JP2014533272A - 増殖性疾患の治療方法 - Google Patents
増殖性疾患の治療方法 Download PDFInfo
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- JP2014533272A JP2014533272A JP2014541283A JP2014541283A JP2014533272A JP 2014533272 A JP2014533272 A JP 2014533272A JP 2014541283 A JP2014541283 A JP 2014541283A JP 2014541283 A JP2014541283 A JP 2014541283A JP 2014533272 A JP2014533272 A JP 2014533272A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
本発明は、BRAF阻害剤による治療に対する耐性を抑制する方法に関する。
増殖性疾患にキナーゼが関与することは、よく知られている。例えば、腫瘍発生に関与するキナーゼには、受容体チロシンキナーゼおよびセリン/スレオニンキナーゼ、Rafキナーゼなどがある。これらのキナーゼは、多くの細胞機能、例えば増殖、分化および生存に影響を及ぼし調節するシグナル伝達経路において重要な役割を果たす。
本発明は、Rafキナーゼ耐性腫瘍細胞がRafキナーゼ阻害剤に対して感受性である腫瘍細胞よりも「よりフィットしていない」状態であり、Rafキナーゼ阻害剤の非存在下で感受性細胞よりも選択的な欠点を有するという発見に基づいている。したがって、本発明によれば、Rafキナーゼ阻害剤による治療に対する耐性は、Rafキナーゼ阻害剤を間欠的投薬計画に従って投与することによって抑制される。
Claims (5)
- BRAF突然変異がV600突然変異である、請求項1に記載の方法。
- 増殖性疾患が、V600突然変異を特徴とする黒色腫、またはV600突然変異を特徴とする結腸直腸癌である、請求項1に記載の方法。
- 増殖性疾患が、BRAFV600Eを特徴とする黒色腫、またはBRAFV600Eを特徴とする結腸直腸癌である、請求項1に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161558619P | 2011-11-11 | 2011-11-11 | |
US61/558,619 | 2011-11-11 | ||
PCT/US2012/064269 WO2013070996A1 (en) | 2011-11-11 | 2012-11-09 | Method of treating a proliferative disease |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014533272A true JP2014533272A (ja) | 2014-12-11 |
JP2014533272A5 JP2014533272A5 (ja) | 2015-12-24 |
JP6150813B2 JP6150813B2 (ja) | 2017-06-21 |
Family
ID=47279036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2014541283A Active JP6150813B2 (ja) | 2011-11-11 | 2012-11-09 | 増殖性疾患の治療方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11007194B2 (ja) |
EP (1) | EP2776037B1 (ja) |
JP (1) | JP6150813B2 (ja) |
CN (2) | CN103917236A (ja) |
AU (1) | AU2012335663B2 (ja) |
BR (1) | BR112014011223A8 (ja) |
CA (1) | CA2855243C (ja) |
HK (1) | HK1198920A1 (ja) |
MX (1) | MX354725B (ja) |
RU (1) | RU2622015C2 (ja) |
WO (1) | WO2013070996A1 (ja) |
Families Citing this family (7)
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AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
AU2013299841B8 (en) * | 2012-08-07 | 2017-01-05 | Array Biopharma Inc. | Pharmaceutical combinations comprising a B-Raf inhibitor, an EGFR inhibitor and optionally a PI3K-alpha inhibitor |
HUE060653T2 (hu) * | 2016-06-03 | 2023-04-28 | Array Biopharma Inc | Gyógyászati kombinációk |
WO2018107146A1 (en) * | 2016-12-11 | 2018-06-14 | Memorial Sloan Kettering Cancer Center | Methods and compositions for treatment of braf mutant cancers |
WO2020011141A1 (zh) * | 2018-07-12 | 2020-01-16 | 深圳市塔吉瑞生物医药有限公司 | 一种二芳基吡唑化合物及包含该化合物的组合物及其用途 |
TWI817018B (zh) | 2019-06-28 | 2023-10-01 | 美商艾瑞生藥股份有限公司 | 用於治療braf相關的疾病和失調症之化合物 |
WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
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2012
- 2012-11-09 WO PCT/US2012/064269 patent/WO2013070996A1/en active Application Filing
- 2012-11-09 CN CN201280054663.0A patent/CN103917236A/zh active Pending
- 2012-11-09 BR BR112014011223A patent/BR112014011223A8/pt not_active Application Discontinuation
- 2012-11-09 EP EP12795175.4A patent/EP2776037B1/en active Active
- 2012-11-09 CA CA2855243A patent/CA2855243C/en active Active
- 2012-11-09 MX MX2014005726A patent/MX354725B/es active IP Right Grant
- 2012-11-09 CN CN201810135736.8A patent/CN108542906A/zh active Pending
- 2012-11-09 AU AU2012335663A patent/AU2012335663B2/en active Active
- 2012-11-09 JP JP2014541283A patent/JP6150813B2/ja active Active
- 2012-11-09 US US14/355,903 patent/US11007194B2/en active Active
- 2012-11-09 RU RU2014117707A patent/RU2622015C2/ru active
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2014
- 2014-12-10 HK HK14112437.0A patent/HK1198920A1/xx unknown
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Title |
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THEORY BIOSCI., VOL.130, NO.3, PP.203-210 (2011), JPN6016029076 * |
Also Published As
Publication number | Publication date |
---|---|
RU2622015C2 (ru) | 2017-06-08 |
AU2012335663A1 (en) | 2014-05-29 |
CA2855243C (en) | 2020-04-14 |
BR112014011223A2 (pt) | 2017-05-09 |
JP6150813B2 (ja) | 2017-06-21 |
BR112014011223A8 (pt) | 2023-01-31 |
WO2013070996A1 (en) | 2013-05-16 |
EP2776037A1 (en) | 2014-09-17 |
AU2012335663B2 (en) | 2015-12-24 |
US20140275136A1 (en) | 2014-09-18 |
CA2855243A1 (en) | 2013-05-16 |
CN103917236A (zh) | 2014-07-09 |
EP2776037B1 (en) | 2019-01-09 |
MX354725B (es) | 2018-03-16 |
US11007194B2 (en) | 2021-05-18 |
RU2014117707A (ru) | 2015-12-20 |
MX2014005726A (es) | 2014-05-28 |
CN108542906A (zh) | 2018-09-18 |
HK1198920A1 (en) | 2015-06-19 |
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