JP2010024184A - Swelling-ameliorating composition and method for ameliorating swelling by utilizing the same - Google Patents
Swelling-ameliorating composition and method for ameliorating swelling by utilizing the same Download PDFInfo
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Description
本発明は、むくみの改善、治療に有用なむくみ改善組成物に関し、更に詳細には、浴湯に投入する浴用剤の形態で利用され、これを投入した浴湯に入浴することによりむくみを改善、治療できるむくみ改善組成物およびこれを利用したむくみ改善方法に関する。 The present invention relates to a swelling improving composition useful for improvement and treatment of swelling, and more particularly, it is used in the form of a bath agent to be poured into bath water, and the swelling is improved by bathing in the bath water into which this is poured. The present invention relates to a swelling improving composition that can be treated and a swelling improving method using the same.
ヒトは、生活環境の中で、夕方になると下肢にむくみが生じたり、立位あるいはデスクワークなどの姿勢を長く続けると下肢にむくみが生じて、だるさ、はり、つかれ、いたみを生じることが知られている。このむくみは、血液などに含まれる水分が本来なら静脈を通って心臓や他の各器官に戻るはずなのに、うまく循環できずに細胞や血管の隙間にたまってしまった状態とされている。 In the living environment, humans are known to experience swelling in the lower limbs in the evening, and swelling in the lower limbs when standing or standing for long periods of time, causing sluggishness, agitation, tension, and itching. ing. This swelling is a state where water contained in blood or the like should normally pass through veins and return to the heart and other organs but cannot circulate well and accumulate in the gaps between cells and blood vessels.
下肢のむくみは、長時間の立位あるいはデスクワーク等の座位により日常的に生じるものである。このむくみの原因は、重力により血液が心臓に戻りにくくなり下肢が鬱血状態となり、毛細血管の静水圧が上昇することによって毛細血管から水分が組織間へ漏出し、かつ毛細血管への再吸収、リンパ管へスムーズに回収されなくなることであると考えられる。このむくみを解消する方法として、マッサージ、ストレッチ、下肢を高く上げる、屈伸運動する、入浴する等が一般的に知られている。しかし、このような一般的なむくみの解消法は、時間的又は経済的に負担が大きく、また日常的に行なうことは難しく、または満足な結果が得られないなどの欠点があった。特に、入浴することによるむくみ解消効果は知られているが、長い時間の入浴が必要で、生体への負担が大きく、より簡便で有効な方法が望まれていた。 Swelling of the lower limbs is caused daily by standing for a long time or sitting such as desk work. The cause of this swelling is that blood is difficult to return to the heart due to gravity, the lower limbs become congested, and the hydrostatic pressure of the capillaries increases, causing water to leak from the capillaries to the tissues, and reabsorption into the capillaries, It is thought that it is not collected smoothly into lymphatic vessels. As methods for relieving this swelling, generally known are massage, stretching, raising the lower limb, bending and stretching, bathing, and the like. However, such a general method for eliminating swelling is time-consuming or economically burdensome, is difficult to perform on a daily basis, or has a drawback that satisfactory results cannot be obtained. In particular, the effect of eliminating swelling due to bathing is known, but a long time bathing is necessary, and the burden on the living body is large, and a simpler and more effective method has been desired.
ところで、炭酸ガスを６０ｐｐｍ以上含有する浴湯に入浴することにむくみ改善効果があることが知られている（特許文献１）。しかし、この方法では、浴湯中の炭酸ガスが高濃度でなければ効果が得られないが、通常の浴湯の温度では、炭酸ガスの濃度を高く維持するのが困難であり、また、その効果も短く、実用的なものとは言えなかった。 By the way, it is known that bathing in bath water containing 60 ppm or more of carbon dioxide gas has a swelling improvement effect (Patent Document 1). However, with this method, the effect cannot be obtained unless the carbon dioxide gas in the bath water is at a high concentration. However, it is difficult to maintain the carbon dioxide gas concentration at a normal bath water temperature. The effect was short and could not be said to be practical.
従って、本発明の課題は、より実用的で、長時間にわたり優れたむくみ改善効果を示すむくみ改善剤を提供することである。 Accordingly, an object of the present invention is to provide a swelling improving agent that is more practical and exhibits an excellent swelling improving effect over a long period of time.
そこで本発明者らは、炭酸ガスを含有する浴湯中での炭酸ガスのむくみ改善効果について鋭意検討を行っていたところ、入浴の場面において、毛細血管を拡張させる炭酸ガスに無機塩類を併用することにより、より優れたむくみ改善効果が得られること、さらに製剤投入後、時間が経過してから入浴しても、むくみ改善効果が持続的に得られることを見出し、本発明を完成した。 Therefore, the present inventors have been diligently examining the effect of improving the swelling of carbon dioxide in a bath containing carbon dioxide, and in the scene of bathing, inorganic salts are used in combination with carbon dioxide that expands capillaries. As a result, it was found that a superior swelling improvement effect can be obtained, and that the swelling improvement effect can be continuously obtained even after taking a bath after the preparation has been added, and the present invention has been completed.
すなわち本発明は、浴湯中に溶解した際に、浴湯中の炭酸ガス濃度を３０〜５５ｐｐｍとすることのできる量の炭酸ガス発生剤と、無機塩類とを含有してなるむくみ改善組成物である。 That is, the present invention provides a swelling improving composition comprising a carbon dioxide gas generator in an amount capable of setting the carbon dioxide concentration in the bath water to 30 to 55 ppm when dissolved in the bath water, and an inorganic salt. It is.
また本発明は、浴湯に上記むくみ改善組成物を投入してむくみ改善用浴湯を調製し、次いで当該浴湯に入浴することを特徴とするむくみ改善方法である。 In addition, the present invention is a swelling improvement method characterized in that the swelling improvement composition is added to a bath water to prepare a swelling bath water, and then bathed in the bath water.
本発明のむくみ改善剤を用いれば、足の位置を高く保持する等の特別な操作なく、通常の足浴、半身浴、全身浴により、短時間にかつ容易にむくみの改善、治療を行うことができる。また、本発明のむくみ改善組成物は、製剤を投入後長時間にわたって、むくみ改善用浴湯のむくみ改善効果を維持することが可能である。 If the swelling agent of the present invention is used, swelling can be easily improved and treated in a short time by a normal foot bath, half body bath, and whole body bath without any special operation such as keeping the foot position high. it can. Moreover, the swelling improving composition of the present invention can maintain the swelling improving effect of the swelling improving bath water for a long time after the preparation is charged.
本発明のむくみ改善組成物において用いられる、炭酸ガス発生剤は、このものを浴湯中に投入した際に、浴湯中の炭酸ガス濃度を３０〜５５ｐｐｍの範囲にすることができるものである。このような炭酸ガス発生剤としては、酸と炭酸塩を組み合わせた炭酸ガス発生組成物や、炭酸ガスを含有するゼオライト、封入糖のようなものを挙げることができるが、酸と炭酸塩とを組み合わせたものが好ましい。 The carbon dioxide generator used in the swelling improvement composition of the present invention is one that can bring the concentration of carbon dioxide in the bath water to a range of 30 to 55 ppm when it is put into the bath water. . Examples of such carbon dioxide generating agents include carbon dioxide generating compositions in which acids and carbonates are combined, zeolites containing carbon dioxide, encapsulated sugars, and the like. Combinations are preferred.
上記炭酸ガス発生組成物における酸としては、有機酸および無機酸の何れでも使用できるが、水溶性で固体のものが好ましく、例えば、コハク酸、フマル酸、リンゴ酸、アジピン酸、酒石酸、安息香酸、クエン酸、ピロリドンカルボン酸、サリチル酸などの有機酸等が好ましい。この中でも、反応性に優れているリンゴ酸、フマル酸が特に好ましい。無機酸としては、ホウ酸、メタケイ酸、無水ケイ酸等が挙げられる。 As the acid in the carbon dioxide generating composition, either an organic acid or an inorganic acid can be used, but a water-soluble and solid acid is preferable. For example, succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, benzoic acid Organic acids such as citric acid, pyrrolidone carboxylic acid and salicylic acid are preferred. Among these, malic acid and fumaric acid which are excellent in reactivity are particularly preferable. Examples of the inorganic acid include boric acid, metasilicic acid, and silicic anhydride.
また、炭酸塩としては、特に限定されないが、好ましいものとして、炭酸ナトリウム、セスキ炭酸ナトリウム、炭酸カリウム、炭酸水素ナトリウム、炭酸マグネシウム、炭酸アンモニウム等が挙げられる。その中でも、炭酸ナトリウム、炭酸水素ナトリウムが特に好ましい。 Moreover, although it does not specifically limit as carbonate, Sodium carbonate, sesquisodium carbonate, potassium carbonate, sodium hydrogencarbonate, magnesium carbonate, ammonium carbonate etc. are mentioned as a preferable thing. Among these, sodium carbonate and sodium hydrogen carbonate are particularly preferable.
上記酸の配合量としては、むくみ改善組成物中２０〜６０質量％が好ましく、特に、３０〜５０質量％であることが好ましい。また、炭酸塩の配合量は、むくみ改善組成物中２０〜６０質量％が好ましく、特に、３０〜５０質量％が好ましい。この範囲を外れると、充分な量の炭酸ガスが発生しない場合がある。 As a compounding quantity of the said acid, 20-60 mass% is preferable in a swelling improvement composition, and it is especially preferable that it is 30-50 mass%. Moreover, 20-60 mass% is preferable in a swelling improvement composition, and, as for the compounding quantity of carbonate, 30-50 mass% is especially preferable. Outside this range, a sufficient amount of carbon dioxide gas may not be generated.
本発明のむくみ改善組成物は、上記の炭酸ガス発生剤に加えて、更に無機塩類を配合する。配合される無機塩類としては、特に限定されないが、硫酸塩類、塩化物類が好ましい。硫酸塩類としては、硫酸マグネシウム、硫酸ナトリウム、チオ硫酸ナトリウム、硫酸アルミニウムカリウム、硫酸鉄等が挙げられ、塩化物類としては、塩化ナトリウム、塩化カリウム、塩化マグネシウム等が挙げられる。その中でも硫酸マグネシウム、硫酸ナトリウム、塩化ナトリウム、塩化カリウムが特に好ましい。 The swelling improvement composition of this invention mix | blends inorganic salt further in addition to said carbon dioxide generator. Although it does not specifically limit as inorganic salt mix | blended, Sulfate and chloride are preferable. Examples of sulfates include magnesium sulfate, sodium sulfate, sodium thiosulfate, potassium aluminum sulfate, and iron sulfate. Examples of chlorides include sodium chloride, potassium chloride, and magnesium chloride. Among these, magnesium sulfate, sodium sulfate, sodium chloride, and potassium chloride are particularly preferable.
この無機塩類の配合量は、浴湯中の濃度が７．５ｐｐｍ以上、好ましくは１０〜６０ｐｐｍとなる範囲が好ましい。この無機塩類の濃度が７．５ｐｐｍ未満であると、満足なむくみ改善効果が得られず、６０ｐｐｍを超えて配合するとむくみ改善効果は得られるが、製剤安定性が低下する場合がある。本発明のむくみ改善組成物中での含有量としては、むくみ改善組成物が３０ｇ／２００Ｌ濃度使用で５〜４０、１００ｇ／２００Ｌ濃度使用で１．５〜１２質量％程度である。 The blending amount of the inorganic salts is preferably in a range where the concentration in the bath water is 7.5 ppm or more, preferably 10 to 60 ppm. If the concentration of this inorganic salt is less than 7.5 ppm, a satisfactory swelling improvement effect cannot be obtained, and if it exceeds 60 ppm, a swelling improvement effect can be obtained, but formulation stability may be reduced. As content in the swelling improvement composition of this invention, a swelling improvement composition is about 5 to 40 mass concentration by 30g / 200L density | concentration use, and about 1.5-12 mass% by 100g / 200L density | concentration use.
なお、硫酸マグネシウム等の無機塩類を含有し、炭酸ガスを発生する入浴剤は既に知られているが（特許文献２）、このような入浴剤にむくみ改善効果があることは全く知られておらず、その作用もこの文献等から容易に類推できるものでない。 In addition, bathing agents that contain inorganic salts such as magnesium sulfate and generate carbon dioxide are already known (Patent Document 2), but it is completely unknown that such bathing agents have an effect of improving swelling. Also, its action cannot be easily inferred from this document.
本発明のむくみ改善組成物において、より高いむくみ改善効果を得るためには、上記必須成分に加え、更に血流促進成分を少なくとも１種配合することが好ましい。配合される血流促進成分は、特に限定されないが、好ましいものとして、リモネン、ピネン、シトラール、オイゲノール、テレビン油、メチルサリシレート、Ｌ‐メントール、カンフェン等が挙げられる。その中でも、リモネン、ピネン、Ｌ‐メントールが特に好ましい。 In the swelling improving composition of the present invention, in order to obtain a higher swelling effect, it is preferable to blend at least one blood flow promoting component in addition to the essential components. The blood flow promoting component to be blended is not particularly limited, but preferred examples include limonene, pinene, citral, eugenol, turpentine oil, methyl salicylate, L-menthol, camphene and the like. Among these, limonene, pinene, and L-menthol are particularly preferable.
この血流促進成分の配合量は、むくみ改善組成物全体の０．０１〜５％、好ましくは０．１〜２％となる範囲が好ましい。血流促進成分の配合量が０．０１未満であると、充分な血流促進効果が得られず、５％を超えて配合すると製剤安定性、香りの風味を損なう場合がある。 The blending amount of this blood flow promoting component is preferably in the range of 0.01 to 5%, preferably 0.1 to 2% of the whole swelling improving composition. If the blending amount of the blood flow promoting component is less than 0.01, a sufficient blood flow promoting effect cannot be obtained, and if it exceeds 5%, the formulation stability and the flavor of the scent may be impaired.
本発明のむくみ改善組成物には、上記各成分の他に、必要に応じて任意成分として、植物成分、無水ケイ酸等の安定剤、結合剤、滑沢剤、香料、着色剤、油性成分、白濁剤、アスパラギン酸ナトリウム等のアミノ酸、保湿剤、溶解剤等を適宜添加することができる。 In the swelling improving composition of the present invention, in addition to the above-mentioned components, as optional components, stabilizers such as plant components, silicic anhydride, binders, lubricants, fragrances, colorants, oily components An amino acid such as a cloudiness agent and sodium aspartate, a moisturizing agent, a solubilizing agent, and the like can be appropriately added.
本発明のむくみ改善組成物は、固形浴用剤として利用することが好ましく、その使用は、全身入浴スタイルのみでなく、足浴、半身浴など使用者により様々とすることができる。なお、本発明のむくみ改善組成物は、固形浴用剤のうちでも、錠剤よりブリケット、フレーク状が好ましく、中でもブリケットは適量使用ができ利便性が高く、成形する際の圧力が比較的低いため、成形性の向上の面から特に好ましい。 The swelling improvement composition of the present invention is preferably used as a solid bath preparation, and its use can be varied depending on the user, such as a foot bath and a half bath, as well as a whole body bathing style. In addition, the swelling improvement composition of the present invention is preferably a briquette or flaky form than a tablet among solid bath preparations, among which briquettes can be used in an appropriate amount and are highly convenient, and the pressure during molding is relatively low. This is particularly preferable from the viewpoint of improving moldability.
以下、ブリケットの形状を例に取り、本発明のむくみ改善組成物の製造方法について説明する。 Hereinafter, the manufacturing method of the swelling improvement composition of this invention is demonstrated taking the shape of a briquette as an example.
まず、リンゴ酸とフマル酸を混合した有機酸、炭酸塩、無機塩および目的に応じた任意成分を充分に混合し、混合物を得る。次いで、この混合物を、ブリケッティングマシンに通し、ピロー状で、３ｍｍ〜６ｍｍのブリケットを製造する。 First, an organic acid obtained by mixing malic acid and fumaric acid, a carbonate, an inorganic salt, and optional components according to the purpose are sufficiently mixed to obtain a mixture. The mixture is then passed through a briquetting machine to produce 3-6 mm briquettes in the form of pillows.
なお、ブリケッティングマシンとは、同速で互いに反対方向に回転する２本のロール間で原料粉体を圧縮し成型する乾式圧縮造粒機の一つであり、このロールの表面には、ブリケットの母型であるポケットが刻まれている。そのポケットの形状や大きさを変更することによって、種々の形状や大きさのブリケットを得ることが可能となる。通常、ブリケット製造においては、ロール間のクリアランスの大きさやロール同士の押さえ圧、フィードスクリューの押圧力などを調整することによりシート状一次成形体が得られる。ブリケットは、更にこの複数のブリケット粒子が連結部を介してシート状に成形されたシート状一次成形体を解砕することにより、得ることができるのである。 The briquetting machine is a dry compression granulator that compresses and molds raw material powder between two rolls rotating in the opposite directions at the same speed. The pocket, which is the base of the briquette, is engraved. By changing the shape and size of the pocket, briquettes of various shapes and sizes can be obtained. Usually, in briquette production, a sheet-like primary molded body is obtained by adjusting the clearance between rolls, the pressing pressure between rolls, the pressing force of a feed screw, and the like. The briquette can be obtained by further crushing a sheet-like primary molded body in which the plurality of briquette particles are formed into a sheet shape via the connecting portion.
得られた浴用剤の一回当たりの使用量は、家庭用浴槽（１５０〜２００Ｌ）に投入した場合、湯中の炭酸ガス濃度は３０ｐｐｍ以上、好ましくは３０〜５５ｐｐｍとなる範囲とすることが好ましい。濃度が３０ｐｐｍ未満であると、満足なむくみ改善効果が得られず、５５ｐｐｍを超えて配合するとむくみ改善効果は得られるが、製剤安定性の低下、入浴中むせるなど不快になる場合がある。 When the amount of the obtained bath agent used per one time is charged into a domestic bathtub (150 to 200 L), the concentration of carbon dioxide in the hot water is preferably 30 ppm or more, preferably 30 to 55 ppm. . If the concentration is less than 30 ppm, a satisfactory swelling improvement effect cannot be obtained, and if it exceeds 55 ppm, a swelling improvement effect can be obtained, but it may be uncomfortable, for example, a decrease in formulation stability or peeling during bathing.
本発明のむくみ改善組成物を用いて高いむくみ改善効果を得る方法としては、この組成物を浴湯中に投入して３５〜４２℃のむくみ改善用浴湯を調製し、ついで、全身入浴、半身入浴または足湯として入浴する方法が挙げられる。この入浴は、好ましくは３７〜４１℃、更に好ましくは、３９〜４０℃のむくみ改善用浴湯を利用することが望ましい。また、入浴する時間は、１分以上であり、好ましくは１０分程度である。 As a method for obtaining a high swell improvement effect using the swell improvement composition of the present invention, this composition is introduced into a bath to prepare a swell improvement bath at 35 to 42 ° C. The method of taking a bath as a half body bathing or footbath is mentioned. In this bathing, it is desirable to use a swelling water bath of preferably 37 to 41 ° C., more preferably 39 to 40 ° C. The bathing time is 1 minute or more, preferably about 10 minutes.
なお、本発明のむくみ改善組成物の、むくみ改善効果が持続する時間は、炭酸ガスのみを利用するものに比べ、充分に長い。すなわち、後記実施例でも示すように、炭酸ガスのみを利用するものでは、投与後３０分はむくみ改善効果が維持されるが、２時間経過後では全く効果を失ってしまう。これに対し、無機塩類を配合した本発明では、投与後２時間経過しても優れたむくみ改善効果が認められ、３時間経過後でもある程度の効果が認められている。 In addition, the time for which the swelling improvement effect of the swelling improvement composition of the present invention lasts is sufficiently longer than that using only carbon dioxide gas. That is, as shown also in the examples described later, when only carbon dioxide is used, the swelling improvement effect is maintained for 30 minutes after administration, but the effect is completely lost after 2 hours. On the other hand, in this invention which mix | blended inorganic salt, the outstanding swelling improvement effect was recognized even if 2 hours passed after administration, and a certain amount of effect was recognized even after 3 hours passed.
以下、実施例および試験例に基づき本発明を更に具体的に説明するが、本発明はこれら実施例等により何ら制約されるものではない。 Hereinafter, the present invention will be described more specifically based on examples and test examples, but the present invention is not limited to these examples and the like.
実 施 例 １〜５ および 比 較 例 １〜４
表１に実施例１〜５および比較例１〜４として示される処方により、ブリケット状のむくみ防止用組成物を調製した。ブリケットは、各処方５ｋｇを万能攪拌混合機にて均一になるまで混合した後、ブリケットマシーンを用い、３〜６ｍｍのブリケットとして得た。なお、表１中には、家庭用浴槽（２００Ｌ）の浴湯（３９℃）に対する投与量と、投与後の浴湯中の炭酸ガス濃度も併せて示した。
Examples 1 to 5 and Comparative Examples 1 to 4
Briquette swelling prevention compositions were prepared according to the formulations shown in Table 1 as Examples 1 to 5 and Comparative Examples 1 to 4. Briquettes were obtained as 3 to 6 mm briquettes using a briquette machine after mixing 5 kg of each formulation until uniform with a universal stirring mixer. In addition, in Table 1, the dose with respect to the bath water (39 degreeC) of a domestic bathtub (200L) and the carbon dioxide gas concentration in the bath water after administration were also shown collectively.
試 験 例 １
実施例１〜５および比較例１〜４で得られた各ブリケットについて、以下に示す評価試験法により、足脹脛部のむくみ改善状態を評価した。
Test example 1
About each briquette obtained in Examples 1-5 and Comparative Examples 1-4, the swelling improvement state of the foot shin part was evaluated by the evaluation test method shown below.
足脹脛部のむくみ改善状態の評価は、足にむくみを感じる健常者６名を、被験者としておこなった。まず、被験者を人工気候室（２５℃５０％ＲＨ）に入室してもらい、馴化させた。次いで、椅子に着座し、足むくみ誘発のため、着座５分以内に水道水（５００ｍｌ）を経口摂取してもらった。経口摂取後、２時間着座位を維持し、足むくみの誘発を確認した。その後、各被検組成物（ブリケット）を、表１に示す量投入した３９℃の浴湯で１０分間の全身入浴を行い、入浴後の足むくみ度合いの改善度を評価した。対照として、さら湯の入浴を同一被験者で別の日に行った。足のむくみ度合いの改善度については、被験者の主観により、下記３段階で評価した。 The evaluation of the swelling improvement state of the foot shin part was performed on 6 healthy subjects who felt swelling on the foot as subjects. First, subjects were admitted to an artificial climate chamber (25 ° C., 50% RH). Next, he sat down on a chair and ingested tap water (500 ml) within 5 minutes of sitting to induce swelling of his legs. After ingestion, the sitting position was maintained for 2 hours, and induction of swelling of the feet was confirmed. Thereafter, each test composition (briquette) was bathed in the whole body for 10 minutes in 39 ° C. bath water charged in the amount shown in Table 1, and the degree of improvement in the degree of swelling of the foot after bathing was evaluated. As a control, the same subject was bathed in Saratou on another day. About the improvement degree of the swelling of a leg, it evaluated in the following three steps by subject's subjectivity.
評価基準
◎ ： 脹脛周囲径によるむくみ度合いが改善し、有効である。
○ ： 脹脛周囲径によるむくみ度合いが少し改善し、やや有効である。
× ： 脹脛周囲径によるむくみ度合いが改善せず、有効でない。
Evaluation Criteria ◎: The degree of swelling due to the circumference of the calf is improved and effective.
○: The degree of swelling due to the circumference of the calf is slightly improved and is somewhat effective.
×: The swelling due to the circumference of the calf does not improve and is not effective.
表２から明らかなように、むくみ改善には実施例１〜５および比較例４の組成物が有効であった。しかし、比較例４の組成物には、入浴中むせるなどのデメリットがあった。なお、血流促進成分を配合しない実施例１と比べると、血流促進成分を配合する実施例２から５は効果感がさらによいものであった。 As apparent from Table 2, the compositions of Examples 1 to 5 and Comparative Example 4 were effective in improving swelling. However, the composition of Comparative Example 4 has a demerit such as letting it go in the bath. In addition, compared with Example 1 which does not mix | blend a blood-flow promotion component, Examples 2 to 5 which mix | blend a blood-flow promotion component had a better effect.
試 験 例 ２
実施例１〜５および比較例１〜４で得られた各ブリケットについて、以下に示す方法により、むくみの抑制効果の持続性を評価した。
Test example 2
About each briquette obtained in Examples 1-5 and Comparative Examples 1-4, the sustainability of the swelling suppression effect was evaluated by the method shown below.
すなわち、試験例１と同様、足にむくみを感じる健常者５名を被験者とした。この被験者を、人工気候室（２５℃５０％ＲＨ）に入室してもらい、馴化させた。次いで、椅子に着座し、足むくみ誘発のため、着座５分以内に水道水（５００ｍｌ）を経口摂取してもらった。経口摂取後、２時間着座位を維持し、足むくみの誘発を確認した。その後、各ブリケットを表１に示す量で投入した３９℃の浴湯に１０分間、全身入浴してもらい、入浴後の足むくみの改善感を、被験者の主観により下の３段階で評価してもらった。評価は、製剤投入後、３０分後、２時間後、３時間経過後の浴湯について行った。この結果を表３に示す。 That is, as in Test Example 1, five healthy subjects who felt swelling on the feet were used as subjects. This test subject was allowed to enter a climate room (25 ° C., 50% RH) and acclimatized. Next, he sat down on a chair and ingested tap water (500 ml) within 5 minutes of sitting to induce swelling of his legs. After ingestion, the sitting position was maintained for 2 hours, and induction of swelling of the feet was confirmed. After that, each of the briquettes was bathed in 39 ° C. bath water in the amount shown in Table 1 for 10 minutes, and the feeling of improvement in foot swelling after bathing was evaluated in the following three stages according to the subjectivity of the subject. received. Evaluation was performed on the hot water 30 minutes later, 2 hours later, and 3 hours later after the formulation was introduced. The results are shown in Table 3.
評価基準
◎ ： 足むくみ改善感が有効であった。
○ ： 足むくみ改善感がやや有効であった。
× ： 足むくみ改善感が有効でなかった。
Evaluation Criteria A: A feeling of improvement in foot swelling was effective.
○: A feeling of improvement in foot swelling was slightly effective.
X: The feeling of improvement in foot swelling was not effective.
表3の結果から明らかなように、実施例１〜５のブリケット（むくみ改善組成物）は、浴剤投入後３時間経過した浴湯を用いた場合にもむくみ改善感が有効に維持されたが、比較例１〜３のブリケットでは３０分経過後は効果がみられず、比較例４は、２時間経過以降はむくみ改善感が得られなかった。 As is clear from the results in Table 3, the briquettes (swelling improving compositions) of Examples 1 to 5 effectively maintained the feeling of swelling even when using 3 hours after bathing. However, in the briquettes of Comparative Examples 1 to 3, no effect was observed after 30 minutes, and in Comparative Example 4, no swelling improvement was obtained after 2 hours.
以上より、浴湯中の炭酸ガス濃度を３０〜５５ｐｐｍとすることができ、かつ無機塩類を含有する組成物は、足むくみ改善作用が長時間維持できることが確認された。 From the above, it was confirmed that the carbon dioxide gas concentration in the bath water can be adjusted to 30 to 55 ppm, and the composition containing inorganic salts can maintain the foot swelling improving action for a long time.
本発明の、むくみ改善組成物を利用して調製するむくみ改善用浴湯は、足むくみ等のむくみを有効に改善するものであり、同時に、足の痛みがとれる、足が軽くなる、こり感がへる、つかれにくい、寝つきがよくなる等の自覚症状の改善が感じられるものである。また、その効果も長時間維持できる。 The bath water for swelling improvement prepared using the swelling improvement composition of the present invention effectively improves swelling of the swelling of the feet, etc., and at the same time, the pain of the feet can be taken, the feet become light, the feeling of stiffness Improvements in subjective symptoms such as being hungry, hard to get rid of, and better sleeping. Moreover, the effect can also be maintained for a long time.
従って、本発明組成物は、通常の足浴、半身浴、全身浴を利用したむくみ改善に極めて有効なものである。
Therefore, the composition of the present invention is extremely effective for improving swelling using a normal foot bath, half body bath, and whole body bath.
Claims (7)
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