass of sorbitol and 30% by mass of water. As 1,3-butylene glycol, 1,3-butylene glycol manufactured by Daicel Chemical Industries, Ltd. and 1,3-butylene glycol manufactured by KH Neochem Co., Ltd. can be used.
As the mucopolysaccharide, hyaluronic acid, sodium hyaluronate, and acetylated hyaluronic acid can be used.
As the organic acid, lactic acid, sodium lactate, citric acid, and sodium citrate can be used.
As amino acids, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine Ornithine and histidine.
In addition, although not exemplified here, substances having a moisturizing function other than those described above are also provided as cosmetic raw materials, as long as the ingredient standards and safety as cosmetics are satisfied, and the present invention. Can be used.
本発明における保湿剤の配合量は、通常化粧品に、化粧品の種類や形態に応じて適切な量を配合する。 The amount of the moisturizing agent in the present invention is usually an appropriate amount for cosmetics depending on the type and form of the cosmetic.
<トリプロピレングリコール>
トリプロピレングリコールは、プロピレンオキサイド水和反応によりプロピレングリコールが製造されるときの副生物として製造され、ポリエステル樹脂の中間原料、水溶性油剤やインキの溶剤として使用されている。本発明に使用する場合は、化粧料として用いることのできる安全性を有するものであれば使用することができる。このようなトリプロピレングリコールとしては、旭硝子(株)社製の「トリプロピレングリコール」を例示することができる。
<Tripropylene glycol>
Tripropylene glycol is produced as a by-product when propylene glycol is produced by a propylene oxide hydration reaction, and is used as an intermediate raw material for a polyester resin, a water-soluble oil agent, and an ink solvent. In the case of use in the present invention, any material having safety that can be used as a cosmetic can be used. As such tripropylene glycol, “Tripropylene glycol” manufactured by Asahi Glass Co., Ltd. can be exemplified.
本発明の化粧料は、保湿剤とトリプロピレングリコールを含有することで、保湿剤に由来するべたつき感、ぬるつき感、きしみ感などの不快な使用感を低減した保湿化粧料となる。保湿剤とトリプロピレングリコールの合計量として、化粧料全質量当たり1〜30質量%、特に好ましくは10〜30質量%配合することが好ましい。また、保湿剤とトリプロピレングリコールの合計量が1質量%に満たないと、保湿効果が不十分になる恐れがあり、30質量%を超えるとべたつき感が生じる恐れがある。
また、保湿剤とトリプロピレングリコールの配合比率が1:1〜10:1となるように配合すると好ましい。
The cosmetic of the present invention contains a moisturizing agent and tripropylene glycol, and thus becomes a moisturizing cosmetic with reduced unpleasant feeling of use such as stickiness, luster, and squeakiness derived from the moisturizing agent. The total amount of the humectant and tripropylene glycol is preferably 1 to 30% by mass, particularly preferably 10 to 30% by mass, based on the total mass of the cosmetic. If the total amount of the humectant and tripropylene glycol is less than 1% by mass, the moisturizing effect may be insufficient, and if it exceeds 30% by mass, a sticky feeling may occur.
Moreover, it is preferable to mix | blend so that the mixture ratio of a moisturizing agent and a tripropylene glycol may be 1: 1-10: 1.
本発明の化粧料には、本発明の効果を損なわない範囲で、油剤として植物油のような油脂類、炭化水素油、高級脂肪酸、高級アルコール、シリコーンを配合できる。また界面活性剤として、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤、非イオン界面活性剤を配合できる。さらに、防腐剤、金属イオン封鎖剤、増粘剤、粉体成分、紫外線吸収剤、紫外線遮断剤、香料、pH調整剤等を含有させることができる。
また、ビタミン類、皮膚賦活剤、血行促進剤、常在菌コントロール剤、活性酸素消去剤、抗炎症剤、抗癌剤、美白剤、殺菌剤等の他の薬効成分、生理活性成分を含有させることもできる。
In the cosmetic of the present invention, fats and oils such as vegetable oils, hydrocarbon oils, higher fatty acids, higher alcohols, and silicones can be blended as oil agents within a range that does not impair the effects of the present invention. As the surfactant, an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant can be blended. Furthermore, preservatives, sequestering agents, thickeners, powder components, UV absorbers, UV blockers, fragrances, pH adjusters, and the like can be included.
In addition, vitamins, skin activators, blood circulation promoters, resident bacteria control agents, active oxygen scavengers, anti-inflammatory agents, anticancer agents, whitening agents, bactericides, and other medicinal and physiologically active ingredients may be included. it can.
油脂類としては、例えばツバキ油、月見草油、マカデミアナッツ油、オリーブ油、ナタネ油、トウモロコシ油、ゴマ油、ホホバ油、胚芽油、小麦胚芽油、トリオクタン酸グリセリン等の液体油脂、カカオ脂、ヤシ油、硬化ヤシ油、パーム油、パーム核油、モクロウ、モクロウ核油、硬化油、硬化ヒマシ油等の固体油脂、ミツロウ、キャンデリラロウ、綿ロウ、ヌカロウ、ラノリン、酢酸ラノリン、液状ラノリン、サトウキビロウ等のロウ類が挙げられる。 Examples of fats and oils include camellia oil, evening primrose oil, macadamia nut oil, olive oil, rapeseed oil, corn oil, sesame oil, jojoba oil, germ oil, wheat germ oil, glycerin trioctanoate, cocoa butter, coconut oil, hardened Solid oils such as coconut oil, palm oil, palm kernel oil, owl, owl kernel oil, hydrogenated oil, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, nutca wax, lanolin, lanolin acetate, liquid lanolin, sugarcane wax, etc. Waxes.
炭化水素油としては、流動パラフィン、スクワレン、スクワラン、マイクロクリスタリンワックス等が挙げられる。 Examples of the hydrocarbon oil include liquid paraffin, squalene, squalane, and microcrystalline wax.
高級脂肪酸としては、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)等が挙げられる。 Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the like.
高級アルコールとしては、ラウリルアルコール、ステアリルアルコール、セチルアルコール、セトステアリルアルコール、ベヘニルアルコール等の直鎖アルコール、モノステアリルグリセリンエーテル、ラノリンアルコール、オクチルドデカノール等の分枝鎖アルコール等が挙げられる。
また、コレステロール、フィトステロールなどのステロール類も使用可能である。
Examples of the higher alcohol include linear alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, cetostearyl alcohol, and behenyl alcohol, and branched chain alcohols such as monostearyl glycerin ether, lanolin alcohol, and octyldodecanol.
Further, sterols such as cholesterol and phytosterol can also be used.
シリコーンとしては、鎖状ポリシロキサンのジメチルポリシロキサン、メチルフェニルポリシロキサン、環状ポリシロキサンのデカメチルシクロペンタシロキサン等が挙げられる。 Examples of silicone include linear polysiloxane dimethylpolysiloxane, methylphenyl polysiloxane, and cyclic polysiloxane decamethylcyclopentasiloxane.
アニオン界面活性剤としては、ラウリン酸ナトリウム等の脂肪酸塩、ラウリル硫酸ナトリウム等の高級アルキル硫酸エステル塩、POEラウリル硫酸トリエタノールアミン等のアルキルエーテル硫酸エステル塩、N−アシルサルコシン酸、スルホコハク酸塩、N−アシルアミノ酸塩等が挙げられる。 Anionic surfactants include fatty acid salts such as sodium laurate, higher alkyl sulfates such as sodium lauryl sulfate, alkyl ether sulfates such as POE lauryl sulfate triethanolamine, N-acyl sarcosine acid, sulfosuccinate, N-acyl amino acid salts and the like can be mentioned.
カチオン界面活性剤としては、塩化ステアリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ベンザルコニウム、塩化ベンゼトニウム等が挙げられる。 Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride.
両性界面活性剤としては、アルキルベタイン、アミドベタイン等のベタイン系界面活性剤等が挙げられる。 Examples of amphoteric surfactants include betaine surfactants such as alkyl betaines and amide betaines.
非イオン界面活性剤としては、ソルビタンモノオレエート等のソルビタン脂肪酸エステル類、硬化ヒマシ油誘導体が挙げられる。 Nonionic surfactants include sorbitan fatty acid esters such as sorbitan monooleate and hydrogenated castor oil derivatives.
防腐剤としては、メチルパラベン、エチルパラベン等が挙げられる。 Examples of the preservative include methyl paraben and ethyl paraben.
金属イオン封鎖剤としては、エチレンジアミン四酢酸二ナトリウム、エデト酸、エデト酸ナトリウム塩等のエデト酸塩が挙げられる。 Examples of the sequestering agent include edetates such as disodium ethylenediaminetetraacetate, edetic acid, and sodium edetate.
増粘剤としては、水溶性高分子物質を配合することができる。このような水溶性高分子物質としては、天然高分子、半合成高分子、合成高分子のいずれでもよい。天然高分子としては、トラガントガム、カラヤガム、キサンタンガム、グアガム、カチオン化グアガム、アニオン化グアガム、タラガム、アラビアガム、タマリンドガム、ジュランガム、ローカストビーンガム、カラギーナン、クインスシード、デキストラン等が例示できる。半合成高分子としては、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロースナトリウム、ヒドロキシプロピルメチルセルロース、メチルセルロース、ヒドロキシプロピルメチルセルロース、カチオン化セルロース、アルギン酸プロピレングリコールエステル、アルギン酸ナトリウム、ベントナイト等が例示できる。合成高分子としては、カルボキシビニルポリマー、ポリビニルピロリドン、ポリビニルアルコール、ジアルキルポリエチレングリコール、ポリオキシエチレンジオレイン酸メチルグルコシド、ポリエチレングリコール、ジステアリン酸ポリエチレングリコール、合成スメクタイト等が挙げられる。 As the thickener, a water-soluble polymer substance can be blended. Such a water-soluble polymer substance may be a natural polymer, a semi-synthetic polymer, or a synthetic polymer. Examples of the natural polymer include tragacanth gum, karaya gum, xanthan gum, guar gum, cationized guar gum, anionized guar gum, tara gum, gum arabic, tamarind gum, juran gum, locust bean gum, carrageenan, quince seed, dextran and the like. Examples of the semisynthetic polymer include hydroxypropylmethylcellulose, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, hydroxypropylmethylcellulose, cationized cellulose, propylene glycol alginate, sodium alginate, bentonite and the like. Examples of the synthetic polymer include carboxyvinyl polymer, polyvinyl pyrrolidone, polyvinyl alcohol, dialkyl polyethylene glycol, polyoxyethylene dioleic acid methyl glucoside, polyethylene glycol, polyethylene glycol distearate, and synthetic smectite.
紫外線吸収剤としては、パラアミノ安息香酸、サリチル酸フェニル、パラメトキシケイ皮酸イソプロピル、パラメトキシケイ皮酸オクチル、2,4−ジヒドロキシベンゾフェノン等が挙げられる。 Examples of the ultraviolet absorber include paraaminobenzoic acid, phenyl salicylate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2,4-dihydroxybenzophenone, and the like.
薬効成分としては、ビタミンA油、レチノール等のビタミンA類、リボフラビン等のビタミンB2類、ピリドキシン塩酸塩等のB6類、L−アスコルビン酸、L−アスコルビン酸リン酸エステル、L−アスコルビン酸モノパルミチン酸エステル、L−アスコルビン酸ジパルミチン酸エステル、L−アスコルビン酸−2−グルコシド等のビタミンC類、パントテン酸カルシウム等のパントテン酸類、ビタミンD2、コレカルシフェロール等のビタミンD類;α−トコフェロール、酢酸トコフェロール、ニコチン酸DL−α−トコフェロール等のビタミンE類等のビタミン類が挙げられる。 Medicinal components include vitamin A oil, vitamin A such as retinol, vitamin B2 such as riboflavin, B6 such as pyridoxine hydrochloride, L-ascorbic acid, L-ascorbic acid phosphate ester, L-ascorbic acid monopalmitin Vitamin C such as acid ester, L-ascorbic acid dipalmitate, L-ascorbic acid-2-glucoside, pantothenic acid such as calcium pantothenate, vitamin D such as vitamin D2, cholecalciferol; α-tocopherol, Vitamins such as vitamin E such as tocopherol acetate and DL-α-tocopherol nicotinate can be mentioned.
また、その他の薬効成分としては、プラセンタエキス、グルタチオン、ユキノシタ抽出物等の美白剤、ローヤルゼリー等の皮膚賦活剤、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、カフェイン、タンニン酸γ−オリザノール等の血行促進剤、グリチルリチン酸誘導体、グリチルレチン酸誘導体、アズレン等の消炎剤、アルギニン、セリン、ロイシン、トリプトファン等のアミノ酸類、常在菌コントロール剤のマルトースショ糖縮合物、塩化リゾチーム等が挙げられる。 Other medicinal ingredients include whitening agents such as placenta extract, glutathione, and yukinoshita extract; skin activators such as royal jelly; Accelerators, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, anti-inflammatory agents such as azulene, amino acids such as arginine, serine, leucine and tryptophan, maltose sucrose condensates of resident bacteria control agents, lysozyme chloride and the like.
さらに、カミツレエキス、パセリエキス、ワイン酵母エキス、グレープフルーツエキス、スイカズラエキス、コメエキス、ブドウエキス、ホップエキス、コメヌカエキス、ビワエキス、オウバクエキス、ヨクイニンエキス、センブリエキス、メリロートエキス、バーチエキス、カンゾウエキス、シャクヤクエキス、サボンソウエキス、ヘチマエキス、トウガラシエキス、レモンエキス、ゲンチアナエキス、シソエキス、アロエエキス、ローズマリーエキス、セージエキス、タイムエキス、茶エキス、海藻エキス、キューカンバーエキス、チョウジエキス、ニンジンエキス、マロニエエキス、ハマメリスエキス、クワエキス等の各種抽出物を配合してもよい。 In addition, chamomile extract, parsley extract, wine yeast extract, grapefruit extract, honeysuckle extract, rice extract, grape extract, hop extract, rice bran extract, loquat extract, buckwheat extract, yakuinin extract, assembly extract, merilot extract, birch extract, licorice extract, peony extract , Savonso extract, loofah extract, capsicum extract, lemon extract, gentian extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, tea extract, seaweed extract, cucumber extract, carrot extract, carrot extract, maronier extract, You may mix | blend various extracts, such as a Hamelis extract and a mulberry extract.
本発明の化粧料は、化粧水、乳液、クリーム、ジェル、パック、マスク等の皮膚化粧料、あるいは、シャンプー、リンス、育毛剤等の頭髪化粧料とすることができる。また、日焼け止め化粧料、メイクアップ化粧料や、入浴剤の形態とすることもできる。さらに、医療用成分を配合した医薬品、医薬部外品とすることもできる。 The cosmetics of the present invention can be skin cosmetics such as lotions, emulsions, creams, gels, packs and masks, or hair cosmetics such as shampoos, rinses and hair restorers. Moreover, it can also be set as the form of sunscreen cosmetics, makeup cosmetics, and a bath agent. Furthermore, it can also be set as the pharmaceutical and quasi-drug which mix | blended the medical component.
本発明の化粧料は常法により製造することができる。 The cosmetic of the present invention can be produced by a conventional method.
以下に試験例、実施例、比較例を示し、本発明の作用効果について説明する。
官能評価試験
試験試料または化粧料を熟練した専門の官能評価員10名に対し、上腕内側部に塗布し、べたつき感、ぬるつき感、肌への馴染み感、馴染んだ後の指どまり(きしみ感)の官能評価項目について評価した。下記の基準により3段階評価とした。
[べたつき感]
○:10名中7名以上が、べたつき感がないと評価した
△:10名中3〜6名が、べたつき感がないと評価した
×:べたつき感がないとする評価が2名以下
[ぬるつき感]
○:10名中7名以上がぬるつき感がないと評価した
△:10名中3〜6名がぬるつき感がないと評価した
×:ぬるつき感がないとする評価が2名以下
[肌への馴染み感]
○:10名中7名以上が肌への馴染みが良いと評価した
△:10名中3〜6名が肌への馴染みが良いと評価した
×:肌への馴染みが良いとする評価が2名以下
[肌へ馴染んだ後の指どまり(きしみ感)]
○:10名中7名以上が肌へ馴染んだ後のきしみ感がないと評価した
△:10名中3〜6名が肌へ馴染んだ後のきしみ感がないと評価した
×:肌へ馴染んだ後のきしみ感がないとする評価が2名以下
Test examples, examples, and comparative examples are shown below, and the effects of the present invention will be described.
Sensory evaluation test
Apply test samples or cosmetics to 10 expert sensory evaluators on the inner side of the upper arm and feel stickiness, sliminess, familiarity to the skin, and sensation of fingering after being familiar (squeaky feeling) Evaluation items were evaluated. A three-step evaluation was made based on the following criteria.
[A feeling of stickiness]
○: 7 or more out of 10 people evaluated that there was no stickiness △: 3-6 out of 10 people evaluated that there was no stickiness ×: 2 people or less evaluated that there was no stickiness
[Smoothness]
○: 7 or more out of 10 people evaluated that there was no slimy feeling △: 3-6 out of 10 people evaluated that there was no slimy feeling ×: 2 people or less evaluated that there was no slimy feeling
[Feeling familiar to skin]
○: 7 or more out of 10 people evaluated that skin familiarity was good. Δ: 3-6 out of 10 people evaluated that skin familiarity was good. ×: Evaluation that skin familiarity was good 2 Below
[Fingering after getting into the skin (squeaking)]
○: 7 or more out of 10 people evaluated that there was no squeaky feeling after getting familiar with the skin
Δ: 3 to 6 out of 10 people evaluated that there was no squeaky feeling after adapting to the skin ×: 2 or less evaluated that there was no squeaking feeling after adapting to the skin
前記した「べたつき感」、「ぬるつき感」、「肌への馴染み感」、「きしみ感」は、いずれも化粧料を肌に塗布する際の主要な官能評価項目であるが、一般的に、保湿化粧料を求める消費者は、目的とする皮膚の「保湿効果」を非常に重視するため、保湿剤に起因する「べたつき感」や「ぬるつき感」が多少生じてもその好ましくない使用感を許容する傾向が見られる。一方、「きしみ感」は許容されない不快な使用感であり、化粧品の処方設計者が最も注意を払う官能評価項目である。 The above-mentioned “stickiness”, “smoothness”, “feeling familiar to skin”, and “squeaking” are all the main sensory evaluation items when applying cosmetics to the skin. Consumers seeking moisturizing cosmetics place great emphasis on the intended “moisturizing effect” of the skin, so even if some “stickiness” or “smoothiness” due to the moisturizing agent occurs, it is not preferable There is a tendency to allow feeling. On the other hand, “squeaking” is an unacceptable unpleasant feeling of use and is a sensory evaluation item to which cosmetic prescription designers pay most attention.
(1)トリプロピレングリコール及び各種保湿剤をそれぞれ水溶液としたときの官能評価試験
トリプロピレングリコール及びグリセリンをはじめとする多価アルコール等の保湿剤をそれぞれ10質量%濃度の水溶液となるように調製した(つまり、ソルビトール(70%)では14.28質量%、マルチトール(75%)では13.33質量%含有となる)。この濃度は、化粧水に保湿剤として配合される濃度を参考に決定した。各水溶液を皮膚に塗布し、官能評価を行った。
試験結果を表1に示す。
(1) Sensory evaluation test when tripropylene glycol and various humectants were each used as an aqueous solution. A humectant such as a polyhydric alcohol including tripropylene glycol and glycerin was prepared to be an aqueous solution having a concentration of 10% by mass. (In other words, sorbitol (70%) contains 14.28% by mass and maltitol (75%) contains 13.33% by mass). This concentration was determined with reference to the concentration blended in the lotion as a humectant. Each aqueous solution was applied to the skin for sensory evaluation.
The test results are shown in Table 1.
10質量%のトリプロピレングリコール水溶液、及び10質量%の保湿剤含有水溶液も、上記の官能評価項目を、すべて満足したものはなかった。トリプロピレングリコールのみが、「きしみ感」が△の評価で、その他の項目が〇の評価であった。また、1,2−ペンタンジオールは、「きしみ感」が×の評価であり、その他の項目が〇の評価であった。この試験結果から、トリプロピレングリコール及び各種保湿剤は、保湿効果を期待できる濃度では、肌に塗布した時の使用感があまり好ましいものではないことが分かった。 None of the 10% by mass tripropylene glycol aqueous solution and the 10% by mass humectant-containing aqueous solution satisfied all the above sensory evaluation items. Only for tripropylene glycol, “feel of squeaking” was evaluated as △, and other items were evaluated as ◯. In addition, 1,2-pentanediol had an evaluation of x for “squeaking” and an evaluation of o for other items. From this test result, it was found that tripropylene glycol and various moisturizing agents are not so preferable in use feeling when applied to the skin at a concentration where a moisturizing effect can be expected.
(2)トリプロピレングリコールと各種保湿剤を組み合わせて配合した水溶液の官能評価試験
トリプロピレングリコール1〜5質量%と保湿剤を5〜10質量%配合した水溶液(保湿化粧料の基礎配合)を調製し(実施例1〜17)、同様に官能評価を行った。保湿剤は、(1)の試験でべたつきがあると評価されたグリセリン、ジグリセリン、ポリグリセリン、1,3−ブチレングリコール、ソルビトール(70%)、マルチトール(75%)、無水結晶ブドウ糖と、マンニトールを選択した。実施例1〜9はトリプロピレングリコール5質量%、各保湿剤5質量%の濃度とした。また実施例10はトリプロピレングリコール5質量%、マンニトール10質量%とした。実施例11は、トリプロピレングリコール1質量%、グリセリン9質量%、実施例12はトリプロピレングリコール2質量%、グリセリン8質量%とした。実施例13〜17は、トリプロピレングリコール5質量%とし、グリセリン、ジグリセリン、ポリグリセリン2種、1,3−ブチレングリコールをそれぞれ10質量%配合している。各実施例の配合量の一覧及び官能評価結果を下記の表2に示す。
(2) Sensory evaluation test of aqueous solution formulated by combining tripropylene glycol and various moisturizers Prepare an aqueous solution (basic formulation of moisturizing cosmetic) containing 1 to 5% by mass of tripropylene glycol and 5 to 10% by mass of moisturizer. (Examples 1 to 17), and sensory evaluation was performed in the same manner. The humectant is glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, sorbitol (70%), maltitol (75%), anhydrous crystalline glucose, which are evaluated to be sticky in the test of (1), Mannitol was selected. In Examples 1 to 9, the concentration was 5% by mass of tripropylene glycol and 5% by mass of each humectant. In Example 10, 5% by mass of tripropylene glycol and 10% by mass of mannitol were used. In Example 11, 1% by mass of tripropylene glycol and 9% by mass of glycerin were used. In Example 12, 2% by mass of tripropylene glycol and 8% by mass of glycerin were used. In Examples 13 to 17, tripropylene glycol was 5% by mass, and 10% by mass of glycerin, diglycerin, two types of polyglycerol, and 1,3-butylene glycol were blended. Table 2 below shows a list of blending amounts and sensory evaluation results of each example.
前述の表1で示しているが、各種保湿剤は、保湿効果を期待できる濃度で単独配合した水溶液では、肌に塗布するとあまり好ましい使用感ではなく官能評価試験結果に「×」の評価が多くみられた。しかし、表2に示すとおり、トリプロピレングリコールと各種保湿剤を組み合わせることで殆ど全ての官能評価項目で、評価は○に改善した。
表2において、保湿化粧料の処方設計において最も重要視される官能評価項目である「肌に馴染んだ後の指どまり(きしみ感)」に注目すると、実施例7〜9のトリプロピレングリコールと、ソルビトール、マルチトールおよび無水結晶ブドウ糖のいずれかを保湿剤として組み合わせた水溶液の、「肌に馴染んだ後の指どまり(きしみ感)」の評価は△であった。トリプロピレングリコールと、保湿剤としてマンニトールを組み合わせた実施例6、10の水溶液では、マンニトールが5質量%の時(実施例6)は「肌に馴染んだ後の指どまり(きしみ感)」の評価は○であり、マンニトールが10質量%の時(実施例10)は「肌に馴染んだ後の指どまり(きしみ感)」の評価は△であった。
一方、グリセリン、ジグリセリン、ポリグリセリンおよび1,3−ブチレングリコールについては、トリプロピレングリコールと組み合わせることで、5質量%から10質量%と保湿剤の配合量を増やしても「肌に馴染んだ後の指どまり(きしみ感)」の評価は○であった(実施例13〜17)。トリプロピレングリコールを組み合わせて配合することが、保湿剤を多く配合する保湿化粧料の処方設計において、とても有効であることが分かった。
また、実施例13〜17のトリプロピレングリコールと、グリセリン、ジグリセリン、ポリグリセリン2種および1,3−ブチレングリコールのいずれかを保湿剤として10質量%配合したときに、「べたつき感」、「ぬるつき感」、「肌への馴染み感」のいずれかの項目に△の評価があるが、これらの保湿剤はいずれも10質量%水溶液の場合にほぼ全て「×」の評価であったことから、トリプロピレングリコールを5質量%組み合わせて配合することで明らかに使用感が改善されたことがわかる。
また、前述したとおり、保湿効果が最重要視される保湿化粧料において「べたつき感」、「ぬるつき感」、「肌への馴染み感の悪さ」は、「きしみ感」よりは許容される官能評価項目であることを考慮すると、保湿剤を10質量%(トリプロピレングリコールと保湿剤の合計量で10〜15質量%)と多く配合した化粧料(実施例13〜17)において、「べたつき感」、「ぬるつき感」、「肌への馴染み感」の評価結果は△ではあるが、おおむね良好な使用感が得られていると判断できる。
また、グリセリンについては、様々な濃度で試験しているが、トリプロピレングリコールを併用すると、グリセリン(9質量%配合)の時にトリプロピレングリコール1質量%の配合で、べたつき感、ぬるつき感、肌へのなじみ感、きしみ感を改善することがわかった(実施例11参照)。このことから、トリプロピレングリコールと保湿剤の配合量は、化粧料に配合する保湿剤に対して10質量%以上配合することでその効果を発揮するものと推定される。
以上のとおり、表1、表2の評価試験を対比してみることで、保湿剤単独では肌に対するべたつき感、ぬるつき感、肌への馴染み感、馴染んだ後の指どまり(きしみ感)が不良であったが、トリプロピレングリコールと併用することでこれらの使用感はいずれも改善されることが分かった。
また、官能評価試験において、官能評価員からは、トリプロピレングリコールの配合量が増えるにしたがって、肌がつるつるするという良好な感触が得られたとのコメントがあった。
As shown in Table 1 above, various moisturizing agents are aqueous solutions formulated solely at a concentration that can be expected to have a moisturizing effect. It was seen. However, as shown in Table 2, by combining tripropylene glycol and various humectants, the evaluation was improved to ○ in almost all sensory evaluation items.
In Table 2, paying attention to the “sensory evaluation item that is most important in the prescription design of moisturizing cosmetics” The evaluation of “fingering (squeaking) after acclimatization to the skin” of an aqueous solution in which any one of sorbitol, maltitol and anhydrous crystalline glucose was combined as a moisturizer was Δ. In the aqueous solutions of Examples 6 and 10 in which tripropylene glycol and mannitol as a moisturizer were combined, when “mannitol was 5% by mass (Example 6)”, evaluation of “fingering after getting into the skin (squeaking)” When the mannitol content was 10% by mass (Example 10), the evaluation of “finger tightness (feeling of squeaking) after getting familiar with the skin” was Δ.
On the other hand, glycerin, diglycerin, polyglycerin and 1,3-butylene glycol can be combined with tripropylene glycol to increase the blending amount of the moisturizer from 5% by mass to 10% by mass. Was evaluated as “Good” (Examples 13 to 17). It has been found that the combination of tripropylene glycol is very effective in the formulation design of a moisturizing cosmetic containing a large amount of a moisturizing agent.
In addition, when 10% by mass of tripropylene glycol of Examples 13 to 17, glycerin, diglycerin, two kinds of polyglycerin and 1,3-butylene glycol were blended as moisturizers, “stickiness”, “ There is a △ evaluation for any of the items “feeling slimy” or “feeling familiar to the skin”, but all of these moisturizers were evaluated as “x” in the case of a 10% by mass aqueous solution. From the results, it can be seen that the usability is clearly improved by blending 5% by mass of tripropylene glycol.
In addition, as described above, in moisturizing cosmetics where the moisturizing effect is regarded as the most important, “stickiness”, “smoothness”, and “poorness to skin” are more acceptable than “squeaking”. Considering that it is an evaluation item, in cosmetics (Examples 13 to 17) containing a large amount of a humectant (10 to 15% by mass in total amount of tripropylene glycol and humectant) (Examples 13 to 17), Although the evaluation results of “feeling of sliminess”, “feeling familiar to skin” are Δ, it can be judged that a good feeling of use is generally obtained.
In addition, glycerin has been tested at various concentrations. When tripropylene glycol is used in combination, when glycerin (9% by mass) is mixed with 1% by mass of tripropylene glycol, the feeling of stickiness, sliminess, and skin It was found that the feeling of familiarity and squeakiness were improved (see Example 11). From this, it is estimated that the compounding quantity of a tripropylene glycol and a moisturizer exhibits the effect by mix | blending 10 mass% or more with respect to the moisturizer mix | blended with cosmetics.
As described above, by comparing the evaluation tests in Table 1 and Table 2, the moisturizer alone gives a feeling of stickiness to the skin, a feeling of stickiness, a feeling of familiarity with the skin, and a finger squeak after being familiar (squeaking feeling). Although it was unsatisfactory, it was found that these feelings of use were all improved by using tripropylene glycol together.
In the sensory evaluation test, the sensory evaluator commented that a good feeling that the skin slippery was obtained as the blending amount of tripropylene glycol increased.
(3)各種保湿剤を2種組み合わせて配合した水溶液の官能評価試験
トリプロピレングリコールと、各種保湿剤とを組み合わせると、優れた使用感になることを確認するため、(1)の試験で使用した保湿剤であるジプロピレングリコール、1,2−ペンタンジオール、1,3−ブチレングリコール、グリセリン、ジグリセリン、ポリグリセリンから2種を選択し、それぞれ5質量%ずつ配合した水溶液(保湿剤の合計量は10質量%になる)を調製し(比較例1〜12)、同様にして官能評価を行った。
配合の組み合わせ及び官能評価結果を表3に示す。
(3) Sensory evaluation test of aqueous solution containing two or more kinds of moisturizers in combination To confirm that combining tripropylene glycol and various moisturizers gives an excellent feeling of use, it is used in the test of (1) Selected from two types of moisturizers, such as dipropylene glycol, 1,2-pentanediol, 1,3-butylene glycol, glycerin, diglycerin, and polyglycerin, each containing 5% by mass (total of moisturizers) The amount was 10% by mass) (Comparative Examples 1 to 12), and sensory evaluation was performed in the same manner.
Table 3 shows the combination of the blends and the sensory evaluation results.
表3に示すように、保湿剤を2種選択して組み合わせても、べたつき感、ぬるつき感、肌への馴染み感、肌に馴染んだ後の指どまり(きしみ感)をすべて改善することはできず、「×」評価が残る結果であった。
保湿化粧料の処方設計において最も重要視される官能評価項目「肌に馴染んだ後の指どまり(きしみ感)」に着目すると、1,3−ブチレングリコールとポリグリセリンPGL#250の組み合わせ(比較例11)では、「きしみ感」が○と評価され、単独成分の時のそれぞれの評価が「×」(表1参照)であったことも考慮すると、その使用感の改善効果は素晴らしい。しかしながら、べたつき感、ぬるつき感、肌への馴染み感の評価では、いずれの評価項目も「×」の評価であり、保湿化粧料としても許容できるレベルを超えており、好ましくない使用感であった。
As shown in Table 3, even when two types of moisturizers are selected and combined, it is possible to improve all the feelings of stickiness, sliminess, familiarity with the skin, and finger tightness (squeaking) after becoming familiar with the skin. The result was that the “x” evaluation remained.
Paying attention to the sensory evaluation item “Fingering after getting familiar with skin (squeaking feeling)” that is most important in the prescription design of moisturizing cosmetics, a combination of 1,3-butylene glycol and polyglycerin PGL # 250 (comparative example) In 11), the “feeling of squeaking” is evaluated as “good”, and the evaluation effect of each component when it is a single component is “×” (see Table 1). However, in the evaluation of the feeling of stickiness, the feeling of stickiness, and the familiarity to the skin, all of the evaluation items were evaluated as “x”, exceeding the level acceptable as a moisturizing cosmetic, and the feeling of use was unfavorable. It was.
以上、実施例、比較例の官能試験結果から、トリプロピレングリコールは、保湿剤と共に化粧料に配合したときに、保湿成分に由来するべたつき感、ぬるつき感、肌への馴染みの悪さ、きしみ感を改善することが明らかとなった。特に、保湿剤としてグリセリン、ジグリセリン、ポリグリセリンおよび1,3−ブチレングリコールを選択した時には、トリプロピレングリコールと組み合わせることで、保湿剤の配合量を増やしても保湿化粧料において重要な使用感である「肌に馴染んだ後の指どまり(きしみ感)」を生じさせない、優れた使用感の化粧料となった。また、グリセリンとトリプロピレングリコールの組み合わせでは、トリプロピレングリコールを1質量%配合することで、グリセリンに由来するべたつき感、ぬるつき感、肌への馴染みの悪さ、きしみ感をすべて改善することが明らかとなった。このことから、トリプロピレングリコールと保湿剤の配合量は、化粧料に配合する保湿剤に対して10質量%以上配合することで、その優れた効果を発揮するものと推定される。グリセリンは保湿効果に優れることから、化粧料に保湿剤として広く配合されている。特に本発明は、使用感が重要視される化粧料に広く応用できる技術である。
以下に、本発明の処方例を示す。また、これを使用した使用者の評価を示す。
As described above, from the results of sensory test of Examples and Comparative Examples, tripropylene glycol is a sticky feeling derived from moisturizing ingredients, a feeling of sliminess, an unfamiliar feeling to skin, and a squeaky feeling when blended in a cosmetic together with a moisturizing agent. It became clear to improve. In particular, when glycerin, diglycerin, polyglycerin, and 1,3-butylene glycol are selected as moisturizers, it is an important feeling in moisturizing cosmetics even if the amount of moisturizer is increased by combining with tripropylene glycol. It was a cosmetic with an excellent feeling of use that did not cause a certain “finger squeak after getting familiar with the skin”. In addition, in the combination of glycerin and tripropylene glycol, it is clear that blending 1% by mass of tripropylene glycol improves all the stickiness, sliminess, unfamiliarity to skin, and squeaky feeling derived from glycerin. It became. From this, it is estimated that the compounding quantity of a tripropylene glycol and a moisturizer exhibits the outstanding effect by mix | blending 10 mass% or more with respect to the moisturizer mix | blended with cosmetics. Since glycerin has an excellent moisturizing effect, it is widely blended as a moisturizing agent in cosmetics. In particular, the present invention is a technology that can be widely applied to cosmetics where use feeling is important.
Below, the formulation example of this invention is shown. Moreover, the evaluation of the user who used this is shown.
処方例1
化粧水
(配合成分) (質量%)
1.グリセリン 10
2.トリプロピレングリコール 1
3.ヒアルロン酸ナトリウム 0.1
4.カルボキシメチルデキストランNa 0.1
5.pH調整剤 適量
6.防腐剤 適量
1〜6の成分を混合し化粧水を得た。処方例1の化粧水はべたつかず、しっとり感が持続する保湿性の良い化粧水であった。なお、きしみ感は全くなかった。
Formulation Example 1
Lotion (Formulation ingredients) (mass%)
1. Glycerin 10
2. Tripropylene glycol 1
3. Sodium hyaluronate 0.1
4). Carboxymethyldextran Na 0.1
5. pH adjuster appropriate amount 6. Preservative appropriate amount
A lotion was obtained by mixing components 1-6. The lotion of Formulation Example 1 was a non-sticky lotion and a moisturizing lotion with a moist feeling. There was no squeaky feeling.
処方例2
乳液
(配合成分) (質量%)
1.グリセリン 8
2.1.3−ブチレングリコール 5
3.トリプロピレングリコール 3
4.1,2−ペンタンジオール 1
5.クエン酸 0.01
6.クエン酸ナトリウム 0.1
7.キサンタンガム 0.08
8.スクワラン 3
9.ジメチコン 1
10.ポリソルベート60 0.8
11.ステアリン酸ソルビタン 0.3
12.精製水 残余
常法により乳液を得た。処方例2の乳液はべたつかず、しっとり感が持続する保湿性の良い乳液であった。なお、きしみ感は全くなかった。
Formulation Example 2
Emulsion (formulation component) (mass%)
1. Glycerin 8
2.1.3-Butylene glycol 5
3. Tripropylene glycol 3
4.1,2-Pentanediol 1
5. Citric acid 0.01
6). Sodium citrate 0.1
7). Xanthan gum 0.08
8). Squalane 3
9. Dimethicone 1
10. Polysorbate 60 0.8
11. Sorbitan stearate 0.3
12 Purified water residue
An emulsion was obtained by a conventional method. The emulsion of Formulation Example 2 was not sticky, and was a moisturizing emulsion that maintained a moist feeling. There was no squeaky feeling.
処方例3
粒子含有パック化粧料
(配合成分) (質量%)
1.ポリエチレン末 0.12
2.1,3−ブチレングリコール 5
3.1,2−ペンタンジオール 1.5
4.グリセリン 10
5.ジグリセリン 8
5.トリプロピレングリコール 5
6.カルボキシメチルセルロースNa 4
7.ローカストビーンガム 0.15
8.pH調整剤 適量
9.精製水 残余
すべての成分を均一に混合し、粒子含有パック化粧料を得た。処方例3の粒子含有パック化粧料は、べたついたりせず、洗い流した後もしっとり感に優れていた。
Formulation Example 3
Particle-containing pack cosmetic (compounding ingredients) (mass%)
1. Polyethylene powder 0.12
2. 1,3-butylene glycol 5
3. 1,2-pentanediol 1.5
4). Glycerin 10
5. Diglycerin 8
5. Tripropylene glycol 5
6). Carboxymethylcellulose Na 4
7). Locust bean gum 0.15
8). pH adjuster appropriate amount9. Purified water residue
All ingredients were mixed uniformly to obtain a particle-containing pack cosmetic. The particle-containing pack cosmetic of Formulation Example 3 was not sticky and was excellent in moist feeling even after being washed away.
処方例4
シート状マスク
(配合成分) (質量%)1.1,3−ブチレングリコール 6
2.1,2−ペンタンジオール 2
3.グリセリン 6
4.トリプロピレングリコール 3
5.テトラエチルヘキサン酸ペンタエリスリチル 5
6.ジメチコン 1
7.ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル) 0.1
8.ステアリン酸ポリグリセリル−10 2
9.(アクリレーツ/アクリル酸アルキル(C10−30))クロスポリマー 0.15
10.水酸化カリウム 0.05
11.pH調整剤 適量
12.精製水 残余
すべての成分を均一に混合し、乳液状の化粧料を得た。不織布に含浸させ、シート状マスクとした。処方例4のマスクを15分間顔面に塗布し、肌になじませ、マスクをはがした後、べたついたりせず、しっとり感に優れ、効果が持続した。なお、きしみ感は全くなかった。
Formulation Example 4
Sheet mask (formulation component) (mass%) 1.1,3-butylene glycol 6
2. 1,2-pentanediol 2
3. Glycerin 6
4). Tripropylene glycol 3
5. Pentaerythrityl tetraethylhexanoate 5
6). Dimethicone 1
7). Lauroyl glutamate di (phytosteryl / octyldodecyl) 0.1
8). Polyglyceryl stearate-10 2
9. (Acrylates / alkyl acrylate (C10-30)) crosspolymer 0.15
10. Potassium hydroxide 0.05
11. pH adjuster appropriate amount12. Purified water residue
All ingredients were mixed uniformly to obtain a milky cosmetic. A sheet-like mask was obtained by impregnating the nonwoven fabric. The mask of Formulation Example 4 was applied to the face for 15 minutes, applied to the skin, and after peeling off the mask, it did not get sticky, had a moist feeling, and maintained the effect. There was no squeaky feeling.
処方例5
ヘアケア トリートメントローション
(配合成分) (質量%)1.1,3−ブチレングリコール 5
2.1,2−ペンタンジオール 1.5
3.ジグリセリン 1
4.トリプロピレングリコール 5
5.塩化ステアリルトリメチルアンモニウム 0.5
6.メチルフェニルポリシロキサン 1
7.ジメチコン 1
8.pH調整剤 適量
9.エタノール 30
10.精製水 残余
すべての成分を均一に混合し、トリートメントローションを得た。処方例5のトリートメントローションは、毛髪においても、べたついたりせず、しっとり感に優れていた。
Formulation Example 5
Hair Care Treatment Lotion (Compounding ingredients) (mass%) 1.1,3-butylene glycol 5
2.1,2-Pentanediol 1.5
3. Diglycerin 1
4). Tripropylene glycol 5
5. Stearyltrimethylammonium chloride 0.5
6). Methylphenyl polysiloxane 1
7). Dimethicone 1
8). pH adjuster appropriate amount9. Ethanol 30
10. Purified water residue
All ingredients were mixed uniformly to obtain a treatment lotion. The treatment lotion of Formulation Example 5 was not sticky even in the hair and was excellent in moist feeling.
処方例6
美容エッセンス
(配合成分) (質量%)1.1,3−ブチレングリコール 2
2.1,2−ペンタンジオール 1.5
3.グリセリン 10
4.トリプロピレングリコール 15
5.水添レシチン 0.1
7.ジメチコン 2
8.SIMULGEL NS 2
9.pH調整剤 適量
10.精製水 残余
すべての成分を均一に混合し、美容エッセンスを得た。べたつきのないしっとり感に優れた美容液を得られた。なお、きしみ感は全くなかった。SIMUGEL NSは、SEPPIC社製の(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)コポリマーを主として含有するプレミックス原料である。
Formulation Example 6
Beauty Essence (Compounding ingredients) (mass%) 1.1,3-butylene glycol 2
2.1,2-Pentanediol 1.5
3. Glycerin 10
4). Tripropylene glycol 15
5. Hydrogenated lecithin 0.1
7). Dimethicone 2
8). SIMULGEL NS 2
9. pH adjuster appropriate amount10. Purified water residue
All ingredients were mixed uniformly to obtain a beauty essence. A essence with a sticky and moist feel was obtained. There was no squeaky feeling. SIMUGEL NS is a premix raw material mainly containing (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer manufactured by SEPPIC.
処方例7
リキッドファンデーション
(配合成分) (質量%)
1.1,3−ブチレングリコール 10
2.グリセリン 10
3.トリプロピレングリコール 8
4.シクロメチコン 10
5.ジメチコンコポリオール 3
6.ジメチコン 0.5
7.ジオクタン酸ネオペンチルグリコール 2.5
8.水添レシチン 0.4
9.ヒアルロン酸Na 0.03
10.加水分解コラーゲン 0.01
11.シリル化シリカ 0.2
12.マイカ 3
13.タルク 2
14.水酸化Al 2
15.ジステアリン酸Al 0.2
16.酸化鉄 1
17.酸化チタン 12
18.精製水 残余
すべての成分を均一に混合し、リキッドファンデーションを得た。処方例7のリキッドファンデーションは、べたついたり、きしんだりせず、しっとり感に優れていた。
Formulation Example 7
Liquid foundation (compounding ingredients) (mass%)
1.1,3-butylene glycol 10
2. Glycerin 10
3. Tripropylene glycol 8
4). Cyclomethicone 10
5. Dimethicone copolyol 3
6). Dimethicone 0.5
7). Neopentyl glycol dioctanoate 2.5
8). Hydrogenated lecithin 0.4
9. Hyaluronic acid Na 0.03
10. Hydrolyzed collagen 0.01
11. Silylated silica 0.2
12 Mica 3
13. Talc 2
14 Hydroxylated Al 2
15. Distearate Al 0.2
16. Iron oxide 1
17. Titanium oxide 12
18. Purified water residue
All ingredients were mixed uniformly to obtain a liquid foundation. The liquid foundation of Formulation Example 7 was not sticky or squeezed and was excellent in moist feeling.
Claims (6)
A moisturizing cosmetic containing at least one selected from glycerin, diglycerin, polyglycerin and 1,3-butylene glycol and tripropylene glycol.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018131392A (en) * | 2017-02-13 | 2018-08-23 | 株式会社コーセー | Aqueous make-up cosmetic |
JP2018154597A (en) * | 2017-03-21 | 2018-10-04 | 株式会社ミルボン | Hair composition and hair treatment method |
JP2018188423A (en) * | 2017-05-09 | 2018-11-29 | 株式会社コーセー | Composition |
KR20220052276A (en) | 2020-10-20 | 2022-04-27 | 니치유 가부시키가이샤 | Cosmetic bases and cosmetics |
Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60218311A (en) * | 1984-04-13 | 1985-11-01 | Shiseido Co Ltd | Sun-care cosmetic |
JPS624214A (en) * | 1985-07-01 | 1987-01-10 | Shiseido Co Ltd | Cosmetic |
JPH09208847A (en) * | 1996-01-31 | 1997-08-12 | Kyowa Hakko Kogyo Co Ltd | Melanin/inorganic oxide composite |
JP2001213756A (en) * | 2000-01-31 | 2001-08-07 | Kose Corp | Humidity keeping cosmetic |
JP2002501544A (en) * | 1997-06-23 | 2002-01-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | Gel deodorant composition with reduced skin irritation |
JP2002508763A (en) * | 1997-06-23 | 2002-03-19 | ザ、プロクター、エンド、ギャンブル、カンパニー | Anhydrogel deodorizing composition |
JP2003267841A (en) * | 2002-03-12 | 2003-09-25 | Lion Corp | Hair care cosmetic |
JP2005002078A (en) * | 2003-04-18 | 2005-01-06 | Kanebo Ltd | Water-based liquid cosmetic |
JP2005350354A (en) * | 2003-09-09 | 2005-12-22 | Kao Corp | Composition for deodorizing hircismus, and skin cosmetic and deodorant for fiber containing the same |
US20070196308A1 (en) * | 2003-09-08 | 2007-08-23 | Christine Popoff | Antiperspirant clear gel with low glycol content |
JP2012001551A (en) * | 2003-09-09 | 2012-01-05 | Kao Corp | Deodorizing composition for hircismus, and skin cosmetic and deodorant for fiber, both containing the composition |
JP2012140337A (en) * | 2010-12-28 | 2012-07-26 | Kao Corp | Cosmetic-containing sheet |
JP2012236791A (en) * | 2011-05-11 | 2012-12-06 | Nihon Kolmar Co Ltd | Foaming aerosol composition |
JP2016166146A (en) * | 2015-03-10 | 2016-09-15 | 株式会社コーセー | Gel lip cosmetics |
JP2016166145A (en) * | 2015-03-10 | 2016-09-15 | 株式会社コーセー | Oily makeup cosmetic |
JP2016179975A (en) * | 2015-03-24 | 2016-10-13 | 株式会社コーセー | Hair cosmetic |
JP2016185938A (en) * | 2015-03-27 | 2016-10-27 | 株式会社コーセー | Hair Cosmetics |
JP2016190806A (en) * | 2015-03-31 | 2016-11-10 | 株式会社コーセー | Hair Cosmetics |
JP2016190840A (en) * | 2015-03-30 | 2016-11-10 | 株式会社コーセー | Water-in-oil type emulsified composition |
-
2015
- 2015-06-29 JP JP2015129525A patent/JP6639816B2/en active Active
Patent Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60218311A (en) * | 1984-04-13 | 1985-11-01 | Shiseido Co Ltd | Sun-care cosmetic |
JPS624214A (en) * | 1985-07-01 | 1987-01-10 | Shiseido Co Ltd | Cosmetic |
JPH09208847A (en) * | 1996-01-31 | 1997-08-12 | Kyowa Hakko Kogyo Co Ltd | Melanin/inorganic oxide composite |
JP2002501544A (en) * | 1997-06-23 | 2002-01-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | Gel deodorant composition with reduced skin irritation |
JP2002508763A (en) * | 1997-06-23 | 2002-03-19 | ザ、プロクター、エンド、ギャンブル、カンパニー | Anhydrogel deodorizing composition |
JP2001213756A (en) * | 2000-01-31 | 2001-08-07 | Kose Corp | Humidity keeping cosmetic |
JP2003267841A (en) * | 2002-03-12 | 2003-09-25 | Lion Corp | Hair care cosmetic |
JP2005002078A (en) * | 2003-04-18 | 2005-01-06 | Kanebo Ltd | Water-based liquid cosmetic |
US20070196308A1 (en) * | 2003-09-08 | 2007-08-23 | Christine Popoff | Antiperspirant clear gel with low glycol content |
JP2005350354A (en) * | 2003-09-09 | 2005-12-22 | Kao Corp | Composition for deodorizing hircismus, and skin cosmetic and deodorant for fiber containing the same |
JP2012001551A (en) * | 2003-09-09 | 2012-01-05 | Kao Corp | Deodorizing composition for hircismus, and skin cosmetic and deodorant for fiber, both containing the composition |
JP2012140337A (en) * | 2010-12-28 | 2012-07-26 | Kao Corp | Cosmetic-containing sheet |
JP2012236791A (en) * | 2011-05-11 | 2012-12-06 | Nihon Kolmar Co Ltd | Foaming aerosol composition |
JP2016166146A (en) * | 2015-03-10 | 2016-09-15 | 株式会社コーセー | Gel lip cosmetics |
JP2016166145A (en) * | 2015-03-10 | 2016-09-15 | 株式会社コーセー | Oily makeup cosmetic |
JP2016179975A (en) * | 2015-03-24 | 2016-10-13 | 株式会社コーセー | Hair cosmetic |
JP2016185938A (en) * | 2015-03-27 | 2016-10-27 | 株式会社コーセー | Hair Cosmetics |
JP2016190840A (en) * | 2015-03-30 | 2016-11-10 | 株式会社コーセー | Water-in-oil type emulsified composition |
JP2016190806A (en) * | 2015-03-31 | 2016-11-10 | 株式会社コーセー | Hair Cosmetics |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018131392A (en) * | 2017-02-13 | 2018-08-23 | 株式会社コーセー | Aqueous make-up cosmetic |
JP2018154597A (en) * | 2017-03-21 | 2018-10-04 | 株式会社ミルボン | Hair composition and hair treatment method |
JP2018188423A (en) * | 2017-05-09 | 2018-11-29 | 株式会社コーセー | Composition |
JP7227702B2 (en) | 2017-05-09 | 2023-02-22 | 株式会社コーセー | Composition |
KR20220052276A (en) | 2020-10-20 | 2022-04-27 | 니치유 가부시키가이샤 | Cosmetic bases and cosmetics |
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