JP2010280403A - Laminated packaging bag - Google Patents

Laminated packaging bag Download PDF

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JP2010280403A
JP2010280403A JP2009133956A JP2009133956A JP2010280403A JP 2010280403 A JP2010280403 A JP 2010280403A JP 2009133956 A JP2009133956 A JP 2009133956A JP 2009133956 A JP2009133956 A JP 2009133956A JP 2010280403 A JP2010280403 A JP 2010280403A
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packaging bag
polyethylene
heat
laminated packaging
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JP5412963B2 (en
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Toshiyuki Maeda
俊之 真枝
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Toppan Inc
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Toppan Printing Co Ltd
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Abstract

<P>PROBLEM TO BE SOLVED: To provide an external packaging bag for storing a percutaneous absorbent capable of making a heat-sealing property of a polyethylene zipper compatible with a low adsorbing property of the content component and impregnating skin with a medicine component. <P>SOLUTION: In a laminated packaging bag for storing the percutaneous absorbent for impregnating the skin with the medicine component, at least one layer of the heat-sealed layers comprises an ethylene-vinyl alcohol copolymer (EVOH) layer, and has a zipper-shaped opening made of polyethylene. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

本発明は、食品や医薬品などの揮発成分を含む内容物を包装する為の積層包装袋に関するものであり、とりわけ貼付剤、パップ剤などを包装する、何回も出し入れ可能なポリエチレン製のチャックが取り付けられた積層包装袋に関する。   The present invention relates to a laminated packaging bag for packaging contents containing volatile components such as foods and pharmaceuticals, and in particular, there is a polyethylene chuck that can be used in and out of a package for packaging patches and poultices. It relates to the attached laminated packaging bag.

食品や医薬品の包装袋において、内容物成分中のとりわけ揮発性が高い成分が、包装袋を構成する層中の熱溶着層に吸着、又は収着される現象が従来から問題となっている。その為従来は、吸着、収着される量も見越して過剰に内容物成分を含有させ、吸着、収着後でも安定的に効果、効能を発現するように作るということが行われてきた。しかし、吸着、収着する成分がかなり高価な医薬品の場合、過剰に加える事はコストアップに繋がるなどの課題は残ったままであった。   2. Description of the Related Art Conventionally, in food and pharmaceutical packaging bags, a phenomenon in which a component having particularly high volatility in the content components is adsorbed or sorbed by a heat welding layer in a layer constituting the packaging bag has been a problem. Therefore, in the past, it has been carried out to allow the content component to be excessively contained in anticipation of the amount adsorbed and sorbed, and to stably exhibit the effect and efficacy even after the adsorption and sorption. However, in the case of a drug with a rather expensive component to be adsorbed and sorbed, problems remain such as excessive addition leads to cost increase.

そこで、近年は熱溶着層として、特許文献１に記載のポリエチレンテレフタレート樹脂（非結晶性ＰＥＴ）や、ポリアクリロニトリル樹脂（ＰＡＮ）などが用いられており、とりわけＰＡＮは吸着性という観点からは、あらゆる成分に対して大きな効果がみられ、実際に医薬品包装袋として広く用いられている。しかし、非結晶性ＰＥＴ、ＰＡＮなどは非常に高価であり、ポリエチレン系熱溶着層に比べてヒートシール強度が小さく、更には開封後に何回も開け閉めする場合に用いるポリエチレン系のチャックは熱溶着できないなどの課題点も多く残されていた。   Therefore, in recent years, polyethylene terephthalate resin (non-crystalline PET) or polyacrylonitrile resin (PAN) described in Patent Document 1 has been used as the heat-welded layer. It has a great effect on the ingredients and is actually widely used as a pharmaceutical packaging bag. However, non-crystalline PET, PAN, etc. are very expensive, and the heat-sealing strength is lower than that of polyethylene-based heat-welded layers. Furthermore, polyethylene-based chucks used for opening and closing many times after opening are heat-welded. Many issues were left unsolved.

特許文献２に示された提案によれば、ＰＡＮのコロナ処理面と直鎖状低密度ポリエチレン（ＬＬＤＰＥ）からなるチャック体のコロナ処理面どうしは熱溶着が可能であるとされているが、その強度は３０Ｎ/１５ｍｍ程度であり、内容物保存後の強度低下などは不明である為、現在実用化されていない。   According to the proposal shown in Patent Document 2, it is said that the corona-treated surface of PAN and the corona-treated surface of the chuck body made of linear low density polyethylene (LLDPE) can be thermally welded. Since the strength is about 30 N / 15 mm and the strength reduction after storage of the contents is unknown, it has not been put into practical use at present.

更には、特許文献３記載の発明によれば、包装袋の最内層部分に無機酸化物を蒸着し、当該部分にはヒートシール剤を塗工する事で熱溶着して袋の形状となすことが出来るとされているが、この方法でもポリエチレン系チャックは熱溶着できないなどの問題があった。   Furthermore, according to the invention described in Patent Document 3, an inorganic oxide is vapor-deposited on the innermost layer portion of the packaging bag, and a heat sealant is applied to the portion to form a bag shape by heat welding. However, even with this method, there was a problem that the polyethylene chuck could not be thermally welded.

更には、特許文献４記載の発明では、熱溶着層に環状オレフィンを用いる事で低吸着性、低溶出性という問題をクリアしているが、環状オレフィンでは５０μｍ未満の薄い熱溶着層の提供は難しく、且つポリオレフィン層よりも薄く環状オレフィン層を設計する事が難しいため、大きなコストアップ要因になりうるという問題が残されている。   Furthermore, in the invention described in Patent Document 4, the problem of low adsorptivity and low elution is cleared by using a cyclic olefin in the heat-welded layer, but in the case of cyclic olefin, a thin heat-welded layer having a thickness of less than 50 μm is provided. Since it is difficult and it is difficult to design a cyclic olefin layer thinner than a polyolefin layer, the problem that it may become a big cost increase factor remains.

特開平８−１４３４５３号公報JP-A-8-143453 特許第３５９４６７８号Japanese Patent No. 3594678 特許第３８１３２７８号Japanese Patent No. 3813278 特開２００５−２５４５０８号公報JP 2005-254508 A

以上のような、従来技術の問題を解決するために、ポリエチレン系チャックの熱溶着性と内容物成分の低吸着性との両立が可能な、皮膚を介して薬効成分を浸透させる経皮吸収
剤を収納する外包装袋の提供が課題となっている。 In order to solve the problems of the prior art as described above, a percutaneous absorbent capable of coexisting the heat-adhesive property of the polyethylene-based chuck and the low adsorptivity of the content component and allowing the medicinal component to penetrate through the skin Providing an outer packaging bag for storing the bag has become a problem.

本発明は上記課題を解決するために成されたものであり、請求項１の発明は、皮膚を介して薬効成分を浸透させる経皮吸収剤を収納する積層包装袋において、熱溶着層の少なくとも１つの層が、エチレン‐ビニルアルコール共重合体（ＥＶＯＨ）層を含む積層包装材からなり、且つポリエチレンからなるチャック状開封口を持っている事を特徴とする積層包装袋である。   The present invention has been made to solve the above-mentioned problems, and the invention of claim 1 is a laminated packaging bag containing a transdermal absorbent that allows a medicinal component to permeate through the skin. One layer is a laminated packaging bag made of a laminated packaging material including an ethylene-vinyl alcohol copolymer (EVOH) layer, and having a zipper opening made of polyethylene.

請求項２の発明は、熱溶着層が、ポリエチレン、接着性樹脂、ＥＶＯＨ、接着性樹脂、ポリエチレンの順に積層されており、且つ表裏対称になっている事を特徴とする請求項１記載の積層包装袋である。   The invention according to claim 2 is characterized in that the heat-welding layer is laminated in the order of polyethylene, adhesive resin, EVOH, adhesive resin, and polyethylene, and is symmetric with respect to the front and back. It is a packaging bag.

請求項３の発明は、熱溶着層のポリエチレン層よりもＥＶＯＨ層の方が薄く、且つ熱溶着層の厚さが５０μｍ未満である事を特徴とする請求項２に記載の積層包装袋である。   The invention according to claim 3 is the laminated packaging bag according to claim 2, wherein the EVOH layer is thinner than the polyethylene layer of the heat welding layer, and the thickness of the heat welding layer is less than 50 μm. .

熱溶着層の少なくとも１つの層に内容物揮発成分の吸着性の低いＥＶＯＨ層を用いる事で、内容物吸着成分の遮断が可能になった。このことによって、内容物に吸着を見込んだ過剰な成分量を付与する必要がなくなり高価な薬剤成分等を効果的に利用することが可能になった。   By using an EVOH layer having a low adsorbability of the content volatile component for at least one of the heat-welded layers, the content adsorbed component can be blocked. As a result, it is not necessary to provide an excessive amount of components that allow the contents to be adsorbed, making it possible to effectively use expensive drug components and the like.

熱溶着層を請求項２記載のように、表裏対称構造とする事で、製膜時の反り（カール）が少なく、ラミネート時に安定生産可能なフィルムを供給可能となる。   By forming the heat-welded layer in a symmetric structure as described in claim 2, it is possible to supply a film that can be stably produced at the time of lamination with less warpage (curl) during film formation.

熱溶着層にＥＶＯＨを用いる事で熱溶着層を薄くする事が可能になり、コストを最小限に抑えた包装材料を提供することが可能となる。   By using EVOH for the heat-welding layer, the heat-welding layer can be thinned, and a packaging material with a minimum cost can be provided.

本発明の積層包装袋の断面模式図Schematic cross-sectional view of the laminated packaging bag of the present invention 本発明の積層包装袋の熱溶着層（５）の一例の断面模式図Sectional schematic diagram of an example of the heat-welding layer (5) of the laminated packaging bag of the present invention 本発明の積層包装袋を用いた包装体の一例の外観図External view of an example of a package using the laminated packaging bag of the present invention

以下に本発明を実施するための形態の例について具体的に説明する。
図１は本発明の断面模式図の１例である。基材層（１）は、印刷基材となりうるフィルムであれば特に制限はなく、ポリエチレンテレフタレート（ＰＥＴ）フィルム、延伸ポリプロピレン（ＯＰＰ）フィルム、延伸ナイロン（ＯＮy）フィルムなど延伸フィルム、及びアルミナやシリカなどが透明蒸着された延伸フィルムであれば各社から上市されているものが使用可能である。フィルムの厚みに関しては特に制限はないが、ＰＥＴフィルムであれば３０μｍ以下、ＯＰＰフィルムであれば２０μｍ〜４０μｍ程度、ＯＮｙフィルムであれば１０μｍ〜３０μｍ程度が適当である。 The example of the form for implementing this invention is demonstrated concretely below.
FIG. 1 is an example of a schematic cross-sectional view of the present invention. The substrate layer (1) is not particularly limited as long as it can be a printing substrate, and is a stretched film such as a polyethylene terephthalate (PET) film, a stretched polypropylene (OPP) film, a stretched nylon (ONy) film, and alumina or silica. As long as it is a stretched film that has been vapor-deposited transparently, a film marketed by each company can be used. Although there is no restriction | limiting in particular regarding the thickness of a film, About 30 micrometers or less are appropriate for a PET film, about 20 micrometers-40 micrometers for an OPP film, and about 10 micrometers-30 micrometers for an ONy film.

接着層（２）は、ドライラミネーションに用いられる１液、あるいは２液硬化型ウレタン系接着剤ならどれも使用可能であり、乾燥時の塗布量は１ｇ／ｍ２から３ｇ／ｍ２程度であれば接着強度の観点から望ましい。更には、ポリエチレンを押し出してラミネートする押し出しラミネート法も用いる事ができ、そのときはアンカーコート剤として上記２液硬化型ウレタン系コート剤、又はポリイミン系、ブタジエン系１液型硬化剤が有用であり、乾燥時の塗布量が０．１ｇ/ｍ２から１ｇ/ｍ２程度が望ましい。 As the adhesive layer (2), any one-component or two-component curable urethane-based adhesive used for dry lamination can be used, and the coating amount when dried is about 1 g / m 2 to 3 g / m 2. From the viewpoint of adhesive strength. Furthermore, an extrusion laminating method in which polyethylene is extruded and laminated can also be used. At that time, the two-component curable urethane-based coating agent or the polyimine-based or butadiene-based one-component curing agent is useful as an anchor coating agent. The coating amount during drying is preferably about 0.1 g / m 2 to 1 g / m 2 .

押し出し樹脂層（３）は、ポリオレフィンを主成分とした上市されている押し出し用ポリオレフィン系樹脂であれば特に制限はなく、とりわけ低密度ポリエチレン（ＬＤＰＥ）が好適である。   The extruded resin layer (3) is not particularly limited as long as it is a polyolefin resin for extrusion that is marketed based on polyolefin, and low density polyethylene (LDPE) is particularly suitable.

バリア層（４）は、アルミ箔、共押し出しされたバリアナイロンフィルム、透明蒸着されたバリアフィルム、エチレン−ビニルアルコール共重合体（ＥＶＯＨ）フィルム、ポリビニルアルコール（ＰＶＡ）フィルムなどが使用可能であり、厚みに関しては特に制限はなく、汎用的な厚みが望ましい。とりわけ、遮光性を含めた観点からアルミ箔が最適である。   For the barrier layer (4), aluminum foil, coextruded barrier nylon film, transparently deposited barrier film, ethylene-vinyl alcohol copolymer (EVOH) film, polyvinyl alcohol (PVA) film, etc. can be used. There is no particular limitation on the thickness, and a general-purpose thickness is desirable. In particular, aluminum foil is optimal from the viewpoint of light shielding properties.

熱溶着層（５）は、少なくとも１つの層にエチレン‐ビニルアルコール共重合体（ＥＶＯＨ）層が含まれていれば特に制限はなく、厚みは２０μｍ〜４０μｍ程度が望ましい。   The heat welding layer (5) is not particularly limited as long as at least one layer contains an ethylene-vinyl alcohol copolymer (EVOH) layer, and the thickness is preferably about 20 to 40 μm.

図２は本発明の積層包装袋の熱溶着層（５）の一例の断面模式図であり、ポリエチレン層（６）としては、低密度ポリエチレン、中密度ポリエチレン、直鎖状低密度ポリエチレンなどが使用可能である。この場合はポリエチレン層となっているがポリプロピレンも使用可能である。   FIG. 2 is a schematic cross-sectional view of an example of the heat-welded layer (5) of the laminated packaging bag of the present invention. As the polyethylene layer (6), low density polyethylene, medium density polyethylene, linear low density polyethylene or the like is used. Is possible. In this case, it is a polyethylene layer, but polypropylene can also be used.

ＥＶＯＨ層（７）としては、上市されているフィルム化可能なＥＶＯＨであれば特に制限はなく、厚みは２μｍ〜１５μｍ程度が望ましい。
接着性樹脂層（ＴＩＥ）（８）としては、上市されている接着性樹脂であれば制限はなく、「アドマー」（三井化学（株））に代表される接着性ポリオレフィン樹脂が好適であり、厚みは５μｍ未満が最適である。 The EVOH layer (7) is not particularly limited as long as it is a commercially available EVOH that can be formed into a film, and the thickness is preferably about 2 μm to 15 μm.
The adhesive resin layer (TIE) (8) is not limited as long as it is a commercially available adhesive resin, and an adhesive polyolefin resin represented by “Admer” (Mitsui Chemicals, Inc.) is suitable. The thickness is optimally less than 5 μm.

図３は本発明の積層包装袋を用いた包装体の外観図であり、（９）は内容物である経皮吸収により薬効成分を吸収させる貼付剤、パップ剤、テープ剤などであり、（１０）はチャック部であり複数回の使用に対してリクローズ性を高めるものである。（１１）は外装袋全体である。   FIG. 3 is an external view of a package using the laminated packaging bag of the present invention, and (9) is a patch, a poultice, a tape or the like that absorbs a medicinal component by percutaneous absorption as a content, Reference numeral 10) denotes a chuck portion which improves recloseability for a plurality of uses. (11) is the entire outer bag.

以下に本発明の実施形態を具体的に示す実施例を挙げて説明する。
＜実施例１＞ The present invention will be described below with reference to examples that specifically illustrate the embodiments of the present invention.
<Example 1>

＜基材層／接着層Ａ／押し出し樹脂層／バリア層／接着層Ｂ／熱溶着層＞
基材層：ＰＥＴフィルム１２μｍ、東洋紡績（株）、Ｅ５１００
接着層Ａ：三井化学ポリウレタン（株）、Ａ−３２１０／Ａ−３０７５、ドライ塗布量１ｇ／ｍ２
押し出し樹脂層：日本ポリエチレン（株）、ＬＣ６００Ａ、１５μｍ
バリア層：アルミ箔、７μｍ、東洋アルミ（株）、１Ｎ３０
接着層Ｂ：三井化学ポリウレタン（株）、Ａ−５２５／Ａ−５２、ドライ塗布量３ｇ／ｍ２
熱溶着層：タマポリ（株）、開発製品４０μｍ、［ＬＬＤＰＥ１４．５μｍ／ＴＩＥ３μｍ／ＥＶＯＨ５μｍ／ＴＩＥ３μｍ／ＬＬＤＰＥ１４．５μｍ］（ＴＩＥ：接着性樹脂層の略）
＜比較例１＞ <Base Material Layer / Adhesive Layer A / Extruded Resin Layer / Barrier Layer / Adhesive Layer B / Heat Welding Layer>
Base material layer: PET film 12 μm, Toyobo Co., Ltd., E5100
Adhesive layer A: Mitsui Chemicals Polyurethanes, A-3210 / A-3075, dry coating amount 1 g / m 2
Extruded resin layer: Nippon Polyethylene Corporation, LC600A, 15 μm
Barrier layer: Aluminum foil, 7 μm, Toyo Aluminum Co., Ltd., 1N30
Adhesive layer B: Mitsui Chemicals Polyurethanes, A-525 / A-52, dry coating amount 3 g / m 2
Thermal weld layer: Tamapoli Co., Ltd., developed product 40 μm, [LLDPE 14.5 μm / TIE 3 μm / EVOH 5 μm / TIE 3 μm / LLDPE 14.5 μm] (TIE: Abbreviation of adhesive resin layer)
<Comparative Example 1>

＜基材層／接着層Ａ／押し出し樹脂層／バリア層／接着層Ｂ／熱溶着層＞
基材層：ＰＥＴフィルム１２μｍ、東洋紡績（株）、Ｅ５１００
接着層Ａ：東洋インキ製造（株）、ＡＤ５０２／ＣＡＴ−１０、ドライ塗布量１ｇ／ｍ２押し出し樹脂層：日本ポリエチレン（株）、ＬＣ６００Ａ、１５μｍ
バリア層：軟質アルミ箔、７μｍ、東洋アルミ（株）、１Ｎ３０
接着層Ｂ：東洋インキ製造（株）、ＡＤ５０２／ＣＡＴ−１０、ドライ塗布量１ｇ／ｍ２熱溶着層：日本ポリエチレン（株）、ＬＣ６００Ａ、２５μｍ
＜比較例２＞ <Base Material Layer / Adhesive Layer A / Extruded Resin Layer / Barrier Layer / Adhesive Layer B / Heat Welding Layer>
Base material layer: PET film 12 μm, Toyobo Co., Ltd., E5100
Adhesive layer A: Toyo Ink Manufacturing Co., Ltd., AD502 / CAT-10, dry coating amount 1 g / m 2 Extruded resin layer: Nippon Polyethylene Co., Ltd., LC600A, 15 μm
Barrier layer: Soft aluminum foil, 7 μm, Toyo Aluminum Co., Ltd., 1N30
Adhesive layer B: Toyo Ink Manufacturing Co., Ltd., AD502 / CAT-10, dry coating amount 1 g / m 2 heat welding layer: Nippon Polyethylene Co., Ltd., LC600A, 25 μm
<Comparative example 2>

＜基材層／接着層Ａ／押し出し樹脂層／バリア層／接着層Ｂ／熱溶着層＞
基材層：ＰＥＴフィルム１２μｍ、東洋紡績（株）、Ｅ５１００
接着層Ａ：三井化学ポリウレタン（株）、Ａ−３２１０／Ａ−３０７５、ドライ塗布量１ｇ／ｍ２
押し出し樹脂層：日本ポリエチレン（株）、ＬＣ６００Ａ、１５μｍ
バリア層：アルミ箔、７μｍ、東洋アルミ（株）、１Ｎ３０
接着層Ｂ：三井化学ポリウレタン（株）、Ａ−５２５／Ａ−５２、ドライ塗布量３ｇ／ｍ２
熱溶着層：タマポリ（株）、開発製品６０μｍ、［ＬＬＤＰＥ２４．５μｍ／ＴＩＥ３μｍ／ＥＶＯＨ５μｍ／ＴＩＥ３μｍ／ＬＬＤＰＥ２４．５μｍ］
＜比較例３＞ <Base Material Layer / Adhesive Layer A / Extruded Resin Layer / Barrier Layer / Adhesive Layer B / Heat Welding Layer>
Base material layer: PET film 12 μm, Toyobo Co., Ltd., E5100
Adhesive layer A: Mitsui Chemicals Polyurethanes, A-3210 / A-3075, dry coating amount 1 g / m 2
Extruded resin layer: Nippon Polyethylene Corporation, LC600A, 15 μm
Barrier layer: Aluminum foil, 7 μm, Toyo Aluminum Co., Ltd., 1N30
Adhesive layer B: Mitsui Chemicals Polyurethanes, A-525 / A-52, dry coating amount 3 g / m 2
Thermal weld layer: Tamapoli Co., Ltd., developed product 60 μm, [LLDPE 24.5 μm / TIE 3 μm / EVOH 5 μm / TIE 3 μm / LLDPE 24.5 μm]
<Comparative Example 3>

＜基材層／接着層Ａ／押し出し樹脂層／バリア層／接着層Ｂ／熱溶着層＞
基材層：ＰＥＴフィルム１２μｍ、東洋紡績（株）、Ｅ５１００
接着層Ａ：三井化学ポリウレタン（株）、Ａ−３２１０／Ａ−３０７５、ドライ塗布量１ｇ／ｍ２
押し出し樹脂層：日本ポリエチレン（株）、ＬＣ６００Ａ、１５μｍ
バリア層：アルミ箔、７μｍ、東洋アルミ（株）、１Ｎ３０
接着層Ｂ：三井化学ポリウレタン（株）、Ａ−５２５／Ａ−５２、ドライ塗布量３ｇ／ｍ２
熱溶着層：タマポリ（株）、開発製品４０μｍ、［ＥＶＯＨ１２μｍ／ＴＩＥ３μｍ／ＬＬＤＰＥ２５μｍ］
＜実験１＞ <Base Material Layer / Adhesive Layer A / Extruded Resin Layer / Barrier Layer / Adhesive Layer B / Heat Welding Layer>
Base material layer: PET film 12 μm, Toyobo Co., Ltd., E5100
Adhesive layer A: Mitsui Chemicals Polyurethanes, A-3210 / A-3075, dry coating amount 1 g / m 2
Extruded resin layer: Nippon Polyethylene Corporation, LC600A, 15 μm
Barrier layer: Aluminum foil, 7 μm, Toyo Aluminum Co., Ltd., 1N30
Adhesive layer B: Mitsui Chemicals Polyurethanes, A-525 / A-52, dry coating amount 3 g / m 2
Thermal welding layer: Tamapoli Co., Ltd., developed product 40 μm, [EVOH 12 μm / TIE 3 μm / LLDPE 25 μm]
<Experiment 1>

吸着量：
上記実施例において、１３０ｍｍ×１５５ｍｍの３方製袋を作成し、三笠製薬（株）より販売されているゼポラステープ４０ｍｇ（１００ｍｍ×１４０ｍｍ）を５枚充填し、ヒートシールにより密封包装する。当該充填品を４０℃、７５％ＲＨ環境下に３ヶ月保存し、フルルビプロフェンの包材への吸着量をエタノール抽出後、ガスクロマトグラフにて検量し、当該成分の初期値からの吸着量を測定した。
＜実験２＞ Adsorption amount:
In the above embodiment, a 130 mm × 155 mm three-sided bag is made, filled with 5 sheets of 40 mg (100 mm × 140 mm) of Zeporus tape sold by Mikasa Pharmaceutical Co., Ltd., and hermetically packaged by heat sealing. The packed product is stored in an environment of 40 ° C. and 75% RH for 3 months, and the amount of flurbiprofen adsorbed on the packaging material is extracted with ethanol and calibrated with a gas chromatograph. Was measured.
<Experiment 2>

加工性：
上記実施例をラミネート時にカールによる加工安定性を目視により判断した。
実験１，２の結果を表１に示す。

Figure 2010280403
Processability:
The processing stability due to curling was judged by visual observation during lamination.
The results of Experiments 1 and 2 are shown in Table 1.
Figure 2010280403

実験１の結果から実施例１のフルルビプロフェンの包材への吸着量は比較例に比べて明らかに少なく本発明の積層包装袋を使用することで、内容物に吸着を見込んだ過剰な成分量を付与する必要がなくなり高価な薬剤成分等を効果的に利用することが可能となることが判明した。   From the results of Experiment 1, the amount of flurbiprofen adsorbed on the packaging material of Example 1 is clearly less than that of the comparative example, and by using the laminated packaging bag of the present invention, an excessive amount expected to be adsorbed on the contents. It has been found that it is no longer necessary to provide component amounts, and that expensive drug components and the like can be used effectively.

さらに、実験１の結果からは、日本薬局方において４０℃、７５％ＲＨ環境下、６ヶ月保存時に薬効成分の吸着量が１０％以下であることという基準があるため、比較例１、２、３は当該規格を外れていることも分かった。   Furthermore, from the results of Experiment 1, there is a standard in the Japanese Pharmacopoeia that the amount of adsorbed medicinal ingredients is 10% or less when stored for 6 months under an environment of 40 ° C. and 75% RH. It was also found that 3 was out of the standard.

実験２の結果からは実施例１の加工性はラミネート時のカールも少なく問題のないことも明らかである。   From the results of Experiment 2, it is also clear that the workability of Example 1 is not a problem because there is little curling during lamination.

本発明は、経皮吸収剤などの外包装袋に利用可能である。   The present invention can be used for outer packaging bags such as transdermal absorbents.

１…基材層
２…接着層
３…押し出し樹脂層
４…バリア層
５…熱溶着層
６…ポリエチレン層
７…ＥＶＯＨ層
８…接着性樹脂層（ＴＩＥ）
９…内容物（貼付剤）
１０…チャック部
１１…外装袋 DESCRIPTION OF SYMBOLS 1 ... Base material layer 2 ... Adhesive layer 3 ... Extrusion resin layer 4 ... Barrier layer 5 ... Thermal welding layer 6 ... Polyethylene layer 7 ... EVOH layer 8 ... Adhesive resin layer (TIE)
9 ... Contents (Patch)
10 ... Chuck part 11 ... Exterior bag

Claims (3)

皮膚を介して薬効成分を浸透させる経皮吸収剤を収納する積層包装袋において、熱溶着層の少なくとも１つの層が、エチレン‐ビニルアルコール共重合体（ＥＶＯＨ）層を含む積層包装材からなり、且つポリエチレンからなるチャック状開封口を持っている事を特徴とする積層包装袋。   In a laminated packaging bag containing a transdermal absorbent that penetrates medicinal ingredients through the skin, at least one of the heat-welded layers is made of a laminated packaging material containing an ethylene-vinyl alcohol copolymer (EVOH) layer, A laminated packaging bag having a zipper opening made of polyethylene. 熱溶着層が、ポリエチレン、接着性樹脂、ＥＶＯＨ、接着性樹脂、ポリエチレンの順に積層されており、且つ表裏対称になっている事を特徴とする請求項１記載の積層包装袋。   The laminated packaging bag according to claim 1, wherein the heat-welding layer is laminated in the order of polyethylene, adhesive resin, EVOH, adhesive resin, and polyethylene, and is symmetric with respect to the front and back. 熱溶着層のポリエチレン層よりもＥＶＯＨ層の方が薄く、且つ熱溶着層の厚さが５０μｍ未満である事を特徴とする請求項２に記載の積層包装袋。   The laminated packaging bag according to claim 2, wherein the EVOH layer is thinner than the polyethylene layer of the heat welding layer, and the thickness of the heat welding layer is less than 50 µm.
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JP2013028061A (en) * 2011-07-28 2013-02-07 Toppan Printing Co Ltd Packaging laminate
JP2013028360A (en) * 2011-07-28 2013-02-07 Toppan Printing Co Ltd Packaging bag for medical product
WO2020044741A1 (en) * 2018-08-30 2020-03-05 株式会社吉野工業所 Tube container
JP2020104865A (en) * 2018-12-26 2020-07-09 岡田紙業株式会社 Packaging bag, percutaneous absorption agent contained in packaging bag, and manufacturing method of packaging bag

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013028061A (en) * 2011-07-28 2013-02-07 Toppan Printing Co Ltd Packaging laminate
JP2013028360A (en) * 2011-07-28 2013-02-07 Toppan Printing Co Ltd Packaging bag for medical product
WO2020044741A1 (en) * 2018-08-30 2020-03-05 株式会社吉野工業所 Tube container
JP2020033060A (en) * 2018-08-30 2020-03-05 株式会社吉野工業所 Tube container
US11542066B2 (en) 2018-08-30 2023-01-03 Yoshino Kogyosho Co., Ltd. Tube container
JP2020104865A (en) * 2018-12-26 2020-07-09 岡田紙業株式会社 Packaging bag, percutaneous absorption agent contained in packaging bag, and manufacturing method of packaging bag

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