JP2009515193A - 血小板の測定を実施するための方法および装置 - Google Patents
血小板の測定を実施するための方法および装置 Download PDFInfo
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Abstract
Description
本発明は、血小板分析を実施するための光学的測定に基づく新規な血液システムに関する。軸方向の光損失(axial light loss)は、分析される血液試料中の血小板を定量化するために使用され得る。更に、所定の光散乱トリガー機構が、2fL未満の細胞のサンプリングを可能にするために使用され得る。
現在使用されているほとんどの血液分析システムは、電気系および/または光学系測定によって、血小板を計数する。電気またはインピーダンス系測定システムにおいて、フローサイトメータの検出口を通過するキャリア液中の粒子は、その流量に比例して電気パルスを発生させる。パルスに基づく閾値化技法を使用して、パルスを立ち上げる粒子は、血小板、赤血球(red blood cellまたはRBC)または白血球(white blood cellまたはWBC)および屑片として分類される。ただし、ほとんどの場合に、電気系測定システムは比較的正確な結果となるが、制限がないわけではない。
本発明は、a)血液試料輸送路の開口を通して血液試料を通過させる工程、b)上記開口を通して光ビームを向ける工程、c)軸方向の光損失シグナルの測定によって上記開口中の上記血液試料を分析する工程、d)工程c)で得られる上記シグナルに基づいて、上記血液試料中の血小板を記録する工程を含む、血液試料中の血小板を非血小板粒子と識別して定量化する方法に関する。
本説明において、低角度光散乱シグナルは10°未満、好ましくは約1°〜約7°の範囲内にあると理解される。下方メジアン角度光散乱は、6°〜26°程度、好ましくは9°〜20°、上方メジアン角度(upper median angle)光散乱は、15°〜50°程度、好ましくは21°〜43°だけ、それぞれビーム軸からずれている。
Claims (20)
- 血液試料中の血小板を非血小板粒子と識別して定量化する方法であって、
(a)血液試料輸送路の開口を通して血液試料を通過させる工程
(b)該開口を通して光ビームを向ける工程
(c)軸方向の光損失シグナルを測定することにより、該開口中の該血液試料を分析する工程;および
(d)工程(c)で得られる該シグナルに基づいて、該血液試料中の血小板を記録する工程を含む、方法。 - 前記軸方向の光損失シグナルの測定が、軸方向の光損失トリガーシグナルに応答する、請求項1に記載の方法。
- 前記軸方向の光損失シグナルの測定が、LMALSトリガーシグナルに応答する、請求項1に記載の方法。
- DCインピーダンス測定による前記血液試料の測定をさらに含む、請求項1に記載の方法。
- 前記血液試料中の赤血球の形状のばらつきを最小化するため、前記血液試料に球状化剤を添加する工程をさらに含む、請求項1に記載の方法。
- 血液試料中の血小板を非血小板粒子と識別して定量化する方法であって、
(a)血液試料輸送路の開口を通して血液試料を通過させる工程
(b)該開口を通して光ビームを向ける工程
(c)軸方向の光損失および下方メジアン角度光散乱シグナルの測定によって該開口中の該血液試料を分析する工程
(d)工程(c)で得られる該シグナルに基づいて該血液試料中の血小板を記録する工程を含む、方法。 - 前記軸方向の光損失シグナルの測定が、軸方向の光損失トリガーシグナルに応答する、請求項6に記載の方法。
- 前記軸方向の光損失シグナルの測定が、LMALSトリガーシグナルに応答する、請求項6に記載の方法。
- DCインピーダンス測定による前記血液試料の測定をさらに含む、請求項6に記載の方法。
- 前記血液試料中の赤血球の形状のばらつきを最小化するため、前記血液試料に球状化剤を添加する工程をさらに含む、請求項6に記載の方法。
- 血液試料中の血小板を非血小板粒子と識別して定量化する方法であって、
(a)血液試料輸送路の開口を通して血液試料を通過させる工程
(b)前記開口を通して光ビームを向ける工程
(c)前記開口を通過する前記血液試料から軸方向の光損失を検出する工程
(d)工程(c)における該軸方向の光損失の検出から得られる軸方向の光損失トリガーシグナルに応答して該光ビームの少なくとも1つのパラメータを測定する工程
(e)工程(d)で得られる該測定されたパラメータに基づいて該血液試料中の血小板を記録する工程を含む、方法。 - 前記光ビームの前記パラメータが、軸方向の光損失に対応している、請求項11に記載の方法。
- 前記光ビームの前記パラメータが、前記光ビームの光散乱に対応している、請求項11に記載の方法。
- 前記光ビームの前記パラメータが、軸方向の光損失および光散乱に対応している、請求項11に記載の方法。
- 前記血液試料中の赤血球の形状のばらつきを最小化するため、前記血液試料に球状化剤を添加する工程をさらに含む、請求項11に記載の方法。
- さらに前記血液試料の既知量に基づいて前記血小板の絶対計数を得る工程(f)を含む、請求項11に記載の方法。
- 分析器によって血液試料中の血小板を非血小板粒子または細胞と識別する方法であって、
(a)該分析器において、血液試料が該血液試料輸送路を通って流れる際に、該血液試料輸送路内のフローセルの開口を通して光ビームを向ける工程
(b)該光ビームが該フローセルの該開口に入射するのに沿って該ビーム軸方向に関して所定の方向で光を検出する工程
(c)工程(b)における光の検出に基づいてトリガーする工程、および前記光ビームの軸方向の光損失ならびに前記光ビームの側方散乱、前記光ビームの軸に沿って前記フローセルを通過する前記光ビームの最小メジアン角度光散乱および下方メジアン角度光散乱からなるパラメータの群から選択される少なくとも1つのその他のパラメータを測定する工程
(d)工程(c)において検出された該光の該測定されたパラメータに基づいて該血液試料中の血小板を特定する工程を含む、方法。 - 前記血液試料の既知量に基づいて前記血小板の絶対計数を得る工程(e)をさらに含む、請求項17に記載の方法。
- 前記パラメータが血小板に関連した第1の利得設定と赤血球に関連した第2の利得設定で検出される、請求項17に記載の方法。
- 工程(c)がさらに電気パラメータ測定による前記血液試料の測定を含み、工程(d)がさらに前記光の前記測定されたパラメータおよび前記血液試料の前記電気パラメータに基づいて、前記血液試料中の血小板を同定する工程を含む、請求項17に記載の方法。
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US11/270,865 US7390662B2 (en) | 2005-11-09 | 2005-11-09 | Method and apparatus for performing platelet measurement |
US11/270,865 | 2005-11-09 | ||
PCT/US2006/060008 WO2007056621A2 (en) | 2005-11-09 | 2006-10-16 | Method and apparatus for performing a platelet measurement |
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WO2007056621A3 (en) | 2007-09-13 |
WO2007056621A2 (en) | 2007-05-18 |
JP5058171B2 (ja) | 2012-10-24 |
US20070105231A1 (en) | 2007-05-10 |
EP1949074A2 (en) | 2008-07-30 |
EP1949074A4 (en) | 2015-07-01 |
US7390662B2 (en) | 2008-06-24 |
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