JP2014500875A - Ｂ型肝炎の予防及び治療のためのｄｎａワクチン組成物 - Google Patents

Ｂ型肝炎の予防及び治療のためのｄｎａワクチン組成物 Download PDF

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JP2014500875A
JP2014500875A JP2013539108A JP2013539108A JP2014500875A JP 2014500875 A JP2014500875 A JP 2014500875A JP 2013539108 A JP2013539108 A JP 2013539108A JP 2013539108 A JP2013539108 A JP 2013539108A JP 2014500875 A JP2014500875 A JP 2014500875A
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hepatitis
plasmid
protein
recombinant
vaccine composition
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Japanese (ja)
Inventor
ヨン リュウ，
ディンフォン リ，
チュンリー ジャーン，
ジェンホア ホウ，
Original Assignee
ベイジン カイン テクノロジー シェア−ホールディング シーオー．， エルティーディー．
ベイジン カイン バイオ−テック シーオー．， エルティーディー．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013539108A 2010-11-19 2010-11-19 Ｂ型肝炎の予防及び治療のためのｄｎａワクチン組成物 Pending JP2014500875A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2010/077979 WO2012065286A1 (zh) 2010-11-19 2010-11-19 一种用于预防和治疗乙型肝炎的dna疫苗组合物

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JP2014500875A true JP2014500875A (ja) 2014-01-16

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JP2013539108A Pending JP2014500875A (ja) 2010-11-19 2010-11-19 Ｂ型肝炎の予防及び治療のためのｄｎａワクチン組成物

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JP (1) JP2014500875A (zh)
KR (1) KR20130118890A (zh)
CN (1) CN103547286B (zh)
WO (1) WO2012065286A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113058033B (zh) * 2019-12-16 2024-07-09 远大赛威信生命科学(南京)有限公司 一种用于预防和治疗乙型肝炎的药物组合物及其用途
WO2023133509A2 (en) * 2022-01-08 2023-07-13 Carogen Corporation Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02163089A (ja) * 1988-12-15 1990-06-22 Dai Ichi Seiyaku Co Ltd Ｈｂｖ−ｄｎａ配列および遺伝子導入動物
WO2008020656A1 (en) * 2006-08-14 2008-02-21 Postech Foundation A dna vaccine for curing chronic hepatitis b and a method of preparing same
JP2010516807A (ja) * 2007-01-31 2010-05-20 トゥビエル カンパニー，リミテッド Ｈｂｖワクチンおよびその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200106C (zh) * 1999-06-18 2005-05-04 中国人民解放军第四五八医院 抗乙型肝炎病毒双质粒基因疫苗、其制备方法及应用
FR2804028B1 (fr) * 2000-01-21 2004-06-04 Merial Sas Vaccins adn ameliores pour animaux de rente
CN101220373B (zh) * 2007-01-10 2012-01-11 深圳市源兴生物医药科技有限公司 一种重组病毒载体及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02163089A (ja) * 1988-12-15 1990-06-22 Dai Ichi Seiyaku Co Ltd Ｈｂｖ−ｄｎａ配列および遺伝子導入動物
WO2008020656A1 (en) * 2006-08-14 2008-02-21 Postech Foundation A dna vaccine for curing chronic hepatitis b and a method of preparing same
JP2010516807A (ja) * 2007-01-31 2010-05-20 トゥビエル カンパニー，リミテッド Ｈｂｖワクチンおよびその製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CSNC201100570033; 大川 和良: '肝炎ワクチンの期待と展望 - Ｂ型肝炎ＤＮＡワクチンの将来性' 医学のあゆみ 別冊（６月）, 19990630, Ｐａｇｅ．１１５-１１７ *
JPN6014024777; 大川 和良: '肝炎ワクチンの期待と展望 - Ｂ型肝炎ＤＮＡワクチンの将来性' 医学のあゆみ 別冊（６月）, 19990630, Ｐａｇｅ．１１５-１１７ *

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Publication number Publication date
KR20130118890A (ko) 2013-10-30
WO2012065286A1 (zh) 2012-05-24
CN103547286A (zh) 2014-01-29
CN103547286B (zh) 2016-10-19

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