JP2008543527A - マイクロニードルアレイ適用装置 - Google Patents
マイクロニードルアレイ適用装置 Download PDFInfo
- Publication number
- JP2008543527A JP2008543527A JP2008519435A JP2008519435A JP2008543527A JP 2008543527 A JP2008543527 A JP 2008543527A JP 2008519435 A JP2008519435 A JP 2008519435A JP 2008519435 A JP2008519435 A JP 2008519435A JP 2008543527 A JP2008543527 A JP 2008543527A
- Authority
- JP
- Japan
- Prior art keywords
- microneedle array
- application device
- housing
- patch
- target site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001133 acceleration Effects 0.000 claims description 28
- 230000007246 mechanism Effects 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 238000005381 potential energy Methods 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 description 54
- 239000003814 drug Substances 0.000 description 10
- 230000037317 transdermal delivery Effects 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- 238000003491 array Methods 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- 238000013461 design Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 230000003116 impacting effect Effects 0.000 description 3
- 150000002605 large molecules Chemical class 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 0 CI1=C*CC1 Chemical compound CI1=C*CC1 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 229940021995 DNA vaccine Drugs 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 229910000639 Spring steel Inorganic materials 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1585—Needle inserters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
本出願は、2005年6月27日出願の米国仮特許出願第60/694,447号及び2006年5月3日出願の米国仮特許出願第60/746,298号の優先権を主張し、それらの全体が本明細書に記載されているものとみなす。
本発明は、マイクロニードルアレイ適用装置及びマイクロニードルアレイを適用する方法に関する。
Claims (42)
- マイクロニードルアレイを適用する適用装置であって、
目標部位に配置可能な開口部を画定する肌当て面を有するハウジング、及び
前記マイクロニードルアレイに衝突して前記マイクロニードルアレイを前記目標部位に向かって加速させる衝突体を備え、
前記衝突体が、実質的に弓状の経路に沿って移動して、前記マイクロニードルアレイを前記目標部位に向かって移動させることができる、適用装置。 - 前記ハウジングの前記肌当て面に沿いかつ該肌当て面から間隔を空けて、前記開口部に隣接して配置された第1の保持具を更に備える、請求項1に記載の適用装置。
- 前記第1の保持具が剥離面を有する、請求項2に記載の適用装置。
- 前記剥離面が前記ハウジングに面する、請求項3に記載の適用装置。
- 前記第1の保持具が該第1の保持具の上に塗布された剥離コーティングを有する、請求項2から4のいずれか一項に記載の適用装置。
- 前記ハウジングの前記肌当て面に沿いかつ該肌当て面からの間隔を空けて、前記開口部に隣接して配置された第2の保持具を更に備える、請求項2〜5のいずれか一項に記載の適用装置。
- 前記肌当て面に沿った窪みを更に備え、前記開口部が前記窪みの中に配置された、請求項1〜6のいずれか一項に記載の適用装置。
- 操作者が前記衝突体を前記実質的に弓状の経路に沿って手動で配置できるようにするための、前記衝突体に接続された作動突出部を更に備える、請求項1〜7のいずれか一項に記載の適用装置。
- 前記開口部が、該開口部をマイクロニードルアレイが通るための通路より広い部分を包含する、請求項1〜8のいずれか一項に記載の適用装置。
- 前記目標部位に向かう前記マイクロニードルアレイの加速度が調節可能である、請求項1〜9のいずれか一項に記載の適用装置。
- 前記マイクロニードルアレイが、少なくとも部分的に弓状の経路に沿って前記目標部位に向かって移動する、請求項1〜10のいずれか一項に記載の適用装置。
- 前記衝突体を前記ハウジングに対して付勢する駆動部材を更に備える、請求項1〜11のいずれか一項に記載の適用装置。
- 前記駆動部材が、前記ハウジングに取り付けられた固定端部から可動端部まで延びる長さ部分を有し、前記駆動部材が前記長さ部分に沿って屈曲可能であり、前記駆動部材の前記可動端部が、前記マイクロニードルアレイに接触して該マイクロニードルアレイを推進させることができるように構成される、請求項12に記載の適用装置。
- 前記駆動部材の前記可動端部が前記衝突体として作用する、請求項13に記載の適用装置。
- マイクロニードルアレイを適用する適用装置であって、
開口部を備えた表面接触面を有するハウジング、及び、
前記ハウジングに取り付けられた固定端部から可動端部まで延びる長さ部分を有するとともに該長さ部分に沿って屈曲可能な駆動部材を有し、前記可動端部が、前記マイクロニードルアレイに接触しそれを推進させることができるように構成される、適用装置。 - 前記駆動部材の前記可動端部を、前記ハウジングの肌当て面から離して保持する保持機構を更に備える、請求項13又は15に記載の適用装置。
- 前記駆動部材の前記可動端部を前記保持機構から解放するトリガーを更に備える、請求項16に記載の適用装置。
- 前記駆動部材が板ばねを備える、請求項13〜17のいずれか一項に記載の適用装置。
- 前記マイクロニードルアレイが前記駆動部材の前記可動端部に固着された、請求項13〜18のいずれか一項に記載の適用装置。
- 前記マイクロニードルアレイが前記駆動部材の前記可動端部に解放可能に固着された、請求項19に記載の適用装置。
- 前記衝突体を前記ハウジングに対して付勢するねじりばねを更に備える、請求項1〜11のいずれか一項に記載の適用装置。
- 第1の位置及び第2の位置が前記実質的に弓状の経路に沿って規定され、前記衝突体が前記第1の位置に対して位置付けられたときに前記ねじりばねに保存されるポテンシャルエネルギーが、前記衝突体が前記第2の位置に対して位置付けられたときとは異なる、請求項21に記載の適用装置。
- マイクロニードルアレイを適用する適用装置であって、
目標部位に配置可能な開口部を画定する肌当て面を有するハウジング、
前記ハウジングによって旋回可能に支持された、衝突部分を有する衝突体であって、前記衝突部分が、実質的に弓状の経路に沿って第1の位置と第2の位置との間を移動可能な衝突体、及び
前記衝突体を前記ハウジングに対して付勢するねじりばねを備える、適用装置。 - 前記ハウジングの前記肌当て面に沿いかつ該肌当て面から間隔を空けて、前記開口部に隣接して配置された第1の保持具を更に備える、請求項23に記載の適用装置。
- 前記第1の保持具が剥離面を有する、請求項24に記載の適用装置。
- 前記剥離面が前記ハウジングに面する、請求項25に記載の適用装置。
- 前記第1の保持具が該第1の保持具の上に塗布された剥離コーティングを有する、請求項24〜26のいずれか一項に記載の適用装置。
- 前記ハウジングの前記肌当て面に沿いかつ該肌当て面から間隔を空けて、前記開口部に隣接して配置された第2の保持具を更に備える、請求項24〜27のいずれか一項に記載の適用装置。
- 前記肌当て面に沿った窪みを更に備え、前記開口部が前記窪みの中に配置された、請求項23〜28のいずれか一項に記載の適用装置。
- 操作者が前記衝突体を前記実質的に弓状の経路に沿って手動で配置できるようにするための、前記衝突体に接続された作動突出部を更に備える、請求項23〜29のいずれか一項に記載の適用装置。
- 前記開口部が、該開口部を前記マイクロニードルアレイが通るための通路より広い部分を包含する、請求項23〜30のいずれか一項に記載の適用装置。
- 前記第1の位置及び前記第2の位置が前記実質的に弓状の経路に沿って規定され、前記衝突体が前記第1の位置に対して位置付けられたときに前記ねじりばねに保存されるポテンシャルエネルギーが、前記衝突体が前記第2の位置に対して位置付けられたときとは異なる、請求項23〜31のいずれか一項に記載の適用装置。
- 前記目標部位に向かう前記マイクロニードルアレイの加速度が調節可能である、請求項23〜32のいずれか一項に記載の適用装置。
- 前記マイクロニードルアレイが、少なくとも部分的に弓状の経路に沿って前記目標部位に向かって動く、請求項23〜33のいずれか一項に記載の適用装置。
- 前記衝突体の質量が約0.4グラムから約2グラムの間である、請求項1〜34のいずれか一項に記載の適用装置。
- マイクロニードル適用装置であって、
肌当て面を有するハウジング、
底部分を有し、前記ハウジングの前記肌当て面に沿って画定された窪み、
前記窪みの前記底部分内に画定された、目標部位の上に配置可能な開口部、及び
前記窪みの前記底部分に沿いかつ前記開口部に隣接して配置された、前記目標部位に適用する前にマイクロニードルアレイを支える貼付剤を保持する少なくとも1つの保持面を備え、前記保持面が前記窪みの前記底部分にほぼ平行であり、前記マイクロニードルアレイを前記開口部の下に整列させることができる、適用装置。 - 前記ハウジングが概ね矩形の多面体として形成された、請求項1〜36のいずれか一項に記載の適用装置。
- マイクロニードルアレイを適用する適用装置であって、
目標部位に配置可能な開口部を画定する、肌当て面を有するハウジング、及び
前記マイクロニードルアレイに衝突して前記マイクロニードルアレイを前記目標部位に向かって加速させる衝突体を備え、
前記衝突体が、磁気マイクロニードルパッチを解放可能に保持するのに適した磁石を備える、適用装置。 - マイクロニードルアレイを目標部位と接触させることができる衝突体を有するマイクロニードルアレイ適用装置を用意する工程、
マイクロニードルアレイを前記マイクロニードル適用装置上に実装する工程、及び
前記マイクロニードルアレイを前記目標部位と接触させるために、前記衝突体を実質的に弓状の経路に沿って動かす工程を含む、マイクロニードルアレイの適用方法。 - 前記マイクロニードルアレイが、前記目標部位と接触するとき、約4m/sから8m/sの間の速度で動いている、請求項38又は39に記載のマイクロニードルアレイの適用方法。
- 前記衝突体が約0.4グラムから約2グラムの間の質量を有する、請求項38、39又は40に記載のマイクロニードルアレイの適用方法。
- マイクロニードルアレイを目標部位に向かって加速させることができるマイクロニードルアレイ適用装置を用意する工程、
前記マイクロニードルアレイを前記マイクロニードル適用装置上に実装する工程、及び
前記マイクロニードルアレイを、前記目標部位に向かって実質的に弓状の経路に沿って動かす工程を含む、マイクロニードルアレイの適用方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69444705P | 2005-06-27 | 2005-06-27 | |
US60/694,447 | 2005-06-27 | ||
US74629806P | 2006-05-03 | 2006-05-03 | |
US60/746,298 | 2006-05-03 | ||
PCT/US2006/024671 WO2007002521A2 (en) | 2005-06-27 | 2006-06-23 | Microneedle array applicator device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008543527A true JP2008543527A (ja) | 2008-12-04 |
JP2008543527A5 JP2008543527A5 (ja) | 2009-06-18 |
JP5144510B2 JP5144510B2 (ja) | 2013-02-13 |
Family
ID=37054466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008519435A Active JP5144510B2 (ja) | 2005-06-27 | 2006-06-23 | マイクロニードルアレイ適用装置 |
Country Status (7)
Country | Link |
---|---|
US (2) | US8784363B2 (ja) |
EP (2) | EP2474338B1 (ja) |
JP (1) | JP5144510B2 (ja) |
CN (1) | CN101208130B (ja) |
AU (1) | AU2006261898B2 (ja) |
CA (1) | CA2613111C (ja) |
WO (1) | WO2007002521A2 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011016230A1 (ja) | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
WO2011089907A1 (ja) | 2010-01-22 | 2011-07-28 | 株式会社メドレックス | マイクロニードル貼付剤の貼付補助具 |
JP2013500773A (ja) * | 2009-07-31 | 2013-01-10 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイ |
WO2013038890A1 (ja) * | 2011-09-16 | 2013-03-21 | 久光製薬株式会社 | アプリケータ |
US8579862B2 (en) | 2009-02-23 | 2013-11-12 | Medrx Co., Ltd. | Applicator for microneedle array |
JP2014525339A (ja) * | 2011-09-07 | 2014-09-29 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイのための送達システム |
JP2015089442A (ja) * | 2013-11-06 | 2015-05-11 | 久光製薬株式会社 | アプリケータ |
JP2016521585A (ja) * | 2013-05-31 | 2016-07-25 | スリーエム イノベイティブ プロパティズ カンパニー | 逆作動アクチュエータを備えるマイクロニードル注射装置 |
WO2016121499A1 (ja) * | 2015-01-27 | 2016-08-04 | 凸版印刷株式会社 | 経皮投与デバイス |
KR101736021B1 (ko) * | 2014-04-30 | 2017-05-15 | 킴벌리-클라크 월드와이드, 인크. | 경피적 약물 전달 장치 및 방법의 제어기 부분 |
KR101746048B1 (ko) * | 2016-09-13 | 2017-06-12 | 주식회사 라파스 | 마이크로니들 패치 어플리케이터 |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
EP1833547A1 (en) | 2004-11-18 | 2007-09-19 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
EP1871459B1 (en) | 2005-04-07 | 2019-06-19 | 3M Innovative Properties Company | System for tool feedback sensing |
CA2613114C (en) | 2005-06-27 | 2015-02-24 | 3M Innovative Properties Company | Microneedle cartridge assembly and method of applying |
WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
WO2008130587A2 (en) | 2007-04-16 | 2008-10-30 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
GB2448493B (en) | 2007-04-16 | 2009-10-14 | Dewan Fazlul Hoque Chowdhury | Microneedle transdermal delivery device |
US9220678B2 (en) | 2007-12-24 | 2015-12-29 | The University Of Queensland | Coating method |
CN102007066B (zh) | 2008-02-07 | 2013-06-26 | 昆士兰大学 | 贴片制造 |
EP2294415A4 (en) | 2008-05-23 | 2011-10-05 | Univ Queensland | ANALYTIC DETECTION BY MEANS OF MICRONADELPFLASTER WITH ANALYTICAL REAGENT |
KR20110086854A (ko) | 2008-11-18 | 2011-08-01 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 중공 마이크로니들 어레이 및 방법 |
US9119578B2 (en) | 2011-04-29 | 2015-09-01 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
EP3566649B1 (en) | 2009-03-02 | 2023-06-07 | YourBio Health, Inc. | Devices for blood sampling |
WO2011094573A1 (en) | 2010-01-28 | 2011-08-04 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
GB201007207D0 (en) * | 2010-04-29 | 2010-06-16 | Univ Cork | Method |
CN102971038B (zh) | 2010-05-04 | 2016-02-03 | 考里安国际公司 | 微针施加器 |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
WO2011163347A2 (en) | 2010-06-23 | 2011-12-29 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
JP5562138B2 (ja) | 2010-06-24 | 2014-07-30 | シスメックス株式会社 | 微細孔形成装置 |
US9943673B2 (en) * | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
JP2013538069A (ja) | 2010-07-16 | 2013-10-10 | セブンス センス バイオシステムズ,インコーポレーテッド | 流体移動デバイスのための低圧環境 |
US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
US20120089118A1 (en) * | 2010-10-08 | 2012-04-12 | A Nevada Corporation | Delivery of bisphosphonates by microinjection systems |
US8808202B2 (en) | 2010-11-09 | 2014-08-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
US9950109B2 (en) | 2010-11-30 | 2018-04-24 | Becton, Dickinson And Company | Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion |
US8795234B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Integrated spring-activated ballistic insertion for drug infusion device |
WO2012075375A1 (en) * | 2010-12-02 | 2012-06-07 | Lanco Biosciences, Inc. | Delivery of parathyroid hormones by microinjection systems |
WO2012075209A1 (en) * | 2010-12-02 | 2012-06-07 | Lanco Biosciences, Inc. | Delivery of triptans by microinjection systems |
US20120143119A1 (en) * | 2010-12-02 | 2012-06-07 | Lanco Biosciences, Inc. | Delivery of Serotonin Receptor Antagonists By Microinjection Systems |
WO2012075339A1 (en) * | 2010-12-02 | 2012-06-07 | Lanco Biosciences, Inc. | Delivery of heparins by microinjection systems |
CA2822428A1 (en) | 2010-12-22 | 2012-06-28 | Valeritas, Inc. | Microneedle patch applicator |
IT1403293B1 (it) | 2010-12-27 | 2013-10-17 | Fond Don Carlo Gnocchi Onlus | Apparecchiatura ad aghi per la somministrazione transdermica di farmaci. |
CN102727992A (zh) * | 2011-03-31 | 2012-10-17 | 株式会社汉比特科技与创新 | ***式针组件 |
KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
WO2012149155A1 (en) | 2011-04-29 | 2012-11-01 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
NL2007461C2 (en) | 2011-09-23 | 2013-03-26 | Ambro B V | System for transporting fluid across or into a biological barrier, device and capsule as part of the system. |
EP4233839A3 (en) | 2011-10-12 | 2023-09-27 | Vaxxas Pty Limited | Delivery device |
KR102071313B1 (ko) * | 2011-10-12 | 2020-01-30 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 통합형 마이크로니들 어레이 전달 시스템 |
AU2012323392A1 (en) | 2011-10-12 | 2014-04-24 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
MX2015008157A (es) | 2012-12-21 | 2016-02-22 | Corium Int Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
KR102236575B1 (ko) * | 2012-12-21 | 2021-04-05 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 접착제 조립체 및 이를 포함하는 마이크로니들 주사 장치 |
US9913970B2 (en) * | 2012-12-21 | 2018-03-13 | Hisamitsu Pharmaceutical Co., Ltd. | Applicator |
CN104884119B (zh) | 2012-12-27 | 2018-04-20 | 3M创新有限公司 | 具有中空微针的制品及其制备方法 |
BR112015022253B1 (pt) | 2013-03-12 | 2022-03-15 | Corium, Inc | Aplicador de microprojeções |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
BR112015022625B1 (pt) | 2013-03-15 | 2023-01-31 | Corium, Inc | Aparelho de microestrutura para entrega de agente terapêutico |
SG11201509722PA (en) | 2013-05-31 | 2015-12-30 | 3M Innovative Properties Co | Microneedle injection apparatus comprising a dual cover |
KR102274902B1 (ko) | 2013-05-31 | 2021-07-07 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로니들 주사 및 주입 장치 및 그의 사용 방법 |
EP3027263A1 (en) | 2013-07-30 | 2016-06-08 | ZP Opco, Inc. | Low-profile microneedle patch applicator |
DK3041548T3 (en) * | 2013-09-05 | 2019-04-01 | Sanofi Aventis Deutschland | DRIVING MECHANISM FOR A CANNEL INSTALLATION DEVICE |
JP6215343B2 (ja) | 2013-11-05 | 2017-10-18 | 久光製薬株式会社 | アプリケータ |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
US10292734B1 (en) | 2014-10-24 | 2019-05-21 | Verily Life Sciences Llc | Micro-structures with magnetic removal capability and optionally clear optical path |
EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
USD776264S1 (en) | 2015-07-30 | 2017-01-10 | Becton, Dickinson And Company | Medical injector |
USD776265S1 (en) | 2015-07-30 | 2017-01-10 | Becton, Dickinson And Company | Medical injector |
USD776262S1 (en) | 2015-07-30 | 2017-01-10 | Becton, Dickinson And Company | Medical injector |
USD774640S1 (en) | 2015-07-30 | 2016-12-20 | Becton, Dickinson And Company | Medical injector |
USD776263S1 (en) | 2015-07-30 | 2017-01-10 | Becton, Dickinson And Company | Medical injector |
USD767120S1 (en) | 2015-07-30 | 2016-09-20 | Becton, Dickinson And Company | Medical injector |
USD794776S1 (en) | 2015-07-30 | 2017-08-15 | Becton, Dickinson And Company | Medical injector |
JP6676644B2 (ja) | 2015-09-02 | 2020-04-08 | 久光製薬株式会社 | アプリケータ |
WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
EP3496681A4 (en) * | 2016-08-08 | 2020-07-22 | Avedro, Inc. | SYSTEMS AND METHODS FOR CROSSLINKING TREATMENT OF DRY EYES |
EP3606760B1 (en) | 2017-03-31 | 2023-09-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
ES2972207T3 (es) | 2017-07-14 | 2024-06-11 | Amgen Inc | Sistema de inserción-retracción de agujas con sistema de resorte de torsión doble |
WO2019023757A1 (en) | 2017-08-04 | 2019-02-07 | Vaxxas Pty Limited | COMPACT MECHANICAL HIGH ENERGY STORAGE ACTUATOR WITH LOW TRIGGER STRENGTH FOR ADMINISTRATION OF MICROPROJECTION NETWORK (PRM) PATCHES |
DE102017007485A1 (de) * | 2017-08-09 | 2019-02-14 | Lts Lohmann Therapie-Systeme Ag | Adaptersystem mit Rahmen, Wirkstoffpad und Deckel |
JP6914359B2 (ja) | 2017-11-30 | 2021-08-04 | 久光製薬株式会社 | アプリケータ、カートリッジ、およびアプリケーション・キット |
US10786203B1 (en) * | 2018-01-30 | 2020-09-29 | Daniel M. Besser | Medical patch applicator device |
WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
DE102019001251A1 (de) * | 2019-02-21 | 2020-08-27 | Lts Lohmann Therapie-Systeme Ag | Applikator für Mikronadelpflaster |
KR20220111304A (ko) * | 2019-12-05 | 2022-08-09 | 폴리카 인코포레이티드 | 니들링 디바이스 및 침투 깊이 |
CN116390688A (zh) * | 2020-06-17 | 2023-07-04 | 比奥林股份有限公司 | 用于施用微针阵列的装置和方法 |
US11389376B2 (en) | 2020-12-21 | 2022-07-19 | Mediccene Inc. | Wearable intravenous fluid delivery system |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
KR20240089125A (ko) | 2021-09-28 | 2024-06-20 | 바이오링크 인코포레이티드 | 마이크로니들 어레이 기반 연속 분석물 모니터링 장치용 어플리케이터 장치 및 마이크로니들 인클로저 |
CN114081538B (zh) * | 2021-11-12 | 2023-09-15 | 江西中医药大学 | 一种用于皮肤组织液穿刺的微针装置 |
USD1033641S1 (en) | 2021-12-17 | 2024-07-02 | Biolinq Incorporated | Microneedle array sensor applicator device |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004009172A1 (en) * | 2002-07-19 | 2004-01-29 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
WO2004098684A2 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation |
Family Cites Families (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123212A (en) * | 1964-03-03 | Multiple disposable intracutaneous injector package | ||
USRE25637E (en) * | 1964-09-08 | Means for vaccinating | ||
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3034507A (en) * | 1960-05-10 | 1962-05-15 | American Cyanamid Co | Intracutaneous injection device |
US3136314A (en) * | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
US3246647A (en) * | 1962-07-23 | 1966-04-19 | American Cyanamid Co | Disposable intracutaneous injector |
US3221740A (en) * | 1962-08-31 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
GB1080986A (en) | 1964-09-02 | 1967-08-31 | Allen And Hanburys Surgical En | Multiple puncture apparatus |
US3322121A (en) * | 1965-11-26 | 1967-05-30 | Oscar H Banker | Skin-puncturing unit with a collapsible protective cover |
US3510933A (en) * | 1967-05-26 | 1970-05-12 | American Cyanamid Co | Apparatus and method for continuously forming intracutaneous injectors |
US3466131A (en) * | 1967-09-07 | 1969-09-09 | Becton Dickinson Co | Dispensing applicator package |
US3512520A (en) * | 1967-11-01 | 1970-05-19 | Michael N Cowan | Antigenic test applicator |
US3596660A (en) * | 1969-05-12 | 1971-08-03 | Illinois Tool Works | Injection device |
US3675766A (en) * | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
US3688764A (en) * | 1970-08-20 | 1972-09-05 | Bard Hamilton Co Inc | Intracutaneous injection system |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
DE2250293A1 (de) * | 1972-10-13 | 1974-04-25 | Bayern Freistaat | Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff |
OA05448A (fr) * | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
US4304241A (en) * | 1978-09-05 | 1981-12-08 | Aller-Screen, Inc. | Skin testing device |
US4237906A (en) * | 1978-12-06 | 1980-12-09 | Havstad Harold R | Antigen injection assembly |
GB2064329B (en) | 1979-11-01 | 1983-06-22 | Matburn Holdings Ltd | Multiple puncture apparatus |
FR2474856A1 (fr) * | 1980-01-31 | 1981-08-07 | Merieux Inst | Dispositif scarificateur |
US4360016A (en) * | 1980-07-01 | 1982-11-23 | Transidyne General Corp. | Blood collecting device |
US4503856A (en) * | 1981-06-29 | 1985-03-12 | Sherwood Medical Company | Lancet injector |
US4517978A (en) * | 1983-01-13 | 1985-05-21 | Levin Paul D | Blood sampling instrument |
US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
GB8710470D0 (en) * | 1987-05-01 | 1987-06-03 | Mumford Ltd Owen | Blood sampling devices |
US4850973A (en) * | 1987-10-16 | 1989-07-25 | Pavel Jordon & Associates | Plastic device for injection and obtaining blood samples |
GB2221394B (en) | 1988-08-05 | 1992-03-04 | Eilert Eilertsen | An injection device |
US4924879A (en) * | 1988-10-07 | 1990-05-15 | Brien Walter J O | Blood lancet device |
US4920977A (en) * | 1988-10-25 | 1990-05-01 | Becton, Dickinson And Company | Blood collection assembly with lancet and microcollection tube |
US4983178A (en) * | 1988-11-14 | 1991-01-08 | Invictus, Inc. | Lancing device |
CA2016900A1 (en) | 1989-07-06 | 1991-01-06 | Ronald J. Filipski | Tines structure in clinical applicator |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5402798A (en) * | 1991-07-18 | 1995-04-04 | Swierczek; Remi | Disposable skin perforator and blood testing device |
DE4212315A1 (de) * | 1992-04-13 | 1993-10-14 | Boehringer Mannheim Gmbh | Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke |
JP2630197B2 (ja) * | 1993-04-28 | 1997-07-16 | 株式会社ニッショー | 血液吸出器具 |
US5611806A (en) * | 1994-05-23 | 1997-03-18 | Samsung Electro-Mechanics Co., Ltd. | Skin perforating device for transdermal medication |
US5487726A (en) * | 1994-06-16 | 1996-01-30 | Ryder International Corporation | Vaccine applicator system |
CA2201315A1 (en) | 1994-09-30 | 1996-04-11 | Peter Ping Ling | Direct introduction of foreign materials into cells |
WO1996037155A1 (en) * | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
AU5869796A (en) * | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
WO1998011937A1 (en) * | 1996-09-17 | 1998-03-26 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US6797276B1 (en) * | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
CN1206004C (zh) * | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
AU739616B2 (en) * | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
WO1999033504A1 (en) * | 1997-12-31 | 1999-07-08 | Minimed Inc. | Insertion device for an insertion set and method of using the same |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
CA2330207C (en) * | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
EP1109594B1 (en) * | 1998-08-31 | 2004-10-27 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
CN2347607Y (zh) * | 1998-10-08 | 1999-11-10 | 郭文学 | 自动注射器 |
US6603998B1 (en) * | 1999-01-28 | 2003-08-05 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
TW480759B (en) | 1999-03-18 | 2002-03-21 | Seiko Epson Corp | Electronic machine, charged electronic machine and control method of electronic machine |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6379324B1 (en) * | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
MXPA02004863A (es) | 1999-11-15 | 2003-01-28 | Velcro Ind | Miembro de sujecion dermica. |
CA2393537C (en) * | 1999-12-10 | 2009-02-03 | Alza Corporation | Skin treatment apparatus for sustained transdermal drug delivery |
WO2001041863A1 (en) * | 1999-12-10 | 2001-06-14 | Alza Corporation | Device and method for enhancing microprotrusion skin piercing |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
WO2001093930A1 (en) * | 2000-06-02 | 2001-12-13 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
US6589202B1 (en) * | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
US6440096B1 (en) * | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
PL360998A1 (en) * | 2000-10-13 | 2004-09-20 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
MXPA03003301A (es) * | 2000-10-13 | 2004-12-13 | Johnson & Johnson | Aplicador de un conjunto de microsalientes mediante impacto. |
JP4104975B2 (ja) | 2000-10-13 | 2008-06-18 | アルザ・コーポレーシヨン | 衝撃適用装置用の微小突起部材保持器 |
US7131987B2 (en) * | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
AU2002237703A1 (en) * | 2000-11-09 | 2002-06-18 | Biovalve Technologies, Inc. | Microneedle adapter |
AU2002241567A1 (en) * | 2000-11-30 | 2002-07-24 | Biovalve Technologies, Inc. | Fluid delivery and measurement systems and methods |
WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20060024673A1 (en) | 2001-06-05 | 2006-02-02 | Lori Friedman | Slc2as as modifiers of the p53 pathway and methods of use |
JP2004532698A (ja) * | 2001-06-08 | 2004-10-28 | ベクトン・ディキンソン・アンド・カンパニー | ニードルまたはアブレーダーアレイの操作のための装置 |
BR0210628A (pt) * | 2001-06-29 | 2004-08-10 | Becton Dickinson Co | Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
WO2003022330A2 (en) * | 2001-09-12 | 2003-03-20 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
AU2002330083A1 (en) * | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
CA2474742C (en) * | 2002-02-04 | 2012-01-17 | Becton, Dickinson And Company | Dermal access member |
US7004928B2 (en) * | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
JP4691445B2 (ja) * | 2002-07-22 | 2011-06-01 | ベクトン・ディキンソン・アンド・カンパニー | パッチ状注入装置 |
EP1531896B1 (en) * | 2002-08-29 | 2016-07-20 | Becton Dickinson and Company | Microprotrusion arrays and methods for using same to deliver substances into tissue |
DE10255133B3 (de) * | 2002-11-26 | 2004-04-08 | Disetronic Licensing Ag | Einführvorrichtung für Nadeleinheiten |
US20050137525A1 (en) * | 2003-06-04 | 2005-06-23 | Georgia Tech Research Corporation | Drilling microneedle device |
AU2004253571A1 (en) * | 2003-07-02 | 2005-01-13 | Alza Corporation | Microprojection array immunization patch and method |
BR122020015611B1 (pt) * | 2003-08-12 | 2021-08-24 | Becton, Dickinson And Company | Dispositivo para distribuir um medicamento para um paciente por injeção |
US8353861B2 (en) * | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
AU2004285484A1 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
US7097631B2 (en) * | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
US20050112135A1 (en) | 2003-11-21 | 2005-05-26 | Cormier Michel J. | Ultrasound assisted transdermal vaccine delivery method and system |
CN1886171A (zh) | 2003-11-28 | 2006-12-27 | 艾克若克斯Dds有限公司 | 快速经皮施用的方法和*** |
WO2005065765A1 (en) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Medical devices and kits including same |
ES2650188T3 (es) | 2004-06-10 | 2018-01-17 | 3M Innovative Properties Company | Dispositivo y kit de aplicación de parches |
EP1868501B1 (en) * | 2005-04-07 | 2015-10-14 | Becton Dickinson and Company | Finger activated lancet device |
-
2006
- 2006-06-23 EP EP12163072.7A patent/EP2474338B1/en not_active Not-in-force
- 2006-06-23 CN CN2006800233630A patent/CN101208130B/zh not_active Expired - Fee Related
- 2006-06-23 WO PCT/US2006/024671 patent/WO2007002521A2/en active Application Filing
- 2006-06-23 JP JP2008519435A patent/JP5144510B2/ja active Active
- 2006-06-23 US US11/993,137 patent/US8784363B2/en active Active
- 2006-06-23 CA CA2613111A patent/CA2613111C/en not_active Expired - Fee Related
- 2006-06-23 EP EP06773934A patent/EP1901799B1/en not_active Not-in-force
- 2006-06-23 AU AU2006261898A patent/AU2006261898B2/en not_active Ceased
-
2014
- 2014-07-17 US US14/333,676 patent/US9789249B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004009172A1 (en) * | 2002-07-19 | 2004-01-29 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
WO2004098684A2 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8579862B2 (en) | 2009-02-23 | 2013-11-12 | Medrx Co., Ltd. | Applicator for microneedle array |
JP2013500773A (ja) * | 2009-07-31 | 2013-01-10 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイ |
WO2011016230A1 (ja) | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
JP5663792B2 (ja) * | 2009-08-07 | 2015-02-04 | 株式会社 メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
US9750924B2 (en) | 2010-01-22 | 2017-09-05 | Medrx Co., Ltd. | Adhesive patching aid for microneedle adhesive skin patch |
WO2011089907A1 (ja) | 2010-01-22 | 2011-07-28 | 株式会社メドレックス | マイクロニードル貼付剤の貼付補助具 |
JP2014525339A (ja) * | 2011-09-07 | 2014-09-29 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイのための送達システム |
WO2013038890A1 (ja) * | 2011-09-16 | 2013-03-21 | 久光製薬株式会社 | アプリケータ |
JPWO2013038890A1 (ja) * | 2011-09-16 | 2015-03-26 | 久光製薬株式会社 | アプリケータ |
JP2016521585A (ja) * | 2013-05-31 | 2016-07-25 | スリーエム イノベイティブ プロパティズ カンパニー | 逆作動アクチュエータを備えるマイクロニードル注射装置 |
JP2015089442A (ja) * | 2013-11-06 | 2015-05-11 | 久光製薬株式会社 | アプリケータ |
KR101736021B1 (ko) * | 2014-04-30 | 2017-05-15 | 킴벌리-클라크 월드와이드, 인크. | 경피적 약물 전달 장치 및 방법의 제어기 부분 |
WO2016121499A1 (ja) * | 2015-01-27 | 2016-08-04 | 凸版印刷株式会社 | 経皮投与デバイス |
KR101746048B1 (ko) * | 2016-09-13 | 2017-06-12 | 주식회사 라파스 | 마이크로니들 패치 어플리케이터 |
WO2018052181A1 (ko) * | 2016-09-13 | 2018-03-22 | 주식회사 라파스 | 마이크로니들 패치 어플리케이터 |
Also Published As
Publication number | Publication date |
---|---|
CA2613111C (en) | 2015-05-26 |
US9789249B2 (en) | 2017-10-17 |
WO2007002521A3 (en) | 2007-06-21 |
CN101208130B (zh) | 2012-05-16 |
US20140330209A1 (en) | 2014-11-06 |
CN101208130A (zh) | 2008-06-25 |
EP2474338B1 (en) | 2013-07-24 |
CA2613111A1 (en) | 2007-01-04 |
EP2474338A1 (en) | 2012-07-11 |
US8784363B2 (en) | 2014-07-22 |
EP1901799A2 (en) | 2008-03-26 |
AU2006261898B2 (en) | 2011-11-03 |
EP1901799B1 (en) | 2012-06-13 |
JP5144510B2 (ja) | 2013-02-13 |
US20100222743A1 (en) | 2010-09-02 |
AU2006261898A1 (en) | 2007-01-04 |
WO2007002521A2 (en) | 2007-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5144510B2 (ja) | マイクロニードルアレイ適用装置 | |
JP4927752B2 (ja) | マイクロニードルアレイアプリケーターおよび保持装置 | |
US8758298B2 (en) | Low-profile microneedle array applicator | |
JP5336538B2 (ja) | マイクロニードルデバイスおよびマイクロニードル送達装置 | |
US20080009811A1 (en) | Non-Skin-Contacting Microneedle Array Applicator | |
EP2766067B1 (en) | Integrated microneedle array delivery system | |
AU2014249471B2 (en) | Microprojection applicators | |
EP3329960A1 (en) | Patch application device and kit | |
JP2008534152A (ja) | 微小突起で皮膚を穿刺する装置及び方法 | |
JP2016517707A (ja) | カウンタ組立体を備えているマイクロニードルアプリケータ | |
KR20030068136A (ko) | 미세 돌기부로 피부를 천공하기 위한 장치 및 방법 | |
AU2012200649A1 (en) | Microneedle array applicator device | |
AU2012201016B2 (en) | Low-profile microneedle array applicator |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090428 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090428 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110322 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110621 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110628 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110909 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120327 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120626 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120703 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20121023 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20121122 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20151130 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5144510 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D02 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |