JP2009520470A - 新規の乳酸桿菌株及びその使用 - Google Patents
新規の乳酸桿菌株及びその使用 Download PDFInfo
- Publication number
- JP2009520470A JP2009520470A JP2008546085A JP2008546085A JP2009520470A JP 2009520470 A JP2009520470 A JP 2009520470A JP 2008546085 A JP2008546085 A JP 2008546085A JP 2008546085 A JP2008546085 A JP 2008546085A JP 2009520470 A JP2009520470 A JP 2009520470A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dsm
- cells
- pharmaceutical
- helicobacter pylori
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
【選択図】なし
Description
乳酸桿菌株の保存は凍結状態で行った。MRS培地(55g/l、pH6.5、Difco、USA)で静止期(OD600/ml 4〜8)まで培養した培養物1mlを500μlの50容量%の滅菌グリセリン溶液と混合し、混合物を−80℃まで急速冷凍した。
乳酸桿菌の培養を37℃のMRS培地で24〜48時間に亘って閉じたファルコン管内で行った。
生体内の条件をシミュレーションするために、実施例2の実験を繰り返したが、乳酸桿菌細胞の再懸濁は人工胃液(5g/lのNaCl及び3g/lのペプシン(Sigma))で行った。pHはHClを用いて2に調節した。この培養は37℃で30分に亘って行った。ヘリコバクター・ピロリ菌は細胞直近領域のpH値をpH4にまで上昇可能なため、実施例2に記載のように、細胞を採取し次にpH4の酢酸塩緩衝液に再懸濁させた。緩衝液の調節のために、41mlの0.1モル/lの酢酸と0.2モル/lの酢酸ナトリウム溶液の溶液をpH4まで調節した。次に水を用いて最終容量の100mlまで満たした。
実施例1に沿って細菌を取り出した。乳酸桿菌培養物の分割量1mlを3200gで10分に亘っての遠心分離により採取した。上清を除去し、ペレットを真空下で2時間に亘って凍結乾燥させた。こうやって得られた本発明の各乳酸桿菌株のペレットをpH7.0の1mlのPBS緩衝液に再懸濁させた。再懸濁させた乳酸桿菌細胞を体積比1:1で新たに取り出したヘリコバクター・ピロリ菌培養物と混合し、凝集の有無を実施例2及び3同様に判断した。乳酸桿菌細胞によるヘリコバクター・ピロリ菌の凝集誘発能は、上記実施例による調査で示されるように、凍結乾燥の影響を受けなかった(但し、写真資料は作成しなかった)。
本発明の乳酸桿菌株の分類学上の種の決定を、その炭化水素発酵パターンを用いて行った。これはAPI50CHシステム(BioMerieux、France)を用いて決定され、分析はAPILAB PLUSソフトウェア(同供給業者によるバージョン3.3.3)で行った。種の決定は供給業者の指示に沿って行った。
本発明の乳酸桿菌株又は幾つかの乳酸桿菌株の細胞を実施例4のようにして取り出し、凍結乾燥させる。その後、ペレットを直径最大約1mmの粒径まで粉砕する。得られた粒状物を以下の比率(重量%)で担体又は補助物質と混合する。
20重量%粒状物
2重量%二酸化ケイ素(Syloid AL−1FP、GRACE Davidson)
1重量%ステアリン酸マグネシウム(MF−2−V、Ackros)
77重量%微結晶性セルロース(Avicel PH112、FMC)
本発明の乳酸桿菌株又は幾つかの乳酸桿菌株の細胞を実施例4のように取り出し、凍結乾燥させる。約107〜108個の乳酸桿菌細胞を含有する凍結乾燥物をそれぞれ約1Lの市販の低温殺菌牛乳と混合し、5℃で短時間均質化する。均質化した牛乳を次に瓶に詰め、慣用の方法で包装する。
Claims (14)
- ヒトの消化管、特には胃の培養条件下でヘリコバクター・ピロリ菌を凝集することが可能な単離された乳酸桿菌細胞。
- DSM17646、DSM17647、DSM17648、DSM17649、DSM17650、DSM17651、DSM17652又はDSM17653として寄託された請求項1に記載の単離された乳酸桿菌細胞。
- 請求項1又は2に記載の生理学的有効量の乳酸桿菌細胞と、生理学的に耐容性である担体を含む医薬品組成物及び/又は食餌療法用組成物。
- 医薬品又は食餌療法用組成物を製造するための請求項1又は2に記載の乳酸桿菌細胞の使用。
- ヘリコバクター・ピロリ菌への感染によって生じる疾患、特には胃潰瘍等の胃腸病の予防及び/又は治療用の医薬品又は食餌療法用組成物を製造するための請求項1又は2に記載の乳酸桿菌細胞の使用。
- 組成物が102〜1015、好ましくは106又は108〜1012、特には108〜1010個の乳酸桿菌細胞を含有する請求項3〜5の1つに記載の医薬品組成物又は使用。
- 組成物が経口投与用に調製される請求項3〜6の1つに記載の医薬品組成物又は使用。
- 乳酸桿菌細胞が凍結乾燥される請求項3〜7の1つに記載の医薬品組成物又は使用。
- 担体がマルトデキストリン、微結晶性セルロース、澱粉、特にはコーンスターチ、レブロース、乳糖、ブドウ糖、及びこういった物質の混合物を含む群から選択される請求項3〜8の1つに記載の医薬品組成物又は使用。
- 組成物が0.1〜95重量%の担体と、5〜99.9重量%の凍結乾燥させた乳酸桿菌細胞を含有する請求項3〜9の1つに記載の医薬品組成物又は使用。
- 組成物が102〜1015、好ましくは106〜109、特には107〜109個の乳酸桿菌細胞を含有する請求項3〜5の1つに記載の食餌療法用組成物又は使用。
- 生理学的に耐容性の担体が食品材料であり、特には乳製品、発酵乳製品、牛乳、ヨーグルト、チーズ、シリアル、ミューズリーバー、及び幼児用加工食品を含む群から選択される請求項3〜5又は11の1つに記載の食餌療法用組成物又は使用。
- 生理学的有効量の凍結乾燥させた又は凍結乾燥させていない乳酸桿菌細胞を生理学的に耐容性の担体と混合し、経口投与用に調製する請求項3〜12に記載の医薬品及び/又は食餌療法用組成物の製造方法。
- 生理学的有効量の請求項3〜12に記載の医薬品及び/又は食餌療法用組成物を患者に1日1〜5回投与する、ヘリコバクター・ピロリ菌への感染によって引き起こされる疾患の予防及び/又はこういった病気に罹患した又は発病すると疑われる患者の治療方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005062731A DE102005062731A1 (de) | 2005-12-22 | 2005-12-22 | Neue Lactobacillus Stämme und deren Verwendung |
DE102005062731.5 | 2005-12-22 | ||
PCT/DE2006/001842 WO2007073709A1 (de) | 2005-12-22 | 2006-10-12 | Neue lactobacillus stämme und deren verwendung gegen helicobacter pylori |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009520470A true JP2009520470A (ja) | 2009-05-28 |
JP5392672B2 JP5392672B2 (ja) | 2014-01-22 |
Family
ID=37770351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008546085A Active JP5392672B2 (ja) | 2005-12-22 | 2006-10-12 | 新規の乳酸桿菌株及びその使用 |
Country Status (10)
Country | Link |
---|---|
US (2) | US20120020942A1 (ja) |
EP (1) | EP1963483B1 (ja) |
JP (1) | JP5392672B2 (ja) |
KR (1) | KR101349452B1 (ja) |
CN (1) | CN101384700B (ja) |
CA (1) | CA2639961C (ja) |
DE (1) | DE102005062731A1 (ja) |
ES (1) | ES2425390T3 (ja) |
PL (1) | PL1963483T3 (ja) |
WO (1) | WO2007073709A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014518897A (ja) * | 2011-06-08 | 2014-08-07 | オルガノバランス ゲーエムベーハー | 噴霧乾燥ラクトバチルス株/細胞およびヘリコバクターピロリに対するその使用 |
JP2014531430A (ja) * | 2011-09-09 | 2014-11-27 | ジョヴァンニ・モーニャGiovanni MOGNA | 胃酸過多の薬物処置中に失われる胃自体の障壁効果を修復することができるプロバイオティック細菌と組み合わされたn−アセチルシステインおよび/またはマイクロカプセル化胃保護型リゾチームを含む組成物 |
US9925224B2 (en) | 2011-05-09 | 2018-03-27 | Probiotical S.P.A. | Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia |
US10286017B2 (en) | 2011-05-09 | 2019-05-14 | Probiotical S.P.A. | Probiotic bacterial strains and symbiotic composition containing the same intended for infant food |
US10384847B2 (en) | 2011-09-23 | 2019-08-20 | Probiotical North America Inc. | Material impermeable to humidity and oxygen for packaging dietary products, cosmetics and medicinal specialities |
US10982184B2 (en) | 2011-05-09 | 2021-04-20 | Probiotical S.P.A. | Bacterial strains capable of metabolizing oxalates |
US11110136B2 (en) | 2013-05-14 | 2021-09-07 | Probiotical S.P.A. | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of recurrent cystitis |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2163239A1 (de) * | 2008-05-27 | 2010-03-17 | Qiagen GmbH | Produkte, die Biopartikel enthalten, Verfahren zu ihrer Herstellung |
TWI392498B (zh) * | 2010-07-19 | 2013-04-11 | Synbio Tech Inc | 戊糖乳桿菌lps16及其在抑制幽門螺旋桿菌之用途 |
GB2484126A (en) * | 2010-09-30 | 2012-04-04 | Univ Plymouth | Foodstuff fermented with lactic acid producing bacteria |
CN102174450B (zh) * | 2011-03-11 | 2012-10-03 | 江南大学 | 一种抗幽门螺杆菌感染的植物乳杆菌及其用途 |
JP6267633B2 (ja) | 2011-05-06 | 2018-01-24 | オルガノバランス メディカル アーゲー | 新規な乳酸菌及びそれを含有する組成物 |
CA2833937C (en) | 2011-05-16 | 2022-04-05 | Organobalance Medical Ag | Lactobacillus strains, compositions containing them and use of the strains to prevent or treat conditions caused by streptococcus pyogenes |
EP2532354A1 (de) | 2011-06-08 | 2012-12-12 | OrganoBalance GmbH | Sprühgetrocknete Lactobacillus Stämme / Zellen und deren Verwendung gegen Helicobacter Pylori |
US10213187B1 (en) | 2012-01-25 | 2019-02-26 | Mubin I. Syed | Method and apparatus for percutaneous superficial temporal artery access for carotid artery stenting |
WO2014081947A1 (en) | 2012-11-21 | 2014-05-30 | Syed Mubin I | System for the intravascular placement of a medical device |
MX370537B (es) * | 2013-02-07 | 2019-12-17 | Novozymes As | Uso de leche descremada como portador de lactobacillus en la elaboración de una composición para la agregación de helycobacter pylori. |
US10058576B2 (en) * | 2013-10-03 | 2018-08-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods comprising a defined microbiome and methods of use thereof |
US9636244B2 (en) | 2015-04-09 | 2017-05-02 | Mubin I. Syed | Apparatus and method for proximal to distal stent deployment |
US9980838B2 (en) | 2015-10-30 | 2018-05-29 | Ram Medical Innovations Llc | Apparatus and method for a bifurcated catheter for use in hostile aortic arches |
US10327929B2 (en) | 2015-10-30 | 2019-06-25 | Ram Medical Innovations, Llc | Apparatus and method for stabilization of procedural catheter in tortuous vessels |
US10492936B2 (en) | 2015-10-30 | 2019-12-03 | Ram Medical Innovations, Llc | Apparatus and method for improved access of procedural catheter in tortuous vessels |
US11020256B2 (en) | 2015-10-30 | 2021-06-01 | Ram Medical Innovations, Inc. | Bifurcated “Y” anchor support for coronary interventions |
US10779976B2 (en) | 2015-10-30 | 2020-09-22 | Ram Medical Innovations, Llc | Apparatus and method for stabilization of procedural catheter in tortuous vessels |
US10086024B2 (en) | 2015-11-30 | 2018-10-02 | Joseph E. Kovarik | Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides |
US10933128B2 (en) | 2015-11-30 | 2021-03-02 | Joseph E. Kovarik | Method and system for protecting honey bees from pesticides |
US10675347B2 (en) | 2015-11-30 | 2020-06-09 | Joseph E. Kovarik | Method and system for protecting honey bees from fipronil pesticides |
US11529412B2 (en) | 2015-11-30 | 2022-12-20 | Seed Health, Inc. | Method and system for protecting honey bees from pesticides |
US10568916B2 (en) | 2015-11-30 | 2020-02-25 | Joseph E. Kovarik | Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides |
US10053693B2 (en) | 2016-01-19 | 2018-08-21 | Mubin I. Syed | Method for controlling obesity using minimally invasive means |
US10173031B2 (en) | 2016-06-20 | 2019-01-08 | Mubin I. Syed | Interchangeable flush/selective catheter |
US20190257832A1 (en) * | 2016-07-18 | 2019-08-22 | Philippe Ulsemer | Natural microorganisms which are naturally capable of binding toxins and/or toxin receptors |
US10857014B2 (en) | 2018-02-18 | 2020-12-08 | Ram Medical Innovations, Llc | Modified fixed flat wire bifurcated catheter and its application in lower extremity interventions |
CN108403725B (zh) * | 2018-05-22 | 2021-02-09 | 浙江海正药业股份有限公司 | 用于治疗消化道溃疡的组合物及其应用 |
BR112021007811A8 (pt) * | 2018-10-24 | 2022-08-30 | Novozymes As | Suplemento probiótico para a saúde metabólica compreendendo lactobacillus |
DE102019007892A1 (de) | 2019-11-14 | 2021-05-20 | Belano Medical Ag | Neue Formulierung von Lactobacillus-Stämmen zur Therapie und Prophylaxe der Besiedlung mit Helicobacter pylori in den oberen Atemwegen und Verdauungssystem |
CN111991429B (zh) * | 2020-08-19 | 2022-08-26 | 湖南天根乐微君科技有限公司 | 罗伊氏乳杆菌在制备抗口腔细菌感染的制品中的应用 |
GB202204335D0 (en) | 2022-03-28 | 2022-05-11 | Hel1X Ltd | Non-antibiotic antimicrobial compositions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002045727A1 (en) * | 2000-12-08 | 2002-06-13 | Plbio Co., Ltd. | Lactic acid bacteria inhibiting adhesion of helicobacter pylori to gastric mucosa |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5716615A (en) * | 1992-02-10 | 1998-02-10 | Renata Maria Anna Cavaliere Vesely | Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use |
US8697051B2 (en) | 1999-06-09 | 2014-04-15 | Vsl Pharmaceuticals Inc. | Composition comprising alkaline sphingomyelinase for use as a dietetic preparation, food supplement or pharmaceutical product |
JP3046303B1 (ja) * | 1999-06-24 | 2000-05-29 | 明治乳業株式会社 | Helicobacterpylori除菌性飲食品 |
AU7675601A (en) | 2000-12-08 | 2002-06-18 | Pl Bio Co Ltd | Lactic acid bacteria with inhibiting activities on (helicobacter pylori) |
KR100424790B1 (ko) * | 2000-12-08 | 2004-03-30 | (주) 피엘바이오 | 헬리코박터 필로리의 활성을 억제하는 유산균 |
KR100449597B1 (ko) * | 2000-12-08 | 2004-09-18 | (주) 피엘바이오 | 헬리코박터 필로리의 활성을 억제하는 유산균 |
KR100419132B1 (ko) * | 2000-12-29 | 2004-02-18 | 조성근 | 위·장 점막 부착성과 증식성, 내산성, 내담즙성 및헬리코박터 파일로리, 대장균 0157:h7에 대한 항균성이우수한 락토바실러스 파라카제이 서브스패시즈 파라카제이csk 01 |
EE04580B1 (et) * | 2001-06-29 | 2006-02-15 | Tartu �likool | Mikroorganismi tüvi Lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum |
EP1432426A2 (en) * | 2001-09-05 | 2004-06-30 | ACTIAL Farmaceutica Lda. | USE OF UNMETHYLATED CpG |
EP1344458A1 (en) * | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
US7105336B2 (en) | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
MXPA05010696A (es) * | 2003-04-02 | 2006-04-18 | Axcan Pharma S A | Cepa de lactobacillus fermentum y usos de la misma. |
WO2005060937A1 (en) | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
-
2005
- 2005-12-22 DE DE102005062731A patent/DE102005062731A1/de not_active Ceased
-
2006
- 2006-10-12 EP EP06805445.1A patent/EP1963483B1/de active Active
- 2006-10-12 KR KR1020087017949A patent/KR101349452B1/ko active IP Right Grant
- 2006-10-12 PL PL06805445T patent/PL1963483T3/pl unknown
- 2006-10-12 JP JP2008546085A patent/JP5392672B2/ja active Active
- 2006-10-12 ES ES06805445T patent/ES2425390T3/es active Active
- 2006-10-12 CA CA2639961A patent/CA2639961C/en active Active
- 2006-10-12 US US12/158,592 patent/US20120020942A1/en not_active Abandoned
- 2006-10-12 CN CN2006800532967A patent/CN101384700B/zh active Active
- 2006-10-12 WO PCT/DE2006/001842 patent/WO2007073709A1/de active Application Filing
- 2006-12-22 US US11/645,363 patent/US7846711B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002045727A1 (en) * | 2000-12-08 | 2002-06-13 | Plbio Co., Ltd. | Lactic acid bacteria inhibiting adhesion of helicobacter pylori to gastric mucosa |
Non-Patent Citations (3)
Title |
---|
JPN6012004602; Gut,1997,41(1),p.49-55 * |
JPN6012004603; Trends Microbiol.,2003,11(2),p.94-100 * |
JPN6012004606; Am.J.Gastroenterol.,1998,93(11),p.2097-101 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9925224B2 (en) | 2011-05-09 | 2018-03-27 | Probiotical S.P.A. | Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia |
US10286017B2 (en) | 2011-05-09 | 2019-05-14 | Probiotical S.P.A. | Probiotic bacterial strains and symbiotic composition containing the same intended for infant food |
US10982184B2 (en) | 2011-05-09 | 2021-04-20 | Probiotical S.P.A. | Bacterial strains capable of metabolizing oxalates |
JP2014518897A (ja) * | 2011-06-08 | 2014-08-07 | オルガノバランス ゲーエムベーハー | 噴霧乾燥ラクトバチルス株/細胞およびヘリコバクターピロリに対するその使用 |
JP2014531430A (ja) * | 2011-09-09 | 2014-11-27 | ジョヴァンニ・モーニャGiovanni MOGNA | 胃酸過多の薬物処置中に失われる胃自体の障壁効果を修復することができるプロバイオティック細菌と組み合わされたn−アセチルシステインおよび/またはマイクロカプセル化胃保護型リゾチームを含む組成物 |
US10028982B2 (en) | 2011-09-09 | 2018-07-24 | Probiotical North America Inc. | Composition comprising N-acetylcysteine and/or microencapsulated gastroprotected lysozyme in association with probiotic bacteria capable of restoring the stomach's own barrier effect which is lost during the pharmacological treatment of gastric hyperacidity |
US10384847B2 (en) | 2011-09-23 | 2019-08-20 | Probiotical North America Inc. | Material impermeable to humidity and oxygen for packaging dietary products, cosmetics and medicinal specialities |
US11110136B2 (en) | 2013-05-14 | 2021-09-07 | Probiotical S.P.A. | Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of recurrent cystitis |
Also Published As
Publication number | Publication date |
---|---|
KR20080081186A (ko) | 2008-09-08 |
CN101384700B (zh) | 2012-12-05 |
US7846711B2 (en) | 2010-12-07 |
EP1963483B1 (de) | 2013-05-22 |
JP5392672B2 (ja) | 2014-01-22 |
KR101349452B1 (ko) | 2014-01-08 |
CA2639961C (en) | 2015-10-06 |
ES2425390T3 (es) | 2013-10-15 |
EP1963483A1 (de) | 2008-09-03 |
PL1963483T3 (pl) | 2013-10-31 |
WO2007073709A1 (de) | 2007-07-05 |
DE102005062731A1 (de) | 2007-06-28 |
CN101384700A (zh) | 2009-03-11 |
CA2639961A1 (en) | 2007-07-05 |
US20120020942A1 (en) | 2012-01-26 |
US20070148149A1 (en) | 2007-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5392672B2 (ja) | 新規の乳酸桿菌株及びその使用 | |
RU2571211C2 (ru) | Бактериальные композиции для профилактики и лечения дегенеративного заболевания | |
JP6062931B2 (ja) | 噴霧乾燥ラクトバチルス株/細胞およびヘリコバクターピロリに対するその使用 | |
KR101618391B1 (ko) | 높은 옥살산 분해능을 갖는 유산균 | |
JP2018111711A (ja) | リボフラビン、リン酸リボフラビン又は生理学上許容されるその塩 | |
DK2478910T3 (en) | ANTI-ADIPOSITY AGENT, ANTI-ADIPOSITA NUTRITION OR DRINK, GLUCOSE TOLERANCE EFFECTIVE AGENT, AND NUTRITION OR DRINK FOR IMPROVING GLUCOSE TOLERANCE | |
JP6018625B2 (ja) | 高コレステロール血症の処置に使用するためのビフィドバクテリウム属に属する菌株 | |
BR112012011315A2 (pt) | cepa de bifidobactéria probiótica | |
CN111372477B (zh) | 在含有gos的培养基中预调理的益生菌及其用途 | |
JP2018532380A (ja) | 腸内細菌の酪酸桿菌(Butyribacter intestini)およびその使用 | |
JP2013538827A (ja) | 腎機能を増強させるための組成物および方法 | |
AU2011212513B2 (en) | Improvement of immunomodulatory properties of Lactobacillus strains | |
CN114468046A (zh) | 一种具有解酒保肝护胃功效的组合物 | |
US20230293607A1 (en) | Lactobacillus formulations with improved stability and efficacy | |
CN114729299A (zh) | 产生血清素的细菌 | |
JP5531283B2 (ja) | 腸管免疫調整剤 | |
JP2007126399A (ja) | グルタチオン増加用組成物 | |
MX2014006556A (es) | Lactobacillus brevis productor de reuterina. | |
JPWO2018003898A1 (ja) | 軟骨再生促進用組成物 | |
Nag | Studies on the stability of probiotic bacteria during long term storage: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Food Technology at Massey University, Palmerston North, New Zealand | |
JP2003238423A (ja) | 血中コレステロール低下剤および血中コレステロール低下飲食品 | |
Brachkova | Evaluation of the viability of Lactobacillus spp. in different dosage forms | |
FR2962134A1 (fr) | Procede de preparation d'un complexe macromoleculaire non separe (totum), et utilisations dudit complexe dans la prevention de troubles arthritiques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090903 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100816 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120207 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120507 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120514 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120807 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130205 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130605 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130808 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130910 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20131007 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5392672 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D02 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |