JP2008183013A - 食物サプリメントとしての植物炭水化物の組成物 - Google Patents
食物サプリメントとしての植物炭水化物の組成物 Download PDFInfo
- Publication number
- JP2008183013A JP2008183013A JP2008095695A JP2008095695A JP2008183013A JP 2008183013 A JP2008183013 A JP 2008183013A JP 2008095695 A JP2008095695 A JP 2008095695A JP 2008095695 A JP2008095695 A JP 2008095695A JP 2008183013 A JP2008183013 A JP 2008183013A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- effective amount
- mannose
- food
- dietary supplement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000011782 vitamin Substances 0.000 claims abstract description 17
- 229930003231 vitamin Natural products 0.000 claims abstract description 17
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 6
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 6
- 108090000288 Glycoproteins Proteins 0.000 claims description 38
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- 235000019312 arabinogalactan Nutrition 0.000 claims description 9
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- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 9
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims description 8
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- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 4
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- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 claims description 3
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Abstract
【解決手段】 1種〜11種の必須のサッカリド(糖栄養物質)の栄養的に有効な量を、食物サプリメントとして種々な組成物に使用する。食物サプリメントは、植物栄養物質、ビタミン、無機質、薬草抽出液および他の非毒性の栄養物質を含有することができる。
【選択図】 なし
Description
* 物理化学的性質、例えば溶解度、粘度、電荷およびタンパク質変性に対する調節
* 細胞内および細胞外からのタンパク質分解に対する保護
* より小さな生成物へのプレカーサータンパク質のタンパク質分解過程に対する影響
* 例えばヒトの絨毛性ゴナドトロピン(HCG)の生物学的活性における関与
* 膜へのタンパク質の挿入、細胞内のタンパク質の移動およびタンパク質選別および分泌に対する影響
* 胚性発生および分化に対する影響
* 代謝に対する影響
* 癌細胞によって選択された転移の部位に対する影響
ヤマノイモ属コンプレックスは、Ayusherbs(Japan)から入手することができる。ヤマノイモ属コンプレックスを本発明の食物サプリメントに含有させる場合は、全体の必須サッカリドに対するヤマノイモ属コンプレックスの比は、質量%を基にして約0.0001/99.9999〜約50/50の範囲にすることができる。特定の実施化においては、全体の必須サッカリドに対するヤマノイモ属コンプレックスの比は、約0.01〜70/99.99〜30または約10〜40/90〜60または約20/80の範囲にある。
以下に例示した与えられた研究に使用したカプセルまたはカプレットの大きさおよび成分によって、食物サプリメントははじめに以下の通り投与した。示された使用量は、#1サイズのカプセルおよび1000〜1200mgのカプレットに基づく。
本発明による生成物に対して適当な組成物は、次の通りである。
ガラクトウロン酸、ガラクトース、フコース、キシロース、アラビノースおよびラムノースの源であるトラガントゴム(100kg)を、ステンレス鋼製リボンブレンダーに充填しそしてマンノースおよびガラクトースの源であるグアーゴム(10kg)をこのステンレス鋼製リボンブレンダーに充填する。トラガントゴムおよびグアーゴムの混合物を5分混合する。それからAerosil380TM(シリカゲル)250gを、流展剤として混合物に加えそしてグルコースの源である米粉200kgをグルテンを含有していない充填剤として加える。それから混合物を15分撹拌する。最後にステアリン酸カルシウム100gを滑沢剤として混合物に加えそして混合物をさらに3分混合してバルク粉末を形成する。それから粉末をModel 8(Elanco)カプセル充填機を使用して、250mgの充填質量でサイズ1ゼラチンカプセルに封入する。
本発明による生成物に対する他の適当な組成物は次の通りである。
Elorida Food ProductならびにAldrich Chemical CompanyおよびSigmaChemicalから入手できるガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミンおよびキシロースのそれぞれ25kgを、ステンレス鋼製リボンブレンダーに充填しそして5分混合する。それからAerosil380TM(シリカゲル)250gを流展剤として混合物に加えそしてグルコースの源である米粉200kgをグルテンを含有していない充填剤として加える。それから混合物を15分撹拌する。最後にステアリン酸カルシウム100gを、滑沢剤として混合物に加えそして混合物をさらに3分撹拌してバルク粉末を形成する。それから粉末をModel 8(Elanco)カプセル充填機を使用して、250mgの充填質量でサイズ#1ゼラチンカプセルに封入する。
標準化検定
次の検定は本発明によって包含される糖の濃度を標準化する方法を記載する。
標準品:炭水化物標準品はすべて、Aldrich Chemical Company,Milwaukee, Wisconsinから入手することができる。
溶離剤:約17MOhmより大なるまたは約17MOhmに等しい抵抗性を有する脱イオン化(DI)水
試料の製造:2N弗化水素酸2mlをねじぶたのついたテフロン(登録商標)内張した10mlの試験管中の分析される試料10mgに加える。それから、試料を120℃で1時間インキュベートして単糖に加水分解する。過剰の試薬を空気の流れ下で除去しそして試料をDI水1mlに再懸濁する。
HPLC分析:分析977.20のAOAC公認法
この実施例の食物サプリメント処方は、上記実施例によって大規模に製造した。Glyco-1と称されるこの処方は、以下に示した量で以下の成分を含有する。
注意欠陥機能亢進障害の治療における薬物−誘発副作用の減少
ADHDに対するマニュアル第4版(DSM-IV)の定義。親がメチルフェニデートを与えなかった5人の子供(NO MED)。メチルフェニデートの2つの異なる使用量の1つの使用量を与えた研究における他の12人の子供、すなわち、(a)正規の規定された使用量を与えた6人の子供(MED)および (b)減少した使用量、すなわち正規の規定された使用量以下の使用量を与えた6人の子供(MED RED)。
評価手段は、DSM-IVにおけるADHDの等級別尺度からなる:18の項目を疾患の程度に対して0−3の尺度に等級別化した。同じ尺度がDSM-IVに挙げられているOppositional Defiant Disorder(ODD)症状およびConductDisorder(CD)行動に対して構成されている。親および教師はそれぞれの評価において上記尺度を完了した。さらに親は子供に対する一般的健康項目を完了した。
結果は、Glyco-1が既にメチルフェニデート単独によって得られた上記のADHD症候の改善以上の他の改善を与えないことを示した。しかしながら、Glyco-1を被試験者に投与した場合は、メチルフェニデートによって起こる副作用の統計学的に有意な減少が得られた。それ故に、全体的な健康の改善が達成される。
Glyco-1によるアルコール中毒症の治療
この研究に使用されたGlyco-1カプセルは、実施例6によって製造した。この研究の目的は、アルコール中毒者における気分状態およびアルコールの欲求に対する食物糖栄養補充の有効性を評価するものである。
Litlle Rock, Arkansasの地方アルコール支持グループから2つのグループの被試験者、すなわち3人の回復するアルコール中毒者および2人の実際のアルコール中毒者を募集した。それぞれのアルコール中毒者は、アルコール依存症に対するDiagnostic and Statistical Manual 4th Ed.(DSM-IV)の基準を満たした。回復するグループにおいては、禁酒は2.5年〜6年11ヶ月に変化した。両方のグループにおいて、アルコール乱用の年数は15〜30年でありそして年令は33〜62である。
評価手段は0〜9に分類されるアルコールに対する欲求の自己−等級別尺度およびProfile of Mood States(POMS)からなる。POMSの65の項目は年数5つの尺度、すなわち、認識力、憂うつ、エネルギー、怒り/かんしゃくおよび積極的な見方に分類した。これらの評価は、糖栄養物質を摂取する前および再び5週間の研究の終わりに完了した。
糖栄養物質は次のようにしてそれぞれのアルコール中毒者の食物に加えた;はじめの日において体重10ポンド当り1カプセルおよびその後、試験の期間中体重20ポンド当り1カプセル。他の介入物は導入しなかった。
結果は、5人の被試験者の平均の初期アルコール欲求が統計学的に有意に減少されたことを示す。同様に結果は、すべての測定された気分状態において統計学的に有意な改善を示す。
糖栄養物質による種々な疾患の治療
以下の表はGlyco-1を、単独でまたはPhyto-1、ヤマノイモ属コンプレックスを含有するGlyco-1およびPROFILETMの1種または2種以上と組み合わせて患者に投与した場合に得られた結果を要約する。以下に示した使用量において、Glyco-1および1種または2種以上のそれぞれのサプリメントの初期使用量を患者に与えた。
Fは糖栄養物質および薬草抽出液を含有する経口用食物サプリメントを示す。
科学者は最近、糖タンパク質はすべての細胞のコミュニケーションにおいて重要な役割を果たすということを証明した。サイトカイン、すなわち細胞のこの語の多くは、結合したグリコシル部分なしには適切に機能しない。身体は植物の炭水化物のような複合多糖を種々な単糖に加水分解しそしてこれらをオリゴ糖に再構成する。それから、このオリゴ糖は細胞のコミュニケーションそしてその結果良好な健康のためにサイトカインにより要求される糖タンパク質を構築するために、身体によって使用される。
上記説明は、本発明の特定の実施化の詳細な説明である。本発明の上記開示からみて、本発明の精神および範囲から離脱することなしに開示した実施化の明らかな変形をなし得ることは当業者に明らかである。開示されたこれらのすべては、本発明の開示からみて、不当な実験なしに実施することができる。本発明の範囲は、上記開示および均等な実施に明確に述べられている。本明細書は、本発明が受け得る保護範囲を不当にせばめるように解釈されるべきではない。
とくにことわらない限り、“a”および“an”なる用語は、“1”、“少なくとも1”または“1または2以上”を意味するものであることを示す。
Claims (17)
- (1) マンノースが単独で存在する場合は、それは単量体の形態で存在し;そして
(2) アセチル化マンノースが単独で存在する場合は、それは単量体の形態で存在するということを条件として、食物サプリメントが、ガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミン、キシロース、アラビノース、グルクロン酸、ガラクトウロン酸、イズロン酸、アラビノガラクタンおよびアセチル化マンノースからなる群から選択された単量体、オリゴマーまたは重合体および誘導化されたまたは誘導化されない形態の少なくとも1種のサッカリドの栄養的に有効な量を含有することからなる哺乳動物における糖タンパク質の必須の成分である栄養生成物サッカリドを与える食物サプリメント。 - 食物サプリメントが、ガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミン、キシロース、アラビノース、グルクロン酸、ガラクトウロン酸、イズロン酸、アラビノガラクタンおよびアセチル化マンノースからなる群から選択された単量体、オリゴマーまたは重合体および誘導化されたまたは誘導化されない形態の少なくとも2種のサッカリドの栄養的に有効な量を含有することからなる哺乳動物における糖タンパク質の必須の成分である栄養生成物サッカリドを与える食物サプリメント。
- 食物サプリメントが、ガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミン、キシロース、アラビノース、グルクロン酸、ガラクトウロン酸、イズロン酸、アラビノガラクタンおよびアセチル化マンノースからなる群から選択された単量体、オリゴマーまたは重合体および誘導化されたまたは誘導化されない形態の少なくとも3種のサッカリドの栄養的に有効な量を含有することからなる哺乳動物における糖タンパク質の必須の成分である栄養生成物サッカリドを与える食物サプリメント。
- 食物サプリメントが、ガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミン、キシロース、アラビノース、グルクロン酸、ガラクトウロン酸、イズロン酸、アラビノガラクタンおよびアセチル化マンノースからなる群から選択された単量体、オリゴマーまたは重合体および誘導化されたまたは誘導化されない形態の少なくとも4種のサッカリドの栄養的に有効な量を含有することからなる哺乳動物における糖タンパク質の必須の成分である栄養生成物サッカリドを与える食物サプリメント。
- 食物サプリメントが、ガラクトース、グルコース、マンノース、N−アセチルノイラミン酸、フコース、N−アセチルガラクトサミン、N−アセチルグルコサミン、キシロース、アラビノース、グルクロン酸、ガラクトウロン酸、イズロン酸、アラビノガラクタンおよびアセチル化マンノースからなる群から選択された単量体、オリゴマーまたは重合体および誘導化されたまたは誘導化されない形態の少なくとも5種のサッカリドの栄養的に有効な量を含有することからなる哺乳動物における糖タンパク質の必須の成分である栄養生成物サッカリドを与える食物サプリメント。
- サッカリドが、トラガカントゴム、グアーゴム、穀類の粒粉、米粉、さとうきび、甜菜糖、馬鈴薯、ミルク、寒天、アルギン、イナゴマメゴム、事前子、イソドゴム、種子ゴム、カラマツの木の抽出液、アロエベラ抽出液、ガッチゴム、澱粉、セルロース、分解したセルロース、フラクトース、高フラクトースコーンシロップ、ペクチン、キチン、アラビアゴム、アルギン酸、カラゲナン、デキストラン、キサンタンゴム、コンドロイチン硫酸、スクロース、アセチル化ポリマンノース、マルトース、グルカン、レンチナン、マンナン、レバン、ヘミ−セルロース、インスリン、フラクタンおよびラクトースに存在するオリゴマーまたは重合体形態で与えられる請求項2、3、4または5記載の食物サプリメント。
- さらに、ヤマノイモ属コンプレックスの栄養的に有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- さらに熟成したそして凍結乾燥した粉末化した生の果実および野菜からなる混合物の栄養的に有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- さらにキサンチンおよび薬草のボディー−トニング剤の栄養的に有効な量を含有する請求項8記載の食物サプリメント。
- 熟成したそして凍結乾燥したそして粉末化した生の果実および野菜からなる混合物がブロッコリー、芽キャベツ、キャベツ、人参、花キャベツ、にんにく、ケール、たまねぎ、パパイア、パイナップル、トマトおよびかぶを包含する請求項8記載の食物サプリメント。
- さらにベータシトステロールの栄養的に有効な量を含有する請求項7記載の食物サプリメント。
- さらにメラトニンの栄養的に有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- さらにサッカリド生物吸収助剤の有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- 生物吸収助剤が大豆レシチンを包含する請求項13記載の食物サプリメント。
- さらにヤマノイモ属コンプレックスおよび熟成したそして凍結乾燥したそして粉末化した生の果実および野菜からなる混合物の栄養的に有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- さらに非毒性のビタミンおよび無機質の栄養的に有効な量を含有する請求項1、2、3、4または5記載の食物サプリメント。
- ビタミンがA、B1、B12、B2、B6、ベータ−カロテン、ビオフラバノイド、ビオチン、C、コリン、D、E、葉酸、イノシトール、K、ナイアシンアミド、パラアミノ安息香酸およびパントテン酸からなりそして無機質が硼素、カルシウム、銅、GTFクロム、沃素、鉄、マグネシウム、マンガン、モリブデン、カリウム、セレン、珪素、バナジウム、亜鉛からなる請求項16記載の食物サプリメント。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US2246796P | 1996-08-09 | 1996-08-09 | |
US60/022,467 | 1996-08-09 | ||
US3031796P | 1996-11-01 | 1996-11-01 | |
US60/030,317 | 1996-11-01 | ||
US5701797P | 1997-07-24 | 1997-07-24 | |
US60/057,017 | 1997-07-24 |
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JP50977298A Division JP5020424B2 (ja) | 1996-08-09 | 1997-08-04 | 食物補強剤としての植物炭水化物の組成物 |
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JP2011050908A Division JP5094981B2 (ja) | 1996-08-09 | 2011-03-09 | 食物サプリメントとしての植物炭水化物の組成物 |
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JP2008183013A true JP2008183013A (ja) | 2008-08-14 |
JP2008183013A5 JP2008183013A5 (ja) | 2010-11-11 |
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JP50977298A Expired - Fee Related JP5020424B2 (ja) | 1996-08-09 | 1997-08-04 | 食物補強剤としての植物炭水化物の組成物 |
JP2008095695A Expired - Fee Related JP4741625B2 (ja) | 1996-08-09 | 2008-04-02 | 食物サプリメントとしての植物炭水化物の組成物 |
JP2011050908A Expired - Lifetime JP5094981B2 (ja) | 1996-08-09 | 2011-03-09 | 食物サプリメントとしての植物炭水化物の組成物 |
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JP50977298A Expired - Fee Related JP5020424B2 (ja) | 1996-08-09 | 1997-08-04 | 食物補強剤としての植物炭水化物の組成物 |
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JP2011050908A Expired - Lifetime JP5094981B2 (ja) | 1996-08-09 | 2011-03-09 | 食物サプリメントとしての植物炭水化物の組成物 |
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EP (2) | EP1172041B2 (ja) |
JP (3) | JP5020424B2 (ja) |
KR (1) | KR100450097B1 (ja) |
CN (1) | CN1227495A (ja) |
AR (1) | AR009037A1 (ja) |
AT (2) | ATE311763T1 (ja) |
AU (2) | AU734183C (ja) |
BR (1) | BR9711054B1 (ja) |
CA (1) | CA2262972C (ja) |
CZ (1) | CZ39699A3 (ja) |
DE (2) | DE69712896T2 (ja) |
DK (1) | DK1172041T4 (ja) |
ES (2) | ES2175442T3 (ja) |
HK (2) | HK1020531A1 (ja) |
IL (1) | IL128335A0 (ja) |
MX (1) | MX212260B (ja) |
MY (1) | MY117459A (ja) |
NO (1) | NO990572L (ja) |
NZ (2) | NZ334021A (ja) |
PH (1) | PH11997057533B1 (ja) |
PL (1) | PL331541A1 (ja) |
SK (1) | SK16399A3 (ja) |
TR (1) | TR199900278T2 (ja) |
TW (1) | TW561051B (ja) |
WO (1) | WO1998006418A1 (ja) |
ZA (1) | ZA977102B (ja) |
Cited By (3)
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US8283338B2 (en) | 2007-11-30 | 2012-10-09 | Kao Corporation | GIP secretion inhibitor |
US8338389B2 (en) | 2009-06-17 | 2012-12-25 | Kao Corporation | Agent for preventing or ameliorating obesity |
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US8338389B2 (en) | 2009-06-17 | 2012-12-25 | Kao Corporation | Agent for preventing or ameliorating obesity |
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