JP2014129289A - Gallate type catechin-containing cosmetics - Google Patents
Gallate type catechin-containing cosmetics Download PDFInfo
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- JP2014129289A JP2014129289A JP2012288222A JP2012288222A JP2014129289A JP 2014129289 A JP2014129289 A JP 2014129289A JP 2012288222 A JP2012288222 A JP 2012288222A JP 2012288222 A JP2012288222 A JP 2012288222A JP 2014129289 A JP2014129289 A JP 2014129289A
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 82
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 235000005487 catechin Nutrition 0.000 title claims abstract description 49
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 title claims abstract description 41
- 229950001002 cianidanol Drugs 0.000 title claims abstract description 41
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 102000008186 Collagen Human genes 0.000 claims abstract description 38
- 108010035532 Collagen Proteins 0.000 claims abstract description 38
- 229920001436 collagen Polymers 0.000 claims abstract description 38
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 34
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 33
- 229940110767 coenzyme Q10 Drugs 0.000 claims abstract description 32
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 29
- 150000004676 glycans Chemical class 0.000 claims abstract description 26
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 26
- 239000005017 polysaccharide Substances 0.000 claims abstract description 26
- 244000068988 Glycine max Species 0.000 claims abstract description 24
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 19
- 239000012798 spherical particle Substances 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 abstract description 21
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- 229940030275 epigallocatechin gallate Drugs 0.000 description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000003963 antioxidant agent Substances 0.000 description 8
- 235000006708 antioxidants Nutrition 0.000 description 8
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- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
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- 230000000694 effects Effects 0.000 description 6
- 238000004945 emulsification Methods 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 5
- 229930003268 Vitamin C Natural products 0.000 description 5
- 150000001765 catechin Chemical class 0.000 description 5
- -1 facial cleansers Substances 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 4
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 4
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 4
- 235000012734 epicatechin Nutrition 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000008406 cosmetic ingredient Substances 0.000 description 3
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- 238000010438 heat treatment Methods 0.000 description 3
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- 239000000463 material Substances 0.000 description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
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- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
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- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000209507 Camellia Species 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
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- 241000282887 Suidae Species 0.000 description 1
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- 238000010306 acid treatment Methods 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 229960005188 collagen Drugs 0.000 description 1
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- 239000012043 crude product Substances 0.000 description 1
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- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、ガレート型カテキン及びコエンザイムＱ１０（酸化型／還元型）を含有する化粧料に関する。 The present invention relates to a cosmetic containing gallate catechin and coenzyme Q10 (oxidized / reduced).
洗顔料、化粧水、美容液、乳液、クリームなどの基礎化粧料は、肌に対して保湿・抗菌・収斂・柔軟効果を与え、肌質を整える化粧料である。基礎化粧料に抗菌・収斂性を与える成分として、カテキン類が知られており、その中でも、ガレート型カテキンは、収斂性が高く、また、紫外線に対する皮膚保護効果などの機能性に優れていることが知られている。 Basic cosmetics such as facial cleansers, lotions, cosmetic liquids, milky lotions, and creams are cosmetics that give the skin a moisturizing, antibacterial, astringent, and softening effect to improve the skin quality. Catechins are known as ingredients that give antibacterial and astringent properties to basic cosmetics. Among them, gallate-type catechins are highly astringent and have excellent functionality such as skin protection against ultraviolet rays. It has been known.
カテキン類を使用した化粧料に関する技術提案は既に多くなされている（例えば、特許文献１〜３）。特に、特許文献３は美白効果を有する化粧料を記載し、該化粧料に含まれる複数の成分の組み合わせとして、メチル化カテキンと、コエンザイムＱ１０と、コラーゲンとの組み合わせを記載し、さらにエピカテキンガレートやエピガロカテキンガレートなどのガレート型カテキンは美白効果が低いことを記載している。 Many technical proposals regarding cosmetics using catechins have already been made (for example, Patent Documents 1 to 3). In particular, Patent Document 3 describes a cosmetic having a whitening effect, describes a combination of methylated catechin, coenzyme Q10, and collagen as a combination of a plurality of components contained in the cosmetic, and further epicatechin gallate. And gallate-type catechins such as epigallocatechin gallate have a low whitening effect.
また、アンチエイジングの観点から、抗酸化などの機能性成分を含有する化粧料も多く存在する。中でもコエンザイムＱ１０や還元型コエンザイムＱ１０は、その高い抗酸化作用・抗老化作用から、近年化粧料にしばしば配合される成分である。しかし、これらの成分は水への溶解度が低く、析出などが起こってしまう。また、油への配合は容易であるものの、効果的な肌への浸透のためには、水溶液中に乳化させる必要があった。そのため、コエンザイムＱ１０を安定に化粧料に配合する研究が数多くなされている（例えば、特許文献４〜６）。これらの特許文献では、コエンザイムＱ１０を容易に溶解する特定の油成分などを用いることにより、製剤中でのコエンザイムＱ１０の分離、凝集、析出などを抑制しようとしている。 In addition, from the viewpoint of anti-aging, there are many cosmetics containing functional components such as antioxidants. Among them, coenzyme Q10 and reduced coenzyme Q10 are components that are often blended in cosmetics in recent years due to their high antioxidant action and anti-aging action. However, these components have low solubility in water, and precipitation occurs. In addition, although it is easy to blend into oil, it has been necessary to emulsify in an aqueous solution for effective skin penetration. For this reason, many studies have been made to stably incorporate Coenzyme Q10 into cosmetics (for example, Patent Documents 4 to 6). In these patent documents, separation, aggregation, precipitation, etc. of coenzyme Q10 in the preparation are to be suppressed by using a specific oil component that easily dissolves coenzyme Q10.
一方、近年の化粧料の傾向として、肌や体内への安全性を考慮して、界面活性剤などを使用しない無添加化粧料が消費者に好まれる傾向にあり、それに対する種々の技術提案もなされている。例えば、特許文献７では、糖質とポリフェノール成分とを含有し、ポリフェノール成分が緑茶抽出物である界面活性剤フリーの乳化組成物が提案されている。しかし、特許文献７にはガレート型カテキンに関する記述はなく、特許文献７に記載の乳化組成物はガレート型カテキンを安定に含有するものではなかった。 On the other hand, as a trend of cosmetics in recent years, in consideration of safety to the skin and the body, additive-free cosmetics that do not use surfactants tend to be preferred by consumers, and various technical proposals for it are also proposed Has been made. For example, Patent Document 7 proposes a surfactant-free emulsified composition containing a saccharide and a polyphenol component, and the polyphenol component is a green tea extract. However, there is no description regarding gallate catechins in Patent Document 7, and the emulsion composition described in Patent Document 7 does not stably contain gallate catechins.
以上のように、コエンザイムＱ１０やカテキンを配合した化粧料についての技術提案は数多くされているが、これまでコエンザイムＱ１０とガレート型カテキンと共に他の特定の成分を併用することによって、新たな物理的特性を有する化粧料が得られることについては知られていなかった。 As described above, many technical proposals have been made on cosmetics containing coenzyme Q10 and catechin, but new physical characteristics can be obtained by using coenzyme Q10 and gallate catechin together with other specific components. It has not been known that a cosmetic material having the following can be obtained.
本発明の目的は、コエンザイムＱ１０や還元型コエンザイムＱ１０を含有しながら、コラーゲン及び大豆多糖類及び強い抗酸化力をもつガレート型カテキンを含有することにより、分離、凝集、沈殿なども生じない、物理化学的に安定な乳液様の化粧料を提供することである。 The object of the present invention is to contain coenzyme Q10 and reduced coenzyme Q10, but also contain collagen, soybean polysaccharide, and gallate catechin having strong antioxidant power, so that separation, aggregation, precipitation, etc. do not occur. It is to provide a chemically stable emulsion-like cosmetic.
前記目的を達成するため、本発明者らは鋭意研究を重ねた結果、コエンザイムＱ１０や還元型コエンザイムＱ１０と共に、ガレート型カテキン、コラーゲン及び大豆多糖類という特定の３成分を含有させ、ガレート型カテキンの含有量とコラーゲンの含有量との比を所定の範囲から選択して乳化することにより、従来技術のようにコエンザイムＱ１０などを溶解し易い油成分や界面活性剤などを用いなくても、得られる乳化組成物中でのコエンザイムＱ１０や還元型コエンザイムＱ１０の分離、凝集、沈殿などを抑制し、これらを物理化学的に安定に含有させることができ、さらに得られる乳化組成物を化粧料として好適に使用できることを発見し、本発明を完成するに至った。 In order to achieve the above-mentioned object, the present inventors have conducted intensive research. As a result, in addition to coenzyme Q10 and reduced coenzyme Q10, the present invention contains three specific components, gallate catechin, collagen and soybean polysaccharide, By selecting and emulsifying the ratio between the content and the collagen content within a predetermined range, it can be obtained without using an oil component or surfactant that easily dissolves coenzyme Q10 or the like as in the prior art. The separation, aggregation, precipitation, etc. of coenzyme Q10 and reduced coenzyme Q10 in the emulsion composition can be suppressed, and these can be contained stably in physicochemical manner, and the resulting emulsion composition is suitable as a cosmetic. It has been found that it can be used, and the present invention has been completed.
即ち、本発明は、下記［１］〜［３］の化粧料に関する。
［１］（ａ）ガレート型カテキン、（ｂ）コラーゲン、（ｃ）大豆多糖類、並びに（ｄ）コエンザイムＱ１０及び／又は還元型コエンザイムＱ１０を含有し、（ａ）成分の含有量Ａ（重量％）と（ｂ）成分の含有量Ｂ（重量％）との比（Ｂ／Ａ）が２．０〜１０．０の範囲にある化粧料。
That is, the present invention relates to cosmetics [1] to [3] below.
[1] containing (a) gallate catechin, (b) collagen, (c) soybean polysaccharide, and (d) coenzyme Q10 and / or reduced coenzyme Q10, and (a) content A (weight%) ) And the content B (weight%) of the component (b) (B / A) is in the range of 2.0 to 10.0.
［２］（ｃ）成分の含有量が０．１〜５．０重量％の範囲にあり、（ｄ）成分の含有量が０．０１〜１．０重量％の範囲にある上記［１］の化粧料。 [2] The above [1], wherein the content of the component (c) is in the range of 0.1 to 5.0% by weight, and the content of the component (d) is in the range of 0.01 to 1.0% by weight. Cosmetics.
［３］（ａ）成分、（ｂ）成分、（ｃ）成分及び（ｄ）成分によって構成される略球状粒子を分散質として含有し、該粒子の平均粒子径が０．０５〜５０μｍである上記［１］又は［２］の化粧料。 [3] Substantially spherical particles composed of the components (a), (b), (c), and (d) are contained as a dispersoid, and the average particle size of the particles is 0.05 to 50 μm. Cosmetics according to [1] or [2] above.
本発明の化粧料は、油成分や界面活性剤などを使用しなくても、ガレート型カテキン、コラーゲン、大豆多糖類、並びにコエンザイムＱ１０及び／又は還元型コエンザイムＱ１０の各種機能性成分を安定に含有し、特にコエンザイムＱ１０及び／又は還元型コエンザイムＱ１０の分離、凝集、沈殿などが抑制された乳化組成物である。本発明の化粧料は、前記した各成分の乳化安定性に優れていることから、肌への使用感が良好である。また、本発明の化粧料における（ａ）〜（ｄ）の成分は食品にも用いられるものであるため、本発明の化粧料は肌に対する安全性が高い。 The cosmetic of the present invention stably contains gallate catechin, collagen, soybean polysaccharide, and various functional components of coenzyme Q10 and / or reduced coenzyme Q10 without using an oil component or a surfactant. In particular, it is an emulsified composition in which the separation, aggregation, precipitation and the like of coenzyme Q10 and / or reduced coenzyme Q10 are suppressed. The cosmetic of the present invention is excellent in emulsification stability of each of the components described above, and thus has a good feeling on the skin. In addition, since the components (a) to (d) in the cosmetic of the present invention are also used in foods, the cosmetic of the present invention has high safety for the skin.
以下、本発明をさらに詳しく説明する。 Hereinafter, the present invention will be described in more detail.
本発明の化粧料は、（ａ）ガレート型カテキン、（ｂ）コラーゲン、（ｃ）大豆多糖類、並びに（ｄ）コエンザイムＱ１０及び／又は還元型コエンザイムＱ１０の４成分を含有することを特徴とする。従来技術では、コエンザイムＱ１０及び／又は還元型コエンザイムＱ１０を良く溶解する油成分や界面活性剤などを用いることにより、これらの製剤中での分離、凝集、析出などを抑制しようとしていた。しかしながら、本発明ではそのような油成分や界面活性剤などを用いることなく、コエンザイムＱ１０及び／又は還元型コエンザイムＱ１０の化粧料中での分離、凝集、析出などを抑制することに成功している。 The cosmetic of the present invention comprises (a) gallate catechin, (b) collagen, (c) soybean polysaccharide, and (d) four components of coenzyme Q10 and / or reduced coenzyme Q10. . In the prior art, an oil component or a surfactant that dissolves coenzyme Q10 and / or reduced coenzyme Q10 well is used to suppress separation, aggregation, and precipitation in these preparations. However, the present invention has succeeded in suppressing the separation, aggregation, precipitation, and the like of coenzyme Q10 and / or reduced coenzyme Q10 in cosmetics without using such an oil component or surfactant. .
〔（ａ）ガレート型カテキン〕
ガレート型カテキンは、例えば、収斂性が高く、紫外線に対する皮膚保護効果などの機能性に優れていることから、化粧料の成分として有用である。ここで、カテキンとは、緑茶、紅茶、ウーロン茶などの、カメリア属に分類される植物（特にその葉）の水、熱水、その他の溶媒などによる抽出液中に多く含まれているポリフェノールの一種であり、主にエピカテキン（ＥＣ）、エピカテキンガレート（ＥＣｇ）、エピガロカテキン（ＥＧＣ）、エピガロカテキンガレート（ＥＧＣｇ）、カテキン（Ｃ）、カテキンガレート（Ｃｇ）などのフラバン−３−オール類の総称であるが、本発明においてガレート型カテキンとは、分子内にガロイル基を有するカテキンであり、具体的には、ＥＣｇ、ＥＧＣｇ、Ｃｇ、ＧＣｇなどを指す。これらは、精製品の他、粗製品でも良く、これらを含有する天然物またはその加工品でも良い。ガレート型カテキンは、１種を単独で又は２種以上を組み合わせて使用できる。
[(A) Galate type catechin]
Galate-type catechin is useful as a cosmetic ingredient because it has high astringency and is excellent in functionality such as skin protection against ultraviolet rays. Here, catechin is a kind of polyphenols that are often contained in extracts of water, hot water, other solvents, etc. of plants (particularly their leaves) classified as Camellia, such as green tea, black tea, and oolong tea. And flavan-3-ols such as epicatechin (EC), epicatechin gallate (ECg), epigallocatechin (EGC), epigallocatechin gallate (EGCg), catechin (C), catechin gallate (Cg), etc. In the present invention, the gallate catechin is a catechin having a galloyl group in the molecule, and specifically refers to ECg, EGCg, Cg, GCg and the like. These may be refined products, crude products, natural products containing these products, or processed products thereof. Galate type catechin can be used individually by 1 type or in combination of 2 or more types.
本発明の化粧料中のガレート型カテキンの含有量は特に限定されず、ガレート型カテキン自体の種類や他成分の種類及び含有量などに応じて広い範囲から適宜選択できるが、好ましくは０．２〜１５．０重量％、より好ましくは０．２〜１２．０重量％、さらに好ましくは０．５〜１０重量％である。ガレート型カテキンの含有量が０．２重量％未満では、ガレート型カテキン自体の効果が十分に発現されないおそれがある。また、ガレート型カテキンの含有量が１５．０重量％を超えると、本発明の化粧料における各成分の乳化安定性が損なわれてしまうおそれがある。 The content of the gallate catechin in the cosmetic of the present invention is not particularly limited and can be appropriately selected from a wide range depending on the type of gallate catechin itself and the type and content of other components, but preferably 0.2. -15.0 wt%, more preferably 0.2-12.0 wt%, still more preferably 0.5-10 wt%. If the content of gallate catechin is less than 0.2% by weight, the effect of gallate catechin itself may not be sufficiently exhibited. Moreover, when content of gallate type catechin exceeds 15.0 weight%, there exists a possibility that the emulsification stability of each component in the cosmetics of this invention may be impaired.
〔（ｂ）コラーゲン〕
コラーゲンは、例えば保湿効果などを有し、化粧料の成分として有用である。本発明に用いられるコラーゲンとは、動物の骨や皮に多く含まれるタンパク質であるコラーゲンを加熱・変性させて得られるゼラチンや、それをさらに酸やアルカリまたは酵素などで加水分解させたコラーゲンペプチドを総称して言う。本発明においてコラーゲンは、由来動物（豚、牛、魚など）や製法（酸処理、アルカリ処理など）に関して特に限定されずに使用することができる。
[(B) Collagen]
Collagen has, for example, a moisturizing effect and is useful as a cosmetic ingredient. Collagen used in the present invention is gelatin obtained by heating and denaturing collagen, which is a protein that is abundant in animal bones and skin, and collagen peptide obtained by further hydrolyzing it with acid, alkali, or enzyme. Collectively say. In the present invention, collagen can be used without any particular limitation with respect to derived animals (pigs, cows, fish, etc.) and production methods (acid treatment, alkali treatment, etc.).
本発明の化粧料中のコラーゲンの含有量は特に限定されず、コラーゲン自体の種類や他成分の種類及び含有量などに応じて広い範囲から適宜選択できるが、コラーゲンの効果を発揮し、化粧料のゲル化や粘度上昇を抑える観点から、１．０〜４０．０重量％が好ましく、２．０〜２０．０重量％であることがより好ましい。コラーゲンの含有量が１．０重量％未満では、コラーゲン自体の効果が十分に発現されないおそれがあるとともに、化粧料における各成分の乳化安定性が低下し、分離、凝集、析出などが発生するおそれがある。また、コラーゲンの含有量が４０重量％を超えると、化粧料の粘度が上昇し、取扱い性が低下したり、肌表面で延びにくくなったりするおそれがある。 The content of collagen in the cosmetic of the present invention is not particularly limited, and can be appropriately selected from a wide range according to the type of collagen itself and the type and content of other components. From the viewpoint of suppressing gelation and viscosity increase, 1.0 to 40.0% by weight is preferable, and 2.0 to 20.0% by weight is more preferable. If the collagen content is less than 1.0% by weight, the effect of collagen itself may not be sufficiently exhibited, and the emulsification stability of each component in the cosmetic may be reduced, and separation, aggregation, precipitation, etc. may occur. There is. On the other hand, when the collagen content exceeds 40% by weight, the viscosity of the cosmetic composition is increased, and the handleability may be deteriorated or it may be difficult to extend on the skin surface.
本発明の化粧料では、ガレート型カテキンの含有量Ａ（重量％）と、コラーゲンの含有量Ｂ（重量％）との比（Ｂ／Ａ）を２．０〜１０．０の範囲に調整することにより、ガレート型カテキン、コラーゲン、大豆多糖類、並びにコエンザイムＱ１０及び／又は還元型コエンザイムＱ１０を含有しながら、これらの成分に起因する分離、沈殿などが生じない安定な状態の外観を有する化粧料（乳化組成物）を得ることができる。Ｂ／Ａが２．０未満である場合、及びＢ／Ａが１０．０を超える場合には、各成分の乳化安定性が低下して化粧料中に沈殿などが生じるおそれがある。なお、Ｂ／Ａは、好ましくは２．０〜６．０である。 In the cosmetic of the present invention, the ratio (B / A) of the content A (% by weight) of gallate catechin and the content B (% by weight) of collagen is adjusted to a range of 2.0 to 10.0. Cosmetics having a stable appearance that contains gallate catechin, collagen, soybean polysaccharide, and coenzyme Q10 and / or reduced coenzyme Q10 but does not cause separation, precipitation, or the like due to these components (Emulsified composition) can be obtained. When B / A is less than 2.0 and when B / A exceeds 10.0, the emulsification stability of each component may be reduced and precipitation may occur in the cosmetic. B / A is preferably 2.0 to 6.0.
〔（ｃ）大豆多糖類〕
大豆多糖類は、例えば、乳化安定性を向上させる効果を有し、特にガレート型カテキン及びコラーゲンの乳化安定性を向上させる効果を有していると考えられる。本発明において大豆多糖類とは、水溶性大豆食物繊維とも呼ばれ、大豆タンパク製造の際に生じる不溶性食物繊維（オカラ）から、弱酸性下で抽出、精製、殺菌、乾燥の工程を経て調製される水溶性の多糖類である。当該水溶性大豆食物繊維は、ガラクトース、アラビノース、ガラクツロン酸、ラムノース、キシロース、フコース、グルコースなどの糖から構成され、主要な構造として、ラムノガラクツロン酸鎖にガラクタンとアラビナンとが結合した構造を有すると推定されている。
[(C) Soybean polysaccharide]
Soy polysaccharides are considered to have, for example, an effect of improving the emulsion stability, and particularly an effect of improving the emulsion stability of gallate catechins and collagen. In the present invention, the soy polysaccharide is also called water-soluble soy dietary fiber, and is prepared from insoluble dietary fiber (Okara) produced during soy protein production through a process of extraction, purification, sterilization, and drying under mild acidity. It is a water-soluble polysaccharide. The water-soluble soybean dietary fiber is composed of sugars such as galactose, arabinose, galacturonic acid, rhamnose, xylose, fucose, and glucose, and has a structure in which galactan and arabinan are bound to the rhamnogalacturonic acid chain. It is estimated that.
このような大豆多糖類としては、例えば、「ソヤファイブ（登録商標）−Ｓ」シリーズ（不二製油株式会社製）等の市販品を使用してもよい。 As such a soybean polysaccharide, you may use commercial items, such as "Soya Five (trademark) -S" series (made by Fuji Oil Co., Ltd.), for example.
本発明の化粧料中の大豆多糖類の含有量は特に限定されず、他成分の種類や含有量などに応じて広い範囲から適宜選択できるが、分離、凝集、沈殿などの発生を抑えて良好な乳化安定性を付与する効果を発揮させるために、０．１〜５．０重量％が好ましく、０．２〜５．０重量％がより好ましく、０．２〜２．０重量％がさらに好ましい。大豆多糖類の含有量が０．１重量％未満では、化粧料中における各成分の分離、凝集、沈殿などの発生を十分に抑制できないおそれがある。大豆多糖類の含有量が５．０重量％を超えると、化粧料の粘度が高くなり、その取扱い性や肌表面での延び性などが低下するおそれがある。 The content of the soybean polysaccharide in the cosmetic of the present invention is not particularly limited, and can be appropriately selected from a wide range depending on the type and content of other components, but is good in suppressing the occurrence of separation, aggregation, precipitation, etc. 0.1 to 5.0% by weight is preferable, 0.2 to 5.0% by weight is more preferable, and 0.2 to 2.0% by weight is more preferable. preferable. If the content of soybean polysaccharide is less than 0.1% by weight, the occurrence of separation, aggregation, precipitation and the like of each component in the cosmetic may not be sufficiently suppressed. When the content of soybean polysaccharide exceeds 5.0% by weight, the viscosity of the cosmetic is increased, and there is a possibility that the handleability, the extensibility on the skin surface, and the like are lowered.
〔（ｄ）コエンザイムＱ１０及び／又は還元型コエンザイムＱ１０〕
コエンザイムＱ１０及び還元型コエンザイムＱ１０は、例えば優れた抗酸化能を有し、化粧料の成分として有用である。コエンザイムＱ１０は、ユビデカレノン、補酵素Ｑ１０、ユビキノンなどともいい、公知の物質である。コエンザイムＱ１０とは、一般的には酸化型を指す。還元型のものについては、還元型コエンザイムＱ１０といい、非常に高い抗酸化力を有する成分である。
[(D) Coenzyme Q10 and / or reduced coenzyme Q10]
Coenzyme Q10 and reduced coenzyme Q10 have, for example, excellent antioxidant ability and are useful as cosmetic ingredients. Coenzyme Q10 is also known as ubidecalenone, coenzyme Q10, ubiquinone, etc., and is a known substance. Coenzyme Q10 generally refers to an oxidized form. The reduced type is referred to as reduced coenzyme Q10, which is a component having a very high antioxidant power.
本発明の化粧料中のコエンザイムＱ１０及び／又は還元型コエンザイムＱ１０の含有量は特に限定されず、コエンザイムＱ１０自体の種類や他成分の種類及び含有量などに応じて広い範囲から適宜選択できるが、一例を挙げれば、０．０１〜１．０重量％が好ましく、０．１〜０．６重量％がより好ましい。これらの含有量が０．０１重量％未満では、それ自体の効果が十分に発現されないおそれがある。また、これらの含有量が１．０重量％を超えると、化粧料の乳化安定性に影響を及ぼす場合があるが、他成分の種類や含有量を調整することにより、１．０重量％よりも多い量を含有させることも可能である。 The content of coenzyme Q10 and / or reduced coenzyme Q10 in the cosmetic of the present invention is not particularly limited, and can be appropriately selected from a wide range depending on the type of coenzyme Q10 itself and the type and content of other components. If an example is given, 0.01 to 1.0 weight% is preferable and 0.1 to 0.6 weight% is more preferable. If these contents are less than 0.01% by weight, the effects themselves may not be sufficiently exhibited. Moreover, if these contents exceed 1.0% by weight, the emulsification stability of the cosmetic may be affected, but by adjusting the type and content of other components, It is also possible to contain a large amount.
〔任意成分〕
また、本発明の化粧料には、その嗜好性や物理化学的安定性に悪影響を与えない範囲で、所望により、化粧料用の一般的な添加剤を任意成分として含有させることができる。該添加剤としては、例えば、香料、色素（顔料も含む）、防腐剤、殺菌剤、保湿剤、紫外線吸収剤、紫外線散乱剤、酸化防止剤、塩、キレート剤、増粘剤、パール剤、界面活性剤、油剤、溶剤、各種薬剤、植物エキスなどが挙げられる。任意成分は１種を単独で又は２種以上を組み合わせて使用できる。
[Optional ingredients]
Moreover, the cosmetics of this invention can contain the general additive for cosmetics as an arbitrary component depending on necessity in the range which does not have a bad influence on the palatability and physicochemical stability. Examples of the additive include fragrances, dyes (including pigments), preservatives, bactericides, moisturizers, UV absorbers, UV scattering agents, antioxidants, salts, chelating agents, thickeners, pearling agents, Surfactants, oils, solvents, various drugs, plant extracts and the like can be mentioned. An arbitrary component can be used individually by 1 type or in combination of 2 or more types.
〔乳化構造〕
本発明の化粧料は、（ａ）成分であるガレート型カテキン、（ｂ）成分であるコラーゲン、（ｃ）成分である大豆多糖類、並びに（ｄ）成分であるコエンザイムＱ１０及び／又は還元型コエンザイムＱ１０によって構成される略球状粒子を分散質として含有するコロイド状乳化組成物である。略球状粒子とは、球体、回転楕円体などのおおよそ球状の粒子を指し、光学顕微鏡によって確認できるものをいう。
[Emulsification structure]
The cosmetic of the present invention comprises (a) component gallate catechin, (b) component collagen, (c) component soy polysaccharide, and (d) component coenzyme Q10 and / or reduced coenzyme. It is a colloidal emulsion composition containing substantially spherical particles constituted by Q10 as a dispersoid. Substantially spherical particles refer to roughly spherical particles such as spheres and spheroids, which can be confirmed with an optical microscope.
また、略球状粒子の平均粒子径は、後述の実施例（特に試験例１）に記載のように、レーザー回析式粒度分布測定装置によって測定できる。平均粒子径は、乳化組成物の安定性の観点から５０μｍ以下であることが好ましい。 Moreover, the average particle diameter of the substantially spherical particles can be measured by a laser diffraction particle size distribution measuring device as described in Examples (especially Test Example 1) described later. The average particle diameter is preferably 50 μm or less from the viewpoint of the stability of the emulsion composition.
〔製造方法〕
前記のような構成を有する本発明の化粧料は、例えば（ｂ）成分及び（ｃ）成分を水に混合、加熱溶解し、次いで（ａ）成分、（ｄ）成分を添加混合することで製造することができる。
また、（ａ）成分は予め水に混合、加熱溶解させておくことで速やかに混合しやすくすることができる。
また、予め加熱した水に（ａ）、（ｂ）、（ｃ）、（ｄ）成分を添加混合してもよい。
その他の任意成分については、適宜任意の段階で添加すればよい。
〔Production method〕
The cosmetic of the present invention having the above-described structure is produced, for example, by mixing (b) component and (c) component in water, dissolving by heating, and then adding and mixing (a) component and (d) component. can do.
In addition, the component (a) can be easily mixed quickly by mixing in water and dissolving in advance by heating.
Further, the components (a), (b), (c), and (d) may be added and mixed in preheated water.
Other optional components may be appropriately added at any stage.
こうして得られる乳化組成物は、そのまま本発明の化粧料として使用できる。本発明の化粧料は、例えば、洗顔料、化粧水、乳液、クリーム、美容液、化粧下地、日焼け止め、ハンドクリーム、リップエッセンスなどとして用いることができる。また、本発明において化粧料として使用される乳化組成物は、（ａ）〜（ｄ）の必須成分が全て食品としても利用可能なものなので、各種食品にも応用可能である。 The emulsion composition thus obtained can be used as it is as the cosmetic of the present invention. The cosmetic of the present invention can be used, for example, as a facial cleanser, lotion, milky lotion, cream, serum, makeup base, sunscreen, hand cream, lip essence and the like. The emulsified composition used as a cosmetic in the present invention can be applied to various foods since all the essential components (a) to (d) can be used as food.
以下、本発明を実施例により具体的に説明するが、本発明はこれらによって何ら制限されるものではない。なお、本実施例で使用する各成分は、具体的には次の通りである。 EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples. In addition, each component used in a present Example is specifically as follows.
［カテキン類］
ＥＧＣｇ（ガレート型カテキン、商品名：サンフェノンＥＧＣｇ、ガレート型カテキン含有率９５重量％以上、太陽化学株式会社製）
なお、本実施例では、上記ＥＧＣｇのガレート型カテキン含有率を１００重量％として換算した。
ＥＣｇ（ガレート型カテキン、和光純薬株式会社製）
ＥＣ（非ガレート型カテキン、和光純薬株式会社製）
[Catechin]
EGCg (gallate type catechin, trade name: Sanphenon EGCg, gallate type catechin content 95% by weight or more, manufactured by Taiyo Chemical Co., Ltd.)
In this example, the content of gallate catechin in EGCg was converted to 100% by weight.
ECg (gallate type catechin, manufactured by Wako Pure Chemical Industries, Ltd.)
EC (non-gallate catechin, manufactured by Wako Pure Chemical Industries, Ltd.)
［コラーゲン］
コラーゲンペプチド（商品名：アクアジェルＣ−５００、新田ゼラチン株式会社製）
ゼラチン（商品名：ＡＰＨ−２５０、新田ゼラチン株式会社製）
[collagen]
Collagen peptide (trade name: Aquagel C-500, manufactured by Nitta Gelatin Co., Ltd.)
Gelatin (trade name: APH-250, manufactured by Nitta Gelatin Co., Ltd.)
大豆多糖類（商品名：ソヤファイブ−Ｓ、不二製油株式会社製）
還元型コエンザイムＱ１０（商品名：カネカＱＨ、株式会社カネカ製）
Soy polysaccharide (trade name: Soya Five-S, manufactured by Fuji Oil Co., Ltd.)
Reduced coenzyme Q10 (trade name: Kaneka QH, manufactured by Kaneka Corporation)
（実施例１）
コラーゲンペプチド１０．０ｇと大豆多糖類１．０ｇとを８０℃の水３０ｇに溶かした。この水溶液に、ＥＧＣｇ２．０ｇを８０℃の水３０ｇに溶かした水溶液を加え、その後、還元型コエンザイムＱ１０を０．１５ｇ、ビタミンＣを０．５g、パラベンを０．１g、グリセリンを２０ｇ加え、ホモミキサーで攪拌混合し、最後に全量１００gとなるように水を加えて混合し、白色の乳液状の化粧料を作製した。得られた化粧料は、成分の沈殿や分離がなく、ガレート型カテキン成分、コラーゲン成分、還元型コエンザイムＱ１０の３つの機能性成分を含有する、安定性に優れた抗酸化能の高い化粧料であった。肌への使用感も市販の乳液と同等のものであった。なお、作製した化粧料の組成等について表１に示す（以下の実施例も同じ）。
Example 1
Collagen peptide 10.0 g and soybean polysaccharide 1.0 g were dissolved in 80 g of water at 80 ° C. To this aqueous solution was added an aqueous solution in which 2.0 g of EGCg was dissolved in 30 g of water at 80 ° C., and then 0.15 g of reduced coenzyme Q10, 0.5 g of vitamin C, 0.1 g of paraben, and 20 g of glycerin were added. The mixture was stirred and mixed with a mixer, and finally, water was added and mixed so that the total amount became 100 g to prepare a white emulsion cosmetic. The obtained cosmetic is a cosmetic with high stability and high anti-oxidation ability, which contains three functional ingredients, gallate catechin ingredient, collagen ingredient, and reduced coenzyme Q10, with no precipitation or separation of ingredients. there were. The feeling on the skin was equivalent to a commercially available emulsion. In addition, it shows in Table 1 about the composition etc. of the produced cosmetics (the following examples are also the same).
（比較例１）
コラーゲンペプチド１０．０ｇと大豆多糖類１．０ｇとを８０℃の水６０ｇに溶かした。この水溶液に、還元型コエンザイムＱ１０を０．１５ｇ、ビタミンＣを０．５g、パラベンを０．１g、グリセリンを２０ｇ加え、ホモミキサーで攪拌混合し、最後に全量１００gとなるように水を加えて混合し、ガレート型カテキンを用いることなく、化粧料を作製した。得られた化粧料は、静置すると還元型コエンザイムＱ１０の油滴が上層に分離してしまった。
(Comparative Example 1)
Collagen peptide 10.0g and soybean polysaccharide 1.0g were melt | dissolved in 60g of 80 degreeC water. To this aqueous solution, 0.15 g of reduced coenzyme Q10, 0.5 g of vitamin C, 0.1 g of paraben and 20 g of glycerin are added and stirred and mixed with a homomixer. Finally, water is added so that the total amount becomes 100 g. A cosmetic was prepared without mixing and using gallate catechins. When the obtained cosmetic was allowed to stand, oil droplets of reduced coenzyme Q10 had separated into the upper layer.
（比較例２）
コラーゲンペプチド１０．０ｇを８０℃の水３０ｇに溶かした。この水溶液に、ＥＧＣｇ２．０ｇを８０℃の水３０ｇに溶かした水溶液を加え、その後、還元型コエンザイムＱ１０を０．１５ｇ、ビタミンＣを０．５g、パラベンを０．１g、グリセリンを２０ｇ加え、ホモミキサーで攪拌混合し、最後に全量１００gとなるように水を加えて混合し、大豆多糖類を用いることなく、化粧料を作製した。得られた化粧料は、白色の凝集沈殿が生じてしまった。
(Comparative Example 2)
10.0 g of collagen peptide was dissolved in 30 g of water at 80 ° C. To this aqueous solution was added an aqueous solution in which 2.0 g of EGCg was dissolved in 30 g of water at 80 ° C., and then 0.15 g of reduced coenzyme Q10, 0.5 g of vitamin C, 0.1 g of paraben, and 20 g of glycerin were added. The mixture was stirred and mixed with a mixer. Finally, water was added and mixed so that the total amount became 100 g, and a cosmetic was prepared without using soybean polysaccharide. In the obtained cosmetic, white aggregated precipitation occurred.
（比較例３）
大豆多糖類１．０ｇを８０℃の水３０ｇに溶かした。この水溶液に、ＥＧＣｇ２．０ｇを８０℃の水３０ｇに溶かした水溶液を加え、その後、還元型コエンザイムＱ１０を０．１５ｇ、ビタミンＣを０．５g、パラベンを０．１g、グリセリンを２０ｇ加え、ホモミキサーで攪拌混合し、最後に全量１００gとなるように水を加えて混合し、コラーゲンペプチドを用いることなく、化粧料を作製した。得られた化粧料は、静置すると還元型コエンザイムＱ１０の油滴が上層に分離してしまった。
(Comparative Example 3)
1.0 g of soybean polysaccharide was dissolved in 30 g of water at 80 ° C. To this aqueous solution was added an aqueous solution in which 2.0 g of EGCg was dissolved in 30 g of water at 80 ° C., and then 0.15 g of reduced coenzyme Q10, 0.5 g of vitamin C, 0.1 g of paraben, and 20 g of glycerin were added. The mixture was stirred and mixed with a mixer. Finally, water was added and mixed so that the total amount became 100 g, and a cosmetic was prepared without using a collagen peptide. When the obtained cosmetic was allowed to stand, oil droplets of reduced coenzyme Q10 had separated into the upper layer.
（実施例２〜９及び比較例４〜５）
（ａ）成分であるＥＧＣｇ、（ｂ）成分であるコラーゲンペプチド、（ｃ）成分である大豆多糖類及び（ｄ）成分である還元型コエンザイムＱ１０の各含有量を表１に示す割合（％）に変更する以外は、実施例１と同様にして化粧料を作製した。
(Examples 2-9 and Comparative Examples 4-5)
(A) EGCg as component, (b) collagen peptide as component, (c) soybean polysaccharide as component, and (d) reduced coenzyme Q10 content as a ratio shown in Table 1 (%) A cosmetic was prepared in the same manner as in Example 1 except that the above was changed.
実施例１、３及び４の乳液並びに実施例５のクリームは、成分の沈殿や分離がなく、ガレート型カテキン成分、コラーゲン成分、還元型コエンザイムＱ１０の３つの機能性成分を含有する、安定性に優れた抗酸化能の高い化粧料であった。肌への使用感も市販の乳液又はクリームと同等のものであった。 The emulsions of Examples 1, 3 and 4 and the cream of Example 5 have no component precipitation or separation, and contain three functional components, a gallate catechin component, a collagen component, and a reduced coenzyme Q10. It was an excellent cosmetic product with high antioxidant ability. The feeling on the skin was also equivalent to a commercially available emulsion or cream.
実施例２、６及び７の乳液は、成分の分離又は凝集沈殿が若干みられるものの、ガレート型カテキン成分、コラーゲン成分、還元型コエンザイムＱ１０の３つの機能性成分を含有する、安定性のある抗酸化能の高い化粧料であった。肌への使用感は市販の乳液とほぼ同等であり、化粧料として問題なく使用できた。実施例８及び９のクリームは、粘度が高く、肌への使用感が市販のクリームよりもやや劣るものの、成分の分離や凝集沈殿はなく、ガレート型カテキン成分、コラーゲン成分、還元型コエンザイムＱ１０の３つの機能性成分を含有する、抗酸化能の高い化粧料として使用できた。 The emulsions of Examples 2, 6 and 7 have a stable antibacterial composition containing three functional components, a gallate catechin component, a collagen component, and a reduced coenzyme Q10, although some separation or coagulation precipitation is observed. It was a cosmetic with high oxidizing ability. The feeling on the skin was almost the same as that of commercially available emulsions and could be used as a cosmetic without problems. Although the creams of Examples 8 and 9 have a high viscosity and are slightly inferior to the commercially available cream, there is no separation of components or aggregation precipitation, and gallate-type catechin components, collagen components, and reduced coenzyme Q10. It could be used as a cosmetic with a high antioxidant capacity, containing three functional ingredients.
また、表１（特に比較例１〜３の結果）から、（ａ）成分であるガレート型カテキン、（ｂ）成分であるコラーゲン及び（ｃ）成分である大豆多糖類を全て配合しないと、（ｄ）成分である還元型コエンザイムＱ１０の分離や他成分の凝集沈殿が起こることが明らかである。このことから、ガレート型カテキンが単に機能性成分として存在しているのではなく、化粧料における各成分の乳化安定性の向上に寄与していることが判る。
比較例４及び５の乳液は、Ｂ／Ａが本発明に規定された範囲を外れることから、成分の凝集沈殿が比較的多く発生し、肌への使用感が市販の乳液よりも明確に劣っていた。
Further, from Table 1 (particularly, the results of Comparative Examples 1 to 3), if all of the gallate type catechin (a), the collagen (b) and the soybean polysaccharide (c) are not blended, It is clear that separation of reduced coenzyme Q10 as a component d) and aggregation and precipitation of other components occur. From this, it can be seen that gallate catechin does not exist merely as a functional ingredient but contributes to the improvement of the emulsion stability of each ingredient in cosmetics.
In the emulsions of Comparative Examples 4 and 5, since B / A is outside the range defined in the present invention, a relatively large amount of aggregation of the components occurs, and the feeling on the skin is clearly inferior to commercially available emulsions. It was.
（実施例１０）
ゼラチン６．０ｇと大豆多糖類０．８ｇとを８０℃の水３０ｇに溶かした。この水溶液に、ＥＣｇ１．２ｇを８０℃の水３０ｇに溶かした水溶液を加え、その後、還元型コエンザイムＱ１０を０．１ｇ、ビタミンＣを０．３g、パラベンを０．１g、香料を０．０５ｇ加え、ホモミキサーで攪拌混合し、最後に全量１００gとなるように水を加えて混合し、化粧料を作製した。得られた化粧料は、さらりとした使用感の、白色化粧水であり、成分の沈殿や分離がなく、ガレート型カテキン成分、コラーゲン成分（ゼラチン）、還元型コエンザイムＱ１０の３つの機能性成分を含有する、安定性に優れた抗酸化能の高い化粧料であった。
(Example 10)
Gelatin 6.0 g and soybean polysaccharide 0.8 g were dissolved in 30 g of 80 ° C. water. To this aqueous solution was added an aqueous solution in which 1.2 g of ECg was dissolved in 30 g of water at 80 ° C., and then 0.1 g of reduced coenzyme Q10, 0.3 g of vitamin C, 0.1 g of paraben, and 0.05 g of fragrance were added. Then, the mixture was stirred and mixed with a homomixer, and finally water was added and mixed so that the total amount became 100 g to prepare a cosmetic. The resulting cosmetic is a white lotion with a smooth feeling of use, without any precipitation or separation of ingredients, and containing three functional ingredients: a gallate catechin ingredient, a collagen ingredient (gelatin), and a reduced coenzyme Q10. It was a cosmetic with excellent anti-oxidant ability and excellent stability.
（比較例６）
ＥＣｇをガレート型カテキンではないＥＣに変える以外は実施例１０と同様にして、化粧料を作製した。得られた化粧料は、白濁した乳液状にはならず、さらに、静置すると還元型コエンザイムＱ１０の油滴が上層に分離してしまった。
(Comparative Example 6)
A cosmetic was prepared in the same manner as in Example 10 except that ECg was changed to EC which was not gallate catechin. The obtained cosmetic did not turn into a cloudy emulsion, and when it was allowed to stand, the oil droplets of reduced coenzyme Q10 separated into the upper layer.
（試験例１：粒子の形状及び平均粒子径の測定）
実施例１並びに比較例１〜３及び６で得られた各化粧料（乳化組成物）を光学顕微鏡（商品名：ＢＸ４１、オリンパス株式会社製）で観察（倍率１０００倍）したところ、実施例１の化粧料にのみ略球状の粒子が存在することが確認できた。このことから、（ａ）、（ｂ）、（ｃ）、（ｄ）の４成分によって略球状の粒子が構成されていると考えられる。
(Test Example 1: Measurement of particle shape and average particle diameter)
When each cosmetic (emulsion composition) obtained in Example 1 and Comparative Examples 1 to 3 and 6 was observed with an optical microscope (trade name: BX41, manufactured by Olympus Corporation) (magnification 1000 times), Example 1 was obtained. It was confirmed that substantially spherical particles were present only in the cosmetic. From this, it is considered that substantially spherical particles are constituted by the four components (a), (b), (c), and (d).
続いて、実施例１の化粧料に関して、レーザー回析式粒度分布測定装置（商品名：ＳＡＬＤ−２０００Ｊ、（株）島津製作所製）を用い、公知の方法によって平均粒子径を測定した。具体的な操作としては、化粧料を５０倍の水に希釈してサンプル攪拌槽に投入し、ポンプ速度調整ツマミを６の位置にして攪拌させながら粒度分布を測定した。分布基準は、体積基準（全粒子の体積の総和中で特定粒子径の粒子がどれだけの体積を占めるか）を用いた。平均粒子径は、当該装置用のソフトウェア（商品名：Ｗｉｎｇ−ＳＡＬＤ−２０００Ｊ、（株）島津製作所製）によって算出した。その結果、実施例１の化粧料中の粒子の平均粒子径は７．２μｍであった。 Subsequently, for the cosmetic material of Example 1, the average particle size was measured by a known method using a laser diffraction particle size distribution analyzer (trade name: SALD-2000J, manufactured by Shimadzu Corporation). As a specific operation, the cosmetic was diluted with 50 times water and charged into a sample stirring tank, and the particle size distribution was measured while stirring with the pump speed adjusting knob at position 6. As a distribution criterion, a volume criterion (how much volume a particle having a specific particle diameter occupies in the total volume of all particles) was used. The average particle size was calculated by software for the apparatus (trade name: Wing-SALD-2000J, manufactured by Shimadzu Corporation). As a result, the average particle size of the particles in the cosmetic material of Example 1 was 7.2 μm.
また、同様にして実施例２〜１０で得られた各化粧料を測定したところ、これらの化粧料中にも略球状粒子が確認でき、平均粒子径は全て０．０５〜５０μｍであった。 Similarly, when the cosmetics obtained in Examples 2 to 10 were measured, substantially spherical particles were confirmed in these cosmetics, and the average particle size was all 0.05 to 50 μm.
（試験例２：物理化学的安定性）
実施例１で作製した化粧料を、褐色ガラス瓶の容器に入れて密封し、そのままの状態で約３ヶ月間室温下にて保管した。保管後のガラス瓶内の化粧料の様子を観察したところ、作製直後と同様の色調や物性を有し、成分の沈殿や分離もなかった。
(Test Example 2: Physicochemical stability)
The cosmetic prepared in Example 1 was sealed in a brown glass bottle container and stored as it was at room temperature for about 3 months. When the appearance of the cosmetic in the glass bottle after storage was observed, it had the same color and physical properties as those immediately after the production, and there was no precipitation or separation of the components.
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| JP2016123348A (en) * | 2014-12-27 | 2016-07-11 | ユーハ味覚糖株式会社 | Production method of nanoparticle |
| CN117327171A (en) * | 2023-12-01 | 2024-01-02 | 江苏亨瑞生物医药科技有限公司 | Modified recombinant humanized collagen and application thereof in vaginal dressing |
| CN117327171B (en) * | 2023-12-01 | 2024-03-12 | 江苏亨瑞生物医药科技有限公司 | Modified recombinant humanized collagen and application thereof in vaginal dressing |
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