JP2009515515A5 - - Google Patents
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- Publication number
- JP2009515515A5 JP2009515515A5 JP2008539502A JP2008539502A JP2009515515A5 JP 2009515515 A5 JP2009515515 A5 JP 2009515515A5 JP 2008539502 A JP2008539502 A JP 2008539502A JP 2008539502 A JP2008539502 A JP 2008539502A JP 2009515515 A5 JP2009515515 A5 JP 2009515515A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- mek inhibitor
- mammalian
- cells
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cells Anatomy 0.000 claims 15
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 6
- 210000004962 mammalian cells Anatomy 0.000 claims 3
- 210000001082 somatic cell Anatomy 0.000 claims 3
- 210000001178 Neural Stem Cells Anatomy 0.000 claims 2
- 210000000287 oocyte Anatomy 0.000 claims 2
- 101710027479 MAP2K1 Proteins 0.000 claims 1
- 102100006473 MAP2K1 Human genes 0.000 claims 1
- 101700028785 MEK1 Proteins 0.000 claims 1
- 101700053443 MKK1 Proteins 0.000 claims 1
- 101700052154 MPK1 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 210000004940 Nucleus Anatomy 0.000 claims 1
- 101700009925 WNK1 Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
Claims (18)
- 細胞をＭＥＫ阻害剤で処理することを含む、体細胞を再プログラム化する方法。
- 体細胞が哺乳動物細胞である、請求項１記載の方法。
- 哺乳動物細胞がマウスまたはヒトのものである、請求項２記載の方法。
- 細胞がインビトロで再プログラム化される、請求項１記載の方法。
- 細胞が神経幹細胞である、請求項１記載の方法。
- ＭＥＫ阻害剤がＭＥＫ１阻害剤である、請求項１記載の方法。
- ＭＥＫ阻害剤がＰＤ１８４３５４である、請求項１記載の方法。
- 細胞がＮａｎｏｇを内在的に発現する、請求項１記載の方法。
- Ｎａｎｏｇを内在的に発現する細胞におけるＮａｎｏｇの発現を上方調節する方法であって、細胞をＭＥＫ阻害剤で処理することを含む方法。
- 細胞が哺乳動物である、請求項９記載の方法。
- 哺乳動物細胞がマウスまたはヒトのものである、請求項１０記載の方法。
- 細胞が神経幹細胞である、請求項９記載の方法。
- ＭＥＫ阻害剤がＰＤ１８４３５２である、請求項９記載の方法。
- 哺乳動物の体細胞の核を哺乳動物のレシピエント細胞に移植して核移植細胞を形成させ、次いで前記核移植細胞をＭＥＫ阻害剤で処理することを含む、核移植の方法。
- レシピエント細胞が卵母細胞である、請求項１４記載の方法。
- レシピエント細胞が除核された卵母細胞である、請求項１４記載の方法。
- 核移植細胞から生きた非ヒト動物を得ることをさらに含む、請求項１４記載の方法。
- 核移植細胞から多能性幹細胞の培養物を得ることをさらに含む、請求項１４記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0523039A GB0523039D0 (en) | 2005-11-11 | 2005-11-11 | Reprogramming and genetic modification of cells |
| GB0605998A GB0605998D0 (en) | 2006-03-24 | 2006-03-24 | Reprogramming And Genetic Modification Of Cells |
| PCT/GB2006/004218 WO2007054720A1 (en) | 2005-11-11 | 2006-11-13 | Reprogramming and genetic modification of cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515515A JP2009515515A (ja) | 2009-04-16 |
| JP2009515515A5 true JP2009515515A5 (ja) | 2010-01-07 |
Family
ID=37763882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539502A Pending JP2009515515A (ja) | 2005-11-11 | 2006-11-13 | 細胞の再プログラム化および遺伝子改変 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1957643A2 (ja) |
| JP (1) | JP2009515515A (ja) |
| AU (1) | AU2006313518A1 (ja) |
| GB (2) | GB2445706A (ja) |
| TW (1) | TW200730623A (ja) |
| WO (1) | WO2007054720A1 (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| AU2006325975B2 (en) | 2005-12-13 | 2011-12-08 | Kyoto University | Nuclear reprogramming factor |
| GB0701062D0 (en) * | 2007-01-19 | 2007-02-28 | Evocell Ltd | Biological materials and uses thereof |
| EP2164951A2 (en) * | 2007-05-30 | 2010-03-24 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| EP2090649A1 (en) | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| AU2009225665B9 (en) * | 2008-03-17 | 2015-01-15 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| AU2015201026B2 (en) * | 2008-03-17 | 2017-03-16 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| KR101661940B1 (ko) | 2008-05-02 | 2016-10-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵 초기화 방법 |
| US10047346B2 (en) | 2008-08-08 | 2018-08-14 | Mayo Foundation For Medical Education And Research | Method of treating heart tissue using induced pluripotent stem cells |
| JP5645197B2 (ja) * | 2009-06-23 | 2014-12-24 | 学校法人日本大学 | 幹細胞の未分化状態を維持する新規方法 |
| US20130029416A1 (en) | 2011-07-22 | 2013-01-31 | Tayaramma Thatava | Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny |
| EP3708680B8 (en) * | 2015-04-15 | 2023-08-30 | University of Massachusetts | Compositions and methods for xi chromosome reactivation |
-
2006
- 2006-11-13 TW TW095141980A patent/TW200730623A/zh unknown
- 2006-11-13 WO PCT/GB2006/004218 patent/WO2007054720A1/en active Application Filing
- 2006-11-13 GB GB0808244A patent/GB2445706A/en not_active Withdrawn
- 2006-11-13 EP EP06808510A patent/EP1957643A2/en not_active Withdrawn
- 2006-11-13 JP JP2008539502A patent/JP2009515515A/ja active Pending
- 2006-11-13 AU AU2006313518A patent/AU2006313518A1/en not_active Abandoned
-
2007
- 2007-02-06 GB GB0702261A patent/GB2434155A/en not_active Withdrawn
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