JP2011509120A - 埋め込み可能な薬物送達デバイス、及び当該デバイスを補充するための装置および方法 - Google Patents
埋め込み可能な薬物送達デバイス、及び当該デバイスを補充するための装置および方法 Download PDFInfo
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Abstract
【選択図】図4
Description
本出願は、2008年1月3日に出願された米国仮特許出願第61/018,747号の優先権を主張し、且つそれらの恩恵を求めており、係る仮特許出願は参照により全体的に本明細書に組み込まれる。
米国政府は、本発明における一括払いライセンス、及び国立科学財団により授与された交付番号ERC EFC-0310723及びEFC-0547544の条件により提供される場合に、妥当な条件で第三者にライセンスを供与するように特許権者に要求する限られた状況における権利を有する。
薬物治療は、患者の体の特定部分に治療薬(例えば、薬剤、薬など)を投与することが必要な場合が多い。しかしながら、いくつかの疾患は、現在利用可能な治療で治療されることが困難であり、及び/又はアクセスを実現することが困難な解剖学的領域に薬を投与することを必要とする。
種々の実施形態において、本発明は、患者の体内に埋め込まれた薬物送達デバイスをそのままで補充するための装置と方法を特徴とする。当該装置は概して、当該デバイスへの損傷の危険性を最小限にし、それによりその有効寿命を最大にするように補充を行うことを可能にする特徴部分を含み、当該方法は一般に、そのような補充を行うことを可能にするステップを含む。例えば、本明細書で説明される補充針の実施形態は、補充の工程中に、当該針が薬物送達デバイスを貫入する度合いを制限するために、針の深さゲージを利用する。別の例として、薬物送達デバイス自体が、針の内部への貫入の範囲を制限するための当たり止めを含むことができる。更に、薬物送達デバイスの針入口の場所を見つける際に医師を助けるために、及び針による偶発的な針刺しから患者を保護するために、本発明の実施形態は、針入口を特定する可視化リングを利用する。これらの特徴は、他の特徴と共に、薬物送達デバイスの迅速な補充を容易にすると同時に、当該デバイスへの損傷および患者への損傷の危険性を最小限にする。従って、薬物送達デバイスを補充する際に医師により費やされる時間が低減され(コスト削減をもたらすことができる)、薬物送達デバイスの有用寿命を長くすることができ、薬物送達デバイスを補充しようとする過程において損傷された薬物送達デバイスを交換する必要性が低減される。
一般に、本発明の実施形態は、例えば患者の目の中のような、患者の体内に埋め込み可能な薬物送達デバイス、及びそれらのデバイスを補充するための装置と方法に関する。特定の実施形態において、埋め込み可能な薬物送達デバイスは、小さいサイズと詰め替え可能なリザーバを兼ねる。小さいサイズは、デバイスから患者への不快感を最小限にすると同時に、詰め替え可能なリザーバにより、デバイスは、交換される代わりにそのままで詰め替えられる(補充される)ことが可能になる。そのようなものだから、単一薬剤の溶液のような流体は、長期間にわたって患者に供給され得る。
Claims (36)
- 針入口を有する埋め込み可能な薬物送達デバイスを補充するための針であって、前記針入口が、貫通する前記針を受け入れるためののど部を含むものにおいて、
先端部において末端をなす中空のシャフトと、
前記先端部に近接して前記シャフトに沿った流体出口と、
前記針入口の中への前記針の進入の範囲を制限するための手段とを含む、針。 - 前記制限の手段が、前記シャフト上の当たり止めからなる、請求項1に記載の針。
- 前記当たり止めが、前記シャフトを取り囲み、且つ前記シャフトに固定的に装着されたリングであり、前記リングが前記のど部の幅より大きい外径を有する、請求項2に記載の針。
- 前記当たり止めが、球状、円筒状、長方形、又はピラミッド形である、請求項2に記載の針。
- 前記制限の手段が生体適合性の材料から構成される、請求項1に記載の針。
- 前記制限の手段が、金属、プラスチック、又は複合材料の少なくとも1つから構成される、請求項1に記載の針。
- 前記制限の手段が、PDMS、ポリイミド、ポリプロピレン、PEEK、ポリカーボネート、アセチルフィルム、ポリオキシメチレンプラスチック、金、ステンレス鋼、ニッケル、及びクロムからなるグループから選択された材料から構成される、請求項1に記載の針。
- 前記先端部が、円錐状である、請求項1に記載の針。
- 前記流体出口が、前記先端部と前記制限の手段の中間に配置されている、請求項1に記載の針。
- 埋め込み可能な薬物送達デバイスであって、
薬リザーバと、
貫通する補充針を受け入れるためののど部を含む針入口と、
前記のど部が通じる玄関部とを含み、前記玄関部が、(i)前記のど部より幅広く、(ii)前記のど部を通り抜けて前記玄関部への針の進行を停止するための、前記のど部に向かい合った壁上に当たり止めを含み、(iii)前記薬リザーバと流体連絡している、埋め込み可能な薬物送達デバイス。 - 前記当たり止めは、出口を含む針の進行が、前記出口が前記玄関部と流体連絡する位置で停止するような大きさになっている、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記当たり止めの上面が、カップ形状である、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記当たり止めが生体適合性の材料から構成される、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記当たり止めが、金属、プラスチック、又は複合材料の少なくとも1つから構成される、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記当たり止めが、PDMS、ポリイミド、ポリプロピレン、PEEK、ポリカーボネート、アセチルフィルム、ポリオキシメチレンプラスチック、金、ステンレス鋼、ニッケル、及びクロムからなるグループから選択された材料から構成される、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記玄関部と前記薬リザーバとの間に配置されたチェックバルブを更に含む、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 前記針入口が更に、セルフシール材料からなる、請求項10に記載の埋め込み可能な薬物送達デバイス。
- 埋め込み可能な薬物送達デバイスであって、
薬リザーバと、
貫通する補充針を受け入れるためののど部を含む針入口であって、前記のど部が、前記薬リザーバと流体連絡する玄関部に通じている、針入口と、
前記針入口を取り囲む可視化リングとを含み、前記可視化リングが、前記針入口の位置を視覚的に示すように眼組織を通して見ることができる、埋め込み可能な薬物送達デバイス。 - 前記可視化リングが生体適合性の材料から構成される、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングが、前記補充針による貫入に耐える材料から構成される、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングが、患者の結膜を通して見ることができる、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングが蛍光性の色素を含む、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記蛍光性の色素が、発光性エーロゲル、ナノ粒子、フタロシアニン色素、フルオレセインイソチオシアネート、ローダミン、クマリン、シアニン、Alexa Fluor(R)、Dylight Fluor(R)、量子ドット、緑色蛍光タンパク質、及びルシフェリンからなるグループから選択される、請求項22に記載の埋め込み可能な薬物送達デバイス
- 前記可視化リングが発光ダイオードを含む、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 発光ダイオード、及び前記可視化リングへ及び前記可視化リングの周りに前記発光ダイオードからの光を伝えるための光ファイバを更に含む、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングが、表面のエコー輝度および音響陰影を強化する材料からなる、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングを動かす又は振動させるための電子回路を更に含む、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 前記可視化リングが磁性材料を含む、請求項18に記載の埋め込み可能な薬物送達デバイス。
- 患者の内部に埋め込まれた薬物送達デバイスを補充するための方法であって、
中空シャフト及びそのシャフト上の当たり止めを含む針の遠位先端部を、前記薬物送達デバイスの針入口へ挿入し、
前記当たり止めが前記入口の中への前記針の更なる進入を制限するまで、前記針を前記針入口の中へ進め、
前記針の前記中空シャフトの中を通って、前記先端部に近接して前記針の前記シャフトに沿って配置された流体出口を出て、前記薬物送達デバイスの中へ薬を供給することを含む、方法。 - 前記当たり止めが、前記針の前記シャフトを取り囲むリングであり、前記リングが前記入口の幅より大きい外径を有する、請求項29に記載の方法。
- 前記針の前記遠位先端部を前記針入口の中へ挿入する前に、前記針入口の位置を視覚的に示す可視化リングの場所を見つけることを更に含む、請求項29に記載の方法。
- 前記可視化リングが、前記の針入口を取り囲み、患者の結膜を通して見ることができる、請求項31に記載の方法。
- 患者の内部に埋め込まれた薬物送達デバイスを補充するための方法であって、
針の遠位先端部を、前記薬物送達デバイスの針入口へ挿入し、
前記針入口に向かい合った玄関部の壁に配置された当たり止めが前記針の更なる進入を止めるまで、前記薬物送達デバイスの前記玄関部の中へ前記針入口を介して前記針を進め、
前記針の中空シャフトの中を通って、前記先端部に近接して前記針の前記シャフトに沿って配置された流体出口を出て、前記玄関部の中へ薬を供給することを含む、方法。 - 前記当たり止めは、前記針の前記出口が前記玄関部と流体連絡する位置で前記針の更なる進入を停止する、請求項33に記載の方法。
- 前記針の前記遠位先端部を前記針入口の中へ挿入する前に、前記針入口の位置を視覚的に示す可視化リングの場所を見つけることを更に含む、請求項33に記載の方法。
- 前記可視化リングが、前記針入口を取り囲み、患者の結膜を通して見ることができる、請求項35に記載の方法。
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2013
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US9901687B2 (en) | 2008-01-03 | 2018-02-27 | University Of Southern California | Implantable drug-delivery devices, and apparatus and methods for refilling the devices |
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US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
JP2015533568A (ja) * | 2012-10-05 | 2015-11-26 | ユニバーシティ オブ サザン カリフォルニア | 埋込型酸素供給器および人体中の領域における酸素処理方法 |
US9919140B2 (en) | 2012-10-05 | 2018-03-20 | University Of Southern California | Implantable oxygenator with self-contained electrolyte |
JP2015182881A (ja) * | 2014-03-26 | 2015-10-22 | 宇部興産株式会社 | テンター装置 |
Also Published As
Publication number | Publication date |
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EP2266643A2 (en) | 2010-12-29 |
WO2009089094A2 (en) | 2009-07-16 |
JP2014028145A (ja) | 2014-02-13 |
EP2240220B1 (en) | 2016-04-13 |
JP5798159B2 (ja) | 2015-10-21 |
ES2577502T3 (es) | 2016-07-15 |
MX2010007382A (es) | 2010-12-20 |
US20090192493A1 (en) | 2009-07-30 |
EP2240220A2 (en) | 2010-10-20 |
US9901687B2 (en) | 2018-02-27 |
WO2009089094A3 (en) | 2009-09-03 |
EP2266643A3 (en) | 2011-03-30 |
DK2240220T3 (en) | 2016-08-01 |
EP2727616A1 (en) | 2014-05-07 |
PL2240220T3 (pl) | 2016-09-30 |
EP2727616B1 (en) | 2017-04-26 |
US20130289482A1 (en) | 2013-10-31 |
WO2009089094A8 (en) | 2009-10-22 |
EP2266643B1 (en) | 2015-06-17 |
ES2546192T3 (es) | 2015-09-21 |
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