JP2016042902A - Gasket for syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a gasket for a syringe in which sealability between an outer cylinder and the gasket is improved so that a medicinal solution may not leak out from the syringe.SOLUTION: A gasket 3 for a syringe has a body 4 made of a rubber material, and a resin film 5 coated on a region 31 coming into contact with an inner circumferential surface 25 of at least an outer cylinder 2 of the body 4 and having a superior slidability. The gasket forms at least one sealing surface 35 coming into contact with an inner circumferential surface 25 of the outer cylinder 2. The sealing surface 35 is configured by two or more slopes 37a, 37b with different inclination angles. Respective slopes 37a, 37b are formed so that a diameter may grow larger from a liquid sealing surface 32 side for sealing up a medicinal solution toward an opposite liquid sealing surface 33 side of an opposite air side between the outer cylinder 2 and itself. Also, two adjacent surfaces of two or more surfaces have at least one relationship in which the inclination angle of the surface of the opposite liquid sealing surface side becomes smaller than an inclination angle of the surface near the liquid sealing surface side.SELECTED DRAWING: Figure 2

Description

本発明は、医療用の注射器に使用されるシリンジ用ガスケットに関する。更に詳述すると、本発明は、弾性材料製のガスケット本体を慴動性に富む樹脂フィルムで覆ったシリンジ用ガスケットに関する。   The present invention relates to a gasket for a syringe used in a medical syringe. More specifically, the present invention relates to a syringe gasket in which a gasket main body made of an elastic material is covered with a resin film rich in peristaltic properties.

加硫ゴムまたは熱可塑性エラストマー等の弾性材料で構成されているシリンジ用ガスケットの場合、外筒の内周面との摺動抵抗が極めて大きくなるため、ガスケット外周面と外筒内周面との間に潤滑剤を付与し、ガスケット外周面と外筒内周面との摺動抵抗を小さくする必要がある。しかし、このガスケットを備えるシリンジでは、例えば、外筒の収納空間内に薬液等を収納した際に、薬液中に潤滑剤が混入（溶解）し、薬液中の薬効成分に潤滑剤が作用（反応）して、活性低下を引き起こす場合がある。また、収納空間内に収納された薬液中の薬効成分が、潤滑剤に吸着（結合）し、薬液中の薬効成分の濃度低下により、十分な量の薬効成分を供給できない場合がある。このことは、薬液等があらかじめ充填されたプレフィルドシリンジにおいて特に好ましくない問題となる。   In the case of a syringe gasket made of an elastic material such as vulcanized rubber or thermoplastic elastomer, the sliding resistance with the inner peripheral surface of the outer cylinder becomes extremely large. It is necessary to apply a lubricant between them to reduce the sliding resistance between the gasket outer peripheral surface and the outer cylinder inner peripheral surface. However, in a syringe equipped with this gasket, for example, when a chemical solution is stored in the storage space of the outer cylinder, the lubricant is mixed (dissolved) in the chemical solution, and the lubricant acts on the medicinal component in the chemical solution (reaction). ) May cause a decrease in activity. In addition, a medicinal component in the chemical solution stored in the storage space may be adsorbed (bonded) to the lubricant, and a sufficient amount of the medicinal component may not be supplied due to a decrease in the concentration of the medicinal component in the chemical solution. This is a particularly undesirable problem in a prefilled syringe prefilled with a chemical solution or the like.

そこで、従来のシリンジ用ガスケットでは、図６に示すように、ゴム材料製のガスケット本体１０４の薬液と接触する部分と外筒の内周面と接触する部位とを慴動性に富む樹脂フィルム１０５で覆ったシリンジ用ガスケット１０３が提案されている（特許文献１）。また、この種のシリンジ用ガスケットは、金型に樹脂フィルム１０５とゴム生地をセットして、圧縮成形によりゴム材料製のガスケット本体を成形すると同時に薬液と接触する部位及び外筒内周面と接触する部位に樹脂フィルム１０５を積層するようにして、ガスケットが製造されている（特許文献２）。   Therefore, in the conventional gasket for a syringe, as shown in FIG. 6, a resin film 105 having a high peristability between a portion in contact with the chemical solution of the gasket main body 104 made of a rubber material and a portion in contact with the inner peripheral surface of the outer cylinder. There has been proposed a syringe gasket 103 covered with (Patent Document 1). In addition, this type of gasket for a syringe has a resin film 105 and a rubber cloth set in a mold, and a gasket body made of rubber material is molded by compression molding. A gasket is manufactured in such a manner that a resin film 105 is laminated on a portion to be processed (Patent Document 2).

このシリンジ用ガスケット１０３によれば、ゴム材料製ガスケット本体１０４の嵌合代により密封性を確保し、薬液と接触する部位及び外筒内周面と接触する部位に樹脂フィルム１０５を積層することで、耐薬品性及び慴動性を確保するようにしている。   According to this syringe gasket 103, the sealing performance is secured by the fitting allowance of the rubber material gasket main body 104, and the resin film 105 is laminated on the portion in contact with the chemical liquid and the portion in contact with the inner peripheral surface of the outer cylinder. The chemical resistance and the peristaltic properties are ensured.

実開平０１−１３８４５４号公報Japanese Utility Model Publication No. 01-138454 特開２００２−８６４８１号公報JP 2002-86481 A

しかしながら、この種のシリンジ用ガスケットにおいては、圧縮成形により製造される際に、ガスケットの形状変化が大きい箇所（換言すれば急激に形状が変化する部分）例えばガスケットの先端面と外周面との交わる隅部並びに外筒内周面と嵌合代をもつて接触して密封面を構成する外周面と外筒内周面とは接触せずに凹んだ外周面部位との境界の隅部（以下、これらをＲ部と呼ぶ。）では、フィルム１０５が部分的に引き延ばされたりするので、Ｒ部付近の密封面は円周上の真円度が悪く密封性が低下してしまう問題がある。   However, in this type of gasket for syringes, when the gasket is manufactured by compression molding, a portion where the shape change of the gasket is large (in other words, a portion where the shape changes abruptly), for example, the front end surface and the outer peripheral surface of the gasket intersect. The corner of the boundary between the outer peripheral surface forming the sealing surface by contacting with the corner portion and the outer peripheral surface of the outer cylinder and the outer peripheral surface portion recessed without contacting the inner peripheral surface of the outer cylinder In these cases, the film 105 is partially stretched. Therefore, the sealing surface near the R portion has a problem that the roundness on the circumference is poor and the sealing performance is deteriorated. is there.

本発明は、薬液等が注射器から漏れ出ないように外筒とガスケットとの密封性を向上させるシリンジ用ガスケットを提供することを目的とする。   An object of this invention is to provide the gasket for syringes which improves the sealing performance of an outer cylinder and a gasket so that a chemical | medical solution etc. may not leak from a syringe.

かかる目的を達成するために請求項１記載の発明は、弾性材料製の本体と、前記本体の少なくとも外筒の内周面と接触する部位に被覆された慴動性に優れる樹脂フィルムとを有するシリンジ用ガスケットにおいて、前記ガスケットには、前記外筒の内周面と接触する少なくとも一つの密封面を形成し、前記密封面は、傾斜角度が異なる複数の面によって構成され、各面が前記外筒との間で薬液を密封する液密封面側からその反対の大気側の反液密封面側に向かって径が大きくなるように形成されると共に、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有するようにしている。   In order to achieve this object, the invention described in claim 1 has a main body made of an elastic material, and a resin film excellent in sliding property that is coated on a portion of the main body that contacts at least the inner peripheral surface of the outer cylinder. In the gasket for a syringe, the gasket includes at least one sealing surface that is in contact with the inner peripheral surface of the outer cylinder, and the sealing surface includes a plurality of surfaces having different inclination angles, and each surface includes the outer surface. It is formed so that the diameter increases from the liquid sealing surface side that seals the chemical solution to the cylinder toward the opposite liquid sealing surface side of the atmosphere, and the two adjacent surfaces are closer to the liquid sealing surface side. At least one relationship is established in which the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface.

ここで、請求項１記載のシリンジ用ガスケットにおいて、密封面に形成される複数の面の傾斜角度は、０°より大きく、５°以下であることが好ましい。より好ましくは面同士の角度差を大きくすることである。これは、面同士の角度差が大きいと、連結部の角部による面圧効果が得られやすくなるからである。   Here, in the syringe gasket according to claim 1, it is preferable that the inclination angle of the plurality of surfaces formed on the sealing surface is larger than 0 ° and not larger than 5 °. More preferably, the angle difference between the surfaces is increased. This is because if the angle difference between the surfaces is large, the surface pressure effect due to the corners of the connecting portion is easily obtained.

また、請求項１または２記載のシリンジ用ガスケットにおいて、液密封面側に形成される傾斜面の長さは、密封面の長さの１０〜８０％であることが好ましい。   In the syringe gasket according to claim 1, the length of the inclined surface formed on the liquid sealing surface side is preferably 10 to 80% of the length of the sealing surface.

請求項１記載のシリンジ用ガスケットによれば、傾斜角度が異なる複数の面によって外筒の内周面と接触する少なくとも一つの密封面が構成され、各面が外筒との間で薬液を密封する液密封面側からその反対の大気側の反液密封面側に向かって径が大きくなるように形成されると共に、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有しているので、傾斜角度が異なる２つの面の間に、角部から成る連結部が形成される。この連結部は、Ｒ部等の形状変化が大きい部位から離れた位置に構成することができるので、真円度は良好なものである。また、連結部は、傾斜角度が異なる複数の面が突き合わされて角部となっているため、外筒の内周面と、ガスケットの密封面との嵌合時の面圧分布において、連結部の面圧が高くなる。したがって、複数の面間に形成される連結部により、面圧が高く、真円度がよいシール部を密封面に構成することができる（図４参照）。そして、ガスケットの密封面の液密封面側端部、及び反液密封面側（大気側）端部の密封性が劣る事態になっても、連結部（シール部）により高い密封性が確保できる。   According to the syringe gasket according to claim 1, at least one sealing surface that comes into contact with the inner peripheral surface of the outer cylinder is constituted by a plurality of surfaces having different inclination angles, and each surface seals the drug solution with the outer cylinder. The liquid sealing surface is formed so that the diameter increases from the liquid sealing surface side to the opposite liquid sealing surface side of the atmosphere, and the two adjacent surfaces are opposite to the inclination angle of the surface closer to the liquid sealing surface side. Since there is at least one relationship in which the inclination angle of the surface on the liquid sealing surface side becomes smaller, a connecting portion composed of a corner portion is formed between two surfaces having different inclination angles. Since this connection part can be comprised in the position away from the site | parts with large shape changes, such as R part, roundness is favorable. In addition, since the connecting portion has a corner portion formed by abutting a plurality of surfaces having different inclination angles, the connecting portion has a surface pressure distribution at the time of fitting between the inner peripheral surface of the outer cylinder and the sealing surface of the gasket. The surface pressure increases. Therefore, a sealing portion having a high surface pressure and good roundness can be formed on the sealing surface by the connecting portions formed between the plurality of surfaces (see FIG. 4). And even if it becomes the situation where the sealing performance of the liquid sealing surface side end part of the sealing surface of a gasket and the anti-liquid sealing surface side (atmosphere side) end part is inferior, high sealing performance can be secured by the connecting part (seal part). .

また、密封面は、液密封側から大気側にかけて径が大きくなる複数の面を形成しているため、外筒に対するガスケットの挿入の際に挿入し易くなる。しかも、液密封面側のガスケットの径は小さくなり、外筒にガスケットを挿入した場合のガスケットの圧縮率が抑えられるため、密封面の皺の発生が抑えられる。特に、液密封面に近い面の圧縮率は小さくなるため、面に皺が発生しにくくなる。このため、液密封面に近い面の皺の発生による密封性の低下を防止できる。   Moreover, since the sealing surface forms a plurality of surfaces whose diameter increases from the liquid sealing side to the atmosphere side, it is easy to insert the gasket when inserting the gasket into the outer cylinder. In addition, the diameter of the gasket on the liquid sealing surface side is reduced, and the compression rate of the gasket when the gasket is inserted into the outer cylinder is suppressed, so that generation of wrinkles on the sealing surface is suppressed. In particular, since the compressibility of the surface close to the liquid sealing surface is small, wrinkles are unlikely to occur on the surface. For this reason, it is possible to prevent deterioration in sealing performance due to generation of wrinkles on the surface close to the liquid sealing surface.

また、本発明にかかるシリンジ用ガスケットにおいて、密封面を構成する複数の面の傾斜角度が０°より大きく、５°以下とする場合、複数の面の間に形成される連結部によって面圧が高く、真円度がよいシール部を構成することができるので、薬液漏れ、滲みが生じない。ここで、傾斜角度が０°あるいはそれよりも小さいと、ガスケットの複数の面に液密封面側から反液密封面側へ拡径するテーパ形状が構成されないことになり、シリンジのガスケットの挿入性が低下する。また、液密封面側寄りの面の径が密封面における最大径部となるため、圧縮率が大きくなり、液密封面側寄りの面に皺が発生し、密封性が低下する危険性が高くなる。また、傾斜角度が５°よりも大きいと、反液密封面側寄りの面以外の面、特に液密封面側寄りの面が外筒内周面と接触しにくくなり、密封性が得られなくなってしまう。   In the syringe gasket according to the present invention, when the inclination angle of the plurality of surfaces constituting the sealing surface is larger than 0 ° and 5 ° or less, the surface pressure is increased by the connecting portion formed between the plurality of surfaces. Since a seal portion having a high roundness can be formed, no chemical leakage or bleeding occurs. Here, when the inclination angle is 0 ° or smaller, the taper shape that expands from the liquid-sealing surface side to the anti-liquid-sealing surface side is not formed on the plurality of surfaces of the gasket. Decreases. In addition, since the diameter of the surface close to the liquid sealing surface is the maximum diameter portion of the sealing surface, the compressibility increases, and there is a high risk of wrinkles occurring on the surface close to the liquid sealing surface, resulting in a decrease in sealing performance. Become. Further, if the inclination angle is larger than 5 °, the surface other than the surface close to the anti-liquid sealing surface side, particularly the surface close to the liquid sealing surface side becomes difficult to contact the inner peripheral surface of the outer cylinder, and the sealing performance cannot be obtained. End up.

また、本発明のシリンジ用ガスケットにおいて、液密封面側に形成される面の長さを密封面の長さの１０〜８０％の範囲内にする場合には、Ｒ部等の形状変化が大きい部位から離れた位置に連結部を構成することができるので、その真円度が良好なものとなる。したがって、連結部でのシール効果が高まり、薬液が漏れることを防止することができる。他方、液密封面側に形成される面の長さが１０％未満あるいは８０％超過の場合には、液密封面側に形成される面とその後ろの面との境界で形成される連結部がＲ部付近に形成されてしまうため、連結部がガスケット成形時のフィルムの変形に巻き込まれ、連結部の真円度が悪くなり、密封性が低下する虞がある。   Further, in the syringe gasket of the present invention, when the length of the surface formed on the liquid sealing surface side is within the range of 10 to 80% of the length of the sealing surface, the shape change of the R portion or the like is large. Since a connection part can be comprised in the position away from the site | part, the roundness becomes favorable. Therefore, the sealing effect at the connecting portion is enhanced, and the chemical liquid can be prevented from leaking. On the other hand, when the length of the surface formed on the liquid sealing surface side is less than 10% or exceeds 80%, the connecting portion formed at the boundary between the surface formed on the liquid sealing surface side and the surface behind the surface. Is formed in the vicinity of the R portion, the connecting portion is caught in the deformation of the film at the time of molding the gasket, the roundness of the connecting portion is deteriorated, and the sealing performance may be deteriorated.

本発明にかかるシリンジ用ガスケットが外筒に装着されている状態を示す説明図である。It is explanatory drawing which shows the state with which the gasket for syringes concerning this invention is mounted | worn with the outer cylinder. 本発明にかかるシリンジ用ガスケットの２つの面を有する実施形態を示す図で、（Ａ）はガスケットの密封面を拡大して示す縦断面図、（Ｂ）は第１の密封面をさらに拡大して示す縦断面図である。It is a figure which shows embodiment which has two surfaces of the gasket for syringes concerning this invention, (A) is a longitudinal cross-sectional view which expands and shows the sealing surface of a gasket, (B) further expands the 1st sealing surface. FIG. 本発明にかかるシリンジ用ガスケットの３つの面を有する実施形態を示す図で、（Ａ）はガスケットの密封面を拡大して示す縦断面図、（Ｂ）は第１の密封面をさらに拡大して示す縦断面図である。It is a figure which shows embodiment which has three surfaces of the gasket for syringes concerning this invention, (A) is a longitudinal cross-sectional view which expands and shows the sealing surface of a gasket, (B) further expands the 1st sealing surface. FIG. 図２に示すシリンジ用ガスケットの第１密封面においては発生する面圧の分布状態を説明する説明図である。It is explanatory drawing explaining the distribution state of the surface pressure which generate | occur | produces in the 1st sealing surface of the gasket for syringes shown in FIG. シリンジ用ガスケットの評価試験を行う装置配置を示す説明図である。It is explanatory drawing which shows the apparatus arrangement | positioning which performs the evaluation test of the gasket for syringes. 従来のシリンジ用ガスケットの一例を示す図で、（Ａ）はガスケット全体を示す縦断面図、（Ｂ）は密封面を拡大して示す縦断面図である。It is a figure which shows an example of the conventional gasket for syringes, (A) is a longitudinal cross-sectional view which shows the whole gasket, (B) is a longitudinal cross-sectional view which expands and shows a sealing surface.

以下、本発明の構成を図面に示す実施形態に基づいて詳細に説明する。   Hereinafter, the configuration of the present invention will be described in detail based on embodiments shown in the drawings.

図１に、本発明のシリンジ用ガスケットをプレフィルドシリンジ用として適用した実施形態の一例を示す。プレフィルドシリンジ１は、薬液等（図示省略）があらかじめ充填された注射器であり、一般に、円筒形の筒（外筒あるいはシリンジとも呼ばれる。以下、外筒と呼ぶ。）２と、図示していない可動式の押子（プランジャとも呼ばれる）と、押子の先端に在って外筒２内で気密を保ちながら摺動し得るガスケット３とで構成されている。尚、本実施形態では本発明をプレフィルドシリンジ用ガスケットに適用した例を挙げているが、これに特に限定されるものではなく、医療用の注射器に使用されるシリンジ用ガスケット全般に適用可能であることは言うまでもない。   In FIG. 1, an example of embodiment which applied the gasket for syringes of this invention as an object for prefilled syringes is shown. The prefilled syringe 1 is a syringe pre-filled with a chemical solution or the like (not shown), and is generally a cylindrical tube (also referred to as an outer tube or a syringe; hereinafter referred to as an outer tube) 2 and a movable not shown. And a gasket 3 which is slidable while maintaining airtightness in the outer cylinder 2 at the tip of the pusher. In this embodiment, the present invention is applied to a prefilled syringe gasket. However, the present invention is not particularly limited to this, and can be applied to all syringe gaskets used in medical syringes. Needless to say.

外筒２は、例えば底部２１を有する有底円筒形の筒であり、底部２１の中央部に縮径部２２が一体的に形成されている。この縮径部２２には、例えば、薬液投与用、採血用等の針管のハブ、各種コネクタ、チューブ、カテーテル等（図示せず）が装着されて使用される。尚、外筒２には、ガスケット３との間で囲まれる薬液収納空間２４が形成され、この薬液収納空間２４は、縮径部２２の内腔２３と連通している。   The outer cylinder 2 is a bottomed cylindrical cylinder having a bottom portion 21, for example, and a reduced diameter portion 22 is integrally formed at the center of the bottom portion 21. The diameter-reduced portion 22 is used with, for example, a hub of needle tubes, various connectors, tubes, catheters and the like (not shown) for drug solution administration and blood collection. The outer cylinder 2 is formed with a chemical solution storage space 24 surrounded by the gasket 3, and the chemical solution storage space 24 communicates with the inner cavity 23 of the reduced diameter portion 22.

収納空間２４内には、例えば、血液、ブドウ糖等の糖質注射液、塩化ナトリウムや乳酸カリウム等の電解質補正用注射液、ビタミン剤、ワクチン、抗生物質注射液、造影剤、ステロイド剤、蛋白質分解酵素阻害剤、脂肪乳剤、抗癌剤、麻酔薬のような各種薬液、あるいは、蒸留水、消毒薬、流動食、アルコール等の液体（本明細書においてはこれらを総称して薬液等と呼ぶ）が収納される。   In the storage space 24, for example, sugar injection solutions such as blood and glucose, electrolyte correction injection solutions such as sodium chloride and potassium lactate, vitamin agents, vaccines, antibiotic injection solutions, contrast agents, steroid agents, and proteolysis Contains various chemical solutions such as enzyme inhibitors, fat emulsions, anticancer agents, anesthetics, or liquids such as distilled water, disinfectant, liquid food, and alcohol (collectively referred to herein as chemical solutions). Is done.

ガスケット３は、図示しないプランジャの先端部分に、着脱可能にあるいは一体的に装着される。例えば、本実施形態の場合には、ガスケット３の内側に雌ねじ３４が形成され、プランジャの先端に形成した雄ねじを螺合させることによって一体化されるように設けられている。   The gasket 3 is detachably or integrally attached to a distal end portion of a plunger (not shown). For example, in the case of this embodiment, the internal thread 34 is formed inside the gasket 3, and it is provided so that it may be integrated by screwing the external thread formed at the front-end | tip of a plunger.

このガスケット３は、弾性材料製のガスケット本体４と、ガスケット本体４の外面を被覆する樹脂フィルム５とで構成されている。通常、ガスケット本体４は弾性材料で形成され、ガスケット３としての最大外径部分が外筒２の内径より若干大きく設定されることにより、ガスケット本体４の弾性力によってガスケット外周が外筒２の内周面２５と圧接して液密性が保たれるように設けられる。   The gasket 3 includes a gasket body 4 made of an elastic material and a resin film 5 that covers the outer surface of the gasket body 4. Usually, the gasket main body 4 is formed of an elastic material, and the maximum outer diameter portion as the gasket 3 is set slightly larger than the inner diameter of the outer cylinder 2, so that the gasket outer periphery is inside the outer cylinder 2 by the elastic force of the gasket main body 4. It is provided so as to maintain liquid tightness by being pressed against the peripheral surface 25.

ガスケット本体４を構成する弾性材料としては、特定の弾性材料に限定されるものではないが、例えば、天然ゴム、ブチルゴム、イソプレンゴム、ブタジエンゴム、スチレン−ブタジエンゴム、ハロゲン化ブチルゴム、シリコーンゴムのような各種ゴム材料や、ポリウレタン系、ポリエステル系、ポリアミド系、オレフィン系、スチレン系等の各種熱可塑性エラストマー等のうちの、１種または２種以上を組み合わせて用いることが好ましい。この中でも、加硫により、弾性が得られる材料がより好ましい。   The elastic material constituting the gasket body 4 is not limited to a specific elastic material, but examples thereof include natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, halogenated butyl rubber, and silicone rubber. Of these various rubber materials, various thermoplastic elastomers such as polyurethane, polyester, polyamide, olefin, and styrene are preferably used in combination of one or more. Among these, a material that can obtain elasticity by vulcanization is more preferable.

本実施形態におけるガスケット３は、図１に示すように、少なくとも外筒２の内周面２５と接する部分即ち外周面３１、好ましくは外筒２の内周面２５と接する部分たる外周面３１及び外筒２内に充填される薬液と接触し密封する面即ち円錐形状の先端面（本明細書においては液密封面と呼ぶ）３２が慴動性に優れる液密性の樹脂フィルム５で覆われている。本実施形態では、ガスケット本体４のプランジャ（図示省略）が接続される大気側７の後端面（本明細書においては反液密封面と呼ぶ）３３を除いて、ガスケット本体４の液密封面３２と外周面３１とが樹脂フィルム５で被覆されている。この樹脂フィルム５は、少なくとも高い摺動性に加えて、高い液密性も要求されることから、少なくとも摺動性に優れる摩擦係数の小さい不透水性の材料で構成されることが必要であるが、充填する液体によってはその他の性質例えば薬剤等であれば耐薬品性を有することが必要となる。したがって、樹脂フィルム５としては、好ましくは摺動性に優れると共に耐薬品性に優れる材質、例えばポリテトラフルオロエチレンまたはその共重合体、ＥＴＦＥ（エチレン−テトラフルオロエチレン共重合体）、四フッ化エチレン、ＰＦＡ（四フッ化エチレン−パーフルオロアルコキシエチレン共重合体（例えば、四フッ化エチレンと、アルコキシル基の炭素数が１〜５のパーフルオロアルコキシエチレンとの共重合体））、ＰＶｄＦ（ポリビニリデンフルオライド）、ＰＣＴＦＥ（ポリクロロトリフルオロエチレン）、ＴＦＥ（テトラフルオロエチレン）、ＦＥＰ（フッ化エチレンプロピレン）等のフッ素系樹脂が挙げられ、これらの１種または２種以上を組み合わせて用いることができる。勿論、樹脂フィルム５の構成材料としては、上述に例示したものに特に限定されない。   As shown in FIG. 1, the gasket 3 according to the present embodiment includes at least a portion in contact with the inner peripheral surface 25 of the outer cylinder 2, that is, an outer peripheral surface 31, preferably an outer peripheral surface 31 that is a portion in contact with the inner peripheral surface 25 of the outer cylinder 2 and A surface that comes into contact with and seals the chemical solution filled in the outer cylinder 2, that is, a conical tip end surface (referred to as a liquid sealing surface in the present specification) 32 is covered with a liquid-tight resin film 5 having excellent peristaltic properties. ing. In the present embodiment, the liquid sealing surface 32 of the gasket body 4 except for the rear end surface 33 (referred to herein as the anti-liquid sealing surface) 33 to which the plunger (not shown) of the gasket body 4 is connected. And the outer peripheral surface 31 are covered with the resin film 5. Since this resin film 5 requires high liquid-tightness in addition to at least high slidability, it is necessary to be composed of a water-impermeable material having a low coefficient of friction and excellent slidability. However, depending on the liquid to be filled, it is necessary to have chemical resistance for other properties such as drugs. Therefore, the resin film 5 is preferably made of a material excellent in slidability and chemical resistance, such as polytetrafluoroethylene or a copolymer thereof, ETFE (ethylene-tetrafluoroethylene copolymer), or tetrafluoroethylene. , PFA (tetrafluoroethylene-perfluoroalkoxyethylene copolymer (for example, a copolymer of tetrafluoroethylene and perfluoroalkoxyethylene whose alkoxyl group has 1 to 5 carbon atoms)), PVdF (polyvinylidene) Fluoride resins such as fluoride), PCTFE (polychlorotrifluoroethylene), TFE (tetrafluoroethylene), and FEP (fluorinated ethylene propylene) can be used, and one or more of these can be used in combination. it can. Of course, the constituent material of the resin film 5 is not particularly limited to those exemplified above.

また、ガスケット３の外筒２の内周面２５と接触する面（外周面）３１には、ガスケット３の最大外径部分となる少なくとも一つの密封面３５が形成される。ここで、外筒２の内周面２５と接触する密封面３５の長さが同じ場合には、一つの密封面で外筒の内周面に接触させるよりも複数の密封面を形成してシール箇所を複数にする方が好ましい。この場合、一方の密封面から漏れてしまっても、他方の密封面でシールができるためシール性を確保することが容易である。また、密封面を分散させることでも、摺動し易くなるので、密封面を２つ形成したものが好ましい。そこで、本実施形態の場合には、液密封面３２寄りの第１の密封面３５ａと大気側７となる後端面３３寄りの第２の密封面３５ｂとの２つの密封面を備えている。   In addition, at least one sealing surface 35 serving as the maximum outer diameter portion of the gasket 3 is formed on a surface (outer peripheral surface) 31 that contacts the inner peripheral surface 25 of the outer cylinder 2 of the gasket 3. Here, when the length of the sealing surface 35 in contact with the inner peripheral surface 25 of the outer cylinder 2 is the same, a plurality of sealing surfaces are formed rather than contacting the inner peripheral surface of the outer cylinder with one sealing surface. It is preferable to use a plurality of seal locations. In this case, even if leaking from one sealing surface, sealing is easy because the sealing can be performed on the other sealing surface. Moreover, since it becomes easy to slide also by disperse | distributing a sealing surface, what formed two sealing surfaces is preferable. Therefore, in the case of the present embodiment, there are provided two sealing surfaces: a first sealing surface 35 a near the liquid sealing surface 32 and a second sealing surface 35 b near the rear end surface 33 that becomes the atmosphere side 7.

そして、第１の密封面３５ａは、傾斜角度が異なる第１と第２の複数の面３７ａ，３７ｂによって構成されており、それら面３７ａ，３７ｂが薬液収納空間２４に臨む液密封面（先端面）３２側からその反対側の大気側寄りの反液密封面３３に向かって径が大きくなるように形成されている。ここで、密封面３５を構成する複数の面のうち、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有していることが望ましい。本実施形態では、液密封面３２側の面３７ａの傾斜角度θ１に対して、反液密封面３３側の第２面３７ｂの傾斜角度θ２が小さくなるように設けられている。このとき、面同士の傾斜角度差例えば第１面３７ａと第２面３７ｂの傾斜角度θ１とθ２との差は大きい方が望ましい。これは、面同士の傾斜角度差が大きいと、２つの面が交わる連結部３８におけるエッジ（角）が尖り易くなるため、連結部の角部による面圧効果が得られ易くなるからである。このように構成することによって、図４に示すように、傾斜角度がθ１とθ２と異なる２つの面即ち第１面３７ａと第２面３７ｂの間に、密封面３５における最大径Ｄｍａｘよりも小径の角部から成る連結部３８が形成される。この連結部３８は、密封面３５における最大径Ｄｍａｘよりも小径で密封面３５の中で圧縮量が最も大きくならないので、皺が発生することがなく、シール効果が保たれる。また、液密封面３２側の端部の最小径Ｄｍｉｎよりも大径となるので、液密封面側の最大面圧よりも高く、大気側の最大面圧部（最大径Ｄｍａｘ部分）の面圧に劣らぬ高い面圧となる。   The first sealing surface 35a is composed of a plurality of first and second surfaces 37a and 37b having different inclination angles, and the surfaces 37a and 37b are liquid sealing surfaces (tip surfaces) facing the chemical solution storage space 24. ) It is formed so that the diameter increases from the 32 side toward the opposite liquid-sealing surface 33 on the air side. Here, among the plurality of surfaces constituting the sealing surface 35, the relationship between the two adjacent surfaces becomes smaller in the inclination angle of the surface on the anti-liquid sealing surface side than the inclination angle of the surface closer to the liquid sealing surface side. It is desirable to have at least one. In the present embodiment, the inclination angle θ2 of the second surface 37b on the anti-liquid sealing surface 33 side is set smaller than the inclination angle θ1 of the surface 37a on the liquid sealing surface 32 side. At this time, it is desirable that the difference between the inclination angles of the surfaces, for example, the difference between the inclination angles θ1 and θ2 of the first surface 37a and the second surface 37b is larger. This is because, when the difference in the inclination angle between the surfaces is large, the edge (corner) at the connecting portion 38 where the two surfaces intersect is likely to be sharpened, and the surface pressure effect by the corner portion of the connecting portion is easily obtained. By configuring in this way, as shown in FIG. 4, the diameter is smaller than the maximum diameter Dmax of the sealing surface 35 between two surfaces different in inclination angle from θ1 and θ2, that is, the first surface 37a and the second surface 37b. The connecting portion 38 is formed of the corner portion. Since the connecting portion 38 has a diameter smaller than the maximum diameter Dmax of the sealing surface 35 and does not have the largest amount of compression in the sealing surface 35, no wrinkles are generated, and the sealing effect is maintained. Further, since the diameter is larger than the minimum diameter Dmin of the end portion on the liquid sealing surface 32 side, it is higher than the maximum surface pressure on the liquid sealing surface side, and the surface pressure of the maximum surface pressure portion (maximum diameter Dmax portion) on the atmosphere side. The contact pressure is as high as

尚、上述の実施形態では、１つの密封面３５が２つの面で構成されている例を挙げて主に説明したが、これに特に限られるものではなく、例えば図３に示すように、第１面３７ａと第２面３７ｂと第３面３７ｃとの３つの面で１つの密封面３５を構成するようにしても良い。この場合にも、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも１つ有していれば、薬液が漏れることを防止できる。また、１つの密封面３５を構成する面の数が多ければ、それだけ面の境界部分に形成される連結部の数が増え、そのことに起因するシール効果が高められることは言うまでもない。   In the above-described embodiment, an example in which one sealing surface 35 is configured by two surfaces has been mainly described. However, the present invention is not limited to this example. For example, as illustrated in FIG. One sealing surface 35 may be constituted by three surfaces of the first surface 37a, the second surface 37b, and the third surface 37c. Also in this case, if at least one of the two adjacent surfaces has a relationship in which the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface closer to the liquid sealing surface side, the chemical solution Can be prevented from leaking. Needless to say, if the number of surfaces constituting one sealing surface 35 is large, the number of connecting portions formed at the boundary portion of the surfaces increases accordingly, and the sealing effect due to that increases.

ここで、１つの密封面３５を構成する複数の面の傾斜角度は、０°より大きく、５°以下であることが好ましい。液密封面３２側寄りの面例えば第１面３７ａの傾斜角度θ１が０°以下であると、第１面３７ａ（特に連結部周辺）及び連結部３８ａが外筒内周面２５に接触しづらくなると共に、ガスケット３の挿入性が低下してしまう。即ち、第１面３７ａの角度が０°を成す場合、第２面３７ｂの径が第１面３７ａよりも大きくなるように傾斜角度θ２を形成すると、第１面３７ａと第２面３７ｂとの連結部３７ａ及び連結部３７ａの周辺の面が外筒２の内周面２５に接触しづらい構成になってしまう。また、第１面の角度θ１が０°より小さな負の角度の場合において、連結部及び連結部周辺の密封面を接触させるには、第２面３７ｂの傾斜角度θ２も同様に第１面３７ａの傾斜角度θ１よりもさらに負の角度にしなければならない。この場合、第１面３７ａの液密封面３２側の径が連結部３８ａよりも大きくなる逆テーパ形状となることから、外筒２へのガスケット３の挿入のし易さが低下し、 液密封面３２側の圧縮率が大きくなるため、第１面３７ａ特に液密封面３２側の端部に皺が発生し、この皺の隙間から薬液が漏れる危険性が高くなる。また、反液密封面３３側寄りの面例えば図２における第２面３７ｂあるいは図３における第３面３７ｃの傾斜角度θ２あるいはθ３が０°の場合においても、その前方の面例えば図２における第１面３７ａあるいは図３における第２面３７ｂとの境界で形成される連結部３８ａあるいは３８ｂが密封面における最大径になって連結部３８の圧縮量が最も大きくなるため、連結部３８ａあるいは３８ｂに皺が発生しやすくなり、連結部３８ａあるいは３８ｂのシール効果が低減し易くなる。このことは、図２における傾斜角度θ２あるいは図３におけるθ３が０°以下、即ち負の角度（逆の傾き、前方よりも後方の方が小径となる逆テーパの関係）においても同様である。反面、図２における液密封面３２側寄りの面たる第１面３７ａの傾斜角度θ１が０°より大きく形成されると、ガスケット３の挿入が容易となるが、５°よりも大きいと、第１面３７ａが外筒２の内周面２５と接触し難くなり、第１面３７ａにおける密封性が得られなくなってしまう。また、図３の実施形態においては第１面３７ａの傾斜角度θ１のみならず、第２面３７ｂの傾斜角度θ２においても５°よりも大きいと、第１面３７ａ及び第２面３７ｂにおける密封性が得られなくなってしまう。さらに、図２の実施形態において傾斜角度θ１＜傾斜角度θ２となってしまった場合、あるいは図３の実施形態において傾斜角度θ１，θ２＜θ３となってしまった場合、その間の連結部３８ａ，３８ｂは、接触状態が良好なものを保つことができない危険性があるため、連結部３８ａ，３８ｂによるシール部が形成されなくなり、密封性が低下してしまう危険性が生じてしまう。   Here, it is preferable that the inclination angle of a plurality of surfaces constituting one sealing surface 35 is larger than 0 ° and not larger than 5 °. When the inclination angle θ1 of the surface close to the liquid sealing surface 32, for example, the first surface 37a is 0 ° or less, the first surface 37a (particularly around the connection portion) and the connection portion 38a are difficult to contact the inner peripheral surface 25 of the outer cylinder. At the same time, the insertability of the gasket 3 is reduced. That is, when the angle of the first surface 37a is 0 °, if the inclination angle θ2 is formed so that the diameter of the second surface 37b is larger than that of the first surface 37a, the first surface 37a and the second surface 37b The connection portion 37a and the peripheral surface of the connection portion 37a are difficult to contact the inner peripheral surface 25 of the outer cylinder 2. Further, when the angle θ1 of the first surface is a negative angle smaller than 0 °, in order to bring the connecting portion and the sealing surface around the connecting portion into contact with each other, the inclination angle θ2 of the second surface 37b is similarly set to the first surface 37a. The inclination angle θ1 must be more negative than the inclination angle θ1. In this case, since the diameter on the liquid sealing surface 32 side of the first surface 37a is larger than that of the connecting portion 38a, the ease of inserting the gasket 3 into the outer cylinder 2 is reduced. Since the compression rate on the surface 32 side is increased, soot is generated at the end of the first surface 37a, particularly on the liquid sealing surface 32 side, and there is a high risk that the chemical liquid leaks from the gap between the soots. Further, even when the tilt angle θ2 or θ3 of the surface close to the anti-liquid sealing surface 33, for example, the second surface 37b in FIG. 2 or the third surface 37c in FIG. 3, is 0 °, the front surface thereof, for example, the second surface in FIG. Since the connecting portion 38a or 38b formed at the boundary with the first surface 37a or the second surface 37b in FIG. 3 has the maximum diameter on the sealing surface and the amount of compression of the connecting portion 38 is the largest, the connecting portion 38a or 38b Wrinkles are likely to occur, and the sealing effect of the connecting portion 38a or 38b is likely to be reduced. This is the same even when the inclination angle θ2 in FIG. 2 or θ3 in FIG. 3 is 0 ° or less, that is, a negative angle (reverse inclination, reverse taper relationship in which the rear has a smaller diameter than the front). On the other hand, when the inclination angle θ1 of the first surface 37a that is closer to the liquid sealing surface 32 in FIG. 2 is formed to be greater than 0 °, the gasket 3 can be easily inserted. It becomes difficult for the first surface 37a to come into contact with the inner peripheral surface 25 of the outer cylinder 2, and the sealing performance on the first surface 37a cannot be obtained. Further, in the embodiment of FIG. 3, not only the inclination angle θ1 of the first surface 37a but also the inclination angle θ2 of the second surface 37b is greater than 5 °, the sealing performance on the first surface 37a and the second surface 37b. Can no longer be obtained. Furthermore, when the inclination angle θ1 <inclination angle θ2 in the embodiment of FIG. 2 or when the inclination angles θ1, θ2 <θ3 in the embodiment of FIG. 3, the connecting portions 38a and 38b therebetween are used. Since there is a risk that a good contact state cannot be maintained, the seal portion by the connecting portions 38a and 38b is not formed, and there is a risk that the sealing performance is lowered.

そこで、１つの密封面３５を構成する複数の面は、好ましくは、少なくとも前述の隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係が、傾斜角度が０°よりも大きく５°以下で、かつ液密封面側寄りの面の傾斜角度よりも反密封面側の面の傾斜角度の方が小さくなる関係を少なくとも１つ有していることである。さらには、１つの密封面を構成する複数の面の傾斜角度が０°よりも大きく５°以下で、且つ液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係にあり、最も反液密封面側に形成される面の傾斜角度が全ての面の中でもっとも小さくされることがより好ましい。   Therefore, the plurality of surfaces constituting one sealing surface 35 are preferably such that at least the two adjacent surfaces described above have an inclination angle of the surface on the side opposite to the liquid sealing surface rather than an inclination angle of the surface closer to the liquid sealing surface side. The relationship that the direction becomes smaller is at least the relationship that the inclination angle is larger than 0 ° and not more than 5 °, and the inclination angle of the surface on the anti-sealing surface side becomes smaller than the inclination angle of the surface closer to the liquid sealing surface side. It is to have one. Furthermore, the inclination angle of the plurality of surfaces constituting one sealing surface is larger than 0 ° and not more than 5 °, and the inclination angle of the surface on the side opposite to the liquid sealing surface is larger than the inclination angle of the surface closer to the liquid sealing surface side. It is more preferable that the inclination angle of the surface formed closest to the anti-liquid sealing surface is the smallest among all the surfaces.

即ち、密封面３５の好ましい形状は、傾斜角度が異なる複数の面によって構成されており、それらの面が薬液収納空間２４に臨む液密封面（先端面）３２側からその反対側の大気側寄りの反液密封面３３に向かって径が大きくなるように形成されると共に、液密封面（先端面）３２側からその反対側の大気側寄りの反液密封面（後端面）３３側にかけて複数の面の傾斜角度が順次小さくなるように形成することである。例えば、図２に示す本実施形態のように第１面３７ａと第２面３７ｂとの２つの面を有する場合には、第１面３７ａの傾斜角度θ１＞第２面３７ｂの傾斜角度θ２となる関係にすることである。また、図３に示すように、第１面３７ａと第２面３７ｂと第３面３７ｃとの３つの面が形成される場合には、第１面３７ａの傾斜角度θ１＞第２面３７ｂの傾斜角度θ２＞第３面３７ｃの傾斜角度θ３となる関係にすることである。尤も、前述の液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係にあり、尚且つ最も反液密封面側に形成される面の傾斜角度が全ての面の中でもっとも小さくされる関係はより好ましい関係ではあるがこれに特に限られるものでない。密封面３５を構成する複数の面のうち、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有しておれば足り、３つ以上の面で構成される場合には、最も反液密封面側に形成される面の傾斜角度が０°以下であっても、あるいはその直前の液密封面側の面の傾斜角度よりも大きな（０°より大きく、５°以下の範囲内の）傾斜角度としても、ある程度のシール性は確保されるものである。   That is, the preferred shape of the sealing surface 35 is composed of a plurality of surfaces having different inclination angles, and these surfaces are closer to the air side opposite to the liquid sealing surface (tip surface) 32 side facing the chemical solution storage space 24. Are formed so as to increase in diameter toward the anti-liquid sealing surface 33, and from the liquid sealing surface (front end surface) 32 side to the opposite anti-liquid sealing surface (rear end surface) 33 side on the opposite side. It is to form so that the inclination | tilt angle of this surface may become small sequentially. For example, in the case of having two surfaces of the first surface 37a and the second surface 37b as in this embodiment shown in FIG. 2, the inclination angle θ1 of the first surface 37a> the inclination angle θ2 of the second surface 37b. To make a relationship. In addition, as shown in FIG. 3, when the three surfaces of the first surface 37a, the second surface 37b, and the third surface 37c are formed, the inclination angle θ1 of the first surface 37a> the second surface 37b. The relationship is such that the inclination angle θ2> the inclination angle θ3 of the third surface 37c. However, the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface close to the liquid sealing surface side, and the inclination of the surface formed on the most anti-liquid sealing surface side. The relationship in which the angle is the smallest among all the surfaces is a more preferable relationship, but is not particularly limited thereto. Among the plurality of surfaces constituting the sealing surface 35, at least one of the two adjacent surfaces has a relationship in which the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface closer to the liquid sealing surface side. If it is composed of three or more surfaces, the liquid-sealed surface immediately before or even if the angle of inclination of the surface formed closest to the anti-liquid-sealed surface is 0 ° or less Even if the inclination angle is larger than the inclination angle of the side surface (greater than 0 ° and within a range of 5 ° or less), a certain degree of sealing performance is ensured.

さらに、液密封面３２側に形成される面の長さは、密封面３５の長さの１０〜８０％の範囲内であることが好ましい。ここで、液密封面３２側に形成される面とは、１つの密封面３５を構成する複数の面のうち、もっとも反液密封面３３側寄りに配置された面を除外する意味であり、もっとも反液密封面３３側寄りに配置された面よりも液密封面３２側寄りに配置された全ての面を含める意味で用いられている。例えば、図２に示すように２つの面３７ａ，３７ｂを有する場合には第１面３７ａであり、図３に示すように３つ以上の面３７ａ，３７ｂ，３７ｃを有する場合には第１面３７ａあるいは第１面３７ａ及び第２面３７ｂである。尤も、異なる傾斜角度の３つ以上の面３７ａ，３７ｂ，３７ｃで密封面３５が構成されている場合において、最も液密封面３２側寄りの第１面３７ａのみの長さを上述の範囲内に収める場合にも、十分な効果を奏することはいうまでもない。このことは、複数の密封面３５を構成する場合においては、液密封面３２側寄りの密封面において特に効果的であるが、反液密封面３３側寄りの密封面においても効果があることは言うまでもない。   Further, the length of the surface formed on the liquid sealing surface 32 side is preferably in the range of 10 to 80% of the length of the sealing surface 35. Here, the surface formed on the liquid sealing surface 32 side means to exclude a surface arranged closest to the anti-liquid sealing surface 33 among a plurality of surfaces constituting one sealing surface 35, However, it is used to include all the surfaces arranged closer to the liquid sealing surface 32 than the surfaces arranged closer to the anti-liquid sealing surface 33. For example, when two surfaces 37a and 37b are provided as shown in FIG. 2, it is the first surface 37a. When three or more surfaces 37a, 37b and 37c are provided as shown in FIG. 37a or the first surface 37a and the second surface 37b. However, in the case where the sealing surface 35 is constituted by three or more surfaces 37a, 37b, 37c having different inclination angles, the length of only the first surface 37a closest to the liquid sealing surface 32 is within the above range. Needless to say, a sufficient effect can be obtained even in the case of being accommodated. This is particularly effective on the sealing surface near the liquid sealing surface 32 when a plurality of sealing surfaces 35 are formed, but it is also effective on the sealing surface near the anti-liquid sealing surface 33. Needless to say.

なお、ガスケット３の樹脂フィルム５は、図示の構成のものに限定されることはなく、ガスケット本体４の少なくとも外周面及び液密封面３２の周縁部分にかけて被覆するものであってもよい。また、その形状も、外筒２の内周面２５との十分な摺動性および液密性を有していれば、いかなるものであってもよい。   The resin film 5 of the gasket 3 is not limited to the one shown in the figure, and may be one that covers at least the outer peripheral surface of the gasket body 4 and the peripheral portion of the liquid sealing surface 32. Further, the shape thereof may be any as long as it has sufficient slidability and liquid tightness with the inner peripheral surface 25 of the outer cylinder 2.

なお、上述の形態は本発明の好適な形態の一例ではあるがこれに限定されるものではなく本発明の要旨を逸脱しない範囲において種々変形実施可能である。例えば、本発明の効果を発揮する上でガスケット３の周面の密封面３５の数は限定されるものではない。このため、密封面３５の数は単数でも複数でも良い。つまり、本実施形態では、２つの密封面を構成した例を挙げて本発明を主に説明しているが、これに特に限られるものではなく、例えば実開平０１−１３８４５４号の図１のように１つの密封面を構成するもの、あるいは例えば特開２００７−１１１５４７号のように３つ以上の密封面を構成するようにしても良い。そして、複数の密封面を備える場合には、必ずしも最も液密封面３２寄りの密封面である第１密封面３５ａに本発明の構成を適用することはなく、全ての密封面に本発明の構成を適用するようにしても良いし、場合によっては反液密封面３３側寄りの密封面例えば第２の密封面３５ｂあるいは図示していない第３の密封面に本発明の構成を適用するようにしても、シリンジ内の薬液が漏れ出ないようするという目的を達成するための密封性向上の効果が得られることは言うまでもない。通常、シリンジにおける液漏れ対策としては、第１密封面３５ａから液体が漏れないことが求められることが多いので、第１密封面３５ａに適用することを前提とした記載内容となっているが、第１密封面３５ａに適用することに限定される特別の意味はない。   The above-described embodiment is an example of a preferred embodiment of the present invention, but is not limited thereto, and various modifications can be made without departing from the scope of the present invention. For example, the number of sealing surfaces 35 on the peripheral surface of the gasket 3 is not limited in order to exert the effect of the present invention. For this reason, the number of sealing surfaces 35 may be single or plural. That is, in the present embodiment, the present invention is mainly described with an example in which two sealing surfaces are configured. However, the present invention is not particularly limited to this, for example, as shown in FIG. 1 of Japanese Utility Model Laid-Open No. 01-138454. One sealing surface may be configured, or three or more sealing surfaces may be configured as disclosed in, for example, Japanese Patent Application Laid-Open No. 2007-111547. When a plurality of sealing surfaces are provided, the configuration of the present invention is not necessarily applied to the first sealing surface 35a that is the sealing surface closest to the liquid sealing surface 32, and the configuration of the present invention is applied to all the sealing surfaces. In some cases, the structure of the present invention may be applied to a sealing surface near the anti-liquid sealing surface 33, such as the second sealing surface 35b or a third sealing surface (not shown). However, it goes without saying that the effect of improving the sealing performance for achieving the purpose of preventing the chemical solution in the syringe from leaking out can be obtained. Usually, as a countermeasure against liquid leakage in the syringe, since it is often required that the liquid does not leak from the first sealing surface 35a, it is described on the assumption that it is applied to the first sealing surface 35a. There is no special meaning limited to being applied to the first sealing surface 35a.

＜評価試験＞
（試験１）
図２に例示する構造のガスケットを次の試験条件で７種類のサンプルを作製し、第１面３７ａと第２面３７ｂとの境界で形成される連結部３８の液密封面３２からの位置（即ち、第１面３７ａの長さ）と液密封性について評価試験を行った。 <Evaluation test>
(Test 1)
Two types of gaskets having the structure illustrated in FIG. 2 are prepared under the following test conditions, and the position of the connecting portion 38 formed at the boundary between the first surface 37a and the second surface 37b from the liquid sealing surface 32 ( That is, an evaluation test was performed on the length of the first surface 37a) and the liquid tightness.

試験条件
（１）ガスケットのゴム材料 ：ブチルゴム
（２）樹脂フィルム ：ＰＴＦＥフィルム
（３）ガスケットの第１面の傾斜角度 ：５°
（４）ガスケットの第２面の傾斜角度 ：１°
（５）試験時間 ：２４時間
（６）雰囲気温度 ：２３℃
（７）ｎ数 ：５ Test conditions (1) Gasket rubber material: Butyl rubber (2) Resin film: PTFE film (3) Angle of inclination of the first surface of the gasket: 5 °
(4) Angle of inclination of the second surface of the gasket: 1 °
(5) Test time: 24 hours (6) Atmospheric temperature: 23 ° C
(7) n number: 5

評価試験は、外筒２の所定位置にガスケット３をセットし、内部に水を入れた。そして、ガスケット表面に気泡が発生しないように、プレフィルドシリンジ１を図５に示すように設置した。この状態で、２４時間放置した。２４時間経過後、第１密封面に水のにじみ、漏れがないかを顕微鏡（倍率５０）で確認した。評価試験の結果を、それぞれ下記表１に示す。   In the evaluation test, the gasket 3 was set at a predetermined position of the outer cylinder 2 and water was put inside. And the prefilled syringe 1 was installed as shown in FIG. 5 so that a bubble might not generate | occur | produce on the gasket surface. In this state, it was left for 24 hours. After the passage of 24 hours, the first sealing surface was blotted with water, and it was confirmed with a microscope (magnification 50) whether there was any leakage. The results of the evaluation test are shown in Table 1 below.

上記試験より、第１密封面３５ａにおける第１面３７ａの長さの割合が５％の場合（サンプル１）及び９０％の場合（サンプル７）において、薬液漏れが生じた。また、第１密封面における第１面３７ａの長さの割合が１０％の場合（サンプル２）及び８０％の場合（サンプル６）において、第１密封面３５ａにおいて僅かな薬液の滲みが生じたが、第２密封面３５ｂ以降において滲みは認められなかった。他方、第１密封面における第１面３７ａの長さの割合が３０％の場合（サンプル３）、５０％の場合（サンプル４）並びに７０％の場合（サンプル５）においては、全てのサンプルガスケットにおいて薬液漏れ、滲みが生じなかった。
このことから、第１密封面における第１面３７ａの長さの割合が１０〜８０％であれば、薬液が漏れることを防止することができることが判明した。尚、１０％未満及び８０％超過の場合は、連結部３８がＲ部付近に形成されてしまうため、連結部３８がガスケット３成形時の樹脂フィルム５の変形に巻き込まれ、連結部３８の真円度が悪くなり、密封性が低下したものだと思われる。

From the above test, chemical leakage occurred when the ratio of the length of the first surface 37a in the first sealing surface 35a was 5% (sample 1) and 90% (sample 7). Further, when the ratio of the length of the first surface 37a in the first sealing surface was 10% (sample 2) and 80% (sample 6), slight chemical liquid bleeding occurred on the first sealing surface 35a. However, no bleeding was observed after the second sealing surface 35b. On the other hand, when the ratio of the length of the first surface 37a to the first sealing surface is 30% (sample 3), 50% (sample 4) and 70% (sample 5), all sample gaskets are used. There was no chemical leakage or bleeding.
From this, it was found that if the ratio of the length of the first surface 37a in the first sealing surface is 10 to 80%, the chemical solution can be prevented from leaking. If the ratio is less than 10% and exceeds 80%, the connecting portion 38 is formed near the R portion. Therefore, the connecting portion 38 is caught in the deformation of the resin film 5 when the gasket 3 is molded, and the connecting portion 38 is It seems that the circularity has deteriorated and the sealing performance has deteriorated.

（試験２）
図２に例示する構造のガスケットを次の試験条件で７種類のサンプルを作製し、好適な連結部３８の位置（即ち、第１面３７ａの長さ）における第１面３７ａの傾斜角度θ１と第２面３７ｂの傾斜角度θ２とが液密封性に与える影響について評価試験を行った。 (Test 2)
Two types of gaskets having the structure illustrated in FIG. 2 were prepared under the following test conditions, and the inclination angle θ1 of the first surface 37a at a suitable position of the connecting portion 38 (that is, the length of the first surface 37a) and An evaluation test was conducted on the influence of the inclination angle θ2 of the second surface 37b on the liquid tightness.

（１）ガスケットのゴム材料 ：ブチルゴム
（２）樹脂フィルム ：ＰＴＦＥフィルム
（３）第1密封面における第1面の長さの割合 ：５０％
（４）試験時間 ：２４時間
（５）雰囲気温度 ：２３℃
（６）ｎ数 ：５ (1) Rubber material of gasket: Butyl rubber (2) Resin film: PTFE film (3) Ratio of length of first surface to first sealing surface: 50%
(4) Test time: 24 hours (5) Atmospheric temperature: 23 ° C
(6) n number: 5

評価試験は、外筒２の所定位置にガスケット３をセットし、内部に水を入れた。そして、ガスケット表面に気泡が発生しないように、プレフィルドシリンジ１を図５に示すように設置した。この状態で、２４時間放置した。２４時間経過後、第１密封面に水のにじみ、漏れがないかを顕微鏡（倍率５０）で確認した。評価試験の結果を、それぞれ下記表２に示す。   In the evaluation test, the gasket 3 was set at a predetermined position of the outer cylinder 2 and water was put inside. And the prefilled syringe 1 was installed as shown in FIG. 5 so that a bubble might not generate | occur | produce on the gasket surface. In this state, it was left for 24 hours. After the passage of 24 hours, the first sealing surface was blotted with water, and it was confirmed with a microscope (magnification 50) whether there was any leakage. The results of the evaluation test are shown in Table 2 below.

上記試験２より、ガスケット３の前端側となる第１の密封面３５ａの第１面３７ａにおいて、傾斜角度θ１が０°（サンプル１）であると、薬液漏れが生じた。また、第２面３７ｂの傾斜角度θ２が０°の場合（サンプル６）においても、薬液漏れが生じた。さらに、傾斜角度θ１が７°（サンプル７）と大き過ぎても、薬液漏れが生じた。他方、傾斜角度θ１及びθ２が共に０°よりも大きく５°以下であり、尚且つ傾斜角度θ２が傾斜角度θ１よりも小さい場合（サンプル２〜５）においては、全てのサンプルガスケットにおいて薬液漏れ、滲みが生じなかった。   From the test 2, when the inclination angle θ1 is 0 ° (sample 1) on the first surface 37a of the first sealing surface 35a on the front end side of the gasket 3, a chemical leakage occurred. Further, even when the inclination angle θ2 of the second surface 37b was 0 ° (sample 6), chemical leakage occurred. Furthermore, even when the inclination angle θ1 was too large as 7 ° (sample 7), chemical leakage occurred. On the other hand, when the inclination angles θ1 and θ2 are both greater than 0 ° and 5 ° or less and the inclination angle θ2 is smaller than the inclination angle θ1 (samples 2 to 5), chemical leakage occurs in all the sample gaskets. There was no bleeding.

即ち、第１面３７ａの傾斜角度θ１が０°の場合には、第１面３７ａは円柱状となってしまうため、密封面（特に連結部周辺）及び連結部がシリンジ内周面に接触しづらくなったり、ガスケットの挿入性が低下してしまう。また、０°未満の負の傾斜角度θ１となる場合には、第１面３７ａにおいて液密封面３２側の径が連結部３８よりも大きくなる逆テーパ形状となるため、外筒２へのガスケット３の挿入のし易さが低下して、液密封面３２側の圧縮率が大きくなり、第１面（特に液密封面３２側の端部）３７ａに皺が発生し、この皺の隙間から薬液が漏れる危険性が高くなる。また、第２面３７ｂの傾斜角度θ２が０°の場合（サンプル６）においても、第１面３７ａとの境界で形成される連結部３８が密封面における最大径になってしまい連結部３８の圧縮量が最も大きくなるため、連結部３８に皺が発生しやすくなり、連結部３８のシール効果が低減し易くなる。このことは、傾斜角度θ２が０°以下、即ち第２面３７ｂが円柱状（０°）もしくは逆テーパ形状（負の傾斜角度）となる場合においても同様である。反面、第１面３７ａの傾斜角度θ１が５°よりも大きいと、第１面３７ａが外筒２の内周面２５と接触し難くなり、第１面３７ａにおける密封性が得られなくなってしまう（サンプル７）。つまり、１つの密封面が２つの面で構成されている場合においては、密封面を構成する面の傾斜角度が０°以下あるいは５°を超える場合には不具合が生じることを意味している。尚、試験結果には含まれていないが、第１面３７ａの傾斜角度θ１よりも第２面３７ｂの傾斜角度θ２が大きくなってしまった場合、連結部３８は、接触状態が良好なものを保つことができない危険性があるため、連結部３８によるシール部が形成されなくなり、密封性が低下してしまう危険性が生じてしまう。   That is, when the inclination angle θ1 of the first surface 37a is 0 °, the first surface 37a becomes a columnar shape, so that the sealing surface (particularly around the connecting portion) and the connecting portion are in contact with the inner peripheral surface of the syringe. It becomes difficult and the insertability of the gasket decreases. Further, when the negative inclination angle θ1 is less than 0 °, the first surface 37a has a reverse taper shape in which the diameter on the liquid sealing surface 32 side is larger than that of the connecting portion 38. 3 is reduced, the compression rate on the liquid sealing surface 32 side is increased, and wrinkles are generated on the first surface (particularly the end portion on the liquid sealing surface 32 side) 37a. There is an increased risk of chemical leakage. Even when the inclination angle θ2 of the second surface 37b is 0 ° (sample 6), the connecting portion 38 formed at the boundary with the first surface 37a becomes the maximum diameter on the sealing surface, and the connecting portion 38 Since the amount of compression becomes the largest, wrinkles are easily generated in the connecting portion 38, and the sealing effect of the connecting portion 38 is easily reduced. The same applies to the case where the inclination angle θ2 is 0 ° or less, that is, the second surface 37b has a cylindrical shape (0 °) or an inversely tapered shape (negative inclination angle). On the other hand, if the inclination angle θ1 of the first surface 37a is larger than 5 °, the first surface 37a becomes difficult to contact the inner peripheral surface 25 of the outer cylinder 2, and the sealing performance on the first surface 37a cannot be obtained. (Sample 7). That is, in the case where one sealing surface is constituted by two surfaces, it means that a problem occurs when the inclination angle of the surface constituting the sealing surface is 0 ° or less or exceeds 5 °. Although not included in the test results, when the inclination angle θ2 of the second surface 37b is larger than the inclination angle θ1 of the first surface 37a, the connecting portion 38 has a good contact state. Since there is a risk that it cannot be maintained, the seal portion by the connecting portion 38 is not formed, and there is a risk that the sealing performance is lowered.

（試験３）
図３に例示する構造のガスケットを次の試験条件で７種類のサンプルを作製し、好適な連結部３８の位置（即ち、第１面３７ａの長さ）における第１面３７ａの傾斜角度θ１と第２面３７ｂの傾斜角度θ２と第２面３７ｃの傾斜角度θ３が液密封性に与える影響について評価試験を行った。 (Test 3)
Three types of samples of the gasket having the structure illustrated in FIG. 3 were prepared under the following test conditions, and the inclination angle θ1 of the first surface 37a at a suitable position of the connecting portion 38 (that is, the length of the first surface 37a) and An evaluation test was performed on the influence of the inclination angle θ2 of the second surface 37b and the inclination angle θ3 of the second surface 37c on the liquid tightness.

（１）ガスケットのゴム材料 ：ブチルゴム
（２）樹脂フィルム ：ＰＴＦＥフィルム
（３）第１密封面における第１面の長さの割合 ：５０％
（４）第１密封面における第２面の長さの割合 ：３０％
（５）第１密封面における第３面の長さの割合 ：２０％
（６）試験時間 ：２４時間
（７）雰囲気温度 ：２３℃
（８）ｎ数 ：５ (1) Rubber material of gasket: butyl rubber (2) Resin film: PTFE film (3) Ratio of length of first surface to first sealing surface: 50%
(4) Ratio of the length of the second surface in the first sealing surface: 30%
(5) Ratio of the length of the third surface in the first sealing surface: 20%
(6) Test time: 24 hours (7) Atmospheric temperature: 23 ° C
(8) n number: 5

評価試験は、外筒２の所定位置にガスケット３をセットし、内部に水を入れた。そして、ガスケット表面に気泡が発生しないように、プレフィルドシリンジ１を図５に示すように設置した。この状態で、２４時間放置した。２４時間経過後、第１密封面に水のにじみ、漏れがないかを顕微鏡（倍率５０）で確認した。評価試験の結果を、それぞれ下記表３に示す。   In the evaluation test, the gasket 3 was set at a predetermined position of the outer cylinder 2 and water was put inside. And the prefilled syringe 1 was installed as shown in FIG. 5 so that a bubble might not generate | occur | produce on the gasket surface. In this state, it was left for 24 hours. After the passage of 24 hours, the first sealing surface was blotted with water, and it was confirmed with a microscope (magnification 50) whether there was any leakage. The results of the evaluation test are shown in Table 3 below.

上記試験３によれば、ガスケット３の前端側となる第１の密封面３５ａの第１面３７ａにおいて、傾斜角度θ１が０°（サンプル１）であると、薬液漏れが生じた。これは、第１面の傾斜角度が０°であること、並びに、θ１＜θ２＜θ３の関係にあることが理由であると考えられる。第１面３７ａが０°の場合、第１面３７ａは外筒内周面２５に接触しづらい構成になってしまう。このため、第２面３７ｂのみ、若しくは第２面３７ｂ、第３面３７ｃとの接触によるシール効果しか確保できなくなる。また、θ１＜θ２＜θ３の関係及びθ１＜θ２の場合は、シリンジ内周面に対し、連結部３８ａ，３８ｂが非接触もしくは微接触となってしまうため、連結部３８ａ，３８ｂの形成によるシール効果を得ることができないからと思われる。さらに、傾斜角度θ１が７°（サンプル７）と大き過ぎても、薬液漏れが生じた。   According to the test 3, when the inclination angle θ1 is 0 ° (sample 1) on the first surface 37a of the first sealing surface 35a on the front end side of the gasket 3, a chemical leakage occurred. This is considered to be because the inclination angle of the first surface is 0 ° and that there is a relationship of θ1 <θ2 <θ3. When the first surface 37a is 0 °, the first surface 37a is difficult to contact the outer peripheral surface 25 of the outer cylinder. For this reason, only the sealing effect by the contact with only the second surface 37b or the second surface 37b and the third surface 37c can be ensured. In the case of θ1 <θ2 <θ3 and θ1 <θ2, the connecting portions 38a and 38b are not in contact with or slightly contacted with the inner peripheral surface of the syringe. Therefore, the seal is formed by forming the connecting portions 38a and 38b. It seems that the effect cannot be obtained. Furthermore, even when the inclination angle θ1 was too large as 7 ° (sample 7), chemical leakage occurred.

その反面、密封面を構成する全ての面３７ａ，３７ｂ、３８ｃの傾斜角度θ１、θ２及びθ３が共に０°よりも大きく５°以下であり、尚且つ傾斜角度がθ１＞θ２＞θ３となり、最も反密封面側に形成される面３７ｃが最も小さな傾斜角度とされる場合（サンプル３及び５）においては、全てのサンプルガスケットにおいて薬液漏れ、滲みが生じなかった。   On the other hand, the inclination angles θ1, θ2, and θ3 of all the surfaces 37a, 37b, and 38c constituting the sealing surface are all greater than 0 ° and less than or equal to 5 °, and the inclination angle is θ1> θ2> θ3. When the surface 37c formed on the anti-sealing surface side had the smallest inclination angle (Samples 3 and 5), no chemical leakage or bleeding occurred in all the sample gaskets.

他方、傾斜角度がθ１＞θ２＞θ３となる場合においても、第３面３７ｃの傾斜角度θ３が０°の場合（サンプル２，６）には、いずれか一方の連結部３７ａあるいは３７ｂ以降ににじみが生じたが、どちらかの連結部３７ａあるいは３８ｂによってシールされているという評価が得られた。   On the other hand, even when the inclination angle is θ1> θ2> θ3, if the inclination angle θ3 of the third surface 37c is 0 ° (samples 2 and 6), it blurs after one of the connecting portions 37a or 37b. However, the evaluation that it was sealed by either of the connecting portions 37a or 38b was obtained.

また、密封面を構成する全ての面３７ａ，３７ｂ，３７ｃの傾斜角度θ１，θ２，θ３が０°よりも大きく５°以下でありながら、θ１＜θ３＜θ２（即ち５°→１°→３°）の関係（サンプル４）であるため、第２面３７ｂと第３面３７ｃとの連結部３８ｂが非接触もしくは微接触となるため密封面３５としてのシール性が若干低下したものと考えられる。しかしながら、密封面のシール性低下により密封面に薬液が侵入しても、傾斜角度がθ１＞θ２の関係にある第１面３７ａと第２面３７ｂとの間の連結部３８ａによるシール効果により、薬液漏れを防止しているものと考えられる。   Further, the inclination angles θ1, θ2, and θ3 of all the surfaces 37a, 37b, and 37c constituting the sealing surface are larger than 0 ° and 5 ° or less, and θ1 <θ3 <θ2 (that is, 5 ° → 1 ° → 3). )) (Sample 4), the connecting portion 38b between the second surface 37b and the third surface 37c is in non-contact or fine contact, so the sealing performance as the sealing surface 35 is considered to be slightly lowered. . However, even if a chemical solution enters the sealing surface due to a decrease in the sealing performance of the sealing surface, due to the sealing effect by the connecting portion 38a between the first surface 37a and the second surface 37b in which the inclination angle is θ1> θ2, This is thought to prevent chemical leakage.

さらに、全ての面３７ａ，３７ｂ，３７ｃの傾斜角度がθ１＞θ２＞θ３の関係にあっても、第３面３７ｃの傾斜角度θ３が０°（サンプル６）の場合、θ３が１°傾斜している場合（サンプル５）に比べて、密封面のシール性が低下してしまうことが判明した。このことから、３つの面（２つ以上の面）で密封面を構成する場合においては、最も反密封面側となる面即ち第３面３７ｃの傾斜角度のシール性に与える影響は他の面よりも小さく、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有していれば、連結部のシール効果が得られることが明らかとなった。   Further, even if the inclination angles of all the surfaces 37a, 37b, and 37c are in the relationship of θ1> θ2> θ3, when the inclination angle θ3 of the third surface 37c is 0 ° (sample 6), θ3 is inclined by 1 °. It has been found that the sealing performance of the sealing surface is reduced as compared with the case (Sample 5). Therefore, in the case where the sealing surface is constituted by three surfaces (two or more surfaces), the influence of the inclination angle of the surface closest to the anti-sealing surface, that is, the third surface 37c, on the sealing performance is the other surface. If the two adjacent surfaces have at least one relationship in which the inclination angle of the surface on the anti-liquid sealing surface side becomes smaller than the inclination angle of the surface closer to the liquid sealing surface side, the connecting portion It became clear that the sealing effect of can be obtained.

以上の試験結果は、隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも１つ有していれば、薬液が漏れることを防止できることを示している。また、好ましくは、前述の隣接する二つの面が液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係が、傾斜角度が０°よりも大きく５°以下で、かつ液密封面側寄りの面の傾斜角度よりも反密封面側の面の傾斜角度の方が小さくなる関係にあることを示している。さらには、１つの密封面を構成する複数の面の全て傾斜角度が０°よりも大きく５°以下で、且つ液密封面側寄りの面の傾斜角度よりも反液密封面側の面の傾斜角度の方が小さくなる関係にあり、最も反液密封面側に形成される面の傾斜角度が全ての面の中でもっとも小さくされることがより好ましいことを示している。   The above test results indicate that the adjacent two surfaces have at least one relationship in which the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface closer to the liquid sealing surface side. It shows that the chemical liquid can be prevented from leaking. Preferably, the relationship between the two adjacent surfaces described above is such that the inclination angle of the surface on the anti-liquid sealing surface side is smaller than the inclination angle of the surface closer to the liquid sealing surface side. This shows that the inclination angle of the surface on the side opposite to the liquid-sealing surface is smaller than the inclination angle of the surface close to the liquid-sealing surface, which is 5 ° or less. Further, the inclination angle of all the surfaces constituting one sealing surface is greater than 0 ° and not more than 5 °, and the inclination of the surface on the anti-liquid sealing surface side is greater than the inclination angle of the surface closer to the liquid sealing surface side. This indicates that the angle is smaller, and it is more preferable that the inclination angle of the surface formed closest to the liquid-tight surface is the smallest among all the surfaces.

１ プレフィルドシリンジ
２ 外筒
２５ 内周面
３ ガスケット
３１ 外周面（外筒の内周面と接触する面）
３２ 液密封面（薬液と接触し密封する面即ちガスケットの先端面）
３３ 反液密封面（液密封面の反対側の大気側の後端面）
３５ 密封面
３５ａ 第１の密封面
３５ｂ 第２の密封面
３７ａ 第１面
３７ｂ 第２面
３７ｃ 第３面
３８ 連結部
３８ａ 液密封面側寄りの連結部
３８ｂ 反液密封面側寄りの連結部
４ ガスケット本体
５ 樹脂製フィルム DESCRIPTION OF SYMBOLS 1 Prefilled syringe 2 Outer cylinder 25 Inner peripheral surface 3 Gasket 31 Outer peripheral surface (surface which contacts the inner peripheral surface of an outer cylinder)
32 Liquid-sealing surface (the surface that comes into contact with and seals with chemicals, that is, the end surface of the gasket)
33 Anti-liquid sealing surface (rear end surface on the air side opposite to the liquid sealing surface)
35 sealing surface 35a first sealing surface 35b second sealing surface 37a first surface 37b second surface 37c third surface 38 connecting portion 38a connecting portion closer to the liquid sealing surface side 38b connecting portion closer to the anti-liquid sealing surface side 4 Gasket body 5 Plastic film

Claims (3)

弾性材料製の本体と、前記本体の少なくとも外筒の内周面と接触する部位に被覆された慴動性に優れる樹脂フィルムとを有するシリンジ用ガスケットにおいて、
前記ガスケットには、前記外筒の内周面と接触する少なくとも一つの密封面を形成し、前記密封面は、傾斜角度が異なる複数の面によって構成され、各面が前記外筒との間で薬液を密封する液密封面側からその反対の大気側の反液密封面側に向かって径が大きくなるように形成されると共に、前記複数の面のうちの隣接する二つの面が前記液密封面側寄りの面の傾斜角度よりも前記反液密封面側の面の傾斜角度の方が小さくなる関係を少なくとも一つ有していることを特徴とするシリンジ用ガスケット。 In a syringe gasket having a main body made of an elastic material and a resin film excellent in peristaltic properties coated on a portion that contacts at least the inner peripheral surface of the outer cylinder of the main body,
The gasket is formed with at least one sealing surface that comes into contact with the inner peripheral surface of the outer cylinder, and the sealing surface includes a plurality of surfaces having different inclination angles, and each surface is between the outer cylinder and the gasket. The liquid sealing surface side that seals the chemical solution is formed to increase in diameter from the opposite air side to the opposite liquid side sealing surface side, and two adjacent surfaces of the plurality of surfaces are the liquid sealing A syringe gasket characterized by having at least one relationship in which the inclination angle of the surface on the anti-liquid sealing surface side becomes smaller than the inclination angle of the surface side surface. 前記密封面に形成される前記複数の面において、隣接する二つの前記面の前記傾斜角度が０°より大きく、５°以下である関係を少なくとも一つ有していることを特徴とする請求項１記載のプレフィルドシリンジ用ガスケット。 The plurality of surfaces formed on the sealing surface have at least one relationship in which the inclination angle between two adjacent surfaces is greater than 0 ° and less than or equal to 5 °. The gasket for prefilled syringes according to 1. 前記液密封面側に形成される前記面の長さが、前記密封面の長さの１０〜８０％であることを特徴とする請求項１または２記載のシリンジ用ガスケット。 The length of the said surface formed in the said liquid sealing surface side is 10 to 80% of the length of the said sealing surface, The gasket for syringes of Claim 1 or 2 characterized by the above-mentioned.

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