JP2008515964A - 置換n−アルキルピリミジノン - Google Patents

置換n−アルキルピリミジノン Download PDF

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JP2008515964A
JP2008515964A JP2007536286A JP2007536286A JP2008515964A JP 2008515964 A JP2008515964 A JP 2008515964A JP 2007536286 A JP2007536286 A JP 2007536286A JP 2007536286 A JP2007536286 A JP 2007536286A JP 2008515964 A JP2008515964 A JP 2008515964A
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oxy
difluorobenzyl
alkyl
isopropyl
amino
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Japanese (ja)
Inventor
リー ベーム テリー
クリストファー クリスティ ランス
デヴァダス バレクドゥル
マーガレット マッドセン ヒーサー
マルフォ ローラ
セルネス ショーン
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ファルマシア・アンド・アップジョン・カンパニー・エルエルシー
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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JP2007536286A 2004-10-13 2005-10-03 置換n−アルキルピリミジノン Withdrawn JP2008515964A (ja)

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Application Number Priority Date Filing Date Title
US61885604P 2004-10-13 2004-10-13
US63794904P 2004-12-21 2004-12-21
PCT/IB2005/003063 WO2006040666A1 (fr) 2004-10-13 2005-10-03 N-alkylpyrimidinones substitues

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JP2008515964A true JP2008515964A (ja) 2008-05-15

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EP (1) EP1802590A1 (fr)
JP (1) JP2008515964A (fr)
BR (1) BRPI0517555A (fr)
CA (1) CA2580497A1 (fr)
MX (1) MX2007004493A (fr)
WO (1) WO2006040666A1 (fr)

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CA2640665A1 (fr) * 2006-02-10 2007-08-16 Pfizer Products Inc. Derives pyridinone-pyrazole-uree et pyrimidinone-pyrazole-uree
EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
US9056110B2 (en) * 2011-12-06 2015-06-16 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
CN108503568A (zh) * 2017-02-27 2018-09-07 无锡杰西医药股份有限公司 一种适用于工业化生产的高纯度异硫氰酸酯类化合物制备方法

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JPS63112566A (ja) * 1986-10-28 1988-05-17 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
JPH01190670A (ja) * 1988-01-22 1989-07-31 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
CA2474239A1 (fr) * 2002-01-18 2003-07-24 Pharmacia Corporation Pyridazinones substituees inhibant la map kinase p38
AP1822A (en) * 2002-02-14 2008-01-30 Pharmacia Corp Substituted pyridinones as modulators of P38 MAP kinase.
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
JP2007500128A (ja) * 2003-07-25 2007-01-11 アムジエン・インコーポレーテツド 置換複素環式化合物及び使用方法

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CA2580497A1 (fr) 2006-04-20
EP1802590A1 (fr) 2007-07-04

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