JP2008515964A - 置換n−アルキルピリミジノン - Google Patents
置換n−アルキルピリミジノン Download PDFInfo
- Publication number
- JP2008515964A JP2008515964A JP2007536286A JP2007536286A JP2008515964A JP 2008515964 A JP2008515964 A JP 2008515964A JP 2007536286 A JP2007536286 A JP 2007536286A JP 2007536286 A JP2007536286 A JP 2007536286A JP 2008515964 A JP2008515964 A JP 2008515964A
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- difluorobenzyl
- alkyl
- isopropyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 0 CC(C)N(*NCCN[Tc]C)C(C(Cl)=C(N)OCC(CCC(F)=C1)=C1F)=O Chemical compound CC(C)N(*NCCN[Tc]C)C(C(Cl)=C(N)OCC(CCC(F)=C1)=C1F)=O 0.000 description 11
- DVGSMMYDMFLJLH-UHFFFAOYSA-N CC(C)N(C1=O)C(N(CC2)CCN2C(CO)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(C)N(C1=O)C(N(CC2)CCN2C(CO)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br DVGSMMYDMFLJLH-UHFFFAOYSA-N 0.000 description 2
- BDLLZGTXWBOLHB-UHFFFAOYSA-N CC(C)N(C1=O)C(OCC(N)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(C)N(C1=O)C(OCC(N)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br BDLLZGTXWBOLHB-UHFFFAOYSA-N 0.000 description 2
- RGTMILHZLXZRGF-UHFFFAOYSA-N CC(C)CNC(N)=S Chemical compound CC(C)CNC(N)=S RGTMILHZLXZRGF-UHFFFAOYSA-N 0.000 description 1
- XKLJYYZWWSJLEW-UHFFFAOYSA-N CC(C)N(C(C)=NC(OCc(cc1)c(CN)cc1F)=C1Br)C1=O Chemical compound CC(C)N(C(C)=NC(OCc(cc1)c(CN)cc1F)=C1Br)C1=O XKLJYYZWWSJLEW-UHFFFAOYSA-N 0.000 description 1
- LLTODSASWXALDV-UHFFFAOYSA-N CC(C)N(C(CCC=C)=NC(OCc(ccc(F)c1)c1F)=C1Cl)C1=O Chemical compound CC(C)N(C(CCC=C)=NC(OCc(ccc(F)c1)c1F)=C1Cl)C1=O LLTODSASWXALDV-UHFFFAOYSA-N 0.000 description 1
- SFBKYINOYJCDFW-UHFFFAOYSA-N CC(C)N(C1=O)C(N(CC2)CC2N)=NC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(C)N(C1=O)C(N(CC2)CC2N)=NC(OCc(c(F)c2)ccc2F)=C1Br SFBKYINOYJCDFW-UHFFFAOYSA-N 0.000 description 1
- AJYUERLDDORHFL-UHFFFAOYSA-N CC(C)N(C1=O)C(N(CC2)CC2NC(OC(C)(C)C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(C)N(C1=O)C(N(CC2)CC2NC(OC(C)(C)C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br AJYUERLDDORHFL-UHFFFAOYSA-N 0.000 description 1
- ZNMIUTCBBSDVAK-UHFFFAOYSA-N CC(C)N(C1=O)C(N(CC2)CCN2C(OC(C)(C)C)=O)=NC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(C)N(C1=O)C(N(CC2)CCN2C(OC(C)(C)C)=O)=NC(OCc(c(F)c2)ccc2F)=C1Br ZNMIUTCBBSDVAK-UHFFFAOYSA-N 0.000 description 1
- VJBSXDMMQBMEHU-HNNXBMFYSA-N CC(C)N(C1=O)C(N(CC2)C[C@H]2NC(C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(C)N(C1=O)C(N(CC2)C[C@H]2NC(C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Cl VJBSXDMMQBMEHU-HNNXBMFYSA-N 0.000 description 1
- PKIHVADBZQXQMG-UHFFFAOYSA-N CC(C)N(C1=O)C(NC(CC2)CCN2C(OC(C)(C)C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(C)N(C1=O)C(NC(CC2)CCN2C(OC(C)(C)C)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br PKIHVADBZQXQMG-UHFFFAOYSA-N 0.000 description 1
- IDDBPDHDDQTFCJ-UHFFFAOYSA-N CC(C)N(C1=O)C(NCC(N2CCCC2)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br Chemical compound CC(C)N(C1=O)C(NCC(N2CCCC2)=O)=NC(OCc(ccc(F)c2)c2F)=C1Br IDDBPDHDDQTFCJ-UHFFFAOYSA-N 0.000 description 1
- SLAHTTLBYXYYQH-UHFFFAOYSA-N CC(C)N(C1=O)C(NCCNC(C(C)(C)O)=O)=NC(OCc(c(F)c2)ccc2F)=C1Cl Chemical compound CC(C)N(C1=O)C(NCCNC(C(C)(C)O)=O)=NC(OCc(c(F)c2)ccc2F)=C1Cl SLAHTTLBYXYYQH-UHFFFAOYSA-N 0.000 description 1
- FIPGOMOPTPRHGR-UHFFFAOYSA-N CC(C)N(C1=O)C(NCCNC(C(C)(C)OC(C)=O)=O)=NC(OCc(c(F)c2)ccc2F)=C1Cl Chemical compound CC(C)N(C1=O)C(NCCNC(C(C)(C)OC(C)=O)=O)=NC(OCc(c(F)c2)ccc2F)=C1Cl FIPGOMOPTPRHGR-UHFFFAOYSA-N 0.000 description 1
- KYLMKACJBOGSSJ-UHFFFAOYSA-N CC(C)N(C1=O)C(OCCCC(O)=O)=NC(OCc(ccc(F)c2)c2F)=C1Cl Chemical compound CC(C)N(C1=O)C(OCCCC(O)=O)=NC(OCc(ccc(F)c2)c2F)=C1Cl KYLMKACJBOGSSJ-UHFFFAOYSA-N 0.000 description 1
- SICJBODXWAWRDO-UHFFFAOYSA-N CC(C)N(C1=O)C(OCCCN)=NC(OCc(c(F)c2)ccc2F)=C1Cl Chemical compound CC(C)N(C1=O)C(OCCCN)=NC(OCc(c(F)c2)ccc2F)=C1Cl SICJBODXWAWRDO-UHFFFAOYSA-N 0.000 description 1
- YCRCHDCQERKBEX-UHFFFAOYSA-N CC(C)N(C1=O)C(OCCNC(C)O)=NC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CC(C)N(C1=O)C(OCCNC(C)O)=NC(OCc(c(F)c2)ccc2F)=C1Br YCRCHDCQERKBEX-UHFFFAOYSA-N 0.000 description 1
- IKOAIXQTNXBPDD-UHFFFAOYSA-N CC(C)N1C(c(cc2)ccc2C(N)=O)=NC(OCc(c(F)c2)ccc2F)=CC1=O Chemical compound CC(C)N1C(c(cc2)ccc2C(N)=O)=NC(OCc(c(F)c2)ccc2F)=CC1=O IKOAIXQTNXBPDD-UHFFFAOYSA-N 0.000 description 1
- UIOJBQQKHTXFHV-UHFFFAOYSA-N CC(C)N1C(c2cc(C(OC)=O)ccc2)=NC(OCc(c(F)c2)ccc2F)=CC1=O Chemical compound CC(C)N1C(c2cc(C(OC)=O)ccc2)=NC(OCc(c(F)c2)ccc2F)=CC1=O UIOJBQQKHTXFHV-UHFFFAOYSA-N 0.000 description 1
- HXBVCTWBTMWKRC-UHFFFAOYSA-N CN(C1=O)C(NCC(N)=O)=NC(OCc(c(F)c2)ccc2F)=C1Br Chemical compound CN(C1=O)C(NCC(N)=O)=NC(OCc(c(F)c2)ccc2F)=C1Br HXBVCTWBTMWKRC-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N OC(c1ccccc1)=O Chemical compound OC(c1ccccc1)=O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61885604P | 2004-10-13 | 2004-10-13 | |
US63794904P | 2004-12-21 | 2004-12-21 | |
PCT/IB2005/003063 WO2006040666A1 (fr) | 2004-10-13 | 2005-10-03 | N-alkylpyrimidinones substitues |
Publications (1)
Publication Number | Publication Date |
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JP2008515964A true JP2008515964A (ja) | 2008-05-15 |
Family
ID=35717699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007536286A Withdrawn JP2008515964A (ja) | 2004-10-13 | 2005-10-03 | 置換n−アルキルピリミジノン |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1802590A1 (fr) |
JP (1) | JP2008515964A (fr) |
BR (1) | BRPI0517555A (fr) |
CA (1) | CA2580497A1 (fr) |
MX (1) | MX2007004493A (fr) |
WO (1) | WO2006040666A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2640665A1 (fr) * | 2006-02-10 | 2007-08-16 | Pfizer Products Inc. | Derives pyridinone-pyrazole-uree et pyrimidinone-pyrazole-uree |
EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
US9056110B2 (en) * | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
CN108503568A (zh) * | 2017-02-27 | 2018-09-07 | 无锡杰西医药股份有限公司 | 一种适用于工业化生产的高纯度异硫氰酸酯类化合物制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63112566A (ja) * | 1986-10-28 | 1988-05-17 | Nissan Chem Ind Ltd | ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤 |
JPH01190670A (ja) * | 1988-01-22 | 1989-07-31 | Nissan Chem Ind Ltd | ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤 |
CA2474239A1 (fr) * | 2002-01-18 | 2003-07-24 | Pharmacia Corporation | Pyridazinones substituees inhibant la map kinase p38 |
AP1822A (en) * | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
US7183287B2 (en) * | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
JP2007500128A (ja) * | 2003-07-25 | 2007-01-11 | アムジエン・インコーポレーテツド | 置換複素環式化合物及び使用方法 |
-
2005
- 2005-10-03 JP JP2007536286A patent/JP2008515964A/ja not_active Withdrawn
- 2005-10-03 CA CA002580497A patent/CA2580497A1/fr not_active Abandoned
- 2005-10-03 BR BRPI0517555-0A patent/BRPI0517555A/pt not_active Application Discontinuation
- 2005-10-03 MX MX2007004493A patent/MX2007004493A/es unknown
- 2005-10-03 EP EP05791810A patent/EP1802590A1/fr not_active Withdrawn
- 2005-10-03 WO PCT/IB2005/003063 patent/WO2006040666A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2006040666A1 (fr) | 2006-04-20 |
MX2007004493A (es) | 2007-05-08 |
BRPI0517555A (pt) | 2008-10-14 |
CA2580497A1 (fr) | 2006-04-20 |
EP1802590A1 (fr) | 2007-07-04 |
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