JP2007063188A - Dentifrice composition - Google Patents
Dentifrice composition Download PDFInfo
- Publication number
- JP2007063188A JP2007063188A JP2005251574A JP2005251574A JP2007063188A JP 2007063188 A JP2007063188 A JP 2007063188A JP 2005251574 A JP2005251574 A JP 2005251574A JP 2005251574 A JP2005251574 A JP 2005251574A JP 2007063188 A JP2007063188 A JP 2007063188A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- gum
- erythritol
- less
- toothpaste composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 239000000551 dentifrice Substances 0.000 title claims abstract description 6
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 40
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000004386 Erythritol Substances 0.000 claims abstract description 37
- 235000019414 erythritol Nutrition 0.000 claims abstract description 37
- 229940009714 erythritol Drugs 0.000 claims abstract description 37
- 239000002245 particle Substances 0.000 claims abstract description 30
- 239000011230 binding agent Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000606 toothpaste Substances 0.000 claims description 33
- 229940034610 toothpaste Drugs 0.000 claims description 33
- 229920000591 gum Polymers 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 240000004584 Tamarindus indica Species 0.000 claims description 2
- 235000004298 Tamarindus indica Nutrition 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000305 astragalus gummifer gum Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 244000134552 Plantago ovata Species 0.000 claims 1
- 235000003421 Plantago ovata Nutrition 0.000 claims 1
- 239000009223 Psyllium Substances 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 229940070687 psyllium Drugs 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 description 11
- 210000000214 mouth Anatomy 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 239000004088 foaming agent Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229910021536 Zeolite Inorganic materials 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 239000010457 zeolite Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
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- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 description 1
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- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- 239000005749 Copper compound Substances 0.000 description 1
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- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
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- 235000019418 amylase Nutrition 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
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- 229960003438 aspartame Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
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- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
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- 230000001680 brushing effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 150000001880 copper compounds Chemical class 0.000 description 1
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- 230000001186 cumulative effect Effects 0.000 description 1
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- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
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- 229960003720 enoxolone Drugs 0.000 description 1
- QYIXCDOBOSTCEI-FBVYSKEZSA-N epidihydrocholesterin Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-FBVYSKEZSA-N 0.000 description 1
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- 229960002217 eugenol Drugs 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
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- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
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- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000011644 potassium salts of orthophosphoric acid Substances 0.000 description 1
- 235000019858 potassium salts of orthophosphoric acid Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
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- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 235000019857 sodium salts of orthophosphoric acid Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
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- 235000019721 spearmint oil Nutrition 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
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- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、エリスリトールを含有する歯磨き組成物に関する。 The present invention relates to a dentifrice composition containing erythritol.
一般的に歯を磨く目的は、口腔内を清潔にし、清涼感を得ることにある。通常歯磨き組成物に配合されているメントールに代表される香料成分は、清涼感を付与するために必要不可欠なものであるが、近年、油っぽい食事や香辛料を多く使った食事が多くなる傾向があり、より高い清涼感を持った歯磨き組成物が望まれている。 In general, the purpose of brushing teeth is to clean the mouth and obtain a refreshing feeling. A fragrance ingredient represented by menthol, which is usually included in a toothpaste composition, is indispensable for imparting a refreshing feeling, but in recent years, there has been a tendency to increase the number of oily meals and meals using spices. Therefore, a toothpaste composition having a higher refreshing feeling is desired.
清涼感を向上させる手段として、香料成分の配合量を増やしたり、エタノール等の溶剤成分を新たに添加するといった方法があるが、これらの成分の配合量を増やすと口腔内への刺激が強くなり、また泡立ちが抑制されるため、磨いたときの使用感を損ねるという問題が生じる。 As a means to improve the refreshing feeling, there are methods such as increasing the blending amount of perfume ingredients or adding a solvent component such as ethanol. However, increasing the blending amount of these ingredients increases the irritation in the oral cavity. Moreover, since foaming is suppressed, there arises a problem that the feeling of use when polished is impaired.
従って、香料成分やエタノール等の溶剤の配合量を増やすことなく、より高い清涼感を得る歯磨き組成物が望まれる。 Therefore, a toothpaste composition that achieves a higher refreshing feeling without increasing the blending amount of a fragrance component or a solvent such as ethanol is desired.
特許文献1には、エリスリトールなどの吸熱水和反応を起こす成分を含有し、かつ、水分量が10質量%以下であることを特徴とした、清涼感に優れる歯磨き組成物が開示されている。しかしながら、水分含量が低いために、粘結剤として配合されている水溶性高分子が十分に溶解せず、経時的に水分や他の液体成分が系外に染み出す現象が見られ、保存安定性に問題があった。また、清涼感は得られるものの口腔内ではっきりとした冷涼感を得るまでには至っていなかった。
本発明は、より高い清涼感を有し、保存安定性及び冷涼感の即効性に優れたエリスリトールを含有する歯磨き組成物を提供することを目的とする。 An object of the present invention is to provide a toothpaste composition containing erythritol having a higher refreshing feeling and excellent storage stability and immediate effect of cooling feeling.
本発明は、次の成分(A)、(B)及び(C):
(A)粒子径が45μm未満のエリスリトール 15〜60質量%
(B)水 15〜30質量%
(C)粘結剤 0.6〜3質量%
を含有する歯磨き組成物である。
また、本発明は、次の成分(A)、(B)及び(C):
(A)粒子径が45μm未満のエリスリトール 20〜60質量%
(B)水 15〜30質量%
(C)粘結剤 0.6〜3質量%
を配合する歯磨き組成物である。
The present invention includes the following components (A), (B) and (C):
(A) Erythritol having a particle size of less than 45 μm 15 to 60% by mass
(B) Water 15-30% by mass
(C) Binder 0.6-3 mass%
A toothpaste composition containing
The present invention also includes the following components (A), (B) and (C):
(A) Erythritol having a particle diameter of less than 45 μm 20 to 60% by mass
(B) Water 15-30% by mass
(C) Binder 0.6-3 mass%
Is a toothpaste composition.
本発明に係る歯磨き組成物は、保存安定性に優れ、口腔に適用すると、即効的な冷涼感が得られることで香料成分やエタノール等の溶剤の配合量を増やすことなくより高い清涼感をも得られる。 The toothpaste composition according to the present invention is excellent in storage stability and, when applied to the oral cavity, provides an immediate cooling feeling without increasing the blending amount of fragrance ingredients and solvents such as ethanol, etc. can get.
本発明の歯磨き組成物は、粒子径が45μm未満のエリスリトール(成分(A))を含有することを特徴とする。通常入手可能なエリスリトールは、ブドウ糖を発酵させた後、再結晶して得られる結晶状のエリスリトールであり、その粒子径は本発明品のものよりも大きい。従って、本発明の歯磨き組成物には入手したエリスリトールを粉砕して粒子径を調整したものを使用することが好ましい。
エリスリトールの粉砕には、ローラミル、ハンマーミル、高速度粉砕機、パルベライザーなどを使用するのが一般的であるが、粒度の調整が簡便で、かつ、生産効率にも優れる高速度粉砕機、ハンマーミルによる粉砕が好ましい。
また、エリスリトールの構造としては、L−エリスリトール、D−エリスリトール、meso−エリスリトールの3種の異性体が存在するが、本発明はこれらいずれの構造のものであってもよい。結晶状のエリスリトールは、市販品としては、日研化学(株)、三菱化学フーズ(株)、セレスター社製等のものが入手可能である。
The dentifrice composition of the present invention is characterized by containing erythritol (component (A)) having a particle size of less than 45 μm. Normally available erythritol is crystalline erythritol obtained by recrystallizing after fermenting glucose, and its particle size is larger than that of the product of the present invention. Therefore, it is preferable to use what obtained the erythritol grind | pulverized and adjusted the particle diameter for the toothbrushing composition of this invention.
A roller mill, hammer mill, high-speed pulverizer, pulverizer, etc. are generally used to pulverize erythritol, but a high-speed pulverizer and hammer mill that are easy to adjust the particle size and excellent in production efficiency. Is preferred.
The structure of erythritol includes three isomers of L-erythritol, D-erythritol, and meso-erythritol, and the present invention may have any of these structures. As crystalline erythritol, commercially available products such as those manufactured by Nikken Chemical Co., Ltd., Mitsubishi Chemical Foods Co., Ltd., and Celestor are available.
本発明の歯磨き組成物中、粒子径が45μm未満のエリスリトールの含有量は、清涼感及び冷涼感の観点から15〜60質量%、より好ましくは20〜55質量%、さらにより好ましくは25〜50質量%、最も好ましくは30〜50質量%である。
このため粒子径が45μm未満のエリスリトールの配合量は、清涼感及び冷涼感の観点から20〜60質量%、より好ましくは25〜55質量%、さらにより好ましくは30〜50質量%、最も好ましくは35〜50質量%である。
In the toothpaste composition of the present invention, the content of erythritol having a particle size of less than 45 μm is 15 to 60% by mass, more preferably 20 to 55% by mass, and even more preferably 25 to 50% from the viewpoints of refreshing feeling and cooling feeling. % By mass, most preferably 30-50% by mass.
For this reason, the blending amount of erythritol having a particle size of less than 45 μm is 20 to 60% by mass, more preferably 25 to 55% by mass, even more preferably 30 to 50% by mass, and most preferably from the viewpoints of coolness and coolness. It is 35-50 mass%.
本発明に用いられるエリスリトールの粒子径は、口腔内で瞬時に溶けて冷涼感が即効的に得られるという観点から45μm未満であるが、好ましくは3μm以上45μm未満、さらに好ましくは5μm以上45μm未満である。また、エリスリトールの粒子径が45μmを超えるものは、口腔内で瞬時に溶けずに徐々に溶けるため、即効的な冷涼感は得られにくい。 The particle size of erythritol used in the present invention is less than 45 μm from the viewpoint that it instantly dissolves in the oral cavity and a cooling sensation can be obtained immediately, preferably 3 μm or more and less than 45 μm, more preferably 5 μm or more and less than 45 μm. is there. In addition, when the erythritol particle diameter exceeds 45 μm, it does not melt instantaneously in the oral cavity but gradually melts, so that it is difficult to obtain an immediate cool feeling.
なお、エリスリトールの粒子径は以下のように測定される。
篩:JIS標準篩 φ75mm
目開き:上段より、それぞれ500μm、355μm、250μm、180μm、125
μm、90μm及び45μmの目開きを有する篩の下に受器を有する。
振盪機:ミクロ型電磁振動機M−2型(筒井理化学器機(株))
方法:試料15gを500μm篩上に載せ、電磁振動機にて5分間分級する。
45μm篩を通過し受器上に存在するエリスリトールが粒子径45μm未満のエリスリトールとする。
また、45μm未満の粒度分布及び平均粒子径は乾式レーザー分布回折式粒度分布測定装置により測定することができる。
The erythritol particle size is measured as follows.
Sieve: JIS standard sieve φ75mm
Aperture: 500 μm, 355 μm, 250 μm, 180 μm, 125 from the top
The receiver is located under a sieve with openings of μm, 90 μm and 45 μm.
Shaker: Micro type electromagnetic vibrator M-2 type (Tsutsui Rikenki Co., Ltd.)
Method: Place 15 g of sample on 500 μm sieve and classify with electromagnetic vibrator for 5 minutes.
The erythritol that passes through the 45 μm sieve and is present on the receiver is erythritol having a particle diameter of less than 45 μm.
The particle size distribution and average particle size of less than 45 μm can be measured with a dry laser distribution diffraction type particle size distribution measuring device.
本発明の歯磨き組成物中、水(成分(B))の含有量は、保存安定性の観点から15質量%以上が好ましく、また高い清涼感及び冷涼感を得る観点から30質量%以下が好ましい。より好ましくは、15〜25質量%である。15質量%未満では粘結剤を溶解しにくく安定性が低下し、他方30質量%を超えると十分な清涼感及び冷涼感を得ることが難しくなる。 In the toothpaste composition of the present invention, the content of water (component (B)) is preferably 15% by mass or more from the viewpoint of storage stability, and is preferably 30% by mass or less from the viewpoint of obtaining a high refreshing feeling and cooling feeling. . More preferably, it is 15-25 mass%. If it is less than 15% by mass, it is difficult to dissolve the binder, and the stability is lowered. On the other hand, if it exceeds 30% by mass, it becomes difficult to obtain a sufficient refreshing feeling and cooling feeling.
本発明に用いられる粘結剤(成分(C))としては、特に制限されないが、アルギン酸ナトリウム、カルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガム、ポリアクリル酸ナトリウム、ヒドロキシエチルセルロース、ヒドロキプロピルセルロース、ペクチン、トラガントガム、アラビアガム、グアーガム、カラヤガム、ローカストビーンガム、ジェランガム、タマリンドガム、サイリウムシードガム、ポリビニルアルコール、コンドロイチン硫酸ナトリウム、メトキシエチレン無水マレイン酸共重合体から選ばれる水溶性高分子を1種または2種以上使用するのが好ましい。
本発明の歯磨き組成物中、粘結剤の含有量は、保存安定性の観点から0.6〜3質量%、より好ましくは、0.7〜2質量%、さらにより好ましくは、0.8〜1.2質量%である。0.6質量%未満では安定性が十分ではなく、他方3質量%を超えると組成物の粘性が高くなって、清涼感が損なわれてしまう。
The binder (component (C)) used in the present invention is not particularly limited, but sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, Arabic One or more water-soluble polymers selected from gum, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and methoxyethylene maleic anhydride copolymer are used. Is preferred.
In the toothpaste composition of the present invention, the content of the binder is from 0.6 to 3% by mass, more preferably from 0.7 to 2% by mass, and even more preferably from the viewpoint of storage stability. It is -1.2 mass%. If it is less than 0.6% by mass, the stability is not sufficient, while if it exceeds 3% by mass, the viscosity of the composition becomes high and the refreshing feeling is impaired.
本発明の歯磨き組成物には、前記成分の他、例えば発泡剤、発泡助剤、研磨剤、湿潤剤、甘味剤、保存料、酵素、pH調整剤、殺菌剤、薬効成分、顔料、色素、香料等を適宜含有させることができる。また、粒子径45μm以上のエリスリトールを含有させてもよい。この場合、組成物中に含有するエリスリトールの平均粒子径又は配合するエリスリトールの平均粒子径は200μm以下が好ましく、更に好ましくは10〜150μmである。なお、平均粒子径は、45μm以上の場合は篩下率(積算量)を正規確立紙にプロットし、50%に対応する値を採用し、45μm未満の場合は乾式レーザー分布回折式粒度分布測定装置の値を採用する。 In the toothpaste composition of the present invention, in addition to the above components, for example, a foaming agent, foaming aid, abrasive, wetting agent, sweetener, preservative, enzyme, pH adjuster, bactericidal agent, medicinal component, pigment, dye, A fragrance | flavor etc. can be contained suitably. Moreover, you may contain the erythritol with a particle diameter of 45 micrometers or more. In this case, the average particle size of erythritol contained in the composition or the average particle size of erythritol to be blended is preferably 200 μm or less, more preferably 10 to 150 μm. When the average particle size is 45 μm or more, the sieving rate (cumulative amount) is plotted on regular established paper, and the value corresponding to 50% is adopted. When the average particle size is less than 45 μm, dry laser distribution diffraction particle size distribution measurement Use the value of the device.
研磨剤としては、沈降性シリカ、シリカゲル、アルミノシリケート、ジルコノシリケート等のシリカ系研磨剤;第2リン酸カルシウム・2水和物及び無水和物、ピロリン酸カルシウム、炭酸カルシウム、アルミナ、水酸化アルミニウム、酢酸マグネシウム、第3リン酸マグネシウム、ゼオライト、合成樹脂系研磨剤等が好適に用いられる。 As abrasives, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate; dicalcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide, acetic acid Magnesium, tribasic magnesium phosphate, zeolite, synthetic resin-based abrasive and the like are preferably used.
湿潤剤としては、グリセリン、ソルビトール、プロピレングリコール、ポリエチレングリコール、キシリトール、マルチット、ラクチット、トレハロース等が好適に用いられる。
更に、甘味剤としては、サッカリンナトリウム、アスパルテーム、ソーマチン、アセスルファムカリウム、ステビオサイド、ステビアエキス、パラメトキシシンナミックアルデヒド、ネオヘスペリジルジヒドロカルコン、ペリラルチン等が挙げられる。
As the wetting agent, glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, maltite, lactit, trehalose and the like are preferably used.
Furthermore, examples of the sweetening agent include saccharin sodium, aspartame, thaumatin, acesulfame potassium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin.
香料としては、l−メントール、カルボン、アネトール、オイゲノール、リモネン、ペパーミント油、スペアミント油、オシメン、n−アミルアルコール、シトロネロール、α−テルピネオール、サリチル酸メチル、メチルアセテート、シトロネオールアセテート、シネオール、リナロール、エチルリナロール、ワニリン、チモール、レモン油、オレンジ油、セージ油、ローズマリー油、桂皮油、ピメント油、シソ油、丁子油、ユーカリ油等が挙げられる。 As a fragrance, 1-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, ocimen, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool, Examples include ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, and eucalyptus oil.
また、その他の各種有効成分としては、正リン酸のカリウム塩、ナトリウム塩等の水溶性リン酸化合物;アラントインクロルヒドロキシアルミニウム、アズレン、グリチルレチン酸、エピジヒドロコレステリン、α−ビサボロール、グリチルリチン酸及びその塩類等の抗炎症剤;ヒノキチオール等のフェノール性化合物;トラネキサム酸、イプシロンアミノカプロン酸等の抗プラスミン剤;酢酸dl−トコフェロールのビタミンE類;銅クロロフィリンナトリウム、グルコン酸銅等の銅化合物;塩化ナトリウム、硝酸カリウム等の塩類;トリクロサン、塩化セチルピリジニウム、塩化ベンゼトニウム等の第四級アンモニウム化合物、クロルヘキシジン塩類、トリクロロカルバニリド等の殺菌剤;デキストラナーゼ、ムタナーゼ、アミラーゼ、塩化リゾチーム等の酵素;トウキ、オウバク、チョウジ、ローズマリー、オウゴン、ベニバナ等の抽出物;乳酸アルミニウム、塩化ストロンチウム、ベルベリン、ヒドロキサム酸及びその誘導体、トリポリリン酸ナトリウム、ゼオライト、ポリビニルピロリドン、ジヒドロコレステロール、クエン酸亜鉛等が挙げられる。 In addition, as other various active ingredients, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid; allantochlorohydroxyaluminum, azulene, glycyrrhetinic acid, epidihydrocholesterin, α-bisabolol, glycyrrhizic acid and Anti-inflammatory agents such as salts; phenolic compounds such as hinokitiol; antiplasmin agents such as tranexamic acid and epsilon aminocaproic acid; vitamin Es of dl-tocopherol acetate; copper compounds such as copper chlorophyllin sodium and copper gluconate; sodium chloride; Salts such as potassium nitrate; bactericides such as quaternary ammonium compounds such as triclosan, cetylpyridinium chloride, benzethonium chloride, chlorhexidine salts, trichlorocarbanilide; dextranase, mutanase, amylase, chloride Enzymes such as lysozyme; extracts such as sugarcane, duck, clove, rosemary, hornon, safflower; aluminum lactate, strontium chloride, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, polyvinylpyrrolidone, dihydrocholesterol, citric acid Zinc etc. are mentioned.
本発明の歯磨き組成物は、より高い清涼感を得る観点から、エリスリトールが粉末の状態で分散しているのが望ましい。そのためには、エリスリトールは製造の最終工程に、粉体のままで投入することが好ましい。このような製造方法を用いることで、エリスリトールは水にほとんど溶解せずに、歯磨き組成物中に粉末の状態で存在させることが可能となる。具体的には、例えば、精製水、湿潤剤、粘結剤、香味剤、保存料、研磨剤、発泡剤、甘味剤及び薬効成分等の各成分を処方量計測した後、一定の製造条件に従って混合し、粘結剤を十分に膨潤させ、さらに、研磨剤及び発泡剤、香味剤、粉末状のエリスリトールを加えて脱泡混合し、本発明の歯磨き組成物を製造できる。 In the toothpaste composition of the present invention, it is desirable that erythritol is dispersed in a powder state from the viewpoint of obtaining a higher refreshing feeling. For this purpose, erythritol is preferably added as a powder to the final step of production. By using such a production method, erythritol can be present in a powder state in the toothpaste composition without being substantially dissolved in water. Specifically, for example, after measuring the prescribed amount of each component such as purified water, wetting agent, binder, flavoring agent, preservative, polishing agent, foaming agent, sweetener, and medicinal component, according to certain production conditions The toothpaste composition of the present invention can be produced by mixing and fully swelling the binder, and further adding a polishing agent, a foaming agent, a flavoring agent, and powdered erythritol and defoaming and mixing.
本発明の歯磨き組成物の25℃における粘度(ヘリパス型粘度計、ロータC、2.5r/min、1分間)は、1500〜5000dPa・s、さらに2000〜4500dPa・s、特に2500〜4000dPa・sが好ましい。 The toothpaste composition of the present invention has a viscosity at 25 ° C. (helicus type viscometer, rotor C, 2.5 r / min, 1 minute) of 1500 to 5000 dPa · s, further 2000 to 4500 dPa · s, particularly 2500 to 4000 dPa · s. Is preferred.
<歯磨き組成物の調製>
表1に示す組成に従って、実施例1〜3及び比較例1〜3の歯磨き組成物を調製した。
なお、エリスリトールは最後に添加した。
<Preparation of toothpaste composition>
According to the composition shown in Table 1, toothpaste compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were prepared.
Erythritol was added last.
(1)清涼感の評価
被験者10名(男性5名、女性5名)が、歯ブラシに歯磨き組成物1gをとり、約2分間自由にブラッシングし、口をすすいだ後のサッパリ感の強さを次の基準で評価した。なお、各表に示す判定の結果は10名中最も評価が多かったものを示した。
<清涼感の評価基準>
◎:口の中のサッパリ感が強い
○:口の中のサッパリ感がやや強い
×:口の中のサッパリ感が弱い
(1) Evaluation of refreshing feeling Ten subjects (5 males and 5 females) took 1 g of a toothpaste composition on a toothbrush, brushed freely for about 2 minutes, and refreshed after the mouth was rinsed. Evaluation was made according to the following criteria. In addition, the result of the determination shown in each table shows the highest evaluation among 10 people.
<Evaluation criteria for coolness>
◎: Strong feeling in mouth ○: Refreshing feeling in mouth is slightly strong ×: Feeling in mouth is weak
(2)保存安定性の評価
表1に示す歯磨き組成物を、保存用の歯磨きチューブに詰め、5℃、室温、40℃で3ヶ月間保存した。その後、チューブを切り開いて、歯磨き組成物から液体成分が分離しているか否か次の基準で評価した。
<保存安定性の評価基準>
◎:液体の分離が全く見られない
○:液体の分離がわずかに見られる
×:明らかに液体の分離が見られる
(2) Evaluation of storage stability The toothpaste composition shown in Table 1 was packed in a toothpaste tube for storage and stored at 5 ° C, room temperature, and 40 ° C for 3 months. Thereafter, the tube was opened and whether or not the liquid component was separated from the toothpaste composition was evaluated according to the following criteria.
<Evaluation criteria for storage stability>
◎: No liquid separation is observed ○: Liquid separation is slightly observed ×: Liquid separation is clearly observed
(3)冷涼感の即効性の評価
被験者10名(男性5名、女性5名)が、歯ブラシに歯磨き組成物1gをとり、約2分間自由にブラッシングし、比較例1の歯磨き組成物を基準として、冷涼感を次の基準で評価した。
<冷涼感の即効性の評価基準>
◎:基準歯磨き組成物よりも明らかに冷涼感の即効性がある
○:基準歯磨き組成物よりもやや冷涼感の即効性がある
×:基準歯磨き組成物と同等又は同等以下の冷涼感の即効性である
(3) Immediate evaluation of cool feeling Ten subjects (5 men, 5 women) took 1 g of a toothbrushing composition on a toothbrush, brushed freely for about 2 minutes, and used the toothpaste composition of Comparative Example 1 as a reference. The coolness was evaluated according to the following criteria.
<Evaluation criteria for immediate effect of coolness>
◎: Cooling feeling is more immediate than standard toothpaste composition ○: Cooling feeling is more immediate than standard toothpaste composition ×: Cooling feeling is equal to or less than that of standard toothpaste composition Is
表1に示したように、実施例1〜3の歯磨き組成物では、粒子径が45μm未満のエリスリトールを多く含んでいるため、冷涼感の即効性に優れるという結果だった。さらに、実施例2及び3の歯磨き組成物では、粒子径が45μm未満のエリスリトールをより多く含有しているため、冷涼感の即効性にさらに優れるという結果だった。また、水分を15〜30質量%及び粘結剤を0.6〜3質量%含むため長期の保存安定性にも優れていた。 As shown in Table 1, the toothpaste compositions of Examples 1 to 3 contained a large amount of erythritol having a particle size of less than 45 μm, and thus were excellent in immediate effect of cooling feeling. Furthermore, since the toothpaste compositions of Examples 2 and 3 contained more erythritol having a particle size of less than 45 μm, the results showed that the immediate effect of cooling feeling was further improved. Moreover, since it contained 15-30 mass% of moisture and 0.6-3 mass% of binder, it was excellent in long-term storage stability.
一方、比較例1の歯磨き組成物では、粒子径が45μm以上355μm未満のエリスリトールを多く含んでいるが、粒子径が45μm未満のエリスリトールをあまり含まないため、冷涼感の即効性は、実施例1〜3に比べて劣るという結果だった。また、比較例3の歯磨き組成物では、粒子径が355μm以上1000μm未満のエリスリトールを多く含んでいるが、粒子径が355μm未満のエリスリトールをあまり含まないため、冷涼感を感じないという結果だった。さらに、比較例2及び3の歯磨き組成物では、水分量が少なく、また粘結剤の含有量も少ないため保存安定性が悪いという結果だった。 On the other hand, the toothpaste composition of Comparative Example 1 contains a large amount of erythritol having a particle size of 45 μm or more and less than 355 μm, but does not contain much erythritol having a particle size of less than 45 μm. The result was inferior to ~ 3. In addition, the toothpaste composition of Comparative Example 3 contained a large amount of erythritol having a particle size of 355 μm or more and less than 1000 μm. However, since it did not contain much erythritol having a particle size of less than 355 μm, the cooling feeling was not felt. Furthermore, in the toothpaste compositions of Comparative Examples 2 and 3, the storage stability was poor because the moisture content was small and the binder content was also small.
Claims (3)
(A)粒子径が45μm未満のエリスリトール 15〜60質量%
(B)水 15〜30質量%
(C)粘結剤 0.6〜3質量%
を含有する歯磨き組成物。 The following components (A), (B) and (C):
(A) Erythritol having a particle size of less than 45 μm 15 to 60% by mass
(B) Water 15-30% by mass
(C) Binder 0.6-3 mass%
A toothpaste composition comprising:
(A)粒子径が45μm未満のエリスリトール 20〜60質量%
(B)水 15〜30質量%
(C)粘結剤 0.6〜3質量%
を配合する歯磨き組成物。 The following components (A), (B) and (C):
(A) Erythritol having a particle diameter of less than 45 μm 20 to 60% by mass
(B) Water 15-30% by mass
(C) Binder 0.6-3 mass%
A toothpaste composition.
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JP2007070261A (en) * | 2005-09-05 | 2007-03-22 | Kao Corp | Dentifrice composition |
JP2008013528A (en) * | 2006-07-10 | 2008-01-24 | Kao Corp | Dentifrice composition |
JP2009023953A (en) * | 2007-07-20 | 2009-02-05 | Kao Corp | Toothpaste composition |
JP2014111674A (en) * | 2014-03-24 | 2014-06-19 | Kao Corp | Dentifrice composition |
US8961938B2 (en) | 2005-09-05 | 2015-02-24 | Kao Corporation | Dentifrice composition |
JP2016023284A (en) * | 2014-07-24 | 2016-02-08 | 長谷川香料株式会社 | Ws-12 fine particle and cool-feeling agent composition containing the same |
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JP2000191483A (en) * | 1998-12-28 | 2000-07-11 | Kao Corp | Dentifrice composition |
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JPH10306048A (en) * | 1997-05-08 | 1998-11-17 | Mitsubishi Chem Corp | Erythritol crystal and its production |
JP2000191483A (en) * | 1998-12-28 | 2000-07-11 | Kao Corp | Dentifrice composition |
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JP2007070261A (en) * | 2005-09-05 | 2007-03-22 | Kao Corp | Dentifrice composition |
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JP2008013528A (en) * | 2006-07-10 | 2008-01-24 | Kao Corp | Dentifrice composition |
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JP2014111674A (en) * | 2014-03-24 | 2014-06-19 | Kao Corp | Dentifrice composition |
JP2016023284A (en) * | 2014-07-24 | 2016-02-08 | 長谷川香料株式会社 | Ws-12 fine particle and cool-feeling agent composition containing the same |
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