JP2012532883A5 - - Google Patents
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- Publication number
- JP2012532883A5 JP2012532883A5 JP2012519731A JP2012519731A JP2012532883A5 JP 2012532883 A5 JP2012532883 A5 JP 2012532883A5 JP 2012519731 A JP2012519731 A JP 2012519731A JP 2012519731 A JP2012519731 A JP 2012519731A JP 2012532883 A5 JP2012532883 A5 JP 2012532883A5
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- JP
- Japan
- Prior art keywords
- compound according
- compound
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- unsubstituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000005842 heteroatoms Chemical group 0.000 claims 4
- -1 n-octyl Chemical group 0.000 claims 4
- 206010002091 Anaesthesia Diseases 0.000 claims 3
- 230000037005 anaesthesia Effects 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- 210000002356 Skeleton Anatomy 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22475109P | 2009-07-10 | 2009-07-10 | |
| US61/224,751 | 2009-07-10 | ||
| PCT/US2010/041379 WO2011005969A2 (en) | 2009-07-10 | 2010-07-08 | Etomidate analogues that do not inhibit adrenocortical steroid synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532883A JP2012532883A (ja) | 2012-12-20 |
| JP2012532883A5 true JP2012532883A5 (pl) | 2013-08-22 |
| JP5925121B2 JP5925121B2 (ja) | 2016-05-25 |
Family
ID=43429834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519731A Expired - Fee Related JP5925121B2 (ja) | 2009-07-10 | 2010-07-08 | 副腎皮質ステロイド合成を阻害しないエトミデート類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8765973B2 (pl) |
| EP (1) | EP2451779B1 (pl) |
| JP (1) | JP5925121B2 (pl) |
| CN (1) | CN102548964B (pl) |
| AU (1) | AU2010271345B2 (pl) |
| BR (1) | BR112012000606A2 (pl) |
| CA (1) | CA2767112C (pl) |
| HK (1) | HK1172026A1 (pl) |
| RU (1) | RU2559888C2 (pl) |
| WO (1) | WO2011005969A2 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014017230A2 (pt) * | 2012-01-13 | 2020-11-24 | The General Hospital Corporation | compostos anestésicos e métodos de uso relacionados |
| US9637469B2 (en) * | 2012-11-14 | 2017-05-02 | Teijin Pharma Limited | Pyridine derivative |
| US20180022698A1 (en) | 2014-10-16 | 2018-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Novel methods, compounds, and compositions for anesthesia |
| IL258525B2 (en) | 2015-10-07 | 2023-03-01 | Apellis Pharmaceuticals Inc | Dosing regimens |
| JP6983416B2 (ja) * | 2015-10-10 | 2021-12-17 | ジアンス・エンファルオカン・ファーマスーティカル・リサーチ・アンド・デベロップメント・カンパニー・リミテッドJiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd. | エトミデート誘導体ならびにその中間体、調製方法および使用 |
| CN107445898A (zh) * | 2016-05-30 | 2017-12-08 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107522662A (zh) * | 2016-06-16 | 2017-12-29 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107641105A (zh) * | 2016-07-22 | 2018-01-30 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107652239B (zh) * | 2017-02-24 | 2020-08-04 | 四川大学华西医院 | N-取代咪唑羧酸酯类化合物、制备方法及用途 |
| EP3606465A4 (en) | 2017-04-07 | 2021-03-24 | Apellis Pharmaceuticals, Inc. | DOSING PLANS, ASSOCIATED COMPOSITIONS AND PROCEDURES |
| CN109776509B (zh) | 2018-01-30 | 2023-07-07 | 成都麻沸散医药科技有限公司 | 一种n-取代咪唑甲酸酯类衍生物及其用途 |
| CN110003188B (zh) * | 2019-03-27 | 2022-08-26 | 成都麻沸散医药科技有限公司 | 取代吡咯甲酸酯类衍生物及其用途 |
| CN110669017B (zh) * | 2019-10-11 | 2023-08-04 | 成都麻沸散医药科技有限公司 | 多取代***甲酸酯类衍生物及其用途 |
| CN112174890B (zh) * | 2020-10-09 | 2022-05-27 | 成都麻沸散医药科技有限公司 | 酮取代杂环化合物及其麻醉作用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354173A (en) | 1964-04-16 | 1967-11-21 | Janssen Pharmaceutica Nv | Imidazole carboxylates |
| US4038286A (en) | 1975-03-10 | 1977-07-26 | Janssen Pharmaceutica N.V. | Racemates and optical isomers of 1-(1-phenylethyl)-1h-imidazole-5-carboylic acid derivatives |
| GR64915B (en) | 1978-09-14 | 1980-06-09 | Janssen Pharmaceutica Nv | Improved etomidate-containing compositions |
| US4878940A (en) | 1987-04-02 | 1989-11-07 | Janssen Pharmaceutica N.V. | Herbicidal 1,5-substituted 1H-imidazoles |
| CA2008616C (en) * | 1989-01-31 | 2000-07-18 | Roger A. Parker | Aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions |
| US5041554A (en) * | 1989-01-31 | 1991-08-20 | Merrell Dow Pharmaceuticals Inc. | Novel aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions |
| US5019583A (en) | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5242939A (en) * | 1990-09-28 | 1993-09-07 | Warner-Lambert Company | Anilide derivatives with angiotensin ii antagonist properties |
| JP3374922B2 (ja) | 1991-05-09 | 2003-02-10 | 日産化学工業株式会社 | 複素環式第３級アミンの製造方法 |
| JPH06345728A (ja) | 1993-06-11 | 1994-12-20 | Nissan Chem Ind Ltd | Ｎ−置換アゾール誘導体の製造方法 |
| US5466700A (en) | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5756528A (en) | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| RU2160265C1 (ru) * | 2000-03-17 | 2000-12-10 | Научно-исследовательский институт физической и органической химии Ростовского государственного университета | Дигидрохлорид 1-(3-пирролидинопропил)-2-фенилимидазо [1,2-а]-бензимидазола, обладающий местноанестезирующим действием |
| AU2002254309B2 (en) | 2001-03-20 | 2006-02-02 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| SI1458386T1 (sl) * | 2001-12-27 | 2007-08-31 | Ortho Mcneil Pharm Inc | Aroil pirol heteroeril in metanoli, uporabni za zdravljenje motnje centralnega živčnega sistema |
| EP1778652A2 (en) | 2004-08-20 | 2007-05-02 | EntreMed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| EP2271627A4 (en) * | 2008-03-31 | 2012-04-11 | Gen Hospital Corp | ETOMIDATE ANALOGUE WITH IMPROVED PHARMACOKINETIC AND PHARMACODDYNAMIC PROPERTIES |
-
2010
- 2010-07-08 CA CA2767112A patent/CA2767112C/en not_active Expired - Fee Related
- 2010-07-08 AU AU2010271345A patent/AU2010271345B2/en not_active Ceased
- 2010-07-08 JP JP2012519731A patent/JP5925121B2/ja not_active Expired - Fee Related
- 2010-07-08 CN CN201080040238.7A patent/CN102548964B/zh not_active Expired - Fee Related
- 2010-07-08 EP EP10797846.2A patent/EP2451779B1/en not_active Not-in-force
- 2010-07-08 BR BR112012000606A patent/BR112012000606A2/pt not_active Application Discontinuation
- 2010-07-08 RU RU2012104761/04A patent/RU2559888C2/ru not_active IP Right Cessation
- 2010-07-08 US US13/382,544 patent/US8765973B2/en not_active Expired - Fee Related
- 2010-07-08 WO PCT/US2010/041379 patent/WO2011005969A2/en active Application Filing
-
2012
- 2012-12-13 HK HK12112892.0A patent/HK1172026A1/xx not_active IP Right Cessation
-
2014
- 2014-05-19 US US14/281,149 patent/US9187421B2/en not_active Expired - Fee Related
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