JP2012501969A - 架橋シリコーンマトリックス中に封入された固体粒子を含む組成物、およびその製造方法 - Google Patents
架橋シリコーンマトリックス中に封入された固体粒子を含む組成物、およびその製造方法 Download PDFInfo
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Abstract
【選択図】図1
Description
(a) 約0.001ミクロン〜約0.5ミクロンの範囲の平均粒径を有するコア粒子をシリコーンによりコーティングし;
(b) コーティングされた粒子を架橋剤(そこにおいて、架橋剤はシリコーンコーティングの架橋を達成することが可能なカルボン酸第一スズを含む)によりコーティングすることにより中にコア粒子を封入した架橋構造体(cross-linked structure)を形成し;
(c) 架橋構造体を、約1ミクロン〜約50ミクロンの範囲の平均粒径を有する被処理粒子に微細化する(reducing)(そこにおいて、被処理粒子のそれぞれは架橋シリコーンマトリックス中に封入された1個以上の前記コア粒子を含む)
ことを含む、被処理粒子を形成する方法に関する。
ticum)、フキタンポポ(Tussilago farfara)およびアカミノキ(Haematoxylum campechianum)の抽出物;ウーロン茶、キナノキ(Cinchona succirubra)、カバノキ(Betula verrucosa)およびカキドオシ(Glechoma hederacea)、乳およびロイヤルゼリー、蜂蜜、システインおよびその誘導体、アスコルビン酸およびその誘導体、BHA、BHT、フェルラ酸およびその誘導体、ブドウ種子抽出物、松樹皮抽出物、セイヨウワサビ抽出物、ヒドロキノン類、ロスマリン酸、ロブスタ種コーヒー種子、カフェ酸、トコフェロールおよびその誘導体、緑茶抽出物、DNAナトリウム、リボ核酸ナトリウム、没食子酸オクチル、プロピルおよびドデシル、尿酸およびチオジプロピオネート(thiodiproprionate)誘導体が挙げられるが、これらに限定されない。好ましくは、活性物質は抗酸化剤であるか、抗酸化活性を有する天然の水溶性抽出物である。より好ましくは、活性物質はブドウ種子抽出物またはフランス海岸松樹皮抽出物(ピクノジェノール(pycnogenol)とも呼ばれる)である。親水性活性物質は、本発明の被処理粒子中に、被処理粒子の約0.01〜50.0重量%、好ましくは約0.25〜30.0重量%の量で存在する。
TiO2粒子をまずGantrez S-97BFポリマーによりコーティングし、次いでKF9909シリコーン液により音波処理しながらコーティングし、次にコーティングされた粒子を主ビーカー中で追加のKF9909シリコーン液と混合し、Caframo(Ontario、カナダ)製のプロミキサー(pro mixer、Model # BDC 1850)を用いて105の数表示で混合し、均一な混合物を形成した。オクタン酸第一スズ(ArkemaよりFascat(登録商標) 2003触媒として市販されている)を室温で主ビーカーに加え、再度約1分間混合をおこなった。得られた混合物をすぐに平らな表面上に注ぎ、30分間静置することにより、架橋した平らなシートを形成した。次に、平らなシートを乳鉢と乳棒により粒子に粉砕した。得られた被処理粒子は、顕微鏡で測定して約1ミクロン〜10ミクロンの範囲の平均粒径を有した。この被処理粒子は約85.31重量%のTiO2、3.52%のGantrez S-97BF、0.41%のオクタン酸第一スズ、および約12.57重量%のKF-9909シリコーン液を含有していた。
Claims (16)
- 化粧品または医薬品として許容される担体中の被処理粒子の分散物を含む局所用組成物であって、それぞれの該被処理粒子が、架橋シリコーンマトリックス中に封入された1個以上のコア粒子を含む、前記組成物。
- 被処理粒子が約1ミクロン〜約5ミクロンの範囲の平均粒径を有し、かつコア粒子が約0.001ミクロン〜約0.5ミクロンの範囲の平均粒径を有する、請求項1に記載の組成物。
- 架橋シリコーンマトリックスが、分枝鎖反応性アルコキシ部分を有するシリコーンを架橋することにより形成される、請求項1に記載の組成物。
- 分枝鎖反応性部分がエトキシまたはエトキシシリルエチル基を含む、請求項3に記載の組成物。
- 架橋シリコーンマトリックスが、トリエトキシシリルエチルポリジメチルシロキシエチルヘキシルジメチコンを架橋することにより形成される、請求項3に記載の組成物。
- コア粒子が1種以上の金属酸化物を含む、請求項1に記載の組成物。
- コア粒子が二酸化チタン、酸化亜鉛、またはそれらの組合せを含む、請求項6に記載の組成物。
- さらに少なくとも1種の酸化的分解または劣化を受けやすい有機化合物を含む、請求項6に記載の組成物。
- 前記有機化合物が、酸化的分解または劣化を受けやすい有機サンスクリーン剤である、請求項8に記載の組成物。
- 有機サンスクリーン剤が4,4’-t-ブチルメトキシジベンゾイルメタンである、請求項9に記載の組成物。
- 前記有機化合物が、酸化的分解または劣化を受けやすい有機染料である、請求項8に記載の組成物。
- コア粒子のそれぞれが、まずグリコール、グリセリン、水溶性ガム、カルボマーゲル、ヒドロゲル、アクリレートコポリマー、メチルビニルエーテルと無水マレイン酸のコポリマー(PVM/MAコポリマー)、および第四級アミン化合物からなる群より選択されるアニオン性ポリマーの内層によりコーティングされ、次に架橋シリコーンマトリックス中に封入されている、請求項1に記載の組成物。
- コア粒子がアニオン性ポリマーおよびシリコーンの密度よりも大きい密度を有し、そこにおいて、アニオン性ポリマーがシリコーンの密度よりも大きい密度を有する、請求項12に記載の組成物。
- 架橋シリコーンマトリックス中に封入された1個以上の二酸化チタンまたは酸化亜鉛コア粒子を含む被処理粒子であって、該被処理粒子が約1ミクロン〜約50ミクロンの範囲の粒径を有する、前記被処理粒子。
- (a) 約0.001ミクロン〜約0.5ミクロンの範囲の平均粒径を有するコア粒子をシリコーンによりコーティングし;
(b) コーティングした粒子を架橋剤と接触させることにより中にコア粒子を封入した架橋構造体を形成し、そこにおいて、架橋剤はシリコーンコーティングの架橋を達成することが可能なカルボン酸第一スズを含み;
(c) 架橋構造体を、約1ミクロン〜約50ミクロンの範囲の平均粒径を有する被処理粒子に微細化し、そこにおいて、それぞれの被処理粒子は、架橋シリコーンマトリックス中に封入された1個以上の該コア粒子を含む
ことを含む、被処理粒子を形成する方法。 - シリコーンが、トリエトキシシリルエチルポリジメチルシロキシエチルヘキシルジメチコンであり、そこにおいて、カルボン酸第一スズがオクタン酸第一スズであり、かつ、そこにおいて、シリコーンコーティングの架橋を室温で連続的に混合しながら達成する、請求項15に記載の方法。
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CA2735526A1 (en) | 2010-03-11 |
CA2735526C (en) | 2012-12-11 |
JP5564046B2 (ja) | 2014-07-30 |
KR20110050553A (ko) | 2011-05-13 |
AU2009288535B2 (en) | 2013-03-07 |
US8246997B2 (en) | 2012-08-21 |
AU2009288535A1 (en) | 2010-03-11 |
EP2331052A4 (en) | 2015-03-18 |
KR101511459B1 (ko) | 2015-04-10 |
WO2010027603A2 (en) | 2010-03-11 |
KR101322000B1 (ko) | 2013-10-29 |
KR20130062378A (ko) | 2013-06-12 |
EP2331052B1 (en) | 2017-06-14 |
US8932564B2 (en) | 2015-01-13 |
US20120269893A1 (en) | 2012-10-25 |
ES2640187T3 (es) | 2017-11-02 |
US20100055139A1 (en) | 2010-03-04 |
WO2010027603A3 (en) | 2010-05-14 |
EP2331052A2 (en) | 2011-06-15 |
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