JP2010505460A - 中空担体の表面上でセルロースを産生する微生物の培養および少なくとも35%の酸素レベルを有するガスの供給による中空セルロース管の調製プロセス - Google Patents
中空担体の表面上でセルロースを産生する微生物の培養および少なくとも35%の酸素レベルを有するガスの供給による中空セルロース管の調製プロセス Download PDFInfo
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3808—Endothelial cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
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- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
Description
チューブの発酵は、酸素透過性材料としてシリコンチューブ(直径4×0.5mm;50ショア;レボ・プロダクション(Lebo production)社、スウェーデン)を使用することによって、70mlのガラス管中にチューブを沈めて行なった。大気圧で、異なる酸素濃度(すなわち、21%(空気)、35%、50%および100%)のガス混合物を、酸素透過性材料内に供給した。複合培地(CSL)(Matsuoka他Biosci., Biotechnol., Biochem. 60 (1996) 575-579)、およびSon他(Bioresource Technology 86 (2003) 215-219)によって記述されたわずかに修飾した合成培地を、発酵培地として使用した。グルコースおよびフルクトースの消費、ならびにpHは、標準的な酵素キット(R−バイオファーム、フード・ダイアグノスティックス(Food Diagnostics)社、スウェーデン)を使用して測定した。生合成に使用した菌株は、アセトバクター・キシリナム亜種スクロフェルメンタス(sucrofermentas)BPR2001、トレードナンバー:1700178(商標)であった。株は米国培養細胞系保存機関から購入した。6つのセルロースを形成するコロニーをラフ(Rough)フラスコ内で2日間培養し、3.7・105cfu/mlの細胞濃度を産出した。生じたBCハイドロゲルから激しい振盪によって細菌を遊離し、2.5mlを各発酵管へ追加した(図1)。発酵は5日後に完了し、前培養からのBCチューブおよびハイドロゲルは0.1MNaOH中で4時間60℃煮沸することによって精製し、その後ミリポア(Millipore)(商標)の水中で煮沸を繰り返した。BCチューブを、20分間のオートクレーブ(120℃、1バール)によって蒸気滅菌し、特性評価および凍結乾燥を行うまで冷蔵庫に保存した。重量変化が記録されなくなるまで50℃のオーブンでチューブを乾燥した後に収率を記録した。
形態
走査電子顕微鏡(SEM)
チューブの内面、外面および断面の形態を検討するために、SEMを使用した。ヘト(Heto)社パワードライ(PowerDry)PL3000を使用して−52℃で24時間凍結乾燥する前に、材料を液体窒素中で凍結した。後でLEO982ジェミニ(Gemini)電界放射型SEMが行う分析の前に、乾燥した材料を金で被覆した。
破裂圧力の測定
水柱を介して圧力を加えることによって、圧力を増加した流れを確立した。すべてのチューブを、上部、中部および下部の3箇所で検査した。管を高圧(1バール/10秒)にさらした。破裂が生じたときの圧力を記録した。
テクスチャーおよび貫入抵抗。
結果
機械特性の異なる2つの評価(すなわち破裂圧力および貫入抵抗)を行った。破裂圧力の結果は、収率で見られるものと同様のパターンに従う(表2を参照)。
内皮細胞(HSVEC)を、ヒト伏在静脈の健康的な部分から単離した。静脈は、冠動脈バイパス手術からの予備部分であるか、または拡張蛇行静脈の手術を受ける患者から採取されたもののいずれかであった。HSVECは酵素技術を使用して単離した。細胞をBCチューブの腔側に播種し、空気95%/CO25%の加湿雰囲気および37℃の静的条件下で7日間培養した。細胞を3.7%ホルムアルデヒド内に固定し、核は4’,6−ジアミジノ−2−フェニルインドール二塩酸塩(DAPI)(シグマ・アルドリッチ(Sigma-Aldrich)社)で対比染色した。
Claims (17)
- 中空担体の外側表面上でのセルロースを産生する微生物の培養および中空担体の内側での酸素含有ガスの供給による中空セルロース管の調製方法であって、大気中酸素よりも高い酸素レベルを有する酸素含有ガスを特徴とする方法。
- 酸素レベルが、35%〜100%の範囲、50%〜100%の範囲、または80%〜100%の範囲である請求項1に記載の方法。
- 酸素レベルが100%である請求項2に記載の方法。
- 酸素含有ガスが大気圧よりも高い圧力で供給される請求項1〜3のいずれかに記載の方法。
- 更に、0.1・10-7(cm3・cm/cm2・s・atm)以上、より好ましくは、1・10-7(cm3・cm/cm2・s・atm)以上、および更により好ましくは、10・10-7(cm3・cm/cm2・s・atm)以上の酸素ガス透過性を備えた非多孔質材を含む中空担体上で実行される培養を特徴とする請求項1〜4のいずれかに記載の方法。
- 更に、30℃未満(20℃未満等)、より好ましくは0℃未満(−20℃未満等)、および更により好ましくは−100℃未満のガラス転移温度を備えた材料を含む中空担体上で実行される培養を特徴とする請求項1〜5のいずれかに記載の方法。
- 中空担体が培養基内での垂直に位置する請求項1〜6のいずれかに記載の方法。
- 中空担体の壁の厚さが、1mm未満、0.5mm未満、好ましくは0.2mm、または更により好ましくは0.1mm未満である請求項1〜7のいずれかに記載の方法。
- 請求項1〜8のいずれかに記載の方法によって産生される、中空セルロース管。
- 層を成したセルロースを含むことを特徴とする微生物セルロースを含む中空セルロース管。
- 管の壁に平行なセルロース層を特徴とする請求項10に記載の中空セルロース管。
- 微生物セルロースを含む中空セルロース管であって、微生物セルロースが、250N/mm2以上、または300N/mm2以上、またはより好ましくは500N/mm2以上(700N/mm2以上等)、または1000N/mm2以上の貫入抵抗を特徴とする中空セルロース管。
- 基本的に請求項8〜12のいずれかに記載の微生物セルロース管を含むチューブであって、250mmHg以上(300mmHg以上または500mmHg以上等の)、またはより好ましくは800mmHg以上の破裂圧力を特徴とする、チューブ。
- 直線状、先細りおよび/または分岐したものである請求項13に記載のチューブ。
- 実質的に請求項8〜12のいずれかに記載の微生物セルロース管を含む人工生体管。
- 実質的に請求項13〜14のいずれかに記載のチューブを含む人工血管。
- 実質的に切断して開いた請求項8〜12のいずれか記載の切開した微生物セルロース管を含む人工生体パッチ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0602110 | 2006-10-02 | ||
PCT/EP2007/060451 WO2008040729A2 (en) | 2006-10-02 | 2007-10-02 | Process for the preparation of hollow cellulose vessels by culturing cellulose- producing microorganisms on the surface of a hollow carrier and providing a gas having an oxygen level of at least 35% |
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JP2010505460A true JP2010505460A (ja) | 2010-02-25 |
JP2010505460A5 JP2010505460A5 (ja) | 2010-09-09 |
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JP2009529718A Pending JP2010505460A (ja) | 2006-10-02 | 2007-10-02 | 中空担体の表面上でセルロースを産生する微生物の培養および少なくとも35%の酸素レベルを有するガスの供給による中空セルロース管の調製プロセス |
Country Status (8)
Country | Link |
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US (1) | US20100042197A1 (ja) |
EP (2) | EP2079845B1 (ja) |
JP (1) | JP2010505460A (ja) |
CN (1) | CN101595225B (ja) |
AU (1) | AU2007304264C1 (ja) |
CA (1) | CA2665290A1 (ja) |
WO (1) | WO2008040729A2 (ja) |
ZA (2) | ZA200902973B (ja) |
Families Citing this family (21)
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BR0205047C1 (pt) * | 2002-11-21 | 2003-11-04 | Ronaldo Da Rocha Loures Bueno | Endoprótese revestida com membrana de celulose biossintética |
DE102007006844B4 (de) * | 2007-02-12 | 2014-06-12 | Bioregeneration Gmbh | Langgestreckter Hohlkörper zum Ersatz eines venösen Blutgefäßes sowie Verfahren und Hohlform zur Herstellung eines kristalline Cellulose umfassenden langgestreckten Hohlkörpers |
US7832857B2 (en) | 2008-08-18 | 2010-11-16 | Levinson Dennis J | Microbial cellulose contact lens |
DE102008056413B4 (de) * | 2008-11-07 | 2014-12-24 | Bioregeneration Gmbh | Verfahren zur Herstellung eines Cellulose enthaltenden Körpers |
WO2010065908A2 (en) * | 2008-12-05 | 2010-06-10 | Catchmark Jeffrey M | Degradable biomolecule compositions |
US20100297239A1 (en) * | 2008-12-22 | 2010-11-25 | Paul Gatenholm | Osseointegrative meniscus and cartilage implants based on beta-glucan nanocomposites |
WO2011038373A2 (en) | 2009-09-28 | 2011-03-31 | Virginia Tech Intellectual Properties, Inc. | Three-dimensional bioprinting of biosynthetic cellulose (bc) implants and scaffolds for tissue engineering |
US20110086236A1 (en) * | 2009-10-13 | 2011-04-14 | The Penn State Research Foundation | Composites containing polypeptides attached to polysaccharides and molecules |
CN101921700B (zh) * | 2010-09-02 | 2015-03-11 | 东华大学 | 一种制备中空异形细菌纤维素材料的装置及方法 |
WO2012106707A2 (en) * | 2011-02-04 | 2012-08-09 | Bc Genesis Llc | Biosynthetic functional cellulose (bc) fibers as surgical sutures and reinforcement of implants and growing tissue |
DE102011051118A1 (de) | 2011-06-16 | 2012-12-20 | Bioregeneration Gmbh | Formgebende Struktur zur Herstellung eines langgestreckten Zellulosekörpers |
DE102012201272B4 (de) | 2012-01-30 | 2019-05-09 | Kkf Ug | Vorrichtung zur Herstellung von Hohlkörpern aus mikrobiellem Polymer |
DE102012201268B4 (de) | 2012-01-30 | 2021-01-21 | Kkf Ug | Verfahren zur Herstellung von Hohlkörpern aus mikrobieller Cellulose |
WO2013113675A1 (de) | 2012-01-30 | 2013-08-08 | Kkf Ug | Verfahren zur herstellung von hohlkörpern aus mikrobieller cellulose |
CN102657561B (zh) * | 2012-04-23 | 2015-03-18 | 东华大学 | 一种复合结构人造血管的静态制备方法 |
CN102641161B (zh) * | 2012-04-23 | 2016-06-08 | 东华大学 | 一种复合结构人造血管及其动态制备方法 |
US9724213B2 (en) | 2012-11-19 | 2017-08-08 | Washington State University | Nanocrystalline cellulose materials and methods for their preparation |
US10202517B2 (en) | 2013-07-26 | 2019-02-12 | The Penn State Research Foundation | Polymer compositions and coatings |
BR112016006038B1 (pt) | 2013-09-19 | 2022-02-01 | ETH Zürich | Método para a produção auto-organizada de um elemento de celulose estruturado topograficamente superficial e elemento de celulose estruturado topograficamente superficial |
WO2017100771A1 (en) * | 2015-12-11 | 2017-06-15 | The University Of Iowa Research Foundation | Methods of producing biosynthetic bacterial cellulose membranes |
WO2021127373A1 (en) * | 2019-12-19 | 2021-06-24 | Paul Gatenholm | Biomimetic three-dimensional device for delivery of therapeutic cells and method of making device |
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2007
- 2007-10-02 US US12/444,141 patent/US20100042197A1/en not_active Abandoned
- 2007-10-02 EP EP07820833.7A patent/EP2079845B1/en not_active Not-in-force
- 2007-10-02 CN CN200780036815.3A patent/CN101595225B/zh not_active Expired - Fee Related
- 2007-10-02 CA CA002665290A patent/CA2665290A1/en not_active Abandoned
- 2007-10-02 WO PCT/EP2007/060451 patent/WO2008040729A2/en active Application Filing
- 2007-10-02 JP JP2009529718A patent/JP2010505460A/ja active Pending
- 2007-10-02 AU AU2007304264A patent/AU2007304264C1/en not_active Ceased
- 2007-10-02 EP EP11188474A patent/EP2426211A1/en not_active Withdrawn
-
2009
- 2009-04-30 ZA ZA2009/02973A patent/ZA200902973B/en unknown
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2010
- 2010-10-26 ZA ZA2010/07628A patent/ZA201007628B/en unknown
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Also Published As
Publication number | Publication date |
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AU2007304264B2 (en) | 2013-05-09 |
CN101595225A (zh) | 2009-12-02 |
EP2079845A2 (en) | 2009-07-22 |
AU2007304264C1 (en) | 2014-05-22 |
US20100042197A1 (en) | 2010-02-18 |
ZA200902973B (en) | 2011-01-26 |
EP2426211A1 (en) | 2012-03-07 |
WO2008040729A2 (en) | 2008-04-10 |
EP2079845B1 (en) | 2014-05-21 |
WO2008040729A3 (en) | 2008-05-22 |
CA2665290A1 (en) | 2008-04-10 |
CN101595225B (zh) | 2014-04-02 |
AU2007304264A1 (en) | 2008-04-10 |
ZA201007628B (en) | 2011-09-28 |
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