JP2007283096A - 多孔質生体吸収性材料およびその製造方法 - Google Patents
多孔質生体吸収性材料およびその製造方法 Download PDFInfo
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- JP2007283096A JP2007283096A JP2007073714A JP2007073714A JP2007283096A JP 2007283096 A JP2007283096 A JP 2007283096A JP 2007073714 A JP2007073714 A JP 2007073714A JP 2007073714 A JP2007073714 A JP 2007073714A JP 2007283096 A JP2007283096 A JP 2007283096A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2207/00—Foams characterised by their intended use
- C08J2207/10—Medical applications, e.g. biocompatible scaffolds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2300/00—Characterised by the use of unspecified polymers
- C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
【解決手段】生体吸収性重合体を相溶性のある該生体吸収性重合体の良溶媒と貧溶媒によりゲル化し、該ゲル化した生体吸収性重合体を凍結乾燥して多孔質化した生体吸収性重合体で構成されたことを特徴とする多孔質生体吸収性材料、および生体吸収性重合体を相溶性のある該生体吸収性重合体の良溶媒と貧溶媒の混合溶媒でゲル化し、該ゲル化したゲル化物を凍結乾燥して多孔質化することを特徴とする多孔質生体吸収性材料の製造方法。
【選択図】図1
Description
本発明において使用する前記生体吸収性重合体のゲル化物は、前記生体吸収性重合体、互いに相溶する該生体吸収性重合体の貧溶媒および良溶媒を有する混合物において、前記貧溶媒として前記生体吸収性重合体をゲル化するに必要な量を配合して前記生体吸収性重合体をゲル化状態として相分離させたものを分離して調製する。また、前記混合物における前記生体吸収性重合体の量は特に制限されないが、通常、0.1〜24質量%、好ましくは2〜8質量%、より好ましくは3〜5質量%である。
構造体であること、(3)凍結乾燥工程の冷却方法が急冷、あるいは徐冷であってもポアサイズ平均の変化が少なく、また孔の大きさが整い、かつポアサイズ平均の小さい多孔質体は貧溶媒が得られる。さらにゲル調製工程の貧溶媒である水の配合量を変化させることにより、凍結乾燥工程の冷却方法が急冷、あるいは徐冷であっても前記の小さく、かつ整った小さなポアサイズ平均という特性を維持したまま、ポアサイズ平均自体も変化させることができる。さらに前記実施例1の試験結果からサンプルD〜Rのラクチド−カプロラクトン共重合体のゲル化物から製造した多孔質体は、生体吸収性材料が最大応力3.4〜23.1(MPa)、気孔率(%)0.1〜82%、ポアサイズ平均9〜21(μm)であることが分かる。
2 サンプリングポート
3 チャンバー(グルコース側)
4 シリコーン膜
5 サンプルD、EおよびAから作製した多孔質体薄膜からなる検体膜
6 チャンバー(RO水側)
7 スターラー
Claims (10)
- 生体吸収性材料が最大応力3〜23(MPa)、気孔率0.1〜82(%)、およびポアサイズ平均9〜34(μm)であることを特徴とする多孔質生体吸収性材料。
- 生体吸収性重合体がラクチドとカプロラクトンとの共重合体である請求項1に記載の多孔質生体吸収性材料。
- 50〜600μmの薄膜である請求項1または2に記載の多孔質生体吸収性材料。
- 50〜500μmの薄膜の腱癒着防止材である請求項3に記載の多孔質生体吸収性材料。
- 生体吸収性重合体を相溶性のある該生体吸収性重合体の良溶媒と貧溶媒によりゲル化し、該ゲル化した生体吸収性重合体を凍結乾燥して製造したことを特徴とする請求項1〜4のいずれかに記載の多孔質生体吸収性材料。
- 生体吸収性重合体を相溶性のある該生体吸収性重合体の良溶媒と貧溶媒の混合溶媒でゲル化し、該ゲル化したゲル化物を凍結乾燥して多孔質化することを特徴とする請求項1〜5のいずれかに記載の多孔質生体吸収性材料の製造方法。
- 良溶媒がジオキサン、貧溶媒が水の組合せであることを特徴とする請求項6に記載の生体吸収性材料の製造方法。
- 貧溶媒の配合量が12〜40重量%である請求項6または7に記載の生体吸収性材料の製造方法。
- 前記ゲル化物の冷却速度を変化させることによって多孔質生体吸収性重合体の孔径をコントロールする請求項6〜8のいずれかに記載の生体吸収性材料の製造方法。
- 前記ゲル化物の調製段階における貧溶媒の配合量を変化させることによって、多孔質生体吸収性重合体の気孔率をコントロールする請求項6〜9のいずれかに記載の生体吸収性材料の製造方法。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2007/055771 WO2007111205A1 (ja) | 2006-03-20 | 2007-03-20 | 多孔質生体吸収性材料およびその製造方法 |
JP2007073714A JP2007283096A (ja) | 2006-03-20 | 2007-03-20 | 多孔質生体吸収性材料およびその製造方法 |
KR1020087021988A KR20090003208A (ko) | 2006-03-20 | 2007-03-20 | 다공질 생체 흡수성 재료 및 그의 제조방법 |
US12/293,153 US20090208586A1 (en) | 2006-03-20 | 2007-03-20 | porous bioabsorbable material and method of producing the same |
EP07739214A EP2002851A4 (en) | 2006-03-20 | 2007-03-20 | POROUS BIOABSORBENT MATERIAL AND PRODUCTION PROCESS |
Applications Claiming Priority (2)
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JP2006076177 | 2006-03-20 | ||
JP2007073714A JP2007283096A (ja) | 2006-03-20 | 2007-03-20 | 多孔質生体吸収性材料およびその製造方法 |
Publications (2)
Publication Number | Publication Date |
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JP2007283096A true JP2007283096A (ja) | 2007-11-01 |
JP2007283096A5 JP2007283096A5 (ja) | 2010-04-30 |
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Application Number | Title | Priority Date | Filing Date |
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JP2007073714A Pending JP2007283096A (ja) | 2006-03-20 | 2007-03-20 | 多孔質生体吸収性材料およびその製造方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090208586A1 (ja) |
EP (1) | EP2002851A4 (ja) |
JP (1) | JP2007283096A (ja) |
KR (1) | KR20090003208A (ja) |
WO (1) | WO2007111205A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012080917A (ja) * | 2010-10-06 | 2012-04-26 | Hitachi Chemical Co Ltd | 癒着防止材 |
JP2012080918A (ja) * | 2010-10-06 | 2012-04-26 | Hitachi Chemical Co Ltd | 手術用衛生材料 |
JP2012512705A (ja) * | 2008-12-19 | 2012-06-07 | キシロス・コーポレーション | 最小限組織付着移植可能材料 |
JP2015231564A (ja) * | 2015-08-19 | 2015-12-24 | 日立化成株式会社 | 癒着防止材 |
JP2016027854A (ja) * | 2015-08-19 | 2016-02-25 | 日立化成株式会社 | 手術用衛生材料 |
JP2018089370A (ja) * | 2016-12-05 | 2018-06-14 | グンゼ株式会社 | 神経癒着防止ラッピング材 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2923825B1 (fr) * | 2007-11-20 | 2013-05-03 | Anaconda Pharma | Nouveaux inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant. |
KR20120088786A (ko) * | 2009-12-08 | 2012-08-08 | 가부시끼가이샤 제이엠에스 | 다공성 부재, 다공화 방법 및 상기 다공성 부재의 제조 방법 |
JP5835769B2 (ja) * | 2011-09-12 | 2015-12-24 | 国立大学法人秋田大学 | 親水性多孔質膜及びその製造方法、並びに、医療用癒着防止膜及び細胞増殖用基材 |
FR2989973B1 (fr) * | 2012-04-27 | 2014-06-06 | Centre Nat Rech Scient | Materiaux nanostructures biodegradables, leur procede de preparation et leur utilisation pour le transport et le relargage de substances d'interet |
US9345817B2 (en) | 2013-02-28 | 2016-05-24 | Arthrex, Inc. | Modified porous materials and methods of creating interconnected porosity in materials |
WO2020205913A1 (en) * | 2019-04-03 | 2020-10-08 | University Of Central Florida Research Foundation, Inc. | Frozen, porous thin films and methods of making and use thereof |
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JPS6456055A (en) * | 1987-08-26 | 1989-03-02 | Nippon Medical Supply | Medical molded article composed of lactic acid/epsilon-caprolactone copolymer and its preparation |
JP2000197693A (ja) * | 1998-10-19 | 2000-07-18 | Jms Co Ltd | 多孔性癒着防止材 |
JP2002538914A (ja) * | 1999-03-18 | 2002-11-19 | コリア アドバンスト インスティテュート オブ サイエンス アンド テクノロジ− | 生体組織工学用多孔性生分解性生適合性高分子支持体の製造方法 |
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JP2006519273A (ja) * | 2003-02-19 | 2006-08-24 | マクマスター ユニバーシティー | 支持型多孔質ゲルを含んでなる複合材 |
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2007
- 2007-03-20 US US12/293,153 patent/US20090208586A1/en not_active Abandoned
- 2007-03-20 KR KR1020087021988A patent/KR20090003208A/ko not_active Application Discontinuation
- 2007-03-20 EP EP07739214A patent/EP2002851A4/en not_active Withdrawn
- 2007-03-20 JP JP2007073714A patent/JP2007283096A/ja active Pending
- 2007-03-20 WO PCT/JP2007/055771 patent/WO2007111205A1/ja active Application Filing
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012512705A (ja) * | 2008-12-19 | 2012-06-07 | キシロス・コーポレーション | 最小限組織付着移植可能材料 |
JP2012080917A (ja) * | 2010-10-06 | 2012-04-26 | Hitachi Chemical Co Ltd | 癒着防止材 |
JP2012080918A (ja) * | 2010-10-06 | 2012-04-26 | Hitachi Chemical Co Ltd | 手術用衛生材料 |
JP2015231564A (ja) * | 2015-08-19 | 2015-12-24 | 日立化成株式会社 | 癒着防止材 |
JP2016027854A (ja) * | 2015-08-19 | 2016-02-25 | 日立化成株式会社 | 手術用衛生材料 |
JP2018089370A (ja) * | 2016-12-05 | 2018-06-14 | グンゼ株式会社 | 神経癒着防止ラッピング材 |
Also Published As
Publication number | Publication date |
---|---|
WO2007111205A1 (ja) | 2007-10-04 |
US20090208586A1 (en) | 2009-08-20 |
KR20090003208A (ko) | 2009-01-09 |
EP2002851A9 (en) | 2009-04-22 |
EP2002851A4 (en) | 2012-08-01 |
EP2002851A2 (en) | 2008-12-17 |
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