JP2005519115A - プロスタミドの製造 - Google Patents
プロスタミドの製造 Download PDFInfo
- Publication number
- JP2005519115A JP2005519115A JP2003572951A JP2003572951A JP2005519115A JP 2005519115 A JP2005519115 A JP 2005519115A JP 2003572951 A JP2003572951 A JP 2003572951A JP 2003572951 A JP2003572951 A JP 2003572951A JP 2005519115 A JP2005519115 A JP 2005519115A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- prostamide
- represented
- produce
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 title claims abstract description 13
- 229960002470 bimatoprost Drugs 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000006243 chemical reaction Methods 0.000 claims abstract description 11
- 125000006239 protecting group Chemical group 0.000 claims abstract description 8
- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 6
- 239000001257 hydrogen Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 4
- 150000001450 anions Chemical class 0.000 claims abstract description 4
- 239000003223 protective agent Substances 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 4
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract 2
- FFFUNXYUTXNQIV-OIBRLDRASA-N C[C@@H](C[C@H](CCc1ccccc1)N=O)[C@H](C1[C@H](C2)OOC1)[C@@H]2N=O Chemical compound C[C@@H](C[C@H](CCc1ccccc1)N=O)[C@H](C1[C@H](C2)OOC1)[C@@H]2N=O FFFUNXYUTXNQIV-OIBRLDRASA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- CDHICTNQMQYRSM-UHFFFAOYSA-N di(propan-2-yl)alumane Chemical compound CC(C)[AlH]C(C)C CDHICTNQMQYRSM-UHFFFAOYSA-N 0.000 description 1
- 230000004406 elevated intraocular pressure Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 125000000686 lactone group Chemical group 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(a)式I:
【化1】
(I)
[式中、Zは保護基であり、破線は二重結合の存在または不存在を表す。]
で示される第1中間体とDIBALとの反応により、式II:
【化2】
(II)
で示される第2中間体を生成し、
(b)前記第2中間体と、Na(TMS)2Nおよび(C6H5)3P+(CH2)6CONR2X−[式中、RはC1−5アルキルまたは水素であり、X−はアニオンである。]との反応により、式IIIで示される第3中間体を生成し、
(c)前記第3中間体と保護剤との反応により、式IVで示される第4中間体を生成し、
(d)前記保護基を除去する前記第4中間体の反応により、式Vで示されるプロスタミドを生成する。
Description
Gandolfiらの米国特許第4195183号を参照されたい。
PCT特許WO01/55101A2を参照されたい。
(a)式I:
で示される第1中間体とDIBALとの反応により、式II:
(a)式I:
で示される第1中間体とDIBALとの反応により、式II:
より好ましくは、ZがTMSである。
より好ましくは、工程(d)が、前記第4中間体をDMSOおよび水性LiClと順次反応させることを含んで成る。
TMSはトリメチルシリルである。
Claims (4)
- 下記工程を含んで成るプロスタミドの製法:
(a)式I:
で示される第1中間体とDIBALとの反応により、式II:
(b)前記第2中間体と、Na(TMS)2Nおよび(C6H5)3P+(CH2)6CONR2X−[式中、RはC1−5アルキルまたは水素であり、X−はアニオンである。]との反応により、式III:
(c)前記第3中間体と保護剤TMSClとの反応により、式IV:
(d)前記保護基を除去する前記第4中間体の反応により、式V:
- 一方のRが水素であり、他方がエチルである請求項1に記載の方法。
- ZがTMSである請求項1に記載の方法。
- 工程(d)が、前記第4中間体をDMSOおよび水性LiClと順次反応させることを含んで成る請求項1に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36084702P | 2002-03-01 | 2002-03-01 | |
PCT/US2003/006071 WO2003074481A2 (en) | 2002-03-01 | 2003-02-28 | Preparation of prostamides |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013006695A Division JP2013082741A (ja) | 2002-03-01 | 2013-01-17 | プロスタミドの製造 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005519115A true JP2005519115A (ja) | 2005-06-30 |
JP2005519115A5 JP2005519115A5 (ja) | 2006-04-13 |
Family
ID=27789035
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003572951A Pending JP2005519115A (ja) | 2002-03-01 | 2003-02-28 | プロスタミドの製造 |
JP2013006695A Pending JP2013082741A (ja) | 2002-03-01 | 2013-01-17 | プロスタミドの製造 |
JP2015022013A Pending JP2015129146A (ja) | 2002-03-01 | 2015-02-06 | プロスタミドの製造 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013006695A Pending JP2013082741A (ja) | 2002-03-01 | 2013-01-17 | プロスタミドの製造 |
JP2015022013A Pending JP2015129146A (ja) | 2002-03-01 | 2015-02-06 | プロスタミドの製造 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1480949B1 (ja) |
JP (3) | JP2005519115A (ja) |
CN (1) | CN1639117A (ja) |
AU (1) | AU2003213610B2 (ja) |
CA (1) | CA2477080C (ja) |
HK (1) | HK1080448A1 (ja) |
HU (1) | HUE025127T2 (ja) |
SI (1) | SI1480949T1 (ja) |
WO (1) | WO2003074481A2 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
EP2135860A1 (en) | 2008-06-20 | 2009-12-23 | Sandoz AG | Improved process for the production of bimatoprost |
CN102757459B (zh) * | 2011-04-29 | 2016-01-27 | 上海源力生物技术有限公司 | 用于合成***素类药物的中间体及其制备方法 |
KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
CN111018766B (zh) * | 2018-10-10 | 2022-04-19 | 广州楷石医药有限公司 | 贝美前列素的合成方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52148044A (en) * | 1976-06-01 | 1977-12-08 | Erba Carlo Spa | Omegaanorraromaticc13*144dehydrooprostaglandin* process for manufacture thereof and pharmacological or veterinary compositions containing said prostaglandin |
JPS545954A (en) * | 1977-06-13 | 1979-01-17 | Pfizer | 155substituteddomegaa pentanoylprostaglandin derivative |
JPS6072859A (ja) * | 1983-09-07 | 1985-04-24 | フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ | 16−フルオロ−16,17−ジデヒドロプロスタノイドおよびそれらの製造法 |
JPH11255740A (ja) * | 1998-03-13 | 1999-09-21 | Asahi Glass Co Ltd | 15−デオキシ−15−モノフルオロ−プロスタグランジン誘導体 |
WO2001055101A2 (en) * | 2000-01-27 | 2001-08-02 | Finetech Laboratories Ltd. | A new process for the preparation of latanoprost |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL143477A (en) * | 2001-05-31 | 2009-07-20 | Finetech Pharmaceutical Ltd | Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives |
US6395787B1 (en) * | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
-
2003
- 2003-02-28 JP JP2003572951A patent/JP2005519115A/ja active Pending
- 2003-02-28 SI SI200332441T patent/SI1480949T1/sl unknown
- 2003-02-28 EP EP20030711292 patent/EP1480949B1/en not_active Expired - Lifetime
- 2003-02-28 WO PCT/US2003/006071 patent/WO2003074481A2/en active Application Filing
- 2003-02-28 HU HUE03711292A patent/HUE025127T2/en unknown
- 2003-02-28 AU AU2003213610A patent/AU2003213610B2/en not_active Ceased
- 2003-02-28 CN CNA038046393A patent/CN1639117A/zh active Pending
- 2003-02-28 CA CA2477080A patent/CA2477080C/en not_active Expired - Lifetime
-
2006
- 2006-01-05 HK HK06100211.7A patent/HK1080448A1/zh unknown
-
2013
- 2013-01-17 JP JP2013006695A patent/JP2013082741A/ja active Pending
-
2015
- 2015-02-06 JP JP2015022013A patent/JP2015129146A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52148044A (en) * | 1976-06-01 | 1977-12-08 | Erba Carlo Spa | Omegaanorraromaticc13*144dehydrooprostaglandin* process for manufacture thereof and pharmacological or veterinary compositions containing said prostaglandin |
JPS545954A (en) * | 1977-06-13 | 1979-01-17 | Pfizer | 155substituteddomegaa pentanoylprostaglandin derivative |
JPS6072859A (ja) * | 1983-09-07 | 1985-04-24 | フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ | 16−フルオロ−16,17−ジデヒドロプロスタノイドおよびそれらの製造法 |
JPH11255740A (ja) * | 1998-03-13 | 1999-09-21 | Asahi Glass Co Ltd | 15−デオキシ−15−モノフルオロ−プロスタグランジン誘導体 |
WO2001055101A2 (en) * | 2000-01-27 | 2001-08-02 | Finetech Laboratories Ltd. | A new process for the preparation of latanoprost |
Also Published As
Publication number | Publication date |
---|---|
CN1639117A (zh) | 2005-07-13 |
SI1480949T1 (sl) | 2015-09-30 |
CA2477080A1 (en) | 2003-09-12 |
WO2003074481A2 (en) | 2003-09-12 |
HK1080448A1 (zh) | 2006-04-28 |
JP2015129146A (ja) | 2015-07-16 |
HUE025127T2 (en) | 2016-01-28 |
CA2477080C (en) | 2010-09-28 |
EP1480949B1 (en) | 2015-04-29 |
AU2003213610B2 (en) | 2008-04-03 |
EP1480949A2 (en) | 2004-12-01 |
AU2003213610A1 (en) | 2003-09-16 |
WO2003074481A3 (en) | 2004-06-03 |
WO2003074481A8 (en) | 2004-10-21 |
JP2013082741A (ja) | 2013-05-09 |
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