JP2014514541A - 多次元液体分析用バルブ及び分割システム - Google Patents
多次元液体分析用バルブ及び分割システム Download PDFInfo
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- JP2014514541A JP2014514541A JP2014501158A JP2014501158A JP2014514541A JP 2014514541 A JP2014514541 A JP 2014514541A JP 2014501158 A JP2014501158 A JP 2014501158A JP 2014501158 A JP2014501158 A JP 2014501158A JP 2014514541 A JP2014514541 A JP 2014514541A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N30/10—Preparation using a splitter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
である)。
Fi=k×Fo
(式中、
Fi=間接流量(indirect flow rate)
k=容積収縮係数
Fo=出口120での流量
である)。
Claims (12)
- 液体の移動相をクロマトグラフ的に分離して、第1流出流量を有する第1次元流出流とするための第1分離カラムを含む第1分離システムと、
前記第1次元流出流を第1分割出口流と第2分割出口流とに分離するためのフロースプリッタと、
前記第2分割出口流をクロマトグラフ的に分離するための第2分離カラムを含む第2分離システムと、
制御された引き込み流量で前記フロースプリッタから前記第2分割出口流を引き込むための流量制御ポンプであって、前記引き込み流量によって、第1分割出口流量が前記第1流出流量と前記引き込み流量との差として定義される、流量制御ポンプと
を備える多次元液体分析システムであって、
前記引き込み流量が、
である)によって制御される、多次元液体分析システム。 - 前記流量制御ポンプが、負変位モードで動作中に前記第2分割出口流を発生させるように配置された容積式ポンプである、請求項1に記載の多次元液体分析システム。
- 前記流量制御ポンプがシリンジポンプである、請求項2に記載の多次元液体分析システム。
- 前記第2分割出口流を前記第2分離カラムに注入するための多ポート・インジェクションバルブを含み、前記インジェクションバルブが、Vd以上の容積を有する第1試料ループを含み、前記第1試料ループによって、前記第2分離カラムへの前記第2分割出口流の第1流路が画成される、請求項1に記載の多次元液体分析システム。
- 前記インジェクションバルブが、Vd以上の容積を有する第2試料ループを含み、前記第2試料ループによって、前記第1流路とは別の、前記第2分離カラムへの前記第2分割出口流の第2流路が画成される、請求項4に記載の多次元液体分析システム。
- 前記フロースプリッタがT字型分岐を備える、請求項1に記載の多次元液体分析システム。
- 前記第1分割流出流を規制して、1〜1000キロパスカルの流体圧力を前記フロースプリッタにおいて作り出すフローリストリクタを含む、請求項1に記載の多次元液体分析システム。
- 前記フロースプリッタの下流で前記第1分割出口流に流体接続された液体分析装置を含む、請求項1に記載の多次元液体分析システム。
- 液体試料を分析する方法であって、
(a)前記液体試料を、該液体試料の1つ以上の化学成分を同定するための第1液体分析装置であって、第1流出流量で第1次元液体流出流を作り出す第1液体分析装置に送達し、
(b)前記第1次元液体流出流を、前記第1流出流量よりも低い引き出し流量でフロースプリッタに圧送して、前記第1次元液体流出流を第1及び第2分割出口流に分離し、
(c)前記第1及び第2分割出口流の一方を、その1つ以上の化学成分を同定するための第2液体分析装置に送達する
ことを含む方法。 - 前記引き込み流量を
である)によって制御する、請求項9に記載の方法。 - 前記第1液体分析装置がクロマトグラフィ分離カラムを含む、請求項9に記載の方法。
- 前記第2液体分析装置がクロマトグラフィ分離カラムを含む、請求項11に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161466739P | 2011-03-23 | 2011-03-23 | |
US61/466,739 | 2011-03-23 | ||
PCT/US2012/029378 WO2012129076A1 (en) | 2011-03-23 | 2012-03-16 | Valve and splitting system for multi-dimensional liquid analysis |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2014514541A true JP2014514541A (ja) | 2014-06-19 |
Family
ID=46876161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2014501158A Pending JP2014514541A (ja) | 2011-03-23 | 2012-03-16 | 多次元液体分析用バルブ及び分割システム |
Country Status (6)
Country | Link |
---|---|
US (3) | US9239319B2 (ja) |
EP (1) | EP2689244B1 (ja) |
JP (1) | JP2014514541A (ja) |
CN (2) | CN108956788B (ja) |
HK (1) | HK1200210A1 (ja) |
WO (1) | WO2012129076A1 (ja) |
Cited By (2)
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JP2017534065A (ja) * | 2014-10-27 | 2017-11-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二次元rplc−sfcクロマトグラフィーのためのシステムおよび方法 |
WO2019207870A1 (ja) * | 2018-04-27 | 2019-10-31 | 株式会社島津製作所 | 分析システム |
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Also Published As
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US9239319B2 (en) | 2016-01-19 |
CN108956788A (zh) | 2018-12-07 |
EP2689244B1 (en) | 2020-06-17 |
EP2689244A4 (en) | 2014-09-24 |
US20160131619A1 (en) | 2016-05-12 |
EP2689244A1 (en) | 2014-01-29 |
CN103930778A (zh) | 2014-07-16 |
US20200025726A1 (en) | 2020-01-23 |
US11692980B2 (en) | 2023-07-04 |
HK1200210A1 (en) | 2015-07-31 |
CN108956788B (zh) | 2022-08-02 |
WO2012129076A1 (en) | 2012-09-27 |
US20120240666A1 (en) | 2012-09-27 |
US10429361B2 (en) | 2019-10-01 |
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