JP2015107953A - 植物エキスを含有するトイレタリー製品用組成物 - Google Patents
植物エキスを含有するトイレタリー製品用組成物 Download PDFInfo
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- JP2015107953A JP2015107953A JP2014214471A JP2014214471A JP2015107953A JP 2015107953 A JP2015107953 A JP 2015107953A JP 2014214471 A JP2014214471 A JP 2014214471A JP 2014214471 A JP2014214471 A JP 2014214471A JP 2015107953 A JP2015107953 A JP 2015107953A
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- skin
- acid
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Abstract
【解決手段】 柑橘類果皮エキス、タイムエキスおよびルイボスティーエキスを含有する、トイレタリー製品用組成物。
【選択図】なし
Description
特許文献1に記載の浴用剤は、一定のアトピー性皮膚炎患者に対して、掻痒軽減作用を有することが記載されている。
また、従来の浴用剤等のトイレタリー製品による保湿作用、皮膚バリア機能の保護作用、改善作用等では満足できない場合があった。したがって、本発明の1つの目的は、良好な保湿作用、皮膚バリア機能の保護作用、改善作用等を有する、トイレタリー製品用組成物を提供することにある。
[1] 柑橘類果皮エキス、タイムエキスおよびルイボスティーエキスを含有する、トイレタリー製品用組成物。
[2] 柑橘類果皮エキスがチンピエキスである、[1]に記載の組成物。
[3] トイレタリー製品が、石けん、化粧水、および浴用剤からなる群より選択される、[1]または[2]に記載の組成物。
[4] トイレタリー製品が浴用剤である、[1]または[2]に記載の組成物。
[5] 組成物質量あたり、柑橘類果皮エキスを0.01〜20質量%、タイムエキスを0.01〜10質量%、およびルイボスティーエキスを0.01〜10質量%含有する、[1]〜[4]のいずれか一項に記載の組成物。
[6] 組成物質量あたり、柑橘類果皮エキスを0.1〜10質量%、タイムエキスを0.05〜3質量%、およびルイボスティーエキスを0.01〜1質量%含有する、[5]に記載の組成物。
[7] [1]〜[6]のいずれか一項に記載の組成物を含む、トイレタリー製品。
さらに、本発明に係る組成物は、従来の組成物が上記効果を十分に発揮できなかった対象(特にヒト)に対して、十分な効果を発揮し得る。
本明細書において、「柑橘類果皮エキス」は、ミカン属の果樹の果皮エキスおよびキンカン属の果樹それぞれの果皮エキスの1種または2種以上の混合エキスであってもよい。特に好ましい柑橘類果皮エキスとしてはチンピエキスが挙げられる。
上記抽出により得られる植物抽出エキスは、前記抽出方法により、医薬品、医薬部外品または化粧品への配合が許容される規格に適合し、本発明の効果を発揮するものであれば、粗精製物であってもよい。
本願発明のトイレタリー製品用組成物は、柑橘類果皮エキス、タイムエキスおよびルイボスティーエキスを、混合割合(質量比)として、通常1:0.025〜2.5:0.01〜1.0(柑橘類果皮エキス:タイムエキス:ルイボスティーエキス)となるよう、好ましくは1:0.1〜1.0:0.05〜0.5となるよう含有する。柑橘類果皮エキス、タイムエキスおよびルイボスティーエキスのトイレタリー製品への配合量は、その製品の特性に応じて適宜定めればよい。
なお、本明細書において、植物抽出エキスの量は、特に断りのない限り、固形分の量を示すものとする。
以下に、上記成分の具体例を挙げるが、これらに限定されるものではない。
以下に、上記成分の具体例を例示するが、これらに限定されるものではない。
以下に、これらの成分の具体例を例示するが、これに限定されるものではない。
表1に記載の成分分量を量り、各成分を攪拌混合して、製造した。
a)チンピ(Citrus unshiu Markovich)の粉末1kgに対して水15Lを加え、撹拌抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮した。濃縮液に、濃縮液の固形分に応じてデキストリンを加え、乾燥してチンピエキス散を得た。
b)タイム(Thymus vulgaris Linne’(Labiatae))の全草の粉末1kgに水20Lを加え、撹拌抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮し、乾燥してタイムエキス末を得た。
c)ルイボス(Aspalathus Linearis)の葉の粗末1kgに水10Lを加え、1時間加熱抽出した。得られた抽出液をろ過し、そのろ液を減圧下にて濃縮し、乾燥してルイボスティーエキス末を得た。
石けん素地に、表3に記載の石けん素地以外の成分を配合、成型して製造した。表3中、チンピエキス散、タイムエキス末およびルイボスティーエキス末は、表1と同様である。
アトピー性皮膚炎患者における痒みの軽減および皮疹の改善について試験した。アトピー性皮膚炎患者30名を被験者とした。被験者は全員13歳以上であった。
試験湯は、実施例1の組成物30グラムを約200リットルの湯(約40℃)に溶解して調製した。試験期間は2週間であった。被験者は、試験期間中、内服薬および外用剤を従前どおり使用した。痒みの程度は、以下の表4に示す5段階の判断基準を用いた。
「非常に有効」:表4の判断基準に示される評価が3段階改善;
「有効」 :表4の判断基準に示される評価が2段階改善;
「やや有効」 :表4の判断基準に示される評価が1段階改善;
「無効」 :表4の判断基準に示される評価に変化が無い、もしくは悪化。
皮疹の改善については、試験前の皮膚(皮疹)の状態と試験後の皮膚(皮疹)の状態とを比較し、臨床所見上、改善がみられたか否かで「有効」および「無効」の判定を行った。
皮膚の乾燥改善効果について試験した。皮膚外側の角層には一定量の水分が保持されている。十分な水分を保持する角層は、外部からの刺激を防御するバリア機能を有する。角層の水分量が低下した皮膚、すなわち乾燥肌(ドライスキン)では、皮膚のバリア機能が低下し、外部からの刺激を受けやすくなり、痒みを感じやすくなるとされる。
平均値±標準偏差(S.D.)、n=12
前値: 試験1日前の測定結果である
* : p<0.05 (対、前値 対応のないt-test)
**: p<0.01 (対、前値 対応のないt-test)
♯ : p<0.05 (対、対照湯 対応のないt-test)
♯♯: p<0.01 (対、対照湯 対応のないt-test)
水道水中の遊離塩素の除去効果について試験した。遊離塩素が皮膚刺激の原因となり、皮膚バリア機能の低下をもたらすことが知られている。
対照水は、40℃の水道水に、遊離塩素2mg/Lとなるように次亜塩素ナトリウム溶液を加えて調製した。試験水は、実施例1の組成物0.3グラムを対照水約300ミリリットルに溶解して調製した。各溶液中の残留遊離塩素濃度、結合塩素濃度および総塩素濃度を、各時点で、衛生試験法に準じたジエチル−p−フェニレンジアミン(DPD)法により測定した。
表6に示す組成になるように、チンピエキス散、タイムエキス末およびルイボスティーエキス末を精製水に溶解し、表6中の各組成物を調製した。表6中、チンピエキス散、タイムエキス末およびルイボスティーエキス末は、表1と同様である。
皮膚の保湿効果について試験した。皮膚の保湿効果の指標として、経表皮水分蒸散量(TEWL)を用いた。TEWLは、水分蒸散量を示していることから、その値が低いほど皮膚からの水分蒸散が抑制されていることとなり、皮膚バリア機能が保持されていると評価することができる。
・被験者を、温度20±2℃、湿度45〜55%の恒温室にて、椅子に着席して静かに20分間馴致して皮膚の状態を安定化させる(文献1)。
・皮膚が安定化した後、荒れ肌処理前のTEWLを機器(Tewameter, Cutometer MPA 580(株式会社インテグラル))にて測定する。
・5%ラウリル硫酸ナトリウム(SDS)5mLをwellに注入して、前腕被験部位に固定して10分間浸漬塗布(荒れ肌処理)する(T. OKA, M, Skin-softening effect of acetylhyaluronate on stratum corneum. J. cosmet, Sci, 50, 171-184(May/June 1999):以下、「文献2」と称する。)。
・荒れ肌処理後、すべてのwellを前腕被験部位より除去し、塗布部位をSDSのヌメリが消えるまで十分に水洗して、タオルで水分を拭き取る。
・その後、すぐに被験薬等を各々5mLずつwellに注入して、前腕被験部位に固定して10分間浸漬塗布する(文献2)。
・浸漬塗布後、すべてのwellを前腕被験部位より除去し、塗布部位の被験薬等をキムワイプで拭き取る。
・被験薬等除去の10分後に、TEWLを測定する。
Claims (7)
- 柑橘類果皮エキス、タイムエキスおよびルイボスティーエキスを含有する、トイレタリー製品用組成物。
- 柑橘類果皮エキスがチンピエキスである、請求項1に記載の組成物。
- トイレタリー製品が、石けん、化粧水、および浴用剤からなる群より選択される、請求項1または2に記載の組成物。
- トイレタリー製品が浴用剤である、請求項1または2に記載の組成物。
- 組成物質量あたり、柑橘類果皮エキスを0.01〜20質量%、タイムエキスを0.01〜10質量%、およびルイボスティーエキスを0.01〜10質量%含有する、請求項1〜4のいずれか一項に記載の組成物。
- 組成物質量あたり、柑橘類果皮エキスを0.1〜10質量%、タイムエキスを0.05〜3質量%、およびルイボスティーエキスを0.01〜1質量%含有する、請求項5に記載の組成物。
- 請求項1〜6のいずれか一項に記載の組成物を含む、トイレタリー製品。
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CN115716763A (zh) * | 2022-11-22 | 2023-02-28 | 青岛苏贝尔作物营养有限公司 | 褐藻中生物活性成分的提取方法及褐藻提取液 |
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CN115716763A (zh) * | 2022-11-22 | 2023-02-28 | 青岛苏贝尔作物营养有限公司 | 褐藻中生物活性成分的提取方法及褐藻提取液 |
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